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The map label for this gene is lysA [H]

Identifier: 29143275

GI number: 29143275

Start: 3015546

End: 3016808

Strand: Reverse

Name: lysA [H]

Synonym: t2923

Alternate gene names: 29143275

Gene position: 3016808-3015546 (Counterclockwise)

Preceding gene: 29143277

Following gene: 29143272

Centisome position: 62.96

GC content: 57.24

Gene sequence:

>1263_bases
ATGTCATTGCCGCATTATCACGCTGAAACTGACCTTAACGCTGAAAATTTGCTCAGATTGCCTGCTGAATTCGGCTGTCC
GGTCTGGGTCTATGACGCGCACATTATTCGCCGTCAGATAGCCGCCCTGCAGCAGTTTGACGTCGTGCGTTTTGCGCAAA
AAGCCTGTTCGAACATTCATATCCTGCGCTTAATGCGCGCGCAGGGTGTCAAGGTGGATTCTGTTTCATTGGGGGAGATC
GAACGTGCGCTGGCGGCGGGCTACGATCCGCAAACGTGCCCTGATGATATCGTTTTTACCGCCGATGTGATTGACGCCGC
CACGCTGGCGCGCGTCAGTGAACTGCATATTCCGGTCAATGCCGGCTCGGTAGATATGCTGACGCAGCTTGGTCAGGTTT
CGCCTGGGCATCGCGTCTGGTTGCGCGTGAATCCTGGCTTTGGTCACGGCCACAGCCAGAAAACCAACACCGGGGGCGAA
AACAGCAAACACGGCATCTGGCATAGCGATCTTCCGGCGGCGCTGGCGGTAATGCAGAAATACCGACTGAAACTTGTCGG
TATCCATATGCACATTGGTTCCGGCGTCGATTATGGCCATCTGGAGCAGGTTTGCGGCGCGATGGTACGCCAGGTGCTGG
AATGTGGTCAGGATGTGGAGGCGATTTCGGCAGGCGGCGGACTCTCGATACCTTATCATGAGGGAGAAGAGCCCGTTGAT
ACGCGCCATTACTATGGTCTGTGGAACGCGGCGCGCGAGCAAATCGCCCGCCATCTGGGACATGCGGTCAAACTTGAGAT
CGAACCCGGACGTTATCTGGTGGCGCAATCGGGCGTGCTGGTAACGCAGGTGCGTAGCGTAAAACAGATGGGAAGCCGCC
ATTTCGTGCTGGTCGACGCTGGTTTTAACGATCTGATGCGCCCGGCGATGTACGGTAGCTATCACCGTATTTCGGCGCTG
GCGGCGGATGGTCGCGCGCTTGAAAATGGCCCGTGGGTCGAGACGGTGGTCGCCGGGCCGCTATGCGAATCAGGCGATGT
TTTTACGCAGCAGGAAGGGGGAATGGTTGAAACACGCGCCTTACCTGCGGTCATCCCCGGCGATTACCTCGTATTGCACG
ATACCGGCGCGTACGGCGCGTCTATGTCATCGAATTACAACAGCCGCCCGCTCCTGCCGGAAGTACTGTTTGACAATGGA
CAGGCGCGGCTGATCCGCCGTCGTCAAACCATTGAAGAGCTGTTAGCGCTGGAGATGCTCTGA

Upstream 100 bases:

>100_bases
TTATCCCATATCATTTTTGCATAGACTGACAATAAAACGATATTTTTTATTCTTTCTAAGGTATGGCGTAATCGTTAAAA
AGCCTGTTCCGGAGTTTGTT

Downstream 100 bases:

>100_bases
AGCGCATCATTAGACCGGACGTTGAAAAAACGGGCCCGCGGCGACGGACTCGCGCAGAATCAGCGTGCCGGTAAAGGGCG
GGATCGGGGCGACCGGCTCG

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MSLPHYHAETDLNAENLLRLPAEFGCPVWVYDAHIIRRQIAALQQFDVVRFAQKACSNIHILRLMRAQGVKVDSVSLGEI
ERALAAGYDPQTCPDDIVFTADVIDAATLARVSELHIPVNAGSVDMLTQLGQVSPGHRVWLRVNPGFGHGHSQKTNTGGE
NSKHGIWHSDLPAALAVMQKYRLKLVGIHMHIGSGVDYGHLEQVCGAMVRQVLECGQDVEAISAGGGLSIPYHEGEEPVD
TRHYYGLWNAAREQIARHLGHAVKLEIEPGRYLVAQSGVLVTQVRSVKQMGSRHFVLVDAGFNDLMRPAMYGSYHRISAL
AADGRALENGPWVETVVAGPLCESGDVFTQQEGGMVETRALPAVIPGDYLVLHDTGAYGASMSSNYNSRPLLPEVLFDNG
QARLIRRRQTIEELLALEML

