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The map label for this gene is sufS [H]

Identifier: 29141705

GI number: 29141705

Start: 1310867

End: 1312087

Strand: Direct

Name: sufS [H]

Synonym: t1241

Alternate gene names: 29141705

Gene position: 1310867-1312087 (Clockwise)

Preceding gene: 29141704

Following gene: 29141706

Centisome position: 27.36

GC content: 57.08

Gene sequence:

>1221_bases
ATGACATTTCCTGTAGAAAAAGTACGGGCGGATTTTCCCATACTGCAGCGTGAAGTTAACGGCCTGCCGCTGGCTTACCT
GGACAGCGCAGCCAGCGCTCAAAAACCTAATCAGGTGATTGATGCTGAATCTGCCTTCTACCGTCACGGCTATGCTGCGG
TACATCGGGGTATCCATACGTTAAGCGCGCAGGCGACCGAAAGCATGGAGAATGTGCGTAAGCAGGCGTCGCGGTTTATT
AACGCCCGCTCCGCAGAAGAACTGGTGTTCGTGCGCGGTACGACGGAGGGCATTAACCTTGTCGCCAACAGTTGGGGAAC
GGAAAATATTCGCGCCGGGGATAACATTATCATCAGCGAGATGGAGCATCACGCCAACATCGTTCCCTGGCAGATGCTGT
GCGAGCGCAAAGGCGCTGAACTGCGCGTGATCCCATTGCATCCTGACGGTACGCTGCGGCTGGAGACCTTAGCTGCGCTG
TTCGATGACCGGACCCGACTGCTGGCCATTACCCATGTATCTAATGTGCTGGGGACGGAAAACCCACTGCCGGACATGAT
TGCGCTGGCGCGCCAGCATGGGGCGAAAGTGCTGGTGGATGGCGCCCAGGCCGTGATGCACCATGCTGTTGACGTCCAGG
CGCTGGACTGCGATTTTTACGTTTTCTCCGGCCATAAACTTTACGGGCCGACCGGCATCGGCATTCTGTATGTTAAAGAG
GCGTTGCTGCAAGAAATGCCGCCGTGGGAAGGGGGCGGGTCGATGATCTCGACCGTCAGCCTGACGCAGGGAACGACATG
GGCGAAAGCGCCCTGGCGTTTTGAGGCGGGAACGCCGAATACTGGCGGCATCATCGGTCTCGGCGCGGCGATTGATTATG
TGACGTCGCTGGGACTGGATAAGATTGGCGATTATGAGCAGATGCTGATGCGCTATGCGCTGGAGCAACTGGCGCAGGTG
CCTGATATCACGCTATATGGCCCGGCGCAGCGGTTGGGCGTCATCGCGTTTAATCTGGGTAAACACCACGCTTACGACGT
CGGCAGCTTTCTTGATAATTACGGTATCGCGGTACGAACGGGGCATCACTGCGCAATGCCGCTCATGGCCTGGTATGGCG
TGCCGGCAATGTGCCGGGCTTCGCTGGCGATGTATAACACCCATGAAGAAGTGGACCGACTGGTGGCAGGATTAACGCGT
ATCCACCGCTTATTGGGATAA

Upstream 100 bases:

>100_bases
TTTACGCGTTTGCCGCAGAGTTAACGGAAGCTATCCATGATAGCGCCCTTAAACAGCAGGTGCTGGCGCGAATCGGCCAG
CGACTGCCCGGAGGCCTGGT

Downstream 100 bases:

>100_bases
CAGTGAGGTTTTATGGCTGCGCTACCGGATAAAGAAAAATTGCTGCGTAACTTTACGCGTTGCGCTAATTGGGAAGAGAA
ATATTTATATATTATTGAGT

Product: bifunctional cysteine desulfurase/selenocysteine lyase

Products: NA

Alternate protein names: Selenocysteine beta-lyase; SCL; Selenocysteine lyase; Selenocysteine reductase [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MTFPVEKVRADFPILQREVNGLPLAYLDSAASAQKPNQVIDAESAFYRHGYAAVHRGIHTLSAQATESMENVRKQASRFI
NARSAEELVFVRGTTEGINLVANSWGTENIRAGDNIIISEMEHHANIVPWQMLCERKGAELRVIPLHPDGTLRLETLAAL
FDDRTRLLAITHVSNVLGTENPLPDMIALARQHGAKVLVDGAQAVMHHAVDVQALDCDFYVFSGHKLYGPTGIGILYVKE
ALLQEMPPWEGGGSMISTVSLTQGTTWAKAPWRFEAGTPNTGGIIGLGAAIDYVTSLGLDKIGDYEQMLMRYALEQLAQV
PDITLYGPAQRLGVIAFNLGKHHAYDVGSFLDNYGIAVRTGHHCAMPLMAWYGVPAMCRASLAMYNTHEEVDRLVAGLTR
IHRLLG

Sequences:

>Translated_406_residues
MTFPVEKVRADFPILQREVNGLPLAYLDSAASAQKPNQVIDAESAFYRHGYAAVHRGIHTLSAQATESMENVRKQASRFI
NARSAEELVFVRGTTEGINLVANSWGTENIRAGDNIIISEMEHHANIVPWQMLCERKGAELRVIPLHPDGTLRLETLAAL
FDDRTRLLAITHVSNVLGTENPLPDMIALARQHGAKVLVDGAQAVMHHAVDVQALDCDFYVFSGHKLYGPTGIGILYVKE
ALLQEMPPWEGGGSMISTVSLTQGTTWAKAPWRFEAGTPNTGGIIGLGAAIDYVTSLGLDKIGDYEQMLMRYALEQLAQV
PDITLYGPAQRLGVIAFNLGKHHAYDVGSFLDNYGIAVRTGHHCAMPLMAWYGVPAMCRASLAMYNTHEEVDRLVAGLTR
IHRLLG
>Mature_405_residues
TFPVEKVRADFPILQREVNGLPLAYLDSAASAQKPNQVIDAESAFYRHGYAAVHRGIHTLSAQATESMENVRKQASRFIN
ARSAEELVFVRGTTEGINLVANSWGTENIRAGDNIIISEMEHHANIVPWQMLCERKGAELRVIPLHPDGTLRLETLAALF
DDRTRLLAITHVSNVLGTENPLPDMIALARQHGAKVLVDGAQAVMHHAVDVQALDCDFYVFSGHKLYGPTGIGILYVKEA
LLQEMPPWEGGGSMISTVSLTQGTTWAKAPWRFEAGTPNTGGIIGLGAAIDYVTSLGLDKIGDYEQMLMRYALEQLAQVP
DITLYGPAQRLGVIAFNLGKHHAYDVGSFLDNYGIAVRTGHHCAMPLMAWYGVPAMCRASLAMYNTHEEVDRLVAGLTRI
HRLLG

Specific function: Cysteine desulfurases mobilize the sulfur from L- cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under speci

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=384, Percent_Identity=23.1770833333333, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI156713448, Length=260, Percent_Identity=26.9230769230769, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1787970, Length=406, Percent_Identity=87.192118226601, Blast_Score=745, Evalue=0.0,
Organism=Escherichia coli, GI1789175, Length=403, Percent_Identity=41.6873449131514, Blast_Score=307, Evalue=8e-85,
Organism=Escherichia coli, GI48994898, Length=225, Percent_Identity=32.8888888888889, Blast_Score=99, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI25143064, Length=320, Percent_Identity=26.875, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI193211090, Length=372, Percent_Identity=24.1935483870968, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319831, Length=228, Percent_Identity=27.1929824561404, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI20129463, Length=255, Percent_Identity=29.8039215686275, Blast_Score=111, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7; =4.4.1.16 [H]

Molecular weight: Translated: 44505; Mature: 44373

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFPVEKVRADFPILQREVNGLPLAYLDSAASAQKPNQVIDAESAFYRHGYAAVHRGIHT
CCCCHHHHHCCCHHHHHHCCCCCEEECCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHH
LSAQATESMENVRKQASRFINARSAEELVFVRGTTEGINLVANSWGTENIRAGDNIIISE
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHEECCCCCCCCCCCCCEEEEE
MEHHANIVPWQMLCERKGAELRVIPLHPDGTLRLETLAALFDDRTRLLAITHVSNVLGTE
HHHCCCCCCHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHCCCCEEEEEEHHHHHHCCC
NPLPDMIALARQHGAKVLVDGAQAVMHHAVDVQALDCDFYVFSGHKLYGPTGIGILYVKE
CCCHHHHHHHHHCCCEEEECHHHHHHHHHCCEEEEEEEEEEEECCEEECCCCCHHHHHHH
ALLQEMPPWEGGGSMISTVSLTQGTTWAKAPWRFEAGTPNTGGIIGLGAAIDYVTSLGLD
HHHHHCCCCCCCCCEEEEEEECCCCCCCCCCEEEECCCCCCCCEEEHHHHHHHHHHCCCC
KIGDYEQMLMRYALEQLAQVPDITLYGPAQRLGVIAFNLGKHHAYDVGSFLDNYGIAVRT
CCCCHHHHHHHHHHHHHHCCCCEEEECCHHHHEEEEEECCCCCHHHHHHHHHCCCEEEEC
GHHCAMPLMAWYGVPAMCRASLAMYNTHEEVDRLVAGLTRIHRLLG
CCCHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
TFPVEKVRADFPILQREVNGLPLAYLDSAASAQKPNQVIDAESAFYRHGYAAVHRGIHT
CCCHHHHHCCCHHHHHHCCCCCEEECCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHH
LSAQATESMENVRKQASRFINARSAEELVFVRGTTEGINLVANSWGTENIRAGDNIIISE
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHEECCCCCCCCCCCCCEEEEE
MEHHANIVPWQMLCERKGAELRVIPLHPDGTLRLETLAALFDDRTRLLAITHVSNVLGTE
HHHCCCCCCHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHCCCCEEEEEEHHHHHHCCC
NPLPDMIALARQHGAKVLVDGAQAVMHHAVDVQALDCDFYVFSGHKLYGPTGIGILYVKE
CCCHHHHHHHHHCCCEEEECHHHHHHHHHCCEEEEEEEEEEEECCEEECCCCCHHHHHHH
ALLQEMPPWEGGGSMISTVSLTQGTTWAKAPWRFEAGTPNTGGIIGLGAAIDYVTSLGLD
HHHHHCCCCCCCCCEEEEEEECCCCCCCCCCEEEECCCCCCCCEEEHHHHHHHHHHCCCC
KIGDYEQMLMRYALEQLAQVPDITLYGPAQRLGVIAFNLGKHHAYDVGSFLDNYGIAVRT
CCCCHHHHHHHHHHHHHHCCCCEEEECCHHHHEEEEEECCCCCHHHHHHHHHCCCEEEEC
GHHCAMPLMAWYGVPAMCRASLAMYNTHEEVDRLVAGLTRIHRLLG
CCCHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA