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The map label for this gene is dut [H]

Identifier: 28377482

GI number: 28377482

Start: 575224

End: 575760

Strand: Direct

Name: dut [H]

Synonym: lp_0604

Alternate gene names: 28377482

Gene position: 575224-575760 (Clockwise)

Preceding gene: 28377478

Following gene: 28377483

Centisome position: 17.39

GC content: 45.07

Gene sequence:

>537_bases
ATGGCACGGGGATTTGAAATTGTAAGTCAATACGCGCAGGCGGGGTTACATGTACCTTACCGCACCACCAAGCAAGCAGC
TGGCTATGACTTCGAAGCGGCGGAAGATTTTACGTTACCGTCAATTTGGAAAATGAACTTTATCAAAGTACTTTGGCAAA
TACATCATGGTGAAACGAGTTCTGCAGCCGATTTGGATGCGGCGGCTAAAGTCCTTAAACCATGGCTTGTTCCAACGGGT
ATTAAGGCATTTATGAATGAAGGTGAATACTTACTATTAGCCAATCGTTCCAGCAACCCCTTGAAGCGTAACTTGATTCT
ACCGAATGGGATTGGCGTCATTGACGCTGACTACTATAACAATCCCAAGAACGAAGGTGCGATTTTCGTCCAATTAATCA
ACATGGGGATTCGCGACGTTCACATTAAAAAGGGTGAACGCATTGCCCAAGGGATTTTTACCCCTTATCTGACTGTTACG
GATGAAACGAATGTGACAACGACACGTTCTGGGGGCTTCGGTTCGACCAATAAATAG

Upstream 100 bases:

>100_bases
AATTAAACCGGTAATTGCCCGTTTTGTCAACGAAACTTCTATAATAAAAGTATGGTAAAATGTGAACACTAAATTAATGT
TGAGAAAGTAGGAATTTGAA

Downstream 100 bases:

>100_bases
GAAATAATAAAAAATCGGTAAAGCCAAGGTGATTTAAAGGCTTTAATGATTAATAATGGTAAAATAAACTTATGATTGTG
AATACCCATAGCATGAAAAT

Product: trimetaphosphatase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 178; Mature: 177

Protein sequence:

>178_residues
MARGFEIVSQYAQAGLHVPYRTTKQAAGYDFEAAEDFTLPSIWKMNFIKVLWQIHHGETSSAADLDAAAKVLKPWLVPTG
IKAFMNEGEYLLLANRSSNPLKRNLILPNGIGVIDADYYNNPKNEGAIFVQLINMGIRDVHIKKGERIAQGIFTPYLTVT
DETNVTTTRSGGFGSTNK

Sequences:

>Translated_178_residues
MARGFEIVSQYAQAGLHVPYRTTKQAAGYDFEAAEDFTLPSIWKMNFIKVLWQIHHGETSSAADLDAAAKVLKPWLVPTG
IKAFMNEGEYLLLANRSSNPLKRNLILPNGIGVIDADYYNNPKNEGAIFVQLINMGIRDVHIKKGERIAQGIFTPYLTVT
DETNVTTTRSGGFGSTNK
>Mature_177_residues
ARGFEIVSQYAQAGLHVPYRTTKQAAGYDFEAAEDFTLPSIWKMNFIKVLWQIHHGETSSAADLDAAAKVLKPWLVPTGI
KAFMNEGEYLLLANRSSNPLKRNLILPNGIGVIDADYYNNPKNEGAIFVQLINMGIRDVHIKKGERIAQGIFTPYLTVTD
ETNVTTTRSGGFGSTNK

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 19706; Mature: 19574

Theoretical pI: Translated: 8.78; Mature: 8.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARGFEIVSQYAQAGLHVPYRTTKQAAGYDFEAAEDFTLPSIWKMNFIKVLWQIHHGETS
CCCHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
SAADLDAAAKVLKPWLVPTGIKAFMNEGEYLLLANRSSNPLKRNLILPNGIGVIDADYYN
CCCHHHHHHHHHHCCCCCCCHHHHHCCCCEEEEECCCCCCCEEEEECCCCCCEEECCCCC
NPKNEGAIFVQLINMGIRDVHIKKGERIAQGIFTPYLTVTDETNVTTTRSGGFGSTNK
CCCCCCEEEEEEECCCCEEEEECCCHHHHHHHCCCEEEEECCCCCEEECCCCCCCCCC
>Mature Secondary Structure 
ARGFEIVSQYAQAGLHVPYRTTKQAAGYDFEAAEDFTLPSIWKMNFIKVLWQIHHGETS
CCHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
SAADLDAAAKVLKPWLVPTGIKAFMNEGEYLLLANRSSNPLKRNLILPNGIGVIDADYYN
CCCHHHHHHHHHHCCