| Definition | Salmonella enterica subsp. enterica serovar Typhi str. Ty2 chromosome, complete genome. |
|---|---|
| Accession | NC_004631 |
| Length | 4,791,961 |
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The map label for this gene is stpA [H]
Identifier: 29143139
GI number: 29143139
Start: 2859938
End: 2861569
Strand: Reverse
Name: stpA [H]
Synonym: t2780
Alternate gene names: 29143139
Gene position: 2861569-2859938 (Counterclockwise)
Preceding gene: 29143140
Following gene: 29143135
Centisome position: 59.72
GC content: 43.63
Gene sequence:
>1632_bases ATGCTAAGGTATGATGAGAGGAAGTTGAATAATTTAACATTGTCTTCATTTTCAAAATCTGGCGTGTCGAGTGATACCCG GCTATATATTGCTAAGGAAAATACTGATAAGGCATATGTTGCGCCTGAAAAATTTTCGTCAAAAGTATTAACCTGGCTTG GAAAAATGCCCTTATTTAAAAACACTGAAGTGGTGCAAAAACACACGGAAAATATCAGAGTACAGAACCAAAAGATTTTA CAGACATTTCTCCAGGCATTAACGGAAAAATATGGGGAAAAAGCGGTCAATAATGCTTTGTACATGTCCAGTATAAATAT GAACAAACCCCTTACCCAACGTTTAGTAGTGCAGATCACGGAGTGTGTAAAAGGTGCTGACGGAGGGTTTATAAATCTTA TTAAGAACAAGGATAATGTTGGTGTCATGAATGCCGCTTTAGTCATAAAAGGCGGCGATACAAAAGTGACAGAACAAAAT AACGATGTTGGTGCAGAAAGTAAGCAACCTTTACTCGATATCGCGCTAAAGGGACTTAAGAGAACAATACCGCAACTGGA ACAAATGGATGGAAATAGCCTGCGAGAAAACTTCCAGGAGATGGCTTCAGGTAACGGCCCGCTGCGTTCATTAATGACGA ATTTACAGAGTTTAAATAAAATTCCAGAGGCTAAACAACTTAATGATTATGTTACAACGTTAAAAAATATTCAGATAGGA GCAGACAGGTTCTCACAATGGGGAACCTGTGGGGGAGAGGTTGAGAGGTGGATTGATAAAGCCTCTACTCATGAATTAAC CCAAGCGGTAAAAAAAATTCACGTTATTGCTAAAGAACTGAAAAACGTTACAGCTGAACTTGAGAAAATAAAAGCCGGTG CGTCAATGCCACAGACGATGAGCGGACCGACACTGGGCCTGGCACGGTTTGCGGTCAGCAGCATTCCCATTAATCAGCAA ACCCAGGTGAAACTGAGCGATGGAATGCCTGTGCCAGTGAATACGTTAACTTTTGACGGTAAGCCTGTGGCATTAGCCGG TTCGTGCCCAAAAAATACGCCGGATGCGCTGGAAGCGCATATGAAAATGCTTCTTGAAAAAGAATGTTCGTGCCTGGTGG TGTTAACGTCGGAAGATCAGATGCAGGCAAAACAATTACCAGCCTATTTCAGAGGGAGCTACACCTTTGGCGAGGTGCAT ACCAACAGCCAAAAAGTGAGCTCAGCCAGTCAGGGAGGAGCGATAGACCAATACAATATGCAACTGTCCTGCGGGGAAAA GCGGTATACAATCCCGGTATTGCATGTGAAAAATTGGCCAGATCACCAGCCGTTACCGTCTACTGATCAGTTAGAATACC TGGCGGATAGGGTGAAAAATAGTAACCAAAATGGCGCGCCGGGGCGTAGTTCATCAGATAAGCATTTACCGATGATTCAT TGTCTGGGCGGAGTGGGAAGAACCGGAACGATGGCGGCGGCTCTTGTACTTAAGGATAATCCTCATAGTAATCTGGAGCA GGTACGTGCAGATTTCCGGAATTCACGGAACAATAGAATGCTGGAAGACGCCTCACAGTTTGTACAACTAAAAGCAATGC AAGCCCAGTTGCTTATGACGACGGCAAGCTGA
Upstream 100 bases:
>100_bases ATACATGCAATTACCGATCTGACAAATATTTATCATATCATATCGCAGCTTGAGTCATTTGTGAATAAGCAGGAAGCGCT CAAAAACATACTACAGGAAT
Downstream 100 bases:
>100_bases TAAAAACATAGCTTACTTTTAGAATTATCTGAAAGTAAGCTATTCCTGTATAATTATTTGTTTACCGCGATAGAAAGTCT TTTGTTTTTCTCTTCTGCTG
Product: tyrosine phosphatase
Products: NA
Alternate protein names: GTPase-activating protein; GAP; Tyrosine-protein phosphatase [H]
Number of amino acids: Translated: 543; Mature: 543
