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The map label for this gene is manC [H]

Identifier: 29141268

GI number: 29141268

Start: 856029

End: 857471

Strand: Direct

Name: manC [H]

Synonym: t0767

Alternate gene names: 29141268

Gene position: 856029-857471 (Clockwise)

Preceding gene: 29141267

Following gene: 29141269

Centisome position: 17.86

GC content: 60.22

Gene sequence:

>1443_bases
ATGATAATGCGTCAGACAAAACTTTACCCGGTTGTGATGGCCGGTGGCTCCGGTAGCCGATTGTGGCCGCTTTCTCGCGT
GCTTTATCCAAAACAGTTTTTGTGCCTGAAAGGCGATCTCACCATGTTGCAAACCACCATTTGCCGTCTGAACGGCGTGG
AGTGCGAAAGCCCGGTGGTTATCTGCAACGAACAGCACCGTTTTATCGTCGCCGAACAGCTCCGCCAGCTCAATAAGCTG
ACGGAGAACATTATTCTTGAGCCCGCCGGGCGCAATACCGCGCCGGCGATTGCGTTGGCGGCGCTGGCAGCGACGCGCCA
GCATACGGACTGCGATCCGCTGATGCTGGTACTGGCGGCGGATCATGCGATCGCCAATGAAGAGGCCTTCCGCGACGCGG
TGCGCGGCGCCATGCCCTATGCCGACGCGGGCAAACTGGTGACCTTCGGTATCGTGCCGGATCTGCCGGAAACCGGCTAT
GGCTATATCCGGCGCGGTGATGTCGTGCCGGGCGCGACGGATGCGGTGGCTTTTGAGGTGGCGCAGTTCGTTGAGAAGCC
GGGGCTGGAAACCGCCCAGGCCTACGTCGCCAGCGGCGATTACTACTGGAACAGCGGCATGTTTCTATTCCGCGCCGGAC
GCTATCTGGAAGAGCTGAAAAAGTTCCGCCCCGATATTCTGGCCGCCTGTGAACAGGCGATGCGCGGCGTCGATCCGGAT
CTTGACTTCATTCGCGTGGATGAAGAGGCCTTCCTCGCCTGTCCGGAAGAGTCCATTGACTACGCGGTGATGGAGCGGAC
GGCGGACGCGGTGGTGATGCCAATGGACGCGGGCTGGAGCGATGTCGGCTCGTGGTCCTCACTGTGGGAAATCAGCGCCC
ACACCCCGGAGGGAAACGTCCACCACGGCGACGTCATCAGTCATAAAACGGAAAACAGCTACGTTTACGCCGAATCCGGC
CTGGTGACCACCGTCGGCGTGAAGGATCTGGTGGTGGTGCAGACCAAAGACGCCGTGCTGATTGCCGATCGCCACGCGGT
GCAGGACGTGAAAAAGGTGGTGGAGAAGATCAAGGCCGACGGACGCCATGAGCACCACATGCACCGCGAGGTTTACCGTC
CGTGGGGCAAATACGACTCCATCGACGCGGGCGAGCGCTATCAGGTGAAGCGCATTACCGTTAAGCCGGGGGAAGGACTG
TCGGTGCAGATGCACCATCACCGTGCCGAGCACTGGGTGGTGGTGGCGGGGACCGCCAGAGTCACCATCAACGGCGAGGT
TAAGCTGCTCGGTGAAAACGAGTCCATCTATATTCCGCTGGGGGCGACCCACTGCCTGGAAAATCCGGGAAAAATACCGC
TCGATTTAATTGAAGTGCGTTCCGGCTCGTATCTCGAAGAGGACGACGTGGTGCGGTTCGAGGACCGTTACGGGCGGGTC
TGA

Upstream 100 bases:

>100_bases
CGCTCGCCATGCCGAAAAACAACACGACGGCACGTGAATACGCCGAACGCACGCTCAATAAAGAGAACGTGCTACGCCAA
TTTATTGCAGATATTCGGGG

Downstream 100 bases:

>100_bases
CGCCTGCAATTATGCCCGGTAAGCGCAACGCGCCATCCGGCAATGAATAACAATAACGATGTTGGCCATTTGCGGTCAGG
GCTAACTGTTGCCTGAAGAA

Product: mannose-1-phosphate guanylyltransferase

Products: NA

Alternate protein names: GDP-mannose pyrophosphorylase; GMP; GMPP [H]

Number of amino acids: Translated: 480; Mature: 480

Protein sequence:

>480_residues
MIMRQTKLYPVVMAGGSGSRLWPLSRVLYPKQFLCLKGDLTMLQTTICRLNGVECESPVVICNEQHRFIVAEQLRQLNKL
TENIILEPAGRNTAPAIALAALAATRQHTDCDPLMLVLAADHAIANEEAFRDAVRGAMPYADAGKLVTFGIVPDLPETGY
GYIRRGDVVPGATDAVAFEVAQFVEKPGLETAQAYVASGDYYWNSGMFLFRAGRYLEELKKFRPDILAACEQAMRGVDPD
LDFIRVDEEAFLACPEESIDYAVMERTADAVVMPMDAGWSDVGSWSSLWEISAHTPEGNVHHGDVISHKTENSYVYAESG
LVTTVGVKDLVVVQTKDAVLIADRHAVQDVKKVVEKIKADGRHEHHMHREVYRPWGKYDSIDAGERYQVKRITVKPGEGL
SVQMHHHRAEHWVVVAGTARVTINGEVKLLGENESIYIPLGATHCLENPGKIPLDLIEVRSGSYLEEDDVVRFEDRYGRV

Sequences:

>Translated_480_residues
MIMRQTKLYPVVMAGGSGSRLWPLSRVLYPKQFLCLKGDLTMLQTTICRLNGVECESPVVICNEQHRFIVAEQLRQLNKL
TENIILEPAGRNTAPAIALAALAATRQHTDCDPLMLVLAADHAIANEEAFRDAVRGAMPYADAGKLVTFGIVPDLPETGY
GYIRRGDVVPGATDAVAFEVAQFVEKPGLETAQAYVASGDYYWNSGMFLFRAGRYLEELKKFRPDILAACEQAMRGVDPD
LDFIRVDEEAFLACPEESIDYAVMERTADAVVMPMDAGWSDVGSWSSLWEISAHTPEGNVHHGDVISHKTENSYVYAESG
LVTTVGVKDLVVVQTKDAVLIADRHAVQDVKKVVEKIKADGRHEHHMHREVYRPWGKYDSIDAGERYQVKRITVKPGEGL
SVQMHHHRAEHWVVVAGTARVTINGEVKLLGENESIYIPLGATHCLENPGKIPLDLIEVRSGSYLEEDDVVRFEDRYGRV
>Mature_480_residues
MIMRQTKLYPVVMAGGSGSRLWPLSRVLYPKQFLCLKGDLTMLQTTICRLNGVECESPVVICNEQHRFIVAEQLRQLNKL
TENIILEPAGRNTAPAIALAALAATRQHTDCDPLMLVLAADHAIANEEAFRDAVRGAMPYADAGKLVTFGIVPDLPETGY
GYIRRGDVVPGATDAVAFEVAQFVEKPGLETAQAYVASGDYYWNSGMFLFRAGRYLEELKKFRPDILAACEQAMRGVDPD
LDFIRVDEEAFLACPEESIDYAVMERTADAVVMPMDAGWSDVGSWSSLWEISAHTPEGNVHHGDVISHKTENSYVYAESG
LVTTVGVKDLVVVQTKDAVLIADRHAVQDVKKVVEKIKADGRHEHHMHREVYRPWGKYDSIDAGERYQVKRITVKPGEGL
SVQMHHHRAEHWVVVAGTARVTINGEVKLLGENESIYIPLGATHCLENPGKIPLDLIEVRSGSYLEEDDVVRFEDRYGRV

Specific function: Involved in the biosynthesis of the capsular polysaccharide colanic acid [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=478, Percent_Identity=91.0041841004184, Blast_Score=881, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 53356; Mature: 53356

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIMRQTKLYPVVMAGGSGSRLWPLSRVLYPKQFLCLKGDLTMLQTTICRLNGVECESPVV
CCCCCCCCEEEEEECCCCCCCCHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCEE
ICNEQHRFIVAEQLRQLNKLTENIILEPAGRNTAPAIALAALAATRQHTDCDPLMLVLAA
EECCCCCCHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEC
DHAIANEEAFRDAVRGAMPYADAGKLVTFGIVPDLPETGYGYIRRGDVVPGATDAVAFEV
CCHHCCHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCEEEECCCCCCCCHHHHHHH
AQFVEKPGLETAQAYVASGDYYWNSGMFLFRAGRYLEELKKFRPDILAACEQAMRGVDPD
HHHHHCCCCCHHHHEEECCCEEECCCEEEEEHHHHHHHHHHHCHHHHHHHHHHHHCCCCC
LDFIRVDEEAFLACPEESIDYAVMERTADAVVMPMDAGWSDVGSWSSLWEISAHTPEGNV
CCEEEECCHHEEECCCHHCCHHHHHCCCCEEEEECCCCCCCCCCCCCEEEEEECCCCCCC
HHGDVISHKTENSYVYAESGLVTTVGVKDLVVVQTKDAVLIADRHAVQDVKKVVEKIKAD
CCCCCCCCCCCCCEEEECCCEEEEECCCEEEEEEECCEEEEECHHHHHHHHHHHHHHHCC
GRHEHHMHREVYRPWGKYDSIDAGERYQVKRITVKPGEGLSVQMHHHRAEHWVVVAGTAR
CCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCCEEEEECCCCCEEEEEEEEEE
VTINGEVKLLGENESIYIPLGATHCLENPGKIPLDLIEVRSGSYLEEDDVVRFEDRYGRV
EEECCEEEEEECCCEEEEECCHHHHHCCCCCCCEEEEEECCCCCCCCCCCEEEHHHCCCC
>Mature Secondary Structure
MIMRQTKLYPVVMAGGSGSRLWPLSRVLYPKQFLCLKGDLTMLQTTICRLNGVECESPVV
CCCCCCCCEEEEEECCCCCCCCHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCEE
ICNEQHRFIVAEQLRQLNKLTENIILEPAGRNTAPAIALAALAATRQHTDCDPLMLVLAA
EECCCCCCHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEC
DHAIANEEAFRDAVRGAMPYADAGKLVTFGIVPDLPETGYGYIRRGDVVPGATDAVAFEV
CCHHCCHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCEEEECCCCCCCCHHHHHHH
AQFVEKPGLETAQAYVASGDYYWNSGMFLFRAGRYLEELKKFRPDILAACEQAMRGVDPD
HHHHHCCCCCHHHHEEECCCEEECCCEEEEEHHHHHHHHHHHCHHHHHHHHHHHHCCCCC
LDFIRVDEEAFLACPEESIDYAVMERTADAVVMPMDAGWSDVGSWSSLWEISAHTPEGNV
CCEEEECCHHEEECCCHHCCHHHHHCCCCEEEEECCCCCCCCCCCCCEEEEEECCCCCCC
HHGDVISHKTENSYVYAESGLVTTVGVKDLVVVQTKDAVLIADRHAVQDVKKVVEKIKAD
CCCCCCCCCCCCCEEEECCCEEEEECCCEEEEEEECCEEEEECHHHHHHHHHHHHHHHCC
GRHEHHMHREVYRPWGKYDSIDAGERYQVKRITVKPGEGLSVQMHHHRAEHWVVVAGTAR
CCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCCEEEEECCCCCEEEEEEEEEE
VTINGEVKLLGENESIYIPLGATHCLENPGKIPLDLIEVRSGSYLEEDDVVRFEDRYGRV
EEECCEEEEEECCCEEEEECCHHHHHCCCCCCCEEEEEECCCCCCCCCCCEEEHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1712067; 11677609 [H]