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The map label for this gene is sipA [H]

Identifier: 29143143

GI number: 29143143

Start: 2862546

End: 2864603

Strand: Reverse

Name: sipA [H]

Synonym: t2784

Alternate gene names: 29143143

Gene position: 2864603-2862546 (Counterclockwise)

Preceding gene: 29143144

Following gene: 29143142

Centisome position: 59.78

GC content: 47.86

Gene sequence:

>2058_bases
ATGGTTACAAGTGTAAGAACTCAGCCCCCCGTCATAATGCCAGGTATGCAGACCGAGATCAAAACGCAGGCCACGAATCT
TGCGGCGAATCTTTCCGCGGTCAGAGAAAGTGCCACAGCAACGCTGTCAGGGGAAATTAAAGGCCAGCAACTGGAAGATT
TTCCCGCGCTGATCAAACAGGCGAGTCTGGATGCGTTGTTTAAATGCGGGAAAGACGCCGAGGCGTTAAAAGAAGTTTTT
ACCAATTCAAATAATGTCGCCGGTAAGAAAGCGATAATGGAGTTTGCCGGCCTCTTTCGTTCAGCGCTCAACGCCACCAG
TGATTCTCCTGAGGCGAAGACGCTACTGATGAAGGTGGGGGCAGAGTATACCGCGCAAATCATAAAAGATGGCCTGAAAG
AAAAGTCAGCTTTTGGGCCATGGCTGCCAGAAACAAAGAAAGCGGAAGCGAAGCTGGAAAACCTGGAAAAGCAGCTGTTA
GATATCATCAAAAATAACACTGGCGGTGAATTAAGTAAATTATCGACGAATCTTGTTATGCAGGAGGTGATGCCCTATAT
TGCCAGCTGCATTGAACATAACTTTGGCTGTACGTTAGATCCGTTAACCCGCAGCAGTCTTACGCAGCTTGTTGACAAAG
CGGCGGCGAAGGCGGTTGAGGCGCTTGATATGTGCCACCAAAAATTAACGCAAGAGCAGGGTACCAGCGTAGGACGGGAA
GCCCGGCACCTTGAAATGCAAACGTTGATACCCCTGCTGCTACGTAATGTTTTTGCACAAATTCCTGCAGATAAACTGCC
TGACCCTAAAATTCCGGAACCTGCGGCTGGACCAGTACCTGATGGTGGGAAAAAAGCAGAACCTACGGGTATTAATATCA
ATATTAATATTGATAGCAGTAACCATAGCGTGGATAACAGTAAGCATATTAACAATAGCCGAAGCCATGTCGATAATAGC
CAGCGCCATATCGATAATAGCAACCATGATAATAGCCGGAAGACGATTGATAATAGCCGAACATTTATTGATAACAGCCA
ACGCCATGGCGAGTCACACCATTCGACTAACAGCAGCAACGTAAGTCATAGTCATTCGCGTGTGGATTCGACTACGCATC
AAACGGAGACCGCACACAGCGCCAGCACAGGGACAATTGACCATGGCATCGCGGGTAAAATTGACGTCACGGCTCATGCG
ACGGCAGAGGCTGTGACCAACTCTTCATCCGAAAGTAAAGATGGAAAGGTGGTCACGTCAGAAAAGGGCACTACGGGTGA
AACAACCTCTTTTGATGAAGTCGATGGCGTAACCAGCAAGAGCATTATCGGCAAGCCGTTACAGGCCACGGTGCACGGCG
TTGATGATAATAAACAGCAAAGCCAGACGGCAGAGATTGTGAATGTGAAGCCGCTTGCCAGTCAACTGGCTGGCGTCGAG
AATGTTAAAATCGATACCTTACAATCAGACTCGACGGTAATTACAGGTAATAAAGCCGGTACGACCGATAATGATAATAG
CCAGACAGATAAGACTGGCCCATTTTCTGGTTTGAAGTTTAAGCAAAATAGTTTCCTCTCAACAGTACCGAGCGTTACGA
ATATGCATTCAATACATTTCAACGCCCGTGAGGCGTTTTTGGGTGTGATACGTAAAGCCCTGGAGCCGGATGCCTCTACA
CCGTTTCCTGTACGCAGAGCGTTTGACGGCTTGCGTGGGGAAATATTACCCAATGACACGATAAAGAGTGCAGCGTTGAA
AGCGCAATGTAGCGATATTGACAAGCACCCAGAATTGAAAGCGAAAATGGAGACGCTCAAAGAGGTCATTACTCATCATC
CACAAAAAGAAAAACTGGCTGAGATTGCATTGCAGTTTGCCAGAGAGGCGGGGTTGACCAGGCAAAAAGGGGAAACTGAC
TATGTGTTAAGTAATGTGCTGGACGGCCTTATCGGAGACGGTAGCTGGCGAGCTGGCCCGGCTTACGAGTCATACCTGAA
TAAACCTGGTGTGGATCGGGTTATTACTACCGTTGATGGCTTGCACATGCAGCGTTAA

Upstream 100 bases:

>100_bases
ATTGTACGACAACCTGGTAAAAGTGCTGAGCAGTACGATAAGTAGCAGCCTGGAAACCGCCAAAAGCTTCCTGCAAGGAT
AACAGAAGAGGATATTAATA

Downstream 100 bases:

>100_bases
TTAACTGGGAAAGATGCGATGAATATGGATATTGAAGCAAGAGTCAAAAAAGTGATCACCTCCTGTATTGCCGTTGATGT
TGATAGTATCAATGGTCAGA

Product: pathogenicity island 1 effector protein

Products: NA

Alternate protein names: Effector protein sipA [H]

Number of amino acids: Translated: 685; Mature: 685

Protein sequence:

>685_residues
MVTSVRTQPPVIMPGMQTEIKTQATNLAANLSAVRESATATLSGEIKGQQLEDFPALIKQASLDALFKCGKDAEALKEVF
TNSNNVAGKKAIMEFAGLFRSALNATSDSPEAKTLLMKVGAEYTAQIIKDGLKEKSAFGPWLPETKKAEAKLENLEKQLL
DIIKNNTGGELSKLSTNLVMQEVMPYIASCIEHNFGCTLDPLTRSSLTQLVDKAAAKAVEALDMCHQKLTQEQGTSVGRE
ARHLEMQTLIPLLLRNVFAQIPADKLPDPKIPEPAAGPVPDGGKKAEPTGINININIDSSNHSVDNSKHINNSRSHVDNS
QRHIDNSNHDNSRKTIDNSRTFIDNSQRHGESHHSTNSSNVSHSHSRVDSTTHQTETAHSASTGTIDHGIAGKIDVTAHA
TAEAVTNSSSESKDGKVVTSEKGTTGETTSFDEVDGVTSKSIIGKPLQATVHGVDDNKQQSQTAEIVNVKPLASQLAGVE
NVKIDTLQSDSTVITGNKAGTTDNDNSQTDKTGPFSGLKFKQNSFLSTVPSVTNMHSIHFNAREAFLGVIRKALEPDAST
PFPVRRAFDGLRGEILPNDTIKSAALKAQCSDIDKHPELKAKMETLKEVITHHPQKEKLAEIALQFAREAGLTRQKGETD
YVLSNVLDGLIGDGSWRAGPAYESYLNKPGVDRVITTVDGLHMQR

Sequences:

>Translated_685_residues
MVTSVRTQPPVIMPGMQTEIKTQATNLAANLSAVRESATATLSGEIKGQQLEDFPALIKQASLDALFKCGKDAEALKEVF
TNSNNVAGKKAIMEFAGLFRSALNATSDSPEAKTLLMKVGAEYTAQIIKDGLKEKSAFGPWLPETKKAEAKLENLEKQLL
DIIKNNTGGELSKLSTNLVMQEVMPYIASCIEHNFGCTLDPLTRSSLTQLVDKAAAKAVEALDMCHQKLTQEQGTSVGRE
ARHLEMQTLIPLLLRNVFAQIPADKLPDPKIPEPAAGPVPDGGKKAEPTGINININIDSSNHSVDNSKHINNSRSHVDNS
QRHIDNSNHDNSRKTIDNSRTFIDNSQRHGESHHSTNSSNVSHSHSRVDSTTHQTETAHSASTGTIDHGIAGKIDVTAHA
TAEAVTNSSSESKDGKVVTSEKGTTGETTSFDEVDGVTSKSIIGKPLQATVHGVDDNKQQSQTAEIVNVKPLASQLAGVE
NVKIDTLQSDSTVITGNKAGTTDNDNSQTDKTGPFSGLKFKQNSFLSTVPSVTNMHSIHFNAREAFLGVIRKALEPDAST
PFPVRRAFDGLRGEILPNDTIKSAALKAQCSDIDKHPELKAKMETLKEVITHHPQKEKLAEIALQFAREAGLTRQKGETD
YVLSNVLDGLIGDGSWRAGPAYESYLNKPGVDRVITTVDGLHMQR
>Mature_685_residues
MVTSVRTQPPVIMPGMQTEIKTQATNLAANLSAVRESATATLSGEIKGQQLEDFPALIKQASLDALFKCGKDAEALKEVF
TNSNNVAGKKAIMEFAGLFRSALNATSDSPEAKTLLMKVGAEYTAQIIKDGLKEKSAFGPWLPETKKAEAKLENLEKQLL
DIIKNNTGGELSKLSTNLVMQEVMPYIASCIEHNFGCTLDPLTRSSLTQLVDKAAAKAVEALDMCHQKLTQEQGTSVGRE
ARHLEMQTLIPLLLRNVFAQIPADKLPDPKIPEPAAGPVPDGGKKAEPTGINININIDSSNHSVDNSKHINNSRSHVDNS
QRHIDNSNHDNSRKTIDNSRTFIDNSQRHGESHHSTNSSNVSHSHSRVDSTTHQTETAHSASTGTIDHGIAGKIDVTAHA
TAEAVTNSSSESKDGKVVTSEKGTTGETTSFDEVDGVTSKSIIGKPLQATVHGVDDNKQQSQTAEIVNVKPLASQLAGVE
NVKIDTLQSDSTVITGNKAGTTDNDNSQTDKTGPFSGLKFKQNSFLSTVPSVTNMHSIHFNAREAFLGVIRKALEPDAST
PFPVRRAFDGLRGEILPNDTIKSAALKAQCSDIDKHPELKAKMETLKEVITHHPQKEKLAEIALQFAREAGLTRQKGETD
YVLSNVLDGLIGDGSWRAGPAYESYLNKPGVDRVITTVDGLHMQR

Specific function: Actin-binding protein that interferes with host cell actin cytoskeleton. It stimulates actin polymerization and counteracts F-actin destabilizing proteins. Potentiates sipC activity; both are required for an efficient bacterial internalization [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted. Note=Secreted via the type III secretion system 1 (SPI-1 TTSS) (By similarity) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sipA/ipaA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015138
- InterPro:   IPR023224
- InterPro:   IPR023225 [H]

Pfam domain/function: PF09052 SipA [H]

EC number: NA

Molecular weight: Translated: 73941; Mature: 73941

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTSVRTQPPVIMPGMQTEIKTQATNLAANLSAVRESATATLSGEIKGQQLEDFPALIKQ
CCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHH
ASLDALFKCGKDAEALKEVFTNSNNVAGKKAIMEFAGLFRSALNATSDSPEAKTLLMKVG
HHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
AEYTAQIIKDGLKEKSAFGPWLPETKKAEAKLENLEKQLLDIIKNNTGGELSKLSTNLVM
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
QEVMPYIASCIEHNFGCTLDPLTRSSLTQLVDKAAAKAVEALDMCHQKLTQEQGTSVGRE
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
ARHLEMQTLIPLLLRNVFAQIPADKLPDPKIPEPAAGPVPDGGKKAEPTGINININIDSS
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCC
NHSVDNSKHINNSRSHVDNSQRHIDNSNHDNSRKTIDNSRTFIDNSQRHGESHHSTNSSN
CCCCCCCHHCCCCHHHCCCHHHHCCCCCCCCCHHHHCCCCHHHCCCHHCCCHHCCCCCCC
VSHSHSRVDSTTHQTETAHSASTGTIDHGIAGKIDVTAHATAEAVTNSSSESKDGKVVTS
CCHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCEEEEEHHHHHHHHHCCCCCCCCCCEEEC
EKGTTGETTSFDEVDGVTSKSIIGKPLQATVHGVDDNKQQSQTAEIVNVKPLASQLAGVE
CCCCCCCCCCCHHHCCCCHHHHHCCCHHHHEECCCCCHHHHHHHHHHCCCHHHHHHCCCC
NVKIDTLQSDSTVITGNKAGTTDNDNSQTDKTGPFSGLKFKQNSFLSTVPSVTNMHSIHF
CCEEEEECCCCEEEECCCCCCCCCCCCCCCCCCCCCCCEECCCHHHHHCCCHHCCCEEEC
NAREAFLGVIRKALEPDASTPFPVRRAFDGLRGEILPNDTIKSAALKAQCSDIDKHPELK
CHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHH
AKMETLKEVITHHPQKEKLAEIALQFAREAGLTRQKGETDYVLSNVLDGLIGDGSWRAGP
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
AYESYLNKPGVDRVITTVDGLHMQR
HHHHHCCCCCHHHHHHHHCCHHCCC
>Mature Secondary Structure
MVTSVRTQPPVIMPGMQTEIKTQATNLAANLSAVRESATATLSGEIKGQQLEDFPALIKQ
CCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHH
ASLDALFKCGKDAEALKEVFTNSNNVAGKKAIMEFAGLFRSALNATSDSPEAKTLLMKVG
HHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
AEYTAQIIKDGLKEKSAFGPWLPETKKAEAKLENLEKQLLDIIKNNTGGELSKLSTNLVM
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
QEVMPYIASCIEHNFGCTLDPLTRSSLTQLVDKAAAKAVEALDMCHQKLTQEQGTSVGRE
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
ARHLEMQTLIPLLLRNVFAQIPADKLPDPKIPEPAAGPVPDGGKKAEPTGINININIDSS
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCC
NHSVDNSKHINNSRSHVDNSQRHIDNSNHDNSRKTIDNSRTFIDNSQRHGESHHSTNSSN
CCCCCCCHHCCCCHHHCCCHHHHCCCCCCCCCHHHHCCCCHHHCCCHHCCCHHCCCCCCC
VSHSHSRVDSTTHQTETAHSASTGTIDHGIAGKIDVTAHATAEAVTNSSSESKDGKVVTS
CCHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCEEEEEHHHHHHHHHCCCCCCCCCCEEEC
EKGTTGETTSFDEVDGVTSKSIIGKPLQATVHGVDDNKQQSQTAEIVNVKPLASQLAGVE
CCCCCCCCCCCHHHCCCCHHHHHCCCHHHHEECCCCCHHHHHHHHHHCCCHHHHHHCCCC
NVKIDTLQSDSTVITGNKAGTTDNDNSQTDKTGPFSGLKFKQNSFLSTVPSVTNMHSIHF
CCEEEEECCCCEEEECCCCCCCCCCCCCCCCCCCCCCCEECCCHHHHHCCCHHCCCEEEC
NAREAFLGVIRKALEPDASTPFPVRRAFDGLRGEILPNDTIKSAALKAQCSDIDKHPELK
CHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHH
AKMETLKEVITHHPQKEKLAEIALQFAREAGLTRQKGETDYVLSNVLDGLIGDGSWRAGP
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
AYESYLNKPGVDRVITTVDGLHMQR
HHHHHCCCCCHHHHHHHHCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA