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The map label for this gene is nox1 [H]

Identifier: 28377618

GI number: 28377618

Start: 693877

End: 695289

Strand: Direct

Name: nox1 [H]

Synonym: lp_0760

Alternate gene names: 28377618

Gene position: 693877-695289 (Clockwise)

Preceding gene: 28377616

Following gene: 28377619

Centisome position: 20.97

GC content: 43.81

Gene sequence:

>1413_bases
ATGAAGATTGTAATTGTTGGATGTACGCATGCGGGGACCGCTGCGGCTGCACAAATTCTGAAGGATCATCCGGAGGCTAC
GGTCACGATTTATGAGCGTGATGACAATATTTCATTCTTATCATGTGGGATCTACCTTTATCTCGGGGGAAAGGTCAATC
ACTTGGAAGATATGTTCTATTCGTCACCAGAAACGTTAGCCAAGTTGGGGGCAATGGTCAGAACCAAACATAACGTGTTA
AAAATTGACGCCCAGTCGAAGACCTTACAAGTGGTTGACATGACTACTGGAAAAGTGTTTGGCGATACTTATGATAAATT
GATTATGACGACTGGTTCAAATGTTGCGGTCCCGCCGATTTTTGGAATCGATGAGTCTAAGGTCCTATTATGCAAGACCT
ACAGCCAAGCACAGGAAATTTACCAAACAGCCCAAGACAATCAGCGGATCGCAATCATTGGGGCGGGTTATATTGGAACC
GAATTATCTGAAAGTTATGCAAATACACATCATGAAGTAACGTTATTCCAATCGCATGATCAAATTTTGAATAATTACAT
TAGTAAAGAAATTTCAGACCAAGCAGTTCAGCTATTAAAAGATCATGGCGTGAACGTGCTATTGAATCACCAAGTAACTG
CCTTTACTGGTAATGATGATGGTGAACTTGTCATTGAAACCAATCAAGGCGATTTTAATGCTGATCTAGCAATTGTCGGA
ACTGGGTTTGTTCCCAATACAGAACTGTTACGCGGTCAAGTTGAGATGGATAAGCACGGTGCCATTATCATCAATGATTA
CGTTCAGACCTCTGACCCAGATATTTACGCTGCTGGTGATTCTTGTGTCGTTAACTTCAACCCAACTGGGCGTTCGGCTT
ATACGCCATTAGCAACCAATGCGGTTCGGCAGGGTGCGTTAGCGGGGGCCAATGTTTTTGGTAACCAGCAACGATATATG
GGGACTCAAGCGACATCGGCCATGCAACTCTTCGATCACACGCTGGCAACCACGGGGTTAACACTGGCAATGGCGAAATT
GAATCATATTCCAGCTGAACGGGTGACTTATGAGGGCAACTGGCGACCAGCTTACATGCCAAGTACGGCGAAACTGACGA
TTGAATTAATTTATAATCCGGAAAATCGTAAAATTCTCGGTGCTCAGTTCTTAAGTGCGCATGAAGTGGCACAGTCTGCT
AATGCGTTATCAATCGCGATTCAAAATGGAAACACCATCGATGATCTAGCATTTGTGGATATGTTATTCTCACCTAATTT
TGATGAACCATTCAATTATCTGAACCTCGTCGCCCAACAAGCGATTGAACAAGAACGCCAGGCAGGCCGCAATCACCCAC
GAATTACGGCCTATGGCGATTGGGCCAAGCAAAATGACAAGGATTTACAATAA

Upstream 100 bases:

>100_bases
ACCTGTATTTATATTGACTATAGTTATGTATTTGCGCAGTAAAGCGGTTATAATATACCTATGGTTAAATAAATAAAATT
ATAATTGGGAGCAAAATGAA

Downstream 100 bases:

>100_bases
GAAGTAAGTCTTACCATGGGTTGAATTCAAGTGAACTGGCATAATTTTATTTATTTAAATCTCGGTTTTTAGTCAATATA
TGGTTAAAAGCTATAATTGA

Product: NADH oxidase

Products: NA

Alternate protein names: NOXase [H]

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MKIVIVGCTHAGTAAAAQILKDHPEATVTIYERDDNISFLSCGIYLYLGGKVNHLEDMFYSSPETLAKLGAMVRTKHNVL
KIDAQSKTLQVVDMTTGKVFGDTYDKLIMTTGSNVAVPPIFGIDESKVLLCKTYSQAQEIYQTAQDNQRIAIIGAGYIGT
ELSESYANTHHEVTLFQSHDQILNNYISKEISDQAVQLLKDHGVNVLLNHQVTAFTGNDDGELVIETNQGDFNADLAIVG
TGFVPNTELLRGQVEMDKHGAIIINDYVQTSDPDIYAAGDSCVVNFNPTGRSAYTPLATNAVRQGALAGANVFGNQQRYM
GTQATSAMQLFDHTLATTGLTLAMAKLNHIPAERVTYEGNWRPAYMPSTAKLTIELIYNPENRKILGAQFLSAHEVAQSA
NALSIAIQNGNTIDDLAFVDMLFSPNFDEPFNYLNLVAQQAIEQERQAGRNHPRITAYGDWAKQNDKDLQ

Sequences:

>Translated_470_residues
MKIVIVGCTHAGTAAAAQILKDHPEATVTIYERDDNISFLSCGIYLYLGGKVNHLEDMFYSSPETLAKLGAMVRTKHNVL
KIDAQSKTLQVVDMTTGKVFGDTYDKLIMTTGSNVAVPPIFGIDESKVLLCKTYSQAQEIYQTAQDNQRIAIIGAGYIGT
ELSESYANTHHEVTLFQSHDQILNNYISKEISDQAVQLLKDHGVNVLLNHQVTAFTGNDDGELVIETNQGDFNADLAIVG
TGFVPNTELLRGQVEMDKHGAIIINDYVQTSDPDIYAAGDSCVVNFNPTGRSAYTPLATNAVRQGALAGANVFGNQQRYM
GTQATSAMQLFDHTLATTGLTLAMAKLNHIPAERVTYEGNWRPAYMPSTAKLTIELIYNPENRKILGAQFLSAHEVAQSA
NALSIAIQNGNTIDDLAFVDMLFSPNFDEPFNYLNLVAQQAIEQERQAGRNHPRITAYGDWAKQNDKDLQ
>Mature_470_residues
MKIVIVGCTHAGTAAAAQILKDHPEATVTIYERDDNISFLSCGIYLYLGGKVNHLEDMFYSSPETLAKLGAMVRTKHNVL
KIDAQSKTLQVVDMTTGKVFGDTYDKLIMTTGSNVAVPPIFGIDESKVLLCKTYSQAQEIYQTAQDNQRIAIIGAGYIGT
ELSESYANTHHEVTLFQSHDQILNNYISKEISDQAVQLLKDHGVNVLLNHQVTAFTGNDDGELVIETNQGDFNADLAIVG
TGFVPNTELLRGQVEMDKHGAIIINDYVQTSDPDIYAAGDSCVVNFNPTGRSAYTPLATNAVRQGALAGANVFGNQQRYM
GTQATSAMQLFDHTLATTGLTLAMAKLNHIPAERVTYEGNWRPAYMPSTAKLTIELIYNPENRKILGAQFLSAHEVAQSA
NALSIAIQNGNTIDDLAFVDMLFSPNFDEPFNYLNLVAQQAIEQERQAGRNHPRITAYGDWAKQNDKDLQ

Specific function: Catalyzes the four-electron reduction of molecular oxygen to water [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI226437568, Length=341, Percent_Identity=21.7008797653959, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI21389617, Length=341, Percent_Identity=21.7008797653959, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI65787454, Length=341, Percent_Identity=21.7008797653959, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI91199540, Length=347, Percent_Identity=24.7838616714697, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI1789065, Length=183, Percent_Identity=31.1475409836066, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1788892, Length=211, Percent_Identity=23.2227488151659, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI87082354, Length=438, Percent_Identity=22.8310502283105, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1789765, Length=325, Percent_Identity=24, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1786307, Length=332, Percent_Identity=22.5903614457831, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17559934, Length=208, Percent_Identity=26.9230769230769, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71983419, Length=230, Percent_Identity=30.8695652173913, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71983429, Length=230, Percent_Identity=30.8695652173913, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI281359715, Length=180, Percent_Identity=25.5555555555556, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI281359713, Length=180, Percent_Identity=25.5555555555556, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24639250, Length=180, Percent_Identity=25.5555555555556, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI18543267, Length=180, Percent_Identity=25.5555555555556, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24639252, Length=180, Percent_Identity=25.5555555555556, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24639257, Length=203, Percent_Identity=25.615763546798, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24585130, Length=228, Percent_Identity=23.6842105263158, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28573993, Length=314, Percent_Identity=26.4331210191083, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24581020, Length=314, Percent_Identity=26.4331210191083, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.99.3 [H]

Molecular weight: Translated: 51518; Mature: 51518

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVIVGCTHAGTAAAAQILKDHPEATVTIYERDDNISFLSCGIYLYLGGKVNHLEDMFY
CEEEEEECCCCCHHHHHHHHHCCCCEEEEEEEECCCEEEEEEEEEEEECCCCHHHHHHHC
SSPETLAKLGAMVRTKHNVLKIDAQSKTLQVVDMTTGKVFGDTYDKLIMTTGSNVAVPPI
CCHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEECCCCCCCCCCCEEEEECCCCEECCCE
FGIDESKVLLCKTYSQAQEIYQTAQDNQRIAIIGAGYIGTELSESYANTHHEVTLFQSHD
ECCCCCCEEEEECHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHCCCCEEEEEEECHH
QILNNYISKEISDQAVQLLKDHGVNVLLNHQVTAFTGNDDGELVIETNQGDFNADLAIVG
HHHHHHHHHHHHHHHHHHHHHCCCEEEEECEEEEEECCCCCEEEEECCCCCCCCEEEEEE
TGFVPNTELLRGQVEMDKHGAIIINDYVQTSDPDIYAAGDSCVVNFNPTGRSAYTPLATN
CCCCCCHHHHCCEEEECCCCEEEEECCCCCCCCCEEECCCEEEEEECCCCCCCCCCHHHH
AVRQGALAGANVFGNQQRYMGTQATSAMQLFDHTLATTGLTLAMAKLNHIPAERVTYEGN
HHHHCCCCCCHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEECCC
WRPAYMPSTAKLTIELIYNPENRKILGAQFLSAHEVAQSANALSIAIQNGNTIDDLAFVD
CCEEECCCCEEEEEEEEECCCCCEEEHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHH
MLFSPNFDEPFNYLNLVAQQAIEQERQAGRNHPRITAYGDWAKQNDKDLQ
HHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MKIVIVGCTHAGTAAAAQILKDHPEATVTIYERDDNISFLSCGIYLYLGGKVNHLEDMFY
CEEEEEECCCCCHHHHHHHHHCCCCEEEEEEEECCCEEEEEEEEEEEECCCCHHHHHHHC
SSPETLAKLGAMVRTKHNVLKIDAQSKTLQVVDMTTGKVFGDTYDKLIMTTGSNVAVPPI
CCHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEECCCCCCCCCCCEEEEECCCCEECCCE
FGIDESKVLLCKTYSQAQEIYQTAQDNQRIAIIGAGYIGTELSESYANTHHEVTLFQSHD
ECCCCCCEEEEECHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHCCCCEEEEEEECHH
QILNNYISKEISDQAVQLLKDHGVNVLLNHQVTAFTGNDDGELVIETNQGDFNADLAIVG
HHHHHHHHHHHHHHHHHHHHHCCCEEEEECEEEEEECCCCCEEEEECCCCCCCCEEEEEE
TGFVPNTELLRGQVEMDKHGAIIINDYVQTSDPDIYAAGDSCVVNFNPTGRSAYTPLATN
CCCCCCHHHHCCEEEECCCCEEEEECCCCCCCCCEEECCCEEEEEECCCCCCCCCCHHHH
AVRQGALAGANVFGNQQRYMGTQATSAMQLFDHTLATTGLTLAMAKLNHIPAERVTYEGN
HHHHCCCCCCHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEECCC
WRPAYMPSTAKLTIELIYNPENRKILGAQFLSAHEVAQSANALSIAIQNGNTIDDLAFVD
CCEEECCCCEEEEEEEEECCCCCEEEHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHH
MLFSPNFDEPFNYLNLVAQQAIEQERQAGRNHPRITAYGDWAKQNDKDLQ
HHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1404382; 12663927; 2511195; 8262333 [H]