Protein sequence:
>543_residues MLRYDERKLNNLTLSSFSKSGVSSDTRLYIAKENTDKAYVAPEKFSSKVLTWLGKMPLFKNTEVVQKHTENIRVQNQKIL QTFLQALTEKYGEKAVNNALYMSSINMNKPLTQRLVVQITECVKGADGGFINLIKNKDNVGVMNAALVIKGGDTKVTEQN NDVGAESKQPLLDIALKGLKRTIPQLEQMDGNSLRENFQEMASGNGPLRSLMTNLQSLNKIPEAKQLNDYVTTLKNIQIG ADRFSQWGTCGGEVERWIDKASTHELTQAVKKIHVIAKELKNVTAELEKIKAGASMPQTMSGPTLGLARFAVSSIPINQQ TQVKLSDGMPVPVNTLTFDGKPVALAGSCPKNTPDALEAHMKMLLEKECSCLVVLTSEDQMQAKQLPAYFRGSYTFGEVH TNSQKVSSASQGGAIDQYNMQLSCGEKRYTIPVLHVKNWPDHQPLPSTDQLEYLADRVKNSNQNGAPGRSSSDKHLPMIH CLGGVGRTGTMAAALVLKDNPHSNLEQVRADFRNSRNNRMLEDASQFVQLKAMQAQLLMTTAS
Sequences:
>Translated_543_residues MLRYDERKLNNLTLSSFSKSGVSSDTRLYIAKENTDKAYVAPEKFSSKVLTWLGKMPLFKNTEVVQKHTENIRVQNQKIL QTFLQALTEKYGEKAVNNALYMSSINMNKPLTQRLVVQITECVKGADGGFINLIKNKDNVGVMNAALVIKGGDTKVTEQN NDVGAESKQPLLDIALKGLKRTIPQLEQMDGNSLRENFQEMASGNGPLRSLMTNLQSLNKIPEAKQLNDYVTTLKNIQIG ADRFSQWGTCGGEVERWIDKASTHELTQAVKKIHVIAKELKNVTAELEKIKAGASMPQTMSGPTLGLARFAVSSIPINQQ TQVKLSDGMPVPVNTLTFDGKPVALAGSCPKNTPDALEAHMKMLLEKECSCLVVLTSEDQMQAKQLPAYFRGSYTFGEVH TNSQKVSSASQGGAIDQYNMQLSCGEKRYTIPVLHVKNWPDHQPLPSTDQLEYLADRVKNSNQNGAPGRSSSDKHLPMIH CLGGVGRTGTMAAALVLKDNPHSNLEQVRADFRNSRNNRMLEDASQFVQLKAMQAQLLMTTAS >Mature_543_residues MLRYDERKLNNLTLSSFSKSGVSSDTRLYIAKENTDKAYVAPEKFSSKVLTWLGKMPLFKNTEVVQKHTENIRVQNQKIL QTFLQALTEKYGEKAVNNALYMSSINMNKPLTQRLVVQITECVKGADGGFINLIKNKDNVGVMNAALVIKGGDTKVTEQN NDVGAESKQPLLDIALKGLKRTIPQLEQMDGNSLRENFQEMASGNGPLRSLMTNLQSLNKIPEAKQLNDYVTTLKNIQIG ADRFSQWGTCGGEVERWIDKASTHELTQAVKKIHVIAKELKNVTAELEKIKAGASMPQTMSGPTLGLARFAVSSIPINQQ TQVKLSDGMPVPVNTLTFDGKPVALAGSCPKNTPDALEAHMKMLLEKECSCLVVLTSEDQMQAKQLPAYFRGSYTFGEVH TNSQKVSSASQGGAIDQYNMQLSCGEKRYTIPVLHVKNWPDHQPLPSTDQLEYLADRVKNSNQNGAPGRSSSDKHLPMIH CLGGVGRTGTMAAALVLKDNPHSNLEQVRADFRNSRNNRMLEDASQFVQLKAMQAQLLMTTAS
Specific function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein includes tyrosine phosphatase and GTPase activating protein (GAP) activities. After bacterial internalization, GAP mediates the reversal
COG id: NA
COG function: NA
Gene ontology:
Cell location: Secreted. Host cytoplasm (By similarity). Note=Secreted via type III secretion system 1 (SPI-1 TTSS), and delivered into the host cytoplasm (By similarity) [H]
Metaboloic importance: NA
Operon status: Not Known
Operon components: None
Similarity: Contains 1 tyrosine-protein phosphatase domain [H]
Homologues:
None
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR000387 - InterPro: IPR011070 - InterPro: IPR015203 - InterPro: IPR016130 - InterPro: IPR003546 - InterPro: IPR000242 - InterPro: IPR014773 [H]
Pfam domain/function: PF09119 SicP-binding; PF00102 Y_phosphatase; PF03545 YopE [H]
EC number: =3.1.3.48 [H]
Molecular weight: Translated: 59898; Mature: 59898
Theoretical pI: Translated: 9.44; Mature: 9.44
Prosite motif: PS00383 TYR_PHOSPHATASE_1 ; PS50056 TYR_PHOSPHATASE_2 ; PS50055 TYR_PHOSPHATASE_PTP
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.3 %Cys (Translated Protein) 3.7 %Met (Translated Protein) 5.0 %Cys+Met (Translated Protein) 1.3 %Cys (Mature Protein) 3.7 %Met (Mature Protein) 5.0 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MLRYDERKLNNLTLSSFSKSGVSSDTRLYIAKENTDKAYVAPEKFSSKVLTWLGKMPLFK CCCCCCHHHCCCCHHHHHCCCCCCCCEEEEEECCCCCEEECHHHHHHHHHHHHHCCCCCC NTEVVQKHTENIRVQNQKILQTFLQALTEKYGEKAVNNALYMSSINMNKPLTQRLVVQIT CHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHH ECVKGADGGFINLIKNKDNVGVMNAALVIKGGDTKVTEQNNDVGAESKQPLLDIALKGLK HHHCCCCCCEEEEEECCCCCCEEEEEEEEECCCCEECCCCCCCCCCCCCHHHHHHHHHHH RTIPQLEQMDGNSLRENFQEMASGNGPLRSLMTNLQSLNKIPEAKQLNDYVTTLKNIQIG HHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCEEC ADRFSQWGTCGGEVERWIDKASTHELTQAVKKIHVIAKELKNVTAELEKIKAGASMPQTM HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC SGPTLGLARFAVSSIPINQQTQVKLSDGMPVPVNTLTFDGKPVALAGSCPKNTPDALEAH CCCCHHHHHHHHHHCCCCCCCEEEECCCCCCCCEEEEECCCCEEEECCCCCCCHHHHHHH MKMLLEKECSCLVVLTSEDQMQAKQLPAYFRGSYTFGEVHTNSQKVSSASQGGAIDQYNM HHHHHHCCCCEEEEECCCHHHHHHHCCHHHCCCCEECEEECCHHHHHCCCCCCCCEEECE QLSCGEKRYTIPVLHVKNWPDHQPLPSTDQLEYLADRVKNSNQNGAPGRSSSDKHLPMIH EEECCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHH CLGGVGRTGTMAAALVLKDNPHSNLEQVRADFRNSRNNRMLEDASQFVQLKAMQAQLLMT HHCCCCCCCHHEEEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHEEE TAS ECC >Mature Secondary Structure MLRYDERKLNNLTLSSFSKSGVSSDTRLYIAKENTDKAYVAPEKFSSKVLTWLGKMPLFK CCCCCCHHHCCCCHHHHHCCCCCCCCEEEEEECCCCCEEECHHHHHHHHHHHHHCCCCCC NTEVVQKHTENIRVQNQKILQTFLQALTEKYGEKAVNNALYMSSINMNKPLTQRLVVQIT CHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHH ECVKGADGGFINLIKNKDNVGVMNAALVIKGGDTKVTEQNNDVGAESKQPLLDIALKGLK HHHCCCCCCEEEEEECCCCCCEEEEEEEEECCCCEECCCCCCCCCCCCCHHHHHHHHHHH RTIPQLEQMDGNSLRENFQEMASGNGPLRSLMTNLQSLNKIPEAKQLNDYVTTLKNIQIG HHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCEEC ADRFSQWGTCGGEVERWIDKASTHELTQAVKKIHVIAKELKNVTAELEKIKAGASMPQTM HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC SGPTLGLARFAVSSIPINQQTQVKLSDGMPVPVNTLTFDGKPVALAGSCPKNTPDALEAH CCCCHHHHHHHHHHCCCCCCCEEEECCCCCCCCEEEEECCCCEEEECCCCCCCHHHHHHH MKMLLEKECSCLVVLTSEDQMQAKQLPAYFRGSYTFGEVHTNSQKVSSASQGGAIDQYNM HHHHHHCCCCEEEEECCCHHHHHHHCCHHHCCCCEECEEECCHHHHHCCCCCCCCEEECE QLSCGEKRYTIPVLHVKNWPDHQPLPSTDQLEYLADRVKNSNQNGAPGRSSSDKHLPMIH EEECCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHH CLGGVGRTGTMAAALVLKDNPHSNLEQVRADFRNSRNNRMLEDASQFVQLKAMQAQLLMT HHCCCCCCCHHEEEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHEEE TAS ECC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA