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The map label for this gene is lrp [H]

Identifier: 29142397

GI number: 29142397

Start: 2033303

End: 2033797

Strand: Reverse

Name: lrp [H]

Synonym: t1975

Alternate gene names: 29142397

Gene position: 2033797-2033303 (Counterclockwise)

Preceding gene: 29142403

Following gene: 29142396

Centisome position: 42.44

GC content: 48.89

Gene sequence:

>495_bases
ATGGTAGATAGCAAGAAGCGCCCTGGCAAAGATCTCGACCGTATCGATCGTAACATTCTTAATGAACTGCAAAAGGATGG
GCGTATTTCCAACGTCGAGCTTTCTAAACGAGTAGGACTTTCGCCGACACCTTGCCTTGAGCGTGTGCGTCGGCTGGAGC
GACAGGGGTTTATCCAGGGCTATACGGCGCTGTTGAACCCGCATTATCTGGATGCGTCACTTCTGGTATTCGTTGAGATT
ACCTTAAATCGCGGCGCGCCGGATGTGTTTGAACAGTTTAATGCCGCCGTGAAAAAGCTTGAAGAGATTCAGGAGTGTCA
TTTGGTTTCCGGCGATTTCGACTACCTGTTGAAAACCCGTGTACCGGATATGTCAGCGTATCGAAAACTATTGGGAGAGA
CGTTGCTGCGCTTGCCAGGTGTGAACGACACCCGAACTTACGTAGTGATGGAAGAGGTAAAACAGAGTAATCGTCTGGTT
ATTAAGACACGCTAA

Upstream 100 bases:

>100_bases
TCCCTCTGGGTTTCGGTCTATTGTGATGGGCAGCGACTCTGAACAGTGATGTGAGTAGAGTCAGGCAGGAGTAGGGAAGG
AATACAGAGAGACAATAATA

Downstream 100 bases:

>100_bases
CACGGAACAGGTGCAAAATCGCCGTAGTTTGATTACACTCCTGTTAATCCATACAGCAACAGTGCCGGGGCAACCCGGTG
CTGTTGTCCGTTTTAGCATC

Product: leucine-responsive transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 164; Mature: 164

Protein sequence:

>164_residues
MVDSKKRPGKDLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEI
TLNRGAPDVFEQFNAAVKKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQSNRLV
IKTR

Sequences:

>Translated_164_residues
MVDSKKRPGKDLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEI
TLNRGAPDVFEQFNAAVKKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQSNRLV
IKTR
>Mature_164_residues
MVDSKKRPGKDLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEI
TLNRGAPDVFEQFNAAVKKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQSNRLV
IKTR

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=164, Percent_Identity=98.780487804878, Blast_Score=330, Evalue=2e-92,
Organism=Escherichia coli, GI87081742, Length=151, Percent_Identity=32.4503311258278, Blast_Score=95, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 18857; Mature: 18857

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDSKKRPGKDLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQG
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHH
YTALLNPHYLDASLLVFVEITLNRGAPDVFEQFNAAVKKLEEIQECHLVSGDFDYLLKTR
HHHHHCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHC
VPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQSNRLVIKTR
CCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEEC
>Mature Secondary Structure
MVDSKKRPGKDLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQG
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHH
YTALLNPHYLDASLLVFVEITLNRGAPDVFEQFNAAVKKLEEIQECHLVSGDFDYLLKTR
HHHHHCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHC
VPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQSNRLVIKTR
CCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]