Sequences:

>Translated_420_residues
MSLPHYHAETDLNAENLLRLPAEFGCPVWVYDAHIIRRQIAALQQFDVVRFAQKACSNIHILRLMRAQGVKVDSVSLGEI
ERALAAGYDPQTCPDDIVFTADVIDAATLARVSELHIPVNAGSVDMLTQLGQVSPGHRVWLRVNPGFGHGHSQKTNTGGE
NSKHGIWHSDLPAALAVMQKYRLKLVGIHMHIGSGVDYGHLEQVCGAMVRQVLECGQDVEAISAGGGLSIPYHEGEEPVD
TRHYYGLWNAAREQIARHLGHAVKLEIEPGRYLVAQSGVLVTQVRSVKQMGSRHFVLVDAGFNDLMRPAMYGSYHRISAL
AADGRALENGPWVETVVAGPLCESGDVFTQQEGGMVETRALPAVIPGDYLVLHDTGAYGASMSSNYNSRPLLPEVLFDNG
QARLIRRRQTIEELLALEML
>Mature_419_residues
SLPHYHAETDLNAENLLRLPAEFGCPVWVYDAHIIRRQIAALQQFDVVRFAQKACSNIHILRLMRAQGVKVDSVSLGEIE
RALAAGYDPQTCPDDIVFTADVIDAATLARVSELHIPVNAGSVDMLTQLGQVSPGHRVWLRVNPGFGHGHSQKTNTGGEN
SKHGIWHSDLPAALAVMQKYRLKLVGIHMHIGSGVDYGHLEQVCGAMVRQVLECGQDVEAISAGGGLSIPYHEGEEPVDT
RHYYGLWNAAREQIARHLGHAVKLEIEPGRYLVAQSGVLVTQVRSVKQMGSRHFVLVDAGFNDLMRPAMYGSYHRISALA
ADGRALENGPWVETVVAGPLCESGDVFTQQEGGMVETRALPAVIPGDYLVLHDTGAYGASMSSNYNSRPLLPEVLFDNGQ
ARLIRRRQTIEELLALEML

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=411, Percent_Identity=88.5644768856448, Blast_Score=749, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 46011; Mature: 45880

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLPHYHAETDLNAENLLRLPAEFGCPVWVYDAHIIRRQIAALQQFDVVRFAQKACSNIH
CCCCCCCCCCCCCHHHHHCCHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
ILRLMRAQGVKVDSVSLGEIERALAAGYDPQTCPDDIVFTADVIDAATLARVSELHIPVN
HHHHHHHCCCEECCCCHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHEEEECC
AGSVDMLTQLGQVSPGHRVWLRVNPGFGHGHSQKTNTGGENSKHGIWHSDLPAALAVMQK
CCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
YRLKLVGIHMHIGSGVDYGHLEQVCGAMVRQVLECGQDVEAISAGGGLSIPYHEGEEPVD
HCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCC
TRHYYGLWNAAREQIARHLGHAVKLEIEPGRYLVAQSGVLVTQVRSVKQMGSRHFVLVDA
CHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEECCCHHHHHHHHHHHCCCEEEEEEC
GFNDLMRPAMYGSYHRISALAADGRALENGPWVETVVAGPLCESGDVFTQQEGGMVETRA
CHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCEEECCCCCEEECCC
LPAVIPGDYLVLHDTGAYGASMSSNYNSRPLLPEVLFDNGQARLIRRRQTIEELLALEML
CCEECCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SLPHYHAETDLNAENLLRLPAEFGCPVWVYDAHIIRRQIAALQQFDVVRFAQKACSNIH
CCCCCCCCCCCCHHHHHCCHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
ILRLMRAQGVKVDSVSLGEIERALAAGYDPQTCPDDIVFTADVIDAATLARVSELHIPVN
HHHHHHHCCCEECCCCHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHEEEECC
AGSVDMLTQLGQVSPGHRVWLRVNPGFGHGHSQKTNTGGENSKHGIWHSDLPAALAVMQK
CCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
YRLKLVGIHMHIGSGVDYGHLEQVCGAMVRQVLECGQDVEAISAGGGLSIPYHEGEEPVD
HCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCC
TRHYYGLWNAAREQIARHLGHAVKLEIEPGRYLVAQSGVLVTQVRSVKQMGSRHFVLVDA
CHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEECCCHHHHHHHHHHHCCCEEEEEEC
GFNDLMRPAMYGSYHRISALAADGRALENGPWVETVVAGPLCESGDVFTQQEGGMVETRA
CHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCEEECCCCCEEECCC
LPAVIPGDYLVLHDTGAYGASMSSNYNSRPLLPEVLFDNGQARLIRRRQTIEELLALEML
CCEECCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6350601; 9278503 [H]