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The map label for this gene is pdhR [H]

Identifier: 29140698

GI number: 29140698

Start: 178454

End: 179218

Strand: Direct

Name: pdhR [H]

Synonym: t0157

Alternate gene names: 29140698

Gene position: 178454-179218 (Clockwise)

Preceding gene: 29140694

Following gene: 29140699

Centisome position: 3.72

GC content: 56.86

Gene sequence:

>765_bases
ATGGCCTACAGCAAAATCCGCCAACCAAAACTCTCCGATGTGATCGAGCAGCAGCTGGAGTTTTTAATCCTTGAGGGAAC
ATTGCGTCCCGGAGAAAAACTCCCACCGGAACGTGAACTGGCAAAACAGTTCGACGTCTCCCGTCCCTCCTTGCGCGAGG
CGATTCAACGTCTCGAAGCGAAGGGATTGTTGCTTCGTCGCCAGGGCGGCGGAACCTTCGTGCAGAGCAGCCTGTGGCAG
AGCTTTAGCGACCCGCTGGTGGAACTGCTCTCCGATCACCCTGAATCCCAGTTTGACCTGCTCGAAACGCGCCATGCGCT
GGAAGGCATTGCGGCTTATTACGCGGCGCTGCGCAGCACCGACGAAGATAAAGACCGTATTCGCGAGCTGCACCACGCTA
TTGAGCTGGCGCAAGAGTCCGGCGATCTGGATGCCGAGTCCGAAGCCGTGCTCCAGTATCAAATCGCCGTCACCGAAGCG
GCGCACAACGTGGTATTGCTTCATCTGCTAAGGTGTATGGAGCCGATGCTGGCGCAAAACGTGCGGCAGAACTTCGAATT
GCTGTATGCGCGTCGGGAGATGCTGCCGCTGGTGAGCACGCATCGCACCCGTATATTTGAAGCCATTATGGCCGGAAAAC
CAGAAGAAGCGCGTGAAGCGTCACACCGACATCTGGCGTTTATCGAAGAGATTATGCTGGACAGAAGCCGTGAGGAGAGC
CGTCGTGAACGCGCTTTACGCCGCCTGGAACAGCGCAAGAATTAG

Upstream 100 bases:

>100_bases
CCTGTATGGACAGAAGGTGAATACTTTGTTACTTTAGCGTCACAGACATGAAATTGGTAAGACCAATTGACTCCGGGCAA
ATGGCTTAAGACAGGAAATC

Downstream 100 bases:

>100_bases
TTTTTTCTGGCAGAACGTTAACCAGAAGATGTTGTGAATAACGCGCAAAAATGTGCGCGGCAACTAAACGCAGAACCTGT
CTTATTAAGCTTTCTGACGA

Product: transcriptional regulator PdhR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MAYSKIRQPKLSDVIEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQSSLWQ
SFSDPLVELLSDHPESQFDLLETRHALEGIAAYYAALRSTDEDKDRIRELHHAIELAQESGDLDAESEAVLQYQIAVTEA
AHNVVLLHLLRCMEPMLAQNVRQNFELLYARREMLPLVSTHRTRIFEAIMAGKPEEAREASHRHLAFIEEIMLDRSREES
RRERALRRLEQRKN

Sequences:

>Translated_254_residues
MAYSKIRQPKLSDVIEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQSSLWQ
SFSDPLVELLSDHPESQFDLLETRHALEGIAAYYAALRSTDEDKDRIRELHHAIELAQESGDLDAESEAVLQYQIAVTEA
AHNVVLLHLLRCMEPMLAQNVRQNFELLYARREMLPLVSTHRTRIFEAIMAGKPEEAREASHRHLAFIEEIMLDRSREES
RRERALRRLEQRKN
>Mature_253_residues
AYSKIRQPKLSDVIEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQSSLWQS
FSDPLVELLSDHPESQFDLLETRHALEGIAAYYAALRSTDEDKDRIRELHHAIELAQESGDLDAESEAVLQYQIAVTEAA
HNVVLLHLLRCMEPMLAQNVRQNFELLYARREMLPLVSTHRTRIFEAIMAGKPEEAREASHRHLAFIEEIMLDRSREESR
RERALRRLEQRKN

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=254, Percent_Identity=96.8503937007874, Blast_Score=464, Evalue=1e-132,
Organism=Escherichia coli, GI1790032, Length=242, Percent_Identity=36.3636363636364, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1789353, Length=231, Percent_Identity=27.7056277056277, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790780, Length=231, Percent_Identity=33.3333333333333, Blast_Score=93, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 29412; Mature: 29281

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYSKIRQPKLSDVIEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEA
CCCHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHH
KGLLLRRQGGGTFVQSSLWQSFSDPLVELLSDHPESQFDLLETRHALEGIAAYYAALRST
HCHHEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
DEDKDRIRELHHAIELAQESGDLDAESEAVLQYQIAVTEAAHNVVLLHLLRCMEPMLAQN
CCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRQNFELLYARREMLPLVSTHRTRIFEAIMAGKPEEAREASHRHLAFIEEIMLDRSREES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHH
RRERALRRLEQRKN
HHHHHHHHHHHHCC
>Mature Secondary Structure 
AYSKIRQPKLSDVIEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEA
CCHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHH
KGLLLRRQGGGTFVQSSLWQSFSDPLVELLSDHPESQFDLLETRHALEGIAAYYAALRST
HCHHEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
DEDKDRIRELHHAIELAQESGDLDAESEAVLQYQIAVTEAAHNVVLLHLLRCMEPMLAQN
CCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRQNFELLYARREMLPLVSTHRTRIFEAIMAGKPEEAREASHRHLAFIEEIMLDRSREES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHHH
RRERALRRLEQRKN
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]