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The map label for this gene is pepQ [H]

Identifier: 28378852

GI number: 28378852

Start: 2040588

End: 2041697

Strand: Direct

Name: pepQ [H]

Synonym: lp_2258

Alternate gene names: 28378852

Gene position: 2040588-2041697 (Clockwise)

Preceding gene: 28378838

Following gene: 28378856

Centisome position: 61.68

GC content: 46.4

Gene sequence:

>1110_bases
TTGACAGATTATACGAAACTGCAACAAGTCCGTCAATGGACCCAAGACAATCACGTTGACGTGACCTACATCAGTAACTT
TCACACAATTTCATATTTGACTGGTTTTGAGAGCAACCCCTACGAACGGACGCTAGCACTGTTTGTTTTCGCGGATGCGG
AACCATTTCTCTTTGCACCCGCTCTCGAAGTTGAAGCAATCAAGGAGATGGGCTGGCCTTACAAAGTTTTCGGCTACCTC
GACCATGAAAATCCATACGCGCTAATTGCTGATCACATTCACGCACAATTGACTGATCCTAAAGTTTGGGCCCTTGAAAC
GGGAAACTTGACGTTAGACCGCTTTACCGCGCTCAAACAGCAATTTCCAGCTGCCCACTTCGATAAGGATCTATCACCTT
ATATTCAGCAATTACGGCTGGTCAAAACAGCTGATGAACTTGAAAAACTAAACATTGCCGGTAAATGGGCCGACTTTGCT
TTTGAACAAGGATTTGCTGCTGTCAAGGCGGGTCGCACCGAACAACAGATTGCTGCCGAATTACAGTATGCCTTAATGAA
AAAGGGAATTATGGAAATGAGTTTCGACACTTTAGTCCAAGCTGGTGAACATGCCGCCAACCCCCATGGTGCAACTAACG
AAACCCAAGTCAAGCCAAATGAATTAGTGCTATTCGACCTCGGCGTCATGTATGAAGGCTATGCTTCTGATGCTTCCCGG
ACAATTGCTTATGGCCAACCGAGTGCCAAGCAAAAGGAAATCTTTGACGTCTGTCTGGAAGCCAACTTGACTGCTCAGGC
AGCCATTAAACCAGGCATGGCAGCCGAAGATGTCGATAAAATCGCACGCGATATCATCACCAAAGCGGGCTATGGCGAAT
ACTTCATTCACCGGTTAGGTCACGGAATCGGCCAAACTGACCACGAATTTCCTTCGATTATGGCTGGTAACCACATGCCA
CTCGTTGAAGGCATGTGCTTCTCAGTAGAACCTGGGATCTACATTCCCGGCGTAGCTGGTGTTCGAATCGAAGACTGTGG
GGTCGTTACTAAGGAAGGCTTTAAGCCATTTACCCATACGCCAAAAGAATTAAAAGTATTAGATCTTTAA

Upstream 100 bases:

>100_bases
CACGAAGATTGTTATTTTGGGCTCATTATTCTCAGCTTTTTATCATCAACAGCGCTATACTAGTATTATTATCTATTATT
TTATCTAAGGAGTGTTTGAA

Downstream 100 bases:

>100_bases
TTAAAAACGTCAAAGAAGGCCGTCACGACATAATCCGTGACGGCCCTCTTTTTTTACCTAGCGTTGACTGGTACTTGCTT
TTAGTGTTATTCCGGTAGCG

Product: Xaa-Pro dipeptidase

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 369; Mature: 368

Protein sequence:

>369_residues
MTDYTKLQQVRQWTQDNHVDVTYISNFHTISYLTGFESNPYERTLALFVFADAEPFLFAPALEVEAIKEMGWPYKVFGYL
DHENPYALIADHIHAQLTDPKVWALETGNLTLDRFTALKQQFPAAHFDKDLSPYIQQLRLVKTADELEKLNIAGKWADFA
FEQGFAAVKAGRTEQQIAAELQYALMKKGIMEMSFDTLVQAGEHAANPHGATNETQVKPNELVLFDLGVMYEGYASDASR
TIAYGQPSAKQKEIFDVCLEANLTAQAAIKPGMAAEDVDKIARDIITKAGYGEYFIHRLGHGIGQTDHEFPSIMAGNHMP
LVEGMCFSVEPGIYIPGVAGVRIEDCGVVTKEGFKPFTHTPKELKVLDL

Sequences:

>Translated_369_residues
MTDYTKLQQVRQWTQDNHVDVTYISNFHTISYLTGFESNPYERTLALFVFADAEPFLFAPALEVEAIKEMGWPYKVFGYL
DHENPYALIADHIHAQLTDPKVWALETGNLTLDRFTALKQQFPAAHFDKDLSPYIQQLRLVKTADELEKLNIAGKWADFA
FEQGFAAVKAGRTEQQIAAELQYALMKKGIMEMSFDTLVQAGEHAANPHGATNETQVKPNELVLFDLGVMYEGYASDASR
TIAYGQPSAKQKEIFDVCLEANLTAQAAIKPGMAAEDVDKIARDIITKAGYGEYFIHRLGHGIGQTDHEFPSIMAGNHMP
LVEGMCFSVEPGIYIPGVAGVRIEDCGVVTKEGFKPFTHTPKELKVLDL
>Mature_368_residues
TDYTKLQQVRQWTQDNHVDVTYISNFHTISYLTGFESNPYERTLALFVFADAEPFLFAPALEVEAIKEMGWPYKVFGYLD
HENPYALIADHIHAQLTDPKVWALETGNLTLDRFTALKQQFPAAHFDKDLSPYIQQLRLVKTADELEKLNIAGKWADFAF
EQGFAAVKAGRTEQQIAAELQYALMKKGIMEMSFDTLVQAGEHAANPHGATNETQVKPNELVLFDLGVMYEGYASDASRT
IAYGQPSAKQKEIFDVCLEANLTAQAAIKPGMAAEDVDKIARDIITKAGYGEYFIHRLGHGIGQTDHEFPSIMAGNHMPL
VEGMCFSVEPGIYIPGVAGVRIEDCGVVTKEGFKPFTHTPKELKVLDL

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=248, Percent_Identity=29.4354838709677, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI149589008, Length=303, Percent_Identity=26.7326732673267, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI260593665, Length=303, Percent_Identity=26.7326732673267, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI264681563, Length=360, Percent_Identity=27.2222222222222, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI93141226, Length=168, Percent_Identity=34.5238095238095, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI264681565, Length=356, Percent_Identity=25.561797752809, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1788728, Length=230, Percent_Identity=41.7391304347826, Blast_Score=174, Evalue=8e-45,
Organism=Escherichia coli, GI1789275, Length=281, Percent_Identity=27.4021352313167, Blast_Score=108, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17509539, Length=218, Percent_Identity=27.5229357798165, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17508215, Length=299, Percent_Identity=23.7458193979933, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320922, Length=254, Percent_Identity=23.2283464566929, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6321118, Length=287, Percent_Identity=23.3449477351916, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322999, Length=202, Percent_Identity=27.7227722772277, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19920384, Length=244, Percent_Identity=26.6393442622951, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI21357079, Length=304, Percent_Identity=25, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 41175; Mature: 41044

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDYTKLQQVRQWTQDNHVDVTYISNFHTISYLTGFESNPYERTLALFVFADAEPFLFAP
CCCHHHHHHHHHHHCCCCEEEEEECCCEEEEEEECCCCCCCCEEEEEEEEECCCCEEEEC
ALEVEAIKEMGWPYKVFGYLDHENPYALIADHIHAQLTDPKVWALETGNLTLDRFTALKQ
CHHHHHHHHCCCCEEEEEEEECCCCEEEEEHHHHHEECCCEEEEEECCCEEHHHHHHHHH
QFPAAHFDKDLSPYIQQLRLVKTADELEKLNIAGKWADFAFEQGFAAVKAGRTEQQIAAE
HCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHCCCHHHHHHHH
LQYALMKKGIMEMSFDTLVQAGEHAANPHGATNETQVKPNELVLFDLGVMYEGYASDASR
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCEECCCCCCCCC
TIAYGQPSAKQKEIFDVCLEANLTAQAAIKPGMAAEDVDKIARDIITKAGYGEYFIHRLG
EEECCCCCCHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHH
HGIGQTDHEFPSIMAGNHMPLVEGMCFSVEPGIYIPGVAGVRIEDCGVVTKEGFKPFTHT
CCCCCCCCCCCHHHCCCCCCHHCCEEEEECCCEEECCCCCCEEECCCCCCCCCCCCCCCC
PKELKVLDL
CCCEEEECC
>Mature Secondary Structure 
TDYTKLQQVRQWTQDNHVDVTYISNFHTISYLTGFESNPYERTLALFVFADAEPFLFAP
CCHHHHHHHHHHHCCCCEEEEEECCCEEEEEEECCCCCCCCEEEEEEEEECCCCEEEEC
ALEVEAIKEMGWPYKVFGYLDHENPYALIADHIHAQLTDPKVWALETGNLTLDRFTALKQ
CHHHHHHHHCCCCEEEEEEEECCCCEEEEEHHHHHEECCCEEEEEECCCEEHHHHHHHHH
QFPAAHFDKDLSPYIQQLRLVKTADELEKLNIAGKWADFAFEQGFAAVKAGRTEQQIAAE
HCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHCCCHHHHHHHH
LQYALMKKGIMEMSFDTLVQAGEHAANPHGATNETQVKPNELVLFDLGVMYEGYASDASR
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCEECCCCCCCCC
TIAYGQPSAKQKEIFDVCLEANLTAQAAIKPGMAAEDVDKIARDIITKAGYGEYFIHRLG
EEECCCCCCHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHH
HGIGQTDHEFPSIMAGNHMPLVEGMCFSVEPGIYIPGVAGVRIEDCGVVTKEGFKPFTHT
CCCCCCCCCCCHHHCCCCCCHHCCEEEEECCCEEECCCCCCEEECCCCCCCCCCCCCCCC
PKELKVLDL
CCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA