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The map label for this gene is hemF [H]

Identifier: 29140934

GI number: 29140934

Start: 482393

End: 483292

Strand: Reverse

Name: hemF [H]

Synonym: t0407

Alternate gene names: 29140934

Gene position: 483292-482393 (Counterclockwise)

Preceding gene: 29140935

Following gene: 29140933

Centisome position: 10.09

GC content: 56.44

Gene sequence:

>900_bases
ATGAAACCCGATGCACATCACGTAAAACAGTTTCTGCTACGCCTGCAGGATGATATTTGCCAAACGTTATCCGCTGTGGA
TGGCGCAAACTTTATCGAAGATAGCTGGCGACGCGAAGCGGGCGGCGGCGGACGCAGCCGGGTATTACGCAACGGCGGAA
TTTTCGAACAGGCGGGCGTTAATTTCTCTCACGTTCACGGCGATGCAATGCCCGCGTCCGCCACCGCACATCGGCCAGAA
CTGGCCGGGCGTAGTTTTGAAGCGATGGGCGTATCGCTGGTGGTGCATCCGCACAATCCGTATATTCCCACCAGCCATGC
TAACGTGCGCTTTTTTATTGCCGAAAAACCGGGCGCCGATCCGGTGTGGTGGTTTGGCGGCGGGTTCGATTTAACGCCCT
ACTACGGCTTTGAAGAGGATGCCGTTCACTGGCACCGCACCGCCCGCGACCTGTGCCAGCCGTTTGGCGACGATGTGTAT
CCGCGCTATAAAAAGTGGTGCGATGACTACTTTTTCCTCAAGCATCGTAACGAGCAGCGCGGTATCGGCGGCCTGTTTTT
TGACGATTTGAATACGCCGGATTTCGACCACTGTTTTGCTTTTATGCAGGCGGTCGGTAACGGCTACACCGAGGCGTATT
TACCGATTGTCGAACGACGCAAAGCGATGGTCTGGGGAGAGCGGGAGCGTAATTTTCAACTTTATCGCCGCGGTCGCTAC
GTGGAGTTCAATCTGGTATGGGACAGAGGCACCCTGTTTGGTCTGCAAACCGGCGGGCGCACTGAATCTATCCTGATGTC
GATGCCGCCGCTGGTGCGCTGGGAGTACGACTGGCAGCCGGAAGCGGGTAGCCCGGAAGCGGCGCTGAGCGAGTTTATTC
AGGTACGCGACTGGATTTAA

Upstream 100 bases:

>100_bases
CGGCGTTTCGCCAGAAAATCGCTACGGCGATCGCCAACGGCATCATCAGTTATTTTCACTGGTTTGATAATCAGAAAGCA
CACACGAAGAAACGGTAATC

Downstream 100 bases:

>100_bases
CTTATTTATAAAGTAAAACAATGCAAACAAATACACGGAAAGTAGTAACCAGTGACGCCAAATGGCATCCCCATCTGGGT
ATAAGTTTTATTGGCTGCCT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MKPDAHHVKQFLLRLQDDICQTLSAVDGANFIEDSWRREAGGGGRSRVLRNGGIFEQAGVNFSHVHGDAMPASATAHRPE
LAGRSFEAMGVSLVVHPHNPYIPTSHANVRFFIAEKPGADPVWWFGGGFDLTPYYGFEEDAVHWHRTARDLCQPFGDDVY
PRYKKWCDDYFFLKHRNEQRGIGGLFFDDLNTPDFDHCFAFMQAVGNGYTEAYLPIVERRKAMVWGERERNFQLYRRGRY
VEFNLVWDRGTLFGLQTGGRTESILMSMPPLVRWEYDWQPEAGSPEAALSEFIQVRDWI

Sequences:

