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The map label for this gene is wecC [H]

Identifier: 29143698

GI number: 29143698

Start: 3475608

End: 3476870

Strand: Reverse

Name: wecC [H]

Synonym: t3376

Alternate gene names: 29143698

Gene position: 3476870-3475608 (Counterclockwise)

Preceding gene: 29143699

Following gene: 29143697

Centisome position: 72.56

GC content: 57.24

Gene sequence:

>1263_bases
ATGAGTTTTACGACCATTTCTGTTATTGGGCTGGGGTATATCGGATTACCGACTGCGGCCGCTTTTGCTTCCCGCCAGAA
GCAGGTTATCGGCGTGGATATCAACCAACATGCTGTAGACACCATAAATCGCGGTGAAATTCACATCGTGGAGCCGGCGT
TGGGCAATGTGGTGAAGATGGCGGTGGAAGGCGGCTTTCTGCGTGCGACGACGACACCTGTCGAGGCCGATGCGTACCTG
ATTGCCGTGCCGACGCCATTCAAAGGCGATCACGACCCTGACATGGCCTATGTGGAAGCCGCGGCGAAATCCATTGCGCC
GGTATTAAAAAAAGGGGCACTGGTGATTCTGGAATCAACATCGCCGGTCGGCGCAACGGAGCAAATGGCTGGCTGGCTGG
CCGGGATGCGCCCGGATCTGACCTTTCCCCAGCAGGCGGGCGAGCAGGCCGACGTGAATATCGCCTATTGTCCGGAGCGT
GTGCTGCCGGGTCAGGTGATGGTGGAACTCATTAAAAATGACCGCGTGATTGGCGGTATGACGCCAGTATGTTCGGCTCG
CGCCAGCGCGCTGTACAAAATTTTCCTTGAGGGCGAATGCGTTGTCACCAACTCGCGCACCGCAGAGATGTGCAAGCTGA
CGGAAAATAGCTTCCGTGATGTGAATATCGCCTTTGCGAATGAATTGTCGCTGATTTGCGCCGAACAGGGGATTAACGTC
TGGGAATTGATCCGCCTGGCGAACCGCCATCCGCGCGTCAATATTTTGCAGCCGGGCCCAGGCGTTGGCGGGCACTGCAT
TGCGGTCGATCCGTGGTTTATTGTGGCGCAAAATCCGCAGCAGGCGAGACTGATTCGCACCGCGCGTGAAGTGAATGACG
GCAAACCGCACTGGGTGGTCGATCAGGTAAAAGCCGCGGTCGCAGATTGCCTGGCAGCCACCGATAAACGCGCCAGCGAA
GTGAAAATCGCCTGTTTTGGGCTGGCCTTTAAGCCGAATATCGACGATCTGCGCGAAAGCCCGGCGATGGGGATCGCGCA
AAGTATCGCCCGCTGGCACAGCGGCGAAACCCTGGTCGTCGAACCGAATATCCGTCAGTTGCCGAAAAAATTGGACGGAC
TTTGCACGCTGGCGAAACTGGACGCGGCGCTGGCCGCCGCCGATGTGCTGGTGATGCTGGTCGATCACGACGAATTTAAA
GCGATTCCCGGCGATGCGGTTCATCAACGTTATGTGGTTGATACCAAAGGGGTCTGGCGCTGA

Upstream 100 bases:

>100_bases
AAAATGAATATCAAACCATGAGCCGCGCCCATAATCCTTATGGTGACGGGCAATCATGCGCGCGCATTTTACAGGCGTTA
AAAAGTTATCGGGTATCGTT

Downstream 100 bases:

>100_bases
TGAAACGCATTCTGGTGACCGGCGGCGCAGGCTTTATCGGATCTGCGGTGGTGCGGCATATCATCCATGAAACGGCAGAC
GCGGTGGTGGTGGTGGATAA

Product: UDP-N-acetyl-D-mannosamine dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: UDP-ManNAc 6-dehydrogenase [H]

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MSFTTISVIGLGYIGLPTAAAFASRQKQVIGVDINQHAVDTINRGEIHIVEPALGNVVKMAVEGGFLRATTTPVEADAYL
IAVPTPFKGDHDPDMAYVEAAAKSIAPVLKKGALVILESTSPVGATEQMAGWLAGMRPDLTFPQQAGEQADVNIAYCPER
VLPGQVMVELIKNDRVIGGMTPVCSARASALYKIFLEGECVVTNSRTAEMCKLTENSFRDVNIAFANELSLICAEQGINV
WELIRLANRHPRVNILQPGPGVGGHCIAVDPWFIVAQNPQQARLIRTAREVNDGKPHWVVDQVKAAVADCLAATDKRASE
VKIACFGLAFKPNIDDLRESPAMGIAQSIARWHSGETLVVEPNIRQLPKKLDGLCTLAKLDAALAAADVLVMLVDHDEFK
AIPGDAVHQRYVVDTKGVWR

Sequences:

>Translated_420_residues
MSFTTISVIGLGYIGLPTAAAFASRQKQVIGVDINQHAVDTINRGEIHIVEPALGNVVKMAVEGGFLRATTTPVEADAYL
IAVPTPFKGDHDPDMAYVEAAAKSIAPVLKKGALVILESTSPVGATEQMAGWLAGMRPDLTFPQQAGEQADVNIAYCPER
VLPGQVMVELIKNDRVIGGMTPVCSARASALYKIFLEGECVVTNSRTAEMCKLTENSFRDVNIAFANELSLICAEQGINV
WELIRLANRHPRVNILQPGPGVGGHCIAVDPWFIVAQNPQQARLIRTAREVNDGKPHWVVDQVKAAVADCLAATDKRASE
VKIACFGLAFKPNIDDLRESPAMGIAQSIARWHSGETLVVEPNIRQLPKKLDGLCTLAKLDAALAAADVLVMLVDHDEFK
AIPGDAVHQRYVVDTKGVWR
>Mature_419_residues
SFTTISVIGLGYIGLPTAAAFASRQKQVIGVDINQHAVDTINRGEIHIVEPALGNVVKMAVEGGFLRATTTPVEADAYLI
AVPTPFKGDHDPDMAYVEAAAKSIAPVLKKGALVILESTSPVGATEQMAGWLAGMRPDLTFPQQAGEQADVNIAYCPERV
LPGQVMVELIKNDRVIGGMTPVCSARASALYKIFLEGECVVTNSRTAEMCKLTENSFRDVNIAFANELSLICAEQGINVW
ELIRLANRHPRVNILQPGPGVGGHCIAVDPWFIVAQNPQQARLIRTAREVNDGKPHWVVDQVKAAVADCLAATDKRASEV
KIACFGLAFKPNIDDLRESPAMGIAQSIARWHSGETLVVEPNIRQLPKKLDGLCTLAKLDAALAAADVLVMLVDHDEFKA
IPGDAVHQRYVVDTKGVWR

Specific function: Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA) [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=443, Percent_Identity=27.0880361173815, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI296040438, Length=345, Percent_Identity=26.3768115942029, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI48994968, Length=420, Percent_Identity=90.9523809523809, Blast_Score=789, Evalue=0.0,
Organism=Escherichia coli, GI1788340, Length=430, Percent_Identity=23.7209302325581, Blast_Score=75, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17560350, Length=442, Percent_Identity=27.1493212669683, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI17136908, Length=458, Percent_Identity=25.764192139738, Blast_Score=112, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 45294; Mature: 45163

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFTTISVIGLGYIGLPTAAAFASRQKQVIGVDINQHAVDTINRGEIHIVEPALGNVVKM
CCEEEEEEEECCCCCCHHHHHHHHCCCEEEEEECCCHHHCCCCCCEEEEECCCCCHHHHH
AVEGGFLRATTTPVEADAYLIAVPTPFKGDHDPDMAYVEAAAKSIAPVLKKGALVILEST
HHCCCEEEEECCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECC
SPVGATEQMAGWLAGMRPDLTFPQQAGEQADVNIAYCPERVLPGQVMVELIKNDRVIGGM
CCCCCHHHHHHHHHCCCCCCCCHHHCCCCCCCEEEECCCCCCCHHHHHHHHHCCCEECCC
TPVCSARASALYKIFLEGECVVTNSRTAEMCKLTENSFRDVNIAFANELSLICAEQGINV
CCHHHHHHHEEEEEEECCEEEEECCCCHHHHHHHCCCCCEEEEEEECCEEEEEHHCCCCH
WELIRLANRHPRVNILQPGPGVGGHCIAVDPWFIVAQNPQQARLIRTAREVNDGKPHWVV
HHHHHHHCCCCEEEEECCCCCCCCEEEEECCEEEEECCCHHHHHHHHHHHCCCCCCCCHH
DQVKAAVADCLAATDKRASEVKIACFGLAFKPNIDDLRESPAMGIAQSIARWHSGETLVV
HHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCHHHHHCCCHHHHHHHHHHHCCCCEEEE
EPNIRQLPKKLDGLCTLAKLDAALAAADVLVMLVDHDEFKAIPGDAVHQRYVVDTKGVWR
CCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCHHCCCCCHHHHCEEEECCCCCCC
>Mature Secondary Structure 
SFTTISVIGLGYIGLPTAAAFASRQKQVIGVDINQHAVDTINRGEIHIVEPALGNVVKM
CEEEEEEEECCCCCCHHHHHHHHCCCEEEEEECCCHHHCCCCCCEEEEECCCCCHHHHH
AVEGGFLRATTTPVEADAYLIAVPTPFKGDHDPDMAYVEAAAKSIAPVLKKGALVILEST
HHCCCEEEEECCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECC
SPVGATEQMAGWLAGMRPDLTFPQQAGEQADVNIAYCPERVLPGQVMVELIKNDRVIGGM
CCCCCHHHHHHHHHCCCCCCCCHHHCCCCCCCEEEECCCCCCCHHHHHHHHHCCCEECCC
TPVCSARASALYKIFLEGECVVTNSRTAEMCKLTENSFRDVNIAFANELSLICAEQGINV
CCHHHHHHHEEEEEEECCEEEEECCCCHHHHHHHCCCCCEEEEEEECCEEEEEHHCCCCH
WELIRLANRHPRVNILQPGPGVGGHCIAVDPWFIVAQNPQQARLIRTAREVNDGKPHWVV
HHHHHHHCCCCEEEEECCCCCCCCEEEEECCEEEEECCCHHHHHHHHHHHCCCCCCCCHH
DQVKAAVADCLAATDKRASEVKIACFGLAFKPNIDDLRESPAMGIAQSIARWHSGETLVV
HHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCHHHHHCCCHHHHHHHHHHHCCCCEEEE
EPNIRQLPKKLDGLCTLAKLDAALAAADVLVMLVDHDEFKAIPGDAVHQRYVVDTKGVWR
CCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCHHCCCCCHHHHCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]