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The map label for this gene is hemH [H]

Identifier: 29142760

GI number: 29142760

Start: 2440199

End: 2441161

Strand: Reverse

Name: hemH [H]

Synonym: t2371

Alternate gene names: 29142760

Gene position: 2441161-2440199 (Counterclockwise)

Preceding gene: 29142761

Following gene: 29142758

Centisome position: 50.94

GC content: 56.59

Gene sequence:

>963_bases
ATGCGTCAGACGAAAACCGGTATCCTGCTGGCTAACCTTGGCACGCCAGATGCCCCAACTCCTGAAGCGGTAAAGCGCTA
CCTGAAACAATTTTTAAGCGACAGACGCGTGGTGGATACTCCTCGTCTGCTGTGGTGGCCGCTGCTGCGTGGCGTTATTT
TACCGCTGCGTTCGCCGCGCGTCGCGAAACTCTATCAATCTATCTGGATGGATGGCGGTTCGCCGCTCATGGTATATAGC
CGCGAACAGCAACAGGCGCTGGCCGCGCGGTTGCCAGACACGCCCGTCGCGCTGGGGATGAGCTACGGCTCGCCCTCGCT
GGAAAGCGCTGTCGATGAACTGTTAGCAAGCGACGTCGACCATATCGTCGTGCTGCCGTTGTACCCGCAATATTCTTGCT
CAACGGTGGGCGCAGTCTGGGACGAACTGGGGCGGATACTGGCGCGTAAACGTCGTATTCCCGGGATCTCATTTATTCGC
GATTACGCGGATGACGGCGCTTATATCGATGCGCTGGCGAAAAGCGCGCGTGAGTCGTTCGCCAGACACGGCGAGCCGGA
TTTACTTCTGCTCTCCTATCACGGCATTCCACAACGTTATGCGGATGAAGGCGATGACTACCCGCAGCGCTGTCGCGATA
CCACGCGTGAACTGGTTTCCGCATTGGGACTGCCGCCGGAAAAGGTAATGATGACGTTCCAGTCGCGCTTTGGCCGTGAA
CCGTGGCTGACGCCGTACACCGATGAAACGCTAAAAATGTTGGGTGAAAAGGGGACTGGCCATATTCAGGTCATGTGTCC
GGGGTTTGCCGCGGATTGTCTGGAGACGCTGGAAGAGATAGCGGAACAGAACCGCGAGATTTTCCTTGAAGCGGGCGGTA
AAAAATATGCGTACATTCAGGCGCTGAACGCGACGCCGGAACATATTGATATGATACTGAAACTCACGGCGCCGTACCGT
TAA

Upstream 100 bases:

>100_bases
GCCATTCGGCAAATTCTCGTCTTACCTCTCGCAGCAATTAGTTCTTCTTTATCGCTTTTCCGCTACAATTATCAACAATT
TGAATAGATAAGAGGCGGCA

Downstream 100 bases:

>100_bases
CGCGGCGTCTTCATCCTCGCCATAAAGAAGCGTGCGCCGTCCTGCAAGGCATCGTCGGCGATTGTCATCATTCGCGAATA
GTGCAGGAAGGCGTGCAGCG

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MRQTKTGILLANLGTPDAPTPEAVKRYLKQFLSDRRVVDTPRLLWWPLLRGVILPLRSPRVAKLYQSIWMDGGSPLMVYS
REQQQALAARLPDTPVALGMSYGSPSLESAVDELLASDVDHIVVLPLYPQYSCSTVGAVWDELGRILARKRRIPGISFIR
DYADDGAYIDALAKSARESFARHGEPDLLLLSYHGIPQRYADEGDDYPQRCRDTTRELVSALGLPPEKVMMTFQSRFGRE
PWLTPYTDETLKMLGEKGTGHIQVMCPGFAADCLETLEEIAEQNREIFLEAGGKKYAYIQALNATPEHIDMILKLTAPYR

Sequences:

>Translated_320_residues
MRQTKTGILLANLGTPDAPTPEAVKRYLKQFLSDRRVVDTPRLLWWPLLRGVILPLRSPRVAKLYQSIWMDGGSPLMVYS
REQQQALAARLPDTPVALGMSYGSPSLESAVDELLASDVDHIVVLPLYPQYSCSTVGAVWDELGRILARKRRIPGISFIR
DYADDGAYIDALAKSARESFARHGEPDLLLLSYHGIPQRYADEGDDYPQRCRDTTRELVSALGLPPEKVMMTFQSRFGRE
PWLTPYTDETLKMLGEKGTGHIQVMCPGFAADCLETLEEIAEQNREIFLEAGGKKYAYIQALNATPEHIDMILKLTAPYR
>Mature_320_residues
MRQTKTGILLANLGTPDAPTPEAVKRYLKQFLSDRRVVDTPRLLWWPLLRGVILPLRSPRVAKLYQSIWMDGGSPLMVYS
REQQQALAARLPDTPVALGMSYGSPSLESAVDELLASDVDHIVVLPLYPQYSCSTVGAVWDELGRILARKRRIPGISFIR
DYADDGAYIDALAKSARESFARHGEPDLLLLSYHGIPQRYADEGDDYPQRCRDTTRELVSALGLPPEKVMMTFQSRFGRE
PWLTPYTDETLKMLGEKGTGHIQVMCPGFAADCLETLEEIAEQNREIFLEAGGKKYAYIQALNATPEHIDMILKLTAPYR

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=324, Percent_Identity=27.4691358024691, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI60499021, Length=323, Percent_Identity=27.5541795665635, Blast_Score=102, Evalue=4e-22,
Organism=Escherichia coli, GI1786681, Length=320, Percent_Identity=88.4375, Blast_Score=567, Evalue=1e-163,
Organism=Saccharomyces cerevisiae, GI6324750, Length=294, Percent_Identity=26.530612244898, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI17864156, Length=336, Percent_Identity=26.4880952380952, Blast_Score=104, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24651774, Length=269, Percent_Identity=27.5092936802974, Blast_Score=93, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 35942; Mature: 35942

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQTKTGILLANLGTPDAPTPEAVKRYLKQFLSDRRVVDTPRLLWWPLLRGVILPLRSPR
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCH
VAKLYQSIWMDGGSPLMVYSREQQQALAARLPDTPVALGMSYGSPSLESAVDELLASDVD
HHHHHHHHHCCCCCEEEEECCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCC
HIVVLPLYPQYSCSTVGAVWDELGRILARKRRIPGISFIRDYADDGAYIDALAKSARESF
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHH
ARHGEPDLLLLSYHGIPQRYADEGDDYPQRCRDTTRELVSALGLPPEKVMMTFQSRFGRE
HHCCCCCEEEEEECCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
PWLTPYTDETLKMLGEKGTGHIQVMCPGFAADCLETLEEIAEQNREIFLEAGGKKYAYIQ
CCCCCCCHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEECCCCEEEEEE
ALNATPEHIDMILKLTAPYR
EECCCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRQTKTGILLANLGTPDAPTPEAVKRYLKQFLSDRRVVDTPRLLWWPLLRGVILPLRSPR
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCH
VAKLYQSIWMDGGSPLMVYSREQQQALAARLPDTPVALGMSYGSPSLESAVDELLASDVD
HHHHHHHHHCCCCCEEEEECCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCC
HIVVLPLYPQYSCSTVGAVWDELGRILARKRRIPGISFIRDYADDGAYIDALAKSARESF
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHH
ARHGEPDLLLLSYHGIPQRYADEGDDYPQRCRDTTRELVSALGLPPEKVMMTFQSRFGRE
HHCCCCCEEEEEECCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
PWLTPYTDETLKMLGEKGTGHIQVMCPGFAADCLETLEEIAEQNREIFLEAGGKKYAYIQ
CCCCCCCHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEECCCCEEEEEE
ALNATPEHIDMILKLTAPYR
EECCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA