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The map label for this gene is fur [H]

Identifier: 29142590

GI number: 29142590

Start: 2248239

End: 2248691

Strand: Direct

Name: fur [H]

Synonym: t2182

Alternate gene names: 29142590

Gene position: 2248239-2248691 (Clockwise)

Preceding gene: 29142589

Following gene: 29142591

Centisome position: 46.92

GC content: 47.68

Gene sequence:

>453_bases
ATGACTGACAACAATACCGCATTAAAGAAGGCTGGCCTGAAAGTAACGCTTCCTCGTTTAAAAATTCTGGAAGTTCTTCA
GGAACCAGATAACCATCACGTCAGTGCGGAAGATTTATACAAACGCCTGATCGACATGGGTGAAGAAATCGGTCTGGCAA
CCGTATACCGTGTGCTGAACCAGTTTGACGATGCCGGTATCGTGACCCGCCATAACTTTGAAGGCGGTAAATCCGTTTTT
GAACTGACGCAACAGCATCATCACGACCATCTTATCTGCCTTGACTGCGGAAAAGTGATTGAATTTAGTGATGACTCTAT
TGAAGCGCGCCAGCGTGAAATTGCGGCGAAACACGGTATTCGTTTAACTAATCACAGCCTCTATCTTTACGGCCACTGCG
CTGAAGGCGACTGCCGCGAAGACGAGCACGCGCACGATGACGCGACTAAATAA

Upstream 100 bases:

>100_bases
ATTTCGGCATGGCAGTCCTATAATGATACGCATTATCTTGAGTGCAATTTCTGTCACTTCTCTAATGAAGTGAATCGTTT
AGCAACAGGACAGATTCCGC

Downstream 100 bases:

>100_bases
GTGTAAATCTTTCGAAGAGCCAACCGCCCGGTTGGCTTTTTTATATCCTCCTCTTTCCTGCCGCTTGATGTTGATTTAAT
GTAAAAAACGCTATCGCATC

Product: ferric uptake regulator

Products: NA

Alternate protein names: Ferric uptake regulator [H]

Number of amino acids: Translated: 150; Mature: 149

Protein sequence:

>150_residues
MTDNNTALKKAGLKVTLPRLKILEVLQEPDNHHVSAEDLYKRLIDMGEEIGLATVYRVLNQFDDAGIVTRHNFEGGKSVF
ELTQQHHHDHLICLDCGKVIEFSDDSIEARQREIAAKHGIRLTNHSLYLYGHCAEGDCREDEHAHDDATK

Sequences:

>Translated_150_residues
MTDNNTALKKAGLKVTLPRLKILEVLQEPDNHHVSAEDLYKRLIDMGEEIGLATVYRVLNQFDDAGIVTRHNFEGGKSVF
ELTQQHHHDHLICLDCGKVIEFSDDSIEARQREIAAKHGIRLTNHSLYLYGHCAEGDCREDEHAHDDATK
>Mature_149_residues
TDNNTALKKAGLKVTLPRLKILEVLQEPDNHHVSAEDLYKRLIDMGEEIGLATVYRVLNQFDDAGIVTRHNFEGGKSVFE
LTQQHHHDHLICLDCGKVIEFSDDSIEARQREIAAKHGIRLTNHSLYLYGHCAEGDCREDEHAHDDATK

Specific function: Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes. Regulates the expression of several outer-membrane proteins including the iron transport operon [H]

COG id: COG0735

COG function: function code P; Fe2+/Zn2+ uptake regulation proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Fur family [H]

Homologues:

Organism=Escherichia coli, GI1786899, Length=146, Percent_Identity=99.3150684931507, Blast_Score=300, Evalue=3e-83,

Paralogues:

None

Copy number: 3432 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002481
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01475 FUR [H]

EC number: NA

Molecular weight: Translated: 17011; Mature: 16880

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDNNTALKKAGLKVTLPRLKILEVLQEPDNHHVSAEDLYKRLIDMGEEIGLATVYRVLN
CCCCCCHHHHCCCEEECHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHH
QFDDAGIVTRHNFEGGKSVFELTQQHHHDHLICLDCGKVIEFSDDSIEARQREIAAKHGI
HCCCCCCEEECCCCCHHHHHHHHHHHCCCCEEEEECCCEEECCCCHHHHHHHHHHHHCCE
RLTNHSLYLYGHCAEGDCREDEHAHDDATK
EEECCEEEEEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TDNNTALKKAGLKVTLPRLKILEVLQEPDNHHVSAEDLYKRLIDMGEEIGLATVYRVLN
CCCCCHHHHCCCEEECHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHH
QFDDAGIVTRHNFEGGKSVFELTQQHHHDHLICLDCGKVIEFSDDSIEARQREIAAKHGI
HCCCCCCEEECCCCCHHHHHHHHHHHCCCCEEEEECCCEEECCCCHHHHHHHHHHHHCCE
RLTNHSLYLYGHCAEGDCREDEHAHDDATK
EEECCEEEEEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9055816 [H]