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The map label for this gene is moeA [H]

Identifier: 29142464

GI number: 29142464

Start: 2101792

End: 2103033

Strand: Direct

Name: moeA [H]

Synonym: t2043

Alternate gene names: 29142464

Gene position: 2101792-2103033 (Clockwise)

Preceding gene: 29142458

Following gene: 29142465

Centisome position: 43.86

GC content: 57.49

Gene sequence:

>1242_bases
ATGTTCATGGAATTTTCCGCCGGATTGATGCCGCTTGAAACGGCGCTGACCCAGATGCTTTCACGTATTACCCCGCTCAC
CGCCGTAGAAACGTTGCCGCTGATGAACTGCTTTGGCCGCATCCTGGCGACCGATATCGTATCTCCCCTTGATGTCCCCG
GCTTTGATAATTCAGCTATGGATGGTTATGCGGTACGTGTGGCGGATTTGTCCGCCGATAAGCCGCTGCCCGTCGCCGGC
AAAGCATTTGCCGGTCAGCCTTACCAAGGAGAATGGCCTGCGGGAACCTGTATTCGCATTATGACCGGCGCCCCGGTGCC
GGCAGGTTGCGAGGCGGTCGTCATGCAAGAGCAGACGGAACAAACTGATGACGGCGTGCGTTTTACCACCGATGTTCGTT
GCGGACAAAACATCCGCCGCCGCGGCGAGGATATTCGCCAGGATGCGGTGGTCTTTCCAGCCGGTACGCGCCTGACTACT
GCCGAACTGCCGGTGCTGGCGTCGCTGGGAATTGCCGATGCGCAGGTAGTACGTAAAGTGCGCGTAGCGCTGTTCTCGAC
CGGCGACGAGCTCCAGCTTCCGGGCCAGCTGCTGGAGGCGGGACAAATTTATGACACTAACCGTCTAACTATACATTTGA
TGCTGCAACAGCTTGGCTGCGAAGTGATCAATTTAGGCATTATTCCTGACGATCCCGGTAAGCTTCGCGCCGCGTTTGTC
GACGCCGACAGCCAGGCCGATGTAGTGATAAGCTCCGGCGGCGTCTCGGTTGGTGAAGCGGACTATACCAAAACCATCCT
TGAGGAGCTGGGCGAAATCGCCTTCTGGAAGCTGGCTATCAAGCCAGGCAAACCGTTTGCCTTCGGCAAGCTCAGTAATA
GCTGGTTCTGTGGCCTGCCGGGGAATCCAGTCTCTGCGGCGCTCACGTTTTATCAACTGGTTCAGCCCTTACTGGCGAAG
CTTGGCGGCAATACGGCAAGCGCTGTACCGCCGCGCCAGCGTGTACGCACAACATCTCGCCTGAAGAAAACGCCGGGGCG
TCTCGATTTCCAGCGCGGCATCCTGCAACGTAGCGCCAACGGCGAACTGGAGGTCACGACCACCGGACACCAGGGCTCAC
ATATTTTCAGCTCGTTTAATCTGGGCAACTGCTTTATTGTGCTGGAGCGTGAACGCGGCAATGTTGAGCCGGGAGAATGG
GTGGAAGTCGAGCCGTTTAATGCTCTGTTCGGAGGCCTGTAA

Upstream 100 bases:

>100_bases
GGTATGTAAAGGCGCAAGGCCGTCTCTAAGACTGAGGTAGCATACTGCCCGCCACTGTTTTCTGACATAATAGCCGGATT
CGATTTTGCCTCGCAGGAGT

Downstream 100 bases:

>100_bases
TGGCGGAACTTAGCGACCAGGAGATGCTGCGCTATAACCGACAAATTATTCTGCGCGGCTTCGATTTTGAAGGGCAGGAA
GCGTTAAAAGATGCGCGGGT

Product: molybdopterin biosynthesis protein MoeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MFMEFSAGLMPLETALTQMLSRITPLTAVETLPLMNCFGRILATDIVSPLDVPGFDNSAMDGYAVRVADLSADKPLPVAG
KAFAGQPYQGEWPAGTCIRIMTGAPVPAGCEAVVMQEQTEQTDDGVRFTTDVRCGQNIRRRGEDIRQDAVVFPAGTRLTT
AELPVLASLGIADAQVVRKVRVALFSTGDELQLPGQLLEAGQIYDTNRLTIHLMLQQLGCEVINLGIIPDDPGKLRAAFV
DADSQADVVISSGGVSVGEADYTKTILEELGEIAFWKLAIKPGKPFAFGKLSNSWFCGLPGNPVSAALTFYQLVQPLLAK
LGGNTASAVPPRQRVRTTSRLKKTPGRLDFQRGILQRSANGELEVTTTGHQGSHIFSSFNLGNCFIVLERERGNVEPGEW
VEVEPFNALFGGL

Sequences:

>Translated_413_residues
MFMEFSAGLMPLETALTQMLSRITPLTAVETLPLMNCFGRILATDIVSPLDVPGFDNSAMDGYAVRVADLSADKPLPVAG
KAFAGQPYQGEWPAGTCIRIMTGAPVPAGCEAVVMQEQTEQTDDGVRFTTDVRCGQNIRRRGEDIRQDAVVFPAGTRLTT
AELPVLASLGIADAQVVRKVRVALFSTGDELQLPGQLLEAGQIYDTNRLTIHLMLQQLGCEVINLGIIPDDPGKLRAAFV
DADSQADVVISSGGVSVGEADYTKTILEELGEIAFWKLAIKPGKPFAFGKLSNSWFCGLPGNPVSAALTFYQLVQPLLAK
LGGNTASAVPPRQRVRTTSRLKKTPGRLDFQRGILQRSANGELEVTTTGHQGSHIFSSFNLGNCFIVLERERGNVEPGEW
VEVEPFNALFGGL
>Mature_413_residues
MFMEFSAGLMPLETALTQMLSRITPLTAVETLPLMNCFGRILATDIVSPLDVPGFDNSAMDGYAVRVADLSADKPLPVAG
KAFAGQPYQGEWPAGTCIRIMTGAPVPAGCEAVVMQEQTEQTDDGVRFTTDVRCGQNIRRRGEDIRQDAVVFPAGTRLTT
AELPVLASLGIADAQVVRKVRVALFSTGDELQLPGQLLEAGQIYDTNRLTIHLMLQQLGCEVINLGIIPDDPGKLRAAFV
DADSQADVVISSGGVSVGEADYTKTILEELGEIAFWKLAIKPGKPFAFGKLSNSWFCGLPGNPVSAALTFYQLVQPLLAK
LGGNTASAVPPRQRVRTTSRLKKTPGRLDFQRGILQRSANGELEVTTTGHQGSHIFSSFNLGNCFIVLERERGNVEPGEW
VEVEPFNALFGGL

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=414, Percent_Identity=36.231884057971, Blast_Score=201, Evalue=9e-52,
Organism=Homo sapiens, GI10880983, Length=414, Percent_Identity=36.231884057971, Blast_Score=201, Evalue=1e-51,
Organism=Escherichia coli, GI1787049, Length=411, Percent_Identity=86.1313868613139, Blast_Score=711, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147659, Length=367, Percent_Identity=30.5177111716621, Blast_Score=151, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17562606, Length=317, Percent_Identity=25.5520504731861, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17136978, Length=278, Percent_Identity=33.0935251798561, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24638841, Length=278, Percent_Identity=33.0935251798561, Blast_Score=135, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44465; Mature: 44465

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFMEFSAGLMPLETALTQMLSRITPLTAVETLPLMNCFGRILATDIVSPLDVPGFDNSAM
CEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
DGYAVRVADLSADKPLPVAGKAFAGQPYQGEWPAGTCIRIMTGAPVPAGCEAVVMQEQTE
CCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEECHHCC
QTDDGVRFTTDVRCGQNIRRRGEDIRQDAVVFPAGTRLTTAELPVLASLGIADAQVVRKV
CCCCCEEEEEECCCCHHHHHCCHHHHHCCEEECCCCEEEECCCCHHHHCCCHHHHHHHHH
RVALFSTGDELQLPGQLLEAGQIYDTNRLTIHLMLQQLGCEVINLGIIPDDPGKLRAAFV
HHHHHCCCCCCCCCHHHHCCCCEECCCCEEEEHHHHHHCCEEEEEECCCCCCCCEEEEEE
DADSQADVVISSGGVSVGEADYTKTILEELGEIAFWKLAIKPGKPFAFGKLSNSWFCGLP
CCCCCCCEEEECCCCCCCCHHHHHHHHHHHCCEEEEEEEECCCCCEEEECCCCCEEECCC
GNPVSAALTFYQLVQPLLAKLGGNTASAVPPRQRVRTTSRLKKTPGRLDFQRGILQRSAN
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCC
GELEVTTTGHQGSHIFSSFNLGNCFIVLERERGNVEPGEWVEVEPFNALFGGL
CCEEEEECCCCCCEEEEECCCCCEEEEEECCCCCCCCCCEEEECCHHHHHCCC
>Mature Secondary Structure
MFMEFSAGLMPLETALTQMLSRITPLTAVETLPLMNCFGRILATDIVSPLDVPGFDNSAM
CEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
DGYAVRVADLSADKPLPVAGKAFAGQPYQGEWPAGTCIRIMTGAPVPAGCEAVVMQEQTE
CCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEECHHCC
QTDDGVRFTTDVRCGQNIRRRGEDIRQDAVVFPAGTRLTTAELPVLASLGIADAQVVRKV
CCCCCEEEEEECCCCHHHHHCCHHHHHCCEEECCCCEEEECCCCHHHHCCCHHHHHHHHH
RVALFSTGDELQLPGQLLEAGQIYDTNRLTIHLMLQQLGCEVINLGIIPDDPGKLRAAFV
HHHHHCCCCCCCCCHHHHCCCCEECCCCEEEEHHHHHHCCEEEEEECCCCCCCCEEEEEE
DADSQADVVISSGGVSVGEADYTKTILEELGEIAFWKLAIKPGKPFAFGKLSNSWFCGLP
CCCCCCCEEEECCCCCCCCHHHHHHHHHHHCCEEEEEEEECCCCCEEEECCCCCEEECCC
GNPVSAALTFYQLVQPLLAKLGGNTASAVPPRQRVRTTSRLKKTPGRLDFQRGILQRSAN
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCC
GELEVTTTGHQGSHIFSSFNLGNCFIVLERERGNVEPGEWVEVEPFNALFGGL
CCEEEEECCCCCCEEEEECCCCCEEEEEECCCCCCCCCCEEEECCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]