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The map label for this gene is ptxR [H]

Identifier: 29143170

GI number: 29143170

Start: 2890900

End: 2891832

Strand: Direct

Name: ptxR [H]

Synonym: t2813

Alternate gene names: 29143170

Gene position: 2890900-2891832 (Clockwise)

Preceding gene: 29143167

Following gene: 29143175

Centisome position: 60.33

GC content: 55.09

Gene sequence:

>933_bases
TTGACAGTAAAGGAGCTCGCCATGCTCAATTTGCAGCGTATGTCGCTGTTTGTCGCCGTGGTAGATAGCGGCAGCTTCAC
GGCGGCGGCCGCCGCATCGGGCCAAACAAAAGCGGTAGTGAGTTTTAATATTCGGCAGCTTGAAAAAGAGCTTGGCGTAA
CGTTACTGCTACGTTCCACCCGACGACTGACGCTCACAGACGCCGGCGTCCTCTTTTACCAAAAAGGCGTGAATTTACTC
AATGCAGCGAAAAATTTGCAGGATGAAGTGCGTGCCAGCCATAGTGGGCTGGGCGGCGAGTTACGTATTACCACTACGCC
CGAGTTTGGCGAACAGGTGGTCATTCCGGTACTGGCGCAGTTTAGTCAGCGCCATCCCGATCTCCGTATTCGGCATATGT
CCTCATCACATCATGCCGATTTAATTGCCGAGCGCTTTGATGTGGCGATTCGGCTTGGCTCGCTGGCGGACTCCCGCTAT
CGCGCCGCGCTGATATCCCGCTTTACCATTCTGCCGGTCGCCGCGCCGCAGTGGCTCGCCCGCCACCCCGTGTCGTCACT
GGAGTCGTTGGCCCAGGCGGAATGGATTATTCATGAGCGATTACCTACGCCGCTACGGTGGACAGTAACGAATAATCATG
GCCAACACTCACGCCTGGAGATAAGCAAAGCCGGCAAAATTTCTGTCGACAGCGCGCGCTCGCTGATGGCCTTCGCTCTC
GCGGGAAGCGGCGTCGCATTACTGCCGCAATGGTTAGTCAACACCGCACTGGAGGATGGAACGTTAATTCACGTGTTACC
CGACTATCATTTTCCCCGTCAGGGCATTTATGCCGTTTATCCAGACGCCCGCCATGTATCGACAAAAGTACGCGCATTTA
TTGATTTTTTACGTTCGCAATGGGATTGCGGGGAGCACGCCCCATCATTGTAG

Upstream 100 bases:

>100_bases
TGCGATACGTCATTATGCATCCTCCGTCAGAGGCGCTAATGTAGCCGTCCGGAGAAAGCCAGATAAGTCCGCGCTTCAAC
GATATACTGTCAAAATAATT

Downstream 100 bases:

>100_bases
CCAGCCCGGGAGCATTGCGCTCCCGGACGGATAATACCGTCTTAATCCTTAACTACCAGTTTGTCTTTGATCCCCTGCGC
CTGCCAACGCACCCACAGCA

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MTVKELAMLNLQRMSLFVAVVDSGSFTAAAAASGQTKAVVSFNIRQLEKELGVTLLLRSTRRLTLTDAGVLFYQKGVNLL
NAAKNLQDEVRASHSGLGGELRITTTPEFGEQVVIPVLAQFSQRHPDLRIRHMSSSHHADLIAERFDVAIRLGSLADSRY
RAALISRFTILPVAAPQWLARHPVSSLESLAQAEWIIHERLPTPLRWTVTNNHGQHSRLEISKAGKISVDSARSLMAFAL
AGSGVALLPQWLVNTALEDGTLIHVLPDYHFPRQGIYAVYPDARHVSTKVRAFIDFLRSQWDCGEHAPSL

Sequences:

>Translated_310_residues
MTVKELAMLNLQRMSLFVAVVDSGSFTAAAAASGQTKAVVSFNIRQLEKELGVTLLLRSTRRLTLTDAGVLFYQKGVNLL
NAAKNLQDEVRASHSGLGGELRITTTPEFGEQVVIPVLAQFSQRHPDLRIRHMSSSHHADLIAERFDVAIRLGSLADSRY
RAALISRFTILPVAAPQWLARHPVSSLESLAQAEWIIHERLPTPLRWTVTNNHGQHSRLEISKAGKISVDSARSLMAFAL
AGSGVALLPQWLVNTALEDGTLIHVLPDYHFPRQGIYAVYPDARHVSTKVRAFIDFLRSQWDCGEHAPSL
>Mature_309_residues
TVKELAMLNLQRMSLFVAVVDSGSFTAAAAASGQTKAVVSFNIRQLEKELGVTLLLRSTRRLTLTDAGVLFYQKGVNLLN
AAKNLQDEVRASHSGLGGELRITTTPEFGEQVVIPVLAQFSQRHPDLRIRHMSSSHHADLIAERFDVAIRLGSLADSRYR
AALISRFTILPVAAPQWLARHPVSSLESLAQAEWIIHERLPTPLRWTVTNNHGQHSRLEISKAGKISVDSARSLMAFALA
GSGVALLPQWLVNTALEDGTLIHVLPDYHFPRQGIYAVYPDARHVSTKVRAFIDFLRSQWDCGEHAPSL

Specific function: Transcriptional activator of the toxA (exotoxin) and regA genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786401, Length=288, Percent_Identity=31.25, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1789440, Length=286, Percent_Identity=31.4685314685315, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI145693193, Length=294, Percent_Identity=30.6122448979592, Blast_Score=131, Evalue=6e-32,
Organism=Escherichia coli, GI87081978, Length=303, Percent_Identity=31.6831683168317, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1789639, Length=292, Percent_Identity=29.1095890410959, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI1787128, Length=303, Percent_Identity=26.0726072607261, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1787589, Length=292, Percent_Identity=28.7671232876712, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1788706, Length=302, Percent_Identity=24.8344370860927, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1788481, Length=297, Percent_Identity=26.2626262626263, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1786448, Length=325, Percent_Identity=26.7692307692308, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1786713, Length=275, Percent_Identity=25.4545454545455, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1789173, Length=291, Percent_Identity=27.1477663230241, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI157672245, Length=194, Percent_Identity=32.9896907216495, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87082132, Length=270, Percent_Identity=27.7777777777778, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1787601, Length=217, Percent_Identity=24.4239631336406, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87082024, Length=266, Percent_Identity=24.0601503759398, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1787879, Length=247, Percent_Identity=26.7206477732794, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34251; Mature: 34120

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVKELAMLNLQRMSLFVAVVDSGSFTAAAAASGQTKAVVSFNIRQLEKELGVTLLLRST
CCHHHHHHHHHHHHEEEEEEECCCCCEEEECCCCCCEEEEEHHHHHHHHHHCEEEEEECC
RRLTLTDAGVLFYQKGVNLLNAAKNLQDEVRASHSGLGGELRITTTPEFGEQVVIPVLAQ
CEEEEECCCCHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHH
FSQRHPDLRIRHMSSSHHADLIAERFDVAIRLGSLADSRYRAALISRFTILPVAAPQWLA
HHHCCCCEEEEECCCCCHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHEEECCCHHHHH
RHPVSSLESLAQAEWIIHERLPTPLRWTVTNNHGQHSRLEISKAGKISVDSARSLMAFAL
HCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEECCCCCEEHHHHHHHHHHHH
AGSGVALLPQWLVNTALEDGTLIHVLPDYHFPRQGIYAVYPDARHVSTKVRAFIDFLRSQ
CCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHC
WDCGEHAPSL
CCCCCCCCCC
>Mature Secondary Structure 
TVKELAMLNLQRMSLFVAVVDSGSFTAAAAASGQTKAVVSFNIRQLEKELGVTLLLRST
CHHHHHHHHHHHHEEEEEEECCCCCEEEECCCCCCEEEEEHHHHHHHHHHCEEEEEECC
RRLTLTDAGVLFYQKGVNLLNAAKNLQDEVRASHSGLGGELRITTTPEFGEQVVIPVLAQ
CEEEEECCCCHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHH
FSQRHPDLRIRHMSSSHHADLIAERFDVAIRLGSLADSRYRAALISRFTILPVAAPQWLA
HHHCCCCEEEEECCCCCHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHEEECCCHHHHH
RHPVSSLESLAQAEWIIHERLPTPLRWTVTNNHGQHSRLEISKAGKISVDSARSLMAFAL
HCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEECCCCCEEHHHHHHHHHHHH
AGSGVALLPQWLVNTALEDGTLIHVLPDYHFPRQGIYAVYPDARHVSTKVRAFIDFLRSQ
CCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHC
WDCGEHAPSL
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8843437; 10984043 [H]