>Translated_299_residues
MKPDAHHVKQFLLRLQDDICQTLSAVDGANFIEDSWRREAGGGGRSRVLRNGGIFEQAGVNFSHVHGDAMPASATAHRPE
LAGRSFEAMGVSLVVHPHNPYIPTSHANVRFFIAEKPGADPVWWFGGGFDLTPYYGFEEDAVHWHRTARDLCQPFGDDVY
PRYKKWCDDYFFLKHRNEQRGIGGLFFDDLNTPDFDHCFAFMQAVGNGYTEAYLPIVERRKAMVWGERERNFQLYRRGRY
VEFNLVWDRGTLFGLQTGGRTESILMSMPPLVRWEYDWQPEAGSPEAALSEFIQVRDWI
>Mature_299_residues
MKPDAHHVKQFLLRLQDDICQTLSAVDGANFIEDSWRREAGGGGRSRVLRNGGIFEQAGVNFSHVHGDAMPASATAHRPE
LAGRSFEAMGVSLVVHPHNPYIPTSHANVRFFIAEKPGADPVWWFGGGFDLTPYYGFEEDAVHWHRTARDLCQPFGDDVY
PRYKKWCDDYFFLKHRNEQRGIGGLFFDDLNTPDFDHCFAFMQAVGNGYTEAYLPIVERRKAMVWGERERNFQLYRRGRY
VEFNLVWDRGTLFGLQTGGRTESILMSMPPLVRWEYDWQPEAGSPEAALSEFIQVRDWI

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=299, Percent_Identity=48.494983277592, Blast_Score=283, Evalue=1e-76,
Organism=Escherichia coli, GI1788777, Length=299, Percent_Identity=90.9698996655518, Blast_Score=580, Evalue=1e-167,
Organism=Saccharomyces cerevisiae, GI6320249, Length=317, Percent_Identity=42.2712933753943, Blast_Score=252, Evalue=4e-68,
Organism=Drosophila melanogaster, GI17864388, Length=304, Percent_Identity=46.3815789473684, Blast_Score=281, Evalue=4e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 34387; Mature: 34387

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPDAHHVKQFLLRLQDDICQTLSAVDGANFIEDSWRREAGGGGRSRVLRNGGIFEQAGV
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHCCCCCHHCCC
NFSHVHGDAMPASATAHRPELAGRSFEAMGVSLVVHPHNPYIPTSHANVRFFIAEKPGAD
CEEEECCCCCCCCCCCCCCHHCCCCEEECCEEEEEECCCCCCCCCCCCEEEEEEECCCCC
PVWWFGGGFDLTPYYGFEEDAVHWHRTARDLCQPFGDDVYPRYKKWCDDYFFLKHRNEQR
CEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCHHEEEECCCCCC
GIGGLFFDDLNTPDFDHCFAFMQAVGNGYTEAYLPIVERRKAMVWGERERNFQLYRRGRY
CCCCEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHEECCCCE
VEFNLVWDRGTLFGLQTGGRTESILMSMPPLVRWEYDWQPEAGSPEAALSEFIQVRDWI
EEEEEEECCCEEEEECCCCCCHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKPDAHHVKQFLLRLQDDICQTLSAVDGANFIEDSWRREAGGGGRSRVLRNGGIFEQAGV
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHCCCCCHHCCC
NFSHVHGDAMPASATAHRPELAGRSFEAMGVSLVVHPHNPYIPTSHANVRFFIAEKPGAD
CEEEECCCCCCCCCCCCCCHHCCCCEEECCEEEEEECCCCCCCCCCCCEEEEEEECCCCC
PVWWFGGGFDLTPYYGFEEDAVHWHRTARDLCQPFGDDVYPRYKKWCDDYFFLKHRNEQR
CEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCHHEEEECCCCCC
GIGGLFFDDLNTPDFDHCFAFMQAVGNGYTEAYLPIVERRKAMVWGERERNFQLYRRGRY
CCCCEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCHHEECCCCE
VEFNLVWDRGTLFGLQTGGRTESILMSMPPLVRWEYDWQPEAGSPEAALSEFIQVRDWI
EEEEEEECCCEEEEECCCCCCHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA