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The map label for this gene is hutH [H]

Identifier: 29142511

GI number: 29142511

Start: 2158306

End: 2159826

Strand: Reverse

Name: hutH [H]

Synonym: t2096

Alternate gene names: 29142511

Gene position: 2159826-2158306 (Counterclockwise)

Preceding gene: 29142512

Following gene: 29142508

Centisome position: 45.07

GC content: 60.36

Gene sequence:

>1521_bases
ATGAACACCATGACACTCACTCCGGGGCAGTTAAGCCTCTCTCAACTGTACGATGTCTGGCGTCATCCGGTACAGCTTCG
GCTGGACGCCAGCGCCATTGACGGCATTAACGCCAGTGTTGCGTGCGTCAATGATATTGTTGCCGAAGGGCGTACCGCCT
ACGGCATCAACACCGGTTTCGGCCTGCTGGCGCAGACGCGCATCGCTGATGAAGACTTGCAAAATCTACAGCGATCGTTG
GTGCTGTCTCACGCCGCGGGCGTAGGCGACCCACTGGATGACGCGATGGTGCGTCTGATCATGGTATTGAAAATCAATAG
CCTGGCGCGCGGGTTTTCCGGGATTCGGTTGAGCGTGATAGAGGCGCTCATCGCTCTGGTGAATGCCGGCGTGTATCCGC
TGATTCCGGCAAAAGGGTCGGTTGGCGCGTCGGGCGACTTAGCGCCTCTGGCGCATCTGTCGCTGACGCTACTTGGCGAA
GGAAAAGCGCGCTGGCAGGGCGAATGGCTTCCGGCGCAGGCGGCGCTAAAAAAGGCCGGACTGGAACCTGTCGCGCTGGC
GGCCAAAGAGGGGCTGGCGCTGCTTAACGGCACCCAGGCGTCGACGGCCTTCGCGCTGCGCGGTTTGTTTGAGGCACAGG
AATTATTTGCCTCCGCCGTCGTCTGCGGCGCGCTGACTACCGAAGCCGTACTGGGATCGTGCCGTCCTTTTGATGCGCGC
ATTCATGCCGCGCGCGGACAACAGGGGCAAATTGACGTCGCGCGGTTGTTCCGGCATCTGCTGACCGATACCAGCGCCAT
TGCTGAATCACATCACCACTGTCATAAAGTTCAGGACCCGTATTCCCTCCGCTGCCAGCCGCAGGTAATGGGCGCTTGTC
TGACCCAGTTACGTCAGACGAAAGAGGTACTGCTGGCTGAGGCCAATGCGGTGTCCGATAATCCGCTGGTCTTTGCCGAG
GCGGGGGAGGTGATCTCCGGCGGTAACTTCCATGCTGAACCGGTTGCCATGGCGGCGGATAATCTGGCGCTGGCGATAGC
GGAAATCGGCGCGCTATCGGAGCGGCGCATCACGCTGATGATGGATAAACATATGTCGCAGTTACCGCCGTTCCTGGTGA
AAAATGGCGGCGTTAATTCCGGTTTTATGATTGCCCAGGTCACCGCCGCGGCGCTTGCCAGCGAGAATAAAGCGCTGGCG
CACCCGCACAGCGTGGATAGCCTGCCGACCTCGGCGAATCAGGAAGATCATGTCTCAATGGCCCCGGCGGCGGGACGGCG
ACTCTGGGAAATGGCGGCGAATACCCGCGGCGTCATTGCCGTGGAGTGGCTGGCTGCCTGTCAGGGGATAGATTTACGGG
AAGGGTTAACCTCCAGCCCGTTACTGGAACAGGCGCGGCAGACACTGCGCGAGCGGGTGGCGCACTATACGCAGGATCGT
TTTTTCGCGCCCGATATTGAGTGTGCGACGACGCTGCTGGCGCAAGGCGCGTTACAGCGTCTGGTGCCGGACTTTATGTG
A

Upstream 100 bases:

>100_bases
ATGCGTCATGCCGATGCCGGATATGATCTCGCGGTGGAATGCGCTGTTGAGCAAGGTCTGAATTTACCGATGGTTGCGGC
GACGCAGGGGAAAGGCTGAT

Downstream 100 bases:

>100_bases
ATGTTGCCGGATGGCGCGGCACGTATTCGGCTTACCCAACCCGTTGGAAGGGTAAGACGTTTATGCCGCCATCCGACACA
GCGTTTAACTGAACATCGCC

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MNTMTLTPGQLSLSQLYDVWRHPVQLRLDASAIDGINASVACVNDIVAEGRTAYGINTGFGLLAQTRIADEDLQNLQRSL
VLSHAAGVGDPLDDAMVRLIMVLKINSLARGFSGIRLSVIEALIALVNAGVYPLIPAKGSVGASGDLAPLAHLSLTLLGE
GKARWQGEWLPAQAALKKAGLEPVALAAKEGLALLNGTQASTAFALRGLFEAQELFASAVVCGALTTEAVLGSCRPFDAR
IHAARGQQGQIDVARLFRHLLTDTSAIAESHHHCHKVQDPYSLRCQPQVMGACLTQLRQTKEVLLAEANAVSDNPLVFAE
AGEVISGGNFHAEPVAMAADNLALAIAEIGALSERRITLMMDKHMSQLPPFLVKNGGVNSGFMIAQVTAAALASENKALA
HPHSVDSLPTSANQEDHVSMAPAAGRRLWEMAANTRGVIAVEWLAACQGIDLREGLTSSPLLEQARQTLRERVAHYTQDR
FFAPDIECATTLLAQGALQRLVPDFM

Sequences:

>Translated_506_residues
MNTMTLTPGQLSLSQLYDVWRHPVQLRLDASAIDGINASVACVNDIVAEGRTAYGINTGFGLLAQTRIADEDLQNLQRSL
VLSHAAGVGDPLDDAMVRLIMVLKINSLARGFSGIRLSVIEALIALVNAGVYPLIPAKGSVGASGDLAPLAHLSLTLLGE
GKARWQGEWLPAQAALKKAGLEPVALAAKEGLALLNGTQASTAFALRGLFEAQELFASAVVCGALTTEAVLGSCRPFDAR
IHAARGQQGQIDVARLFRHLLTDTSAIAESHHHCHKVQDPYSLRCQPQVMGACLTQLRQTKEVLLAEANAVSDNPLVFAE
AGEVISGGNFHAEPVAMAADNLALAIAEIGALSERRITLMMDKHMSQLPPFLVKNGGVNSGFMIAQVTAAALASENKALA
HPHSVDSLPTSANQEDHVSMAPAAGRRLWEMAANTRGVIAVEWLAACQGIDLREGLTSSPLLEQARQTLRERVAHYTQDR
FFAPDIECATTLLAQGALQRLVPDFM
>Mature_506_residues
MNTMTLTPGQLSLSQLYDVWRHPVQLRLDASAIDGINASVACVNDIVAEGRTAYGINTGFGLLAQTRIADEDLQNLQRSL
VLSHAAGVGDPLDDAMVRLIMVLKINSLARGFSGIRLSVIEALIALVNAGVYPLIPAKGSVGASGDLAPLAHLSLTLLGE
GKARWQGEWLPAQAALKKAGLEPVALAAKEGLALLNGTQASTAFALRGLFEAQELFASAVVCGALTTEAVLGSCRPFDAR
IHAARGQQGQIDVARLFRHLLTDTSAIAESHHHCHKVQDPYSLRCQPQVMGACLTQLRQTKEVLLAEANAVSDNPLVFAE
AGEVISGGNFHAEPVAMAADNLALAIAEIGALSERRITLMMDKHMSQLPPFLVKNGGVNSGFMIAQVTAAALASENKALA
HPHSVDSLPTSANQEDHVSMAPAAGRRLWEMAANTRGVIAVEWLAACQGIDLREGLTSSPLLEQARQTLRERVAHYTQDR
FFAPDIECATTLLAQGALQRLVPDFM

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=491, Percent_Identity=46.2321792260692, Blast_Score=418, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17567831, Length=480, Percent_Identity=43.75, Blast_Score=372, Evalue=1e-103,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 53832; Mature: 53832

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTMTLTPGQLSLSQLYDVWRHPVQLRLDASAIDGINASVACVNDIVAEGRTAYGINTGF
CCCCCCCCCCCCHHHHHHHHCCCEEEEECHHHHCCCCCHHHHHHHHHHCCCEEEECCCCH
GLLAQTRIADEDLQNLQRSLVLSHAAGVGDPLDDAMVRLIMVLKINSLARGFSGIRLSVI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
EALIALVNAGVYPLIPAKGSVGASGDLAPLAHLSLTLLGEGKARWQGEWLPAQAALKKAG
HHHHHHHCCCCCEEECCCCCCCCCCCCCHHHHEEEEEEECCCCCCCCCCCCHHHHHHHCC
LEPVALAAKEGLALLNGTQASTAFALRGLFEAQELFASAVVCGALTTEAVLGSCRPFDAR
CCHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
IHAARGQQGQIDVARLFRHLLTDTSAIAESHHHCHKVQDPYSLRCQPQVMGACLTQLRQT
HEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
KEVLLAEANAVSDNPLVFAEAGEVISGGNFHAEPVAMAADNLALAIAEIGALSERRITLM
HHHHHHHCCCCCCCCEEEEECCCEECCCCCCCCCHHHHHCHHHHHHHHHCCCCCCEEEEH
MDKHMSQLPPFLVKNGGVNSGFMIAQVTAAALASENKALAHPHSVDSLPTSANQEDHVSM
HHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEE
APAAGRRLWEMAANTRGVIAVEWLAACQGIDLREGLTSSPLLEQARQTLRERVAHYTQDR
CCHHHHHHHHHHCCCCCEEEEHHHHHHCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHCC
FFAPDIECATTLLAQGALQRLVPDFM
CCCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNTMTLTPGQLSLSQLYDVWRHPVQLRLDASAIDGINASVACVNDIVAEGRTAYGINTGF
CCCCCCCCCCCCHHHHHHHHCCCEEEEECHHHHCCCCCHHHHHHHHHHCCCEEEECCCCH
GLLAQTRIADEDLQNLQRSLVLSHAAGVGDPLDDAMVRLIMVLKINSLARGFSGIRLSVI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
EALIALVNAGVYPLIPAKGSVGASGDLAPLAHLSLTLLGEGKARWQGEWLPAQAALKKAG
HHHHHHHCCCCCEEECCCCCCCCCCCCCHHHHEEEEEEECCCCCCCCCCCCHHHHHHHCC
LEPVALAAKEGLALLNGTQASTAFALRGLFEAQELFASAVVCGALTTEAVLGSCRPFDAR
CCHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
IHAARGQQGQIDVARLFRHLLTDTSAIAESHHHCHKVQDPYSLRCQPQVMGACLTQLRQT
HEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
KEVLLAEANAVSDNPLVFAEAGEVISGGNFHAEPVAMAADNLALAIAEIGALSERRITLM
HHHHHHHCCCCCCCCEEEEECCCEECCCCCCCCCHHHHHCHHHHHHHHHCCCCCCEEEEH
MDKHMSQLPPFLVKNGGVNSGFMIAQVTAAALASENKALAHPHSVDSLPTSANQEDHVSM
HHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEE
APAAGRRLWEMAANTRGVIAVEWLAACQGIDLREGLTSSPLLEQARQTLRERVAHYTQDR
CCHHHHHHHHHHCCCCCEEEEHHHHHHCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHCC
FFAPDIECATTLLAQGALQRLVPDFM
CCCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA