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The map label for this gene is emrA [H]

Identifier: 29143075

GI number: 29143075

Start: 2800530

End: 2801702

Strand: Direct

Name: emrA [H]

Synonym: t2711

Alternate gene names: 29143075

Gene position: 2800530-2801702 (Clockwise)

Preceding gene: 29143074

Following gene: 29143076

Centisome position: 58.44

GC content: 54.65

Gene sequence:

>1173_bases
ATGAGCGCAAATGCGGAGATCCAACCCCCGCAGCAACCGGCTAAGAAGAAAGGCAAACGCAAAACAGCGCTGCTACTTCT
TACCTTGCTCTTTGTTATTATTGCCGTGGCATATGGAATTTATTGGTTTTTAGTATTGCGTCATATTGAAGAGACAGATG
ATGCTTACGTGGCAGGGAACCAGGTTCAAATCATGGCGCAGGTGTCAGGCAGCGTGACGAAAGTCTGGGCTGATAACACC
GACTTTGTAAAAGAGGGCGATGTTCTGGTCACGCTCGATCAGACTGACGCCAAACAAGCGTTTGAAAGAGCCAAAACGGC
GCTGGCCTCCAGCGTGCGCCAGACGCACCAGTTGATGATTAACAGTAAGCAGTTGCAGGCGAATATCGACGTGCAAAAAA
CCGCCCTGGCGCAAGCGCAGAGCGACCTTAACCGTCGTGTGCCGCTGGGTAATGCCAATCTTATTGGCCGGGAAGAGCTG
CAACACGCCCGCGATGCCGTCGCCAGCGCGCAGGCACAGCTTGATGTCGCCATTCAACAGTACAATGCCAACCAGGCAAT
GATACTTAACAGTAATCTGGAAGATCAGCCTGCGGTTCAACAAGCGGCGACCGAAGTGCGTAACGCCTGGCTGGCGCTGG
AGCGTACTCGCATCGTCAGTCCAATGACCGGTTATGTCTCCCGCCGCGCCGTCCAGCCTGGCGCGCAGATCAGCCCCACC
ACGCCGCTGATGGCCGTGGTGCCTGCAACCGATCTGTGGGTGGACGCTAACTTTAAAGAGACCCAATTAGCGAATATGCG
CATTGGGCAGCCAGTGACGATTATTACTGACATTTATGGCGACGACGTAAAATACACCGGTAAAGTCGTCGGTCTGGATA
TGGGGACAGGTAGCGCCTTCTCCCTGCTGCCCGCGCAAAATGCGACGGGTAACTGGATTAAAGTGGTTCAACGTCTGCCG
GTACGCGTCGAACTGGACGCCCGCCAGTTAGAACAACATCCGCTGCGCATTGGTTTATCGACGCTGGTCACCGTGGATAC
CGCTAATCGCGACGGTCAGGTACTGGCCAGCCAGGTACGAACGACGCCGGTTGCCGAAAGTAACGCACGCGAAATTAATC
TCGCGCCGGTCAATAAACTGATCGACGACATCGTACAGGCTAACGCGGGTTAA

Upstream 100 bases:

>100_bases
TTAATAACAGGAAAGCGGACAGGCCGGCACGCGTTACTGCTGGCCTTTCTGACAACAGGTCGGCTCAGCCGATGTGAATA
ATAAGATCGTGGAGAACAAC

Downstream 100 bases:

>100_bases
TCCTGAGGTGCGTGTGATGCAACAGCAAAAACCGCTGGAAGGCGCGCAGCTCATCATCATGACGATCGCGCTGTCGCTGG
CGACATTCATGCAGGTGCTG

Product: multidrug resistance protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MSANAEIQPPQQPAKKKGKRKTALLLLTLLFVIIAVAYGIYWFLVLRHIEETDDAYVAGNQVQIMAQVSGSVTKVWADNT
DFVKEGDVLVTLDQTDAKQAFERAKTALASSVRQTHQLMINSKQLQANIDVQKTALAQAQSDLNRRVPLGNANLIGREEL
QHARDAVASAQAQLDVAIQQYNANQAMILNSNLEDQPAVQQAATEVRNAWLALERTRIVSPMTGYVSRRAVQPGAQISPT
TPLMAVVPATDLWVDANFKETQLANMRIGQPVTIITDIYGDDVKYTGKVVGLDMGTGSAFSLLPAQNATGNWIKVVQRLP
VRVELDARQLEQHPLRIGLSTLVTVDTANRDGQVLASQVRTTPVAESNAREINLAPVNKLIDDIVQANAG

Sequences:

>Translated_390_residues
MSANAEIQPPQQPAKKKGKRKTALLLLTLLFVIIAVAYGIYWFLVLRHIEETDDAYVAGNQVQIMAQVSGSVTKVWADNT
DFVKEGDVLVTLDQTDAKQAFERAKTALASSVRQTHQLMINSKQLQANIDVQKTALAQAQSDLNRRVPLGNANLIGREEL
QHARDAVASAQAQLDVAIQQYNANQAMILNSNLEDQPAVQQAATEVRNAWLALERTRIVSPMTGYVSRRAVQPGAQISPT
TPLMAVVPATDLWVDANFKETQLANMRIGQPVTIITDIYGDDVKYTGKVVGLDMGTGSAFSLLPAQNATGNWIKVVQRLP
VRVELDARQLEQHPLRIGLSTLVTVDTANRDGQVLASQVRTTPVAESNAREINLAPVNKLIDDIVQANAG
>Mature_389_residues
SANAEIQPPQQPAKKKGKRKTALLLLTLLFVIIAVAYGIYWFLVLRHIEETDDAYVAGNQVQIMAQVSGSVTKVWADNTD
FVKEGDVLVTLDQTDAKQAFERAKTALASSVRQTHQLMINSKQLQANIDVQKTALAQAQSDLNRRVPLGNANLIGREELQ
HARDAVASAQAQLDVAIQQYNANQAMILNSNLEDQPAVQQAATEVRNAWLALERTRIVSPMTGYVSRRAVQPGAQISPTT
PLMAVVPATDLWVDANFKETQLANMRIGQPVTIITDIYGDDVKYTGKVVGLDMGTGSAFSLLPAQNATGNWIKVVQRLPV
RVELDARQLEQHPLRIGLSTLVTVDTANRDGQVLASQVRTTPVAESNAREINLAPVNKLIDDIVQANAG

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789041, Length=390, Percent_Identity=89.4871794871795, Blast_Score=702, Evalue=0.0,
Organism=Escherichia coli, GI1788711, Length=378, Percent_Identity=50, Blast_Score=373, Evalue=1e-104,
Organism=Escherichia coli, GI1790519, Length=310, Percent_Identity=27.4193548387097, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87081951, Length=313, Percent_Identity=27.4760383386581, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789637, Length=330, Percent_Identity=25.4545454545455, Blast_Score=69, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42540; Mature: 42409

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSANAEIQPPQQPAKKKGKRKTALLLLTLLFVIIAVAYGIYWFLVLRHIEETDDAYVAGN
CCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECC
QVQIMAQVSGSVTKVWADNTDFVKEGDVLVTLDQTDAKQAFERAKTALASSVRQTHQLMI
EEEEEEECCCCEEEEECCCCCCEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
NSKQLQANIDVQKTALAQAQSDLNRRVPLGNANLIGREELQHARDAVASAQAQLDVAIQQ
CCHHHEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEE
YNANQAMILNSNLEDQPAVQQAATEVRNAWLALERTRIVSPMTGYVSRRAVQPGAQISPT
CCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCC
TPLMAVVPATDLWVDANFKETQLANMRIGQPVTIITDIYGDDVKYTGKVVGLDMGTGSAF
CCEEEEECCCEEEEECCCCHHHHCCEECCCCEEEEEECCCCCEEECCEEEEEECCCCCCE
SLLPAQNATGNWIKVVQRLPVRVELDARQLEQHPLRIGLSTLVTVDTANRDGQVLASQVR
EEECCCCCCCHHHHHHHHCCCEEEECHHHHHCCCHHEEEEEEEEEECCCCCCHHHHHHHH
TTPVAESNAREINLAPVNKLIDDIVQANAG
CCCCCCCCCCEEECHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SANAEIQPPQQPAKKKGKRKTALLLLTLLFVIIAVAYGIYWFLVLRHIEETDDAYVAGN
CCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECC
QVQIMAQVSGSVTKVWADNTDFVKEGDVLVTLDQTDAKQAFERAKTALASSVRQTHQLMI
EEEEEEECCCCEEEEECCCCCCEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
NSKQLQANIDVQKTALAQAQSDLNRRVPLGNANLIGREELQHARDAVASAQAQLDVAIQQ
CCHHHEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEE
YNANQAMILNSNLEDQPAVQQAATEVRNAWLALERTRIVSPMTGYVSRRAVQPGAQISPT
CCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCC
TPLMAVVPATDLWVDANFKETQLANMRIGQPVTIITDIYGDDVKYTGKVVGLDMGTGSAF
CCEEEEECCCEEEEECCCCHHHHCCEECCCCEEEEEECCCCCEEECCEEEEEECCCCCCE
SLLPAQNATGNWIKVVQRLPVRVELDARQLEQHPLRIGLSTLVTVDTANRDGQVLASQVR
EEECCCCCCCHHHHHHHHCCCEEEECHHHHHCCCHHEEEEEEEEEECCCCCCHHHHHHHH
TTPVAESNAREINLAPVNKLIDDIVQANAG
CCCCCCCCCCEEECHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1409590; 9205837; 9278503; 8203018 [H]