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The map label for this gene is gcp

Identifier: 28377586

GI number: 28377586

Start: 659208

End: 660254

Strand: Direct

Name: gcp

Synonym: lp_0721

Alternate gene names: 28377586

Gene position: 659208-660254 (Clockwise)

Preceding gene: 28377585

Following gene: 28377588

Centisome position: 19.93

GC content: 46.7

Gene sequence:

>1047_bases
ATGGGAACCGTGGAAAAACAAAACTTGATTTTAGCGTTTGAGTCCAGTTGTGACGAGACTAGTGTGGCAGTGATCAAAGA
TGGCCATGAGATTTTATCCAACGTGATTGCAACGCAGATTAATAGTCACAAACGGTTTGGTGGCGTGGTTCCTGAAGTTG
CCAGCCGTCATCATATTGAACAAATTACAATTTGTATTGAAGCCGCACTTCAAGAGGCACACGTGACGTATGCTGACCTT
GATGCTGTTGCCGTGACGTATGGCCCCGGTCTAGTGGGGGCACTGTTAGTCGGTGTTAATGCAGCTAAGACAGTGGCATA
CGCGCACCAATTACCGCTGATTCCAGTTAACCATATGGCTGGGCACATTTATGCTGCTCGGTTCGTTAAGCCGTTCGAAT
TTCCGCTAATGGCACTATTAGTTTCTGGCGGTCATACTGAATTGGTCTACATGCAAGCAGATGGGCAATTTGAGATTATA
GGTGAAACACGTGACGATGCGGCTGGTGAAGCCTATGATAAAATCGGTCGGGTATTGGGTGTTCCATATCCGGCAGGTAA
AGTCATTGACGAGATGGCACATGCAGGCCACGACACTTTCAAATTTCCGCGAGCAATGATTGATGAAGATAATTACGATT
TTAGTTTTAGTGGGCTGAAGAGTGCGTTCATCAATACGGTCCATCACGCAGATCAAATTGGCGCGACTCTGGATAAGAAC
GATTTAGCGGCTAGCTTTCAGGCTAGCGTGGTTGATGTCCTGATGAGTAAAACGTTACGAGTCCTTAAACAATATCCAGT
TAAGCAATTGGTCTTAGCCGGTGGCGTTGCAGCTAACCAGGGGCTACGTGAACGGTTACAACAAGATTTACCAGCCGCTT
TCCCTGACACCGAACTAATCTTAGCGCCTCTAAAGTTATGCGGTGATAATGGTGCCATGATTGGTGCTGCGGGCTATGTT
CAATATCAGCATCACCAATTCGGCGACGCGACGCTGAATGCCGATCCAAGCTTAGAATTTGATTGGATGCCAGGTATGTT
GAAGTAA

Upstream 100 bases:

>100_bases
TATCAGCAATGCGGCTTTGACCAGATTGCCACGCGTAAGGAATATTATCATGATCCCGAAGAAGATGCGTGGATCATGCG
TAAAATGATTAATTAAAAGG

Downstream 100 bases:

>100_bases
TGAAGCAGTTATAAACGGGTGTGAAAAGTCAGTCCTTTTCACACCCGTTTTAGTATCTTTTCATTAATTATGATTAAAAG
AGGATGATTCCTAGAATCAA

Product: putative DNA-binding/iron metalloprotein/AP endonuclease

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MGTVEKQNLILAFESSCDETSVAVIKDGHEILSNVIATQINSHKRFGGVVPEVASRHHIEQITICIEAALQEAHVTYADL
DAVAVTYGPGLVGALLVGVNAAKTVAYAHQLPLIPVNHMAGHIYAARFVKPFEFPLMALLVSGGHTELVYMQADGQFEII
GETRDDAAGEAYDKIGRVLGVPYPAGKVIDEMAHAGHDTFKFPRAMIDEDNYDFSFSGLKSAFINTVHHADQIGATLDKN
DLAASFQASVVDVLMSKTLRVLKQYPVKQLVLAGGVAANQGLRERLQQDLPAAFPDTELILAPLKLCGDNGAMIGAAGYV
QYQHHQFGDATLNADPSLEFDWMPGMLK

Sequences:

>Translated_348_residues
MGTVEKQNLILAFESSCDETSVAVIKDGHEILSNVIATQINSHKRFGGVVPEVASRHHIEQITICIEAALQEAHVTYADL
DAVAVTYGPGLVGALLVGVNAAKTVAYAHQLPLIPVNHMAGHIYAARFVKPFEFPLMALLVSGGHTELVYMQADGQFEII
GETRDDAAGEAYDKIGRVLGVPYPAGKVIDEMAHAGHDTFKFPRAMIDEDNYDFSFSGLKSAFINTVHHADQIGATLDKN
DLAASFQASVVDVLMSKTLRVLKQYPVKQLVLAGGVAANQGLRERLQQDLPAAFPDTELILAPLKLCGDNGAMIGAAGYV
QYQHHQFGDATLNADPSLEFDWMPGMLK
>Mature_347_residues
GTVEKQNLILAFESSCDETSVAVIKDGHEILSNVIATQINSHKRFGGVVPEVASRHHIEQITICIEAALQEAHVTYADLD
AVAVTYGPGLVGALLVGVNAAKTVAYAHQLPLIPVNHMAGHIYAARFVKPFEFPLMALLVSGGHTELVYMQADGQFEIIG
ETRDDAAGEAYDKIGRVLGVPYPAGKVIDEMAHAGHDTFKFPRAMIDEDNYDFSFSGLKSAFINTVHHADQIGATLDKND
LAASFQASVVDVLMSKTLRVLKQYPVKQLVLAGGVAANQGLRERLQQDLPAAFPDTELILAPLKLCGDNGAMIGAAGYVQ
YQHHQFGDATLNADPSLEFDWMPGMLK

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=339, Percent_Identity=31.2684365781711, Blast_Score=151, Evalue=8e-37,
Organism=Homo sapiens, GI8923380, Length=322, Percent_Identity=33.5403726708075, Blast_Score=138, Evalue=8e-33,
Organism=Escherichia coli, GI1789445, Length=337, Percent_Identity=44.213649851632, Blast_Score=278, Evalue=4e-76,
Organism=Caenorhabditis elegans, GI17557464, Length=329, Percent_Identity=34.0425531914894, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI71995670, Length=314, Percent_Identity=31.8471337579618, Blast_Score=129, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6320099, Length=342, Percent_Identity=32.7485380116959, Blast_Score=142, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6322891, Length=311, Percent_Identity=27.9742765273312, Blast_Score=105, Evalue=8e-24,
Organism=Drosophila melanogaster, GI20129063, Length=347, Percent_Identity=31.700288184438, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI21357207, Length=321, Percent_Identity=29.2834890965732, Blast_Score=135, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_LACPL (Q88YN0)

Other databases:

- EMBL:   AL935253
- RefSeq:   NP_784478.1
- ProteinModelPortal:   Q88YN0
- MEROPS:   M22.001
- GeneID:   1063334
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_0721
- NMPDR:   fig|220668.1.peg.612
- HOGENOM:   HBG304663
- OMA:   PAVGVHH
- ProtClustDB:   PRK09604
- BioCyc:   LPLA220668:LP_0721-MONOMER
- BRENDA:   3.4.24.57
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017860
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 37564; Mature: 37433

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTVEKQNLILAFESSCDETSVAVIKDGHEILSNVIATQINSHKRFGGVVPEVASRHHIE
CCCCCCCCEEEEEECCCCCCEEEEEECCHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHH
QITICIEAALQEAHVTYADLDAVAVTYGPGLVGALLVGVNAAKTVAYAHQLPLIPVNHMA
HHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHH
GHIYAARFVKPFEFPLMALLVSGGHTELVYMQADGQFEIIGETRDDAAGEAYDKIGRVLG
HHHHHHHHCCCHHHHHHHHHHCCCCEEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHC
VPYPAGKVIDEMAHAGHDTFKFPRAMIDEDNYDFSFSGLKSAFINTVHHADQIGATLDKN
CCCCCHHHHHHHHHCCCCHHHCCHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCH
DLAASFQASVVDVLMSKTLRVLKQYPVKQLVLAGGVAANQGLRERLQQDLPAAFPDTELI
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHH
LAPLKLCGDNGAMIGAAGYVQYQHHQFGDATLNADPSLEFDWMPGMLK
HHHHHHHCCCCCEEECCCEEEEECCCCCCEEECCCCCEEECCCCCCCC
>Mature Secondary Structure 
GTVEKQNLILAFESSCDETSVAVIKDGHEILSNVIATQINSHKRFGGVVPEVASRHHIE
CCCCCCCEEEEEECCCCCCEEEEEECCHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHH
QITICIEAALQEAHVTYADLDAVAVTYGPGLVGALLVGVNAAKTVAYAHQLPLIPVNHMA
HHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHH
GHIYAARFVKPFEFPLMALLVSGGHTELVYMQADGQFEIIGETRDDAAGEAYDKIGRVLG
HHHHHHHHCCCHHHHHHHHHHCCCCEEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHC
VPYPAGKVIDEMAHAGHDTFKFPRAMIDEDNYDFSFSGLKSAFINTVHHADQIGATLDKN
CCCCCHHHHHHHHHCCCCHHHCCHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCH
DLAASFQASVVDVLMSKTLRVLKQYPVKQLVLAGGVAANQGLRERLQQDLPAAFPDTELI
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHH
LAPLKLCGDNGAMIGAAGYVQYQHHQFGDATLNADPSLEFDWMPGMLK
HHHHHHHCCCCCEEECCCEEEEECCCCCCEEECCCCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12566566