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The map label for this gene is lspA

Identifier: 28572409

GI number: 28572409

Start: 277872

End: 278324

Strand: Direct

Name: lspA

Synonym: TW250

Alternate gene names: 28572409

Gene position: 277872-278324 (Clockwise)

Preceding gene: 28572408

Following gene: 28572410

Centisome position: 30.01

GC content: 42.38

Gene sequence:

>453_bases
TTGACGACTAGAACCCTGCGGTTCTACGCTCTGGTGGGTTTTTTAGTTTTTCTGGATCAGGTTACCAAGTATCTTGCGCA
TGCTTATCTTGCGCGCGATTTTATTGTTATTCCGAATCTTTTTAGGCTTACTCTTGCGAAGAATTCGGGTGCTGCCTTCT
CTTTTGGAACTGGCTTTTCTTGGCTTTTCTTTTTGCTCGGGATTATTGCCCTTATTTTTATTGGATGGTTTTTACCGAGG
ACAACTGGATCGATAGTATTTTTGGCCCTGTTACAGGGAGGTATTGCTGGCAATGTGTTTGATAGGCTTTTCAAGCCTCC
ATATTTTGGTAATGGCGAGGTGGTGGATTTTCTAAACACCCCATTGTTCTCTGGAGTTGTGTTTAACATTGCCGATCTTT
TCATATTGGCTGGAGTCTTTGGGACGTTCTTGTTTTTGAAGGGGTCAAAGTAA

Upstream 100 bases:

>100_bases
AGCGTGTTCTTGATTTGCGTGCTTTCGAGAGTGACTATAGGGACAGGTTGCGTGCTTTTTTGCAGAGCGGGCTGCGTGAC
CTAGAGCCTAAGAACCCCTC

Downstream 100 bases:

>100_bases
TATCTGGGTCAAAAGTTTTTGTTATCCCTCCGCATCTTGATGGATGCAGGATTGATTTTGCAATCTCCAGTCTTAGCGGA
ATGTCAAGGAGTTGTGTTGC

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 150; Mature: 149

Protein sequence:

>150_residues
MTTRTLRFYALVGFLVFLDQVTKYLAHAYLARDFIVIPNLFRLTLAKNSGAAFSFGTGFSWLFFLLGIIALIFIGWFLPR
TTGSIVFLALLQGGIAGNVFDRLFKPPYFGNGEVVDFLNTPLFSGVVFNIADLFILAGVFGTFLFLKGSK

Sequences:

>Translated_150_residues
MTTRTLRFYALVGFLVFLDQVTKYLAHAYLARDFIVIPNLFRLTLAKNSGAAFSFGTGFSWLFFLLGIIALIFIGWFLPR
TTGSIVFLALLQGGIAGNVFDRLFKPPYFGNGEVVDFLNTPLFSGVVFNIADLFILAGVFGTFLFLKGSK
>Mature_149_residues
TTRTLRFYALVGFLVFLDQVTKYLAHAYLARDFIVIPNLFRLTLAKNSGAAFSFGTGFSWLFFLLGIIALIFIGWFLPRT
TGSIVFLALLQGGIAGNVFDRLFKPPYFGNGEVVDFLNTPLFSGVVFNIADLFILAGVFGTFLFLKGSK

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_TROW8 (Q83I41)

Other databases:

- EMBL:   BX251410
- RefSeq:   NP_789189.1
- STRING:   Q83I41
- GeneID:   1064541
- GenomeReviews:   BX072543_GR
- KEGG:   tws:TW250
- eggNOG:   NOG120397
- HOGENOM:   HBG724422
- OMA:   YLARDFI
- ProtClustDB:   CLSK229600
- BioCyc:   TWHI218496:TW0234-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 16643; Mature: 16512

Theoretical pI: Translated: 10.37; Mature: 10.37

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 101-101 ACT_SITE 132-132

Signals:

None

Transmembrane regions:

HASH(0xbaf9ab4)-; HASH(0xc6a0550)-; HASH(0xb029c5c)-; HASH(0xbc37d5c)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTRTLRFYALVGFLVFLDQVTKYLAHAYLARDFIVIPNLFRLTLAKNSGAAFSFGTGFS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHEEECCCCCEEECCCCHH
WLFFLLGIIALIFIGWFLPRTTGSIVFLALLQGGIAGNVFDRLFKPPYFGNGEVVDFLNT
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCHHHHCC
PLFSGVVFNIADLFILAGVFGTFLFLKGSK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
>Mature Secondary Structure 
TTRTLRFYALVGFLVFLDQVTKYLAHAYLARDFIVIPNLFRLTLAKNSGAAFSFGTGFS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHEEECCCCCEEECCCCHH
WLFFLLGIIALIFIGWFLPRTTGSIVFLALLQGGIAGNVFDRLFKPPYFGNGEVVDFLNT
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCHHHHCC
PLFSGVVFNIADLFILAGVFGTFLFLKGSK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12606174