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The map label for this gene is lysR [H]

Identifier: 29143276

GI number: 29143276

Start: 3016926

End: 3017861

Strand: Direct

Name: lysR [H]

Synonym: t2924

Alternate gene names: 29143276

Gene position: 3016926-3017861 (Clockwise)

Preceding gene: 29143274

Following gene: 29143283

Centisome position: 62.96

GC content: 58.65

Gene sequence:

>936_bases
ATGGCTGCCGTTAATTTACGTCACATTGAAATTTTTCATGCCGTAATGACCGCCGGAAATCTCACCGAAGCGGCGCGGCT
GCTGCATACCTCGCAGCCTACCGTCAGTCGCGAGCTGGCGCGTTTTGAGAAAGTGCTGGGATTAACGCTGTTTGAGCGCA
CACGCGGGCGCTTACATCCGACGGTGCAAGGGCTACGCCTGTTCGAAGAGGTACAACGCTCCTGGTATGGGTTGGATCGC
ATCGTCAGCGCGGCGGAAAGTCTGCGCGAGTTCCGTCAGGGCGAACTCTCTATCGCCTGCCTGCCGGTCTTTTCACAATC
CTTTTTGCCGCCGCTACTACCGCCTTTTTTGGCGCGTTATCCGGATGTCAGCCTGAATATTGTGCCGCAGGAGTCGCCGT
TGCTGGAAGAGTGGCTCTCCGCTCAGCGCCACGACTTAGGGCTGACGGAGACGCTTCATGCCCCGGCAGGAACAACCCGC
ACCGAGTTACTAACGCTGAATGAAGTGTGCGTACTGCCCTGCGACCATCCGCTTGCCGCCAAAACGGTACTGACGCCAGA
CGATTTTCAGGGGGAAAACTTTATCAGCCTCTCCCGCCTGGACAGCTATCGACAGTTGTTGGATACGTTATTTGCCGAAC
ATCAGGTGAAGCGCAGAATGGTGGTGGAAACGCATAGCGCGGCCTCCGTCTGCGCGATGGTGCGCGCCGGGGCGGGCGTT
TCGATCGTTAACCCGCTGACCGCGCTGGACTATGCCGCCAGCGGCGTCACCGTCCGCCGCTTCAGCATTGACGTGCCCTT
TACCGTCAGCCTGATTCGCCCGCTACACCGCCCCGCCTCCGCGCTGGTTGACGCCTTCAGTAAGCATTTACAAACGCATC
TTTCGCGCCTGGTCGAACCGCTGGAGGTTATTCTGGGGCCGATGACGAAAGCATAA

Upstream 100 bases:

>100_bases
GCTTTTTAACGATTACGCCATACCTTAGAAAGAATAAAAAATATCGTTTTATTGTCAGTCTATGCAAAAATGATATGGGA
TAAATGATTCAGGGAAACGT

Downstream 100 bases:

>100_bases
AGCTCACGGCATCTGCGGCATGAATTGCCGTGGTATCGAAAACCGGTAGCGCGCTTTGCGTCTGGGGAACAAGCAAACCT
ATTTCAGTACAGCCAAAAAT

Product: DNA-binding transcriptional regulator LysR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MAAVNLRHIEIFHAVMTAGNLTEAARLLHTSQPTVSRELARFEKVLGLTLFERTRGRLHPTVQGLRLFEEVQRSWYGLDR
IVSAAESLREFRQGELSIACLPVFSQSFLPPLLPPFLARYPDVSLNIVPQESPLLEEWLSAQRHDLGLTETLHAPAGTTR
TELLTLNEVCVLPCDHPLAAKTVLTPDDFQGENFISLSRLDSYRQLLDTLFAEHQVKRRMVVETHSAASVCAMVRAGAGV
SIVNPLTALDYAASGVTVRRFSIDVPFTVSLIRPLHRPASALVDAFSKHLQTHLSRLVEPLEVILGPMTKA

Sequences:

>Translated_311_residues
MAAVNLRHIEIFHAVMTAGNLTEAARLLHTSQPTVSRELARFEKVLGLTLFERTRGRLHPTVQGLRLFEEVQRSWYGLDR
IVSAAESLREFRQGELSIACLPVFSQSFLPPLLPPFLARYPDVSLNIVPQESPLLEEWLSAQRHDLGLTETLHAPAGTTR
TELLTLNEVCVLPCDHPLAAKTVLTPDDFQGENFISLSRLDSYRQLLDTLFAEHQVKRRMVVETHSAASVCAMVRAGAGV
SIVNPLTALDYAASGVTVRRFSIDVPFTVSLIRPLHRPASALVDAFSKHLQTHLSRLVEPLEVILGPMTKA
>Mature_310_residues
AAVNLRHIEIFHAVMTAGNLTEAARLLHTSQPTVSRELARFEKVLGLTLFERTRGRLHPTVQGLRLFEEVQRSWYGLDRI
VSAAESLREFRQGELSIACLPVFSQSFLPPLLPPFLARYPDVSLNIVPQESPLLEEWLSAQRHDLGLTETLHAPAGTTRT
ELLTLNEVCVLPCDHPLAAKTVLTPDDFQGENFISLSRLDSYRQLLDTLFAEHQVKRRMVVETHSAASVCAMVRAGAGVS
IVNPLTALDYAASGVTVRRFSIDVPFTVSLIRPLHRPASALVDAFSKHLQTHLSRLVEPLEVILGPMTKA

Specific function: This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789204, Length=311, Percent_Identity=86.8167202572347, Blast_Score=545, Evalue=1e-156,
Organism=Escherichia coli, GI157672245, Length=232, Percent_Identity=28.8793103448276, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI145693105, Length=238, Percent_Identity=26.0504201680672, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788887, Length=275, Percent_Identity=28.3636363636364, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1787530, Length=248, Percent_Identity=27.0161290322581, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1790262, Length=211, Percent_Identity=29.3838862559242, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1788297, Length=250, Percent_Identity=24, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788481, Length=298, Percent_Identity=24.8322147651007, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1787879, Length=251, Percent_Identity=27.0916334661355, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790208, Length=306, Percent_Identity=26.797385620915, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1786401, Length=129, Percent_Identity=35.6589147286822, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34534; Mature: 34403

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAVNLRHIEIFHAVMTAGNLTEAARLLHTSQPTVSRELARFEKVLGLTLFERTRGRLHP
CCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCH
TVQGLRLFEEVQRSWYGLDRIVSAAESLREFRQGELSIACLPVFSQSFLPPLLPPFLARY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHCCCCCCCHHHHHC
PDVSLNIVPQESPLLEEWLSAQRHDLGLTETLHAPAGTTRTELLTLNEVCVLPCDHPLAA
CCCEEEEECCCCHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHEEEECCEEEEECCCCCCC
KTVLTPDDFQGENFISLSRLDSYRQLLDTLFAEHQVKRRMVVETHSAASVCAMVRAGAGV
CEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SIVNPLTALDYAASGVTVRRFSIDVPFTVSLIRPLHRPASALVDAFSKHLQTHLSRLVEP
CHHHHHHHHHHHHCCEEEEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
LEVILGPMTKA
HHHHHCCCCCC
>Mature Secondary Structure 
AAVNLRHIEIFHAVMTAGNLTEAARLLHTSQPTVSRELARFEKVLGLTLFERTRGRLHP
CCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCH
TVQGLRLFEEVQRSWYGLDRIVSAAESLREFRQGELSIACLPVFSQSFLPPLLPPFLARY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHCCCCCCCHHHHHC
PDVSLNIVPQESPLLEEWLSAQRHDLGLTETLHAPAGTTRTELLTLNEVCVLPCDHPLAA
CCCEEEEECCCCHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHEEEECCEEEEECCCCCCC
KTVLTPDDFQGENFISLSRLDSYRQLLDTLFAEHQVKRRMVVETHSAASVCAMVRAGAGV
CEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SIVNPLTALDYAASGVTVRRFSIDVPFTVSLIRPLHRPASALVDAFSKHLQTHLSRLVEP
CHHHHHHHHHHHHCCEEEEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
LEVILGPMTKA
HHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350602; 9278503; 2836407 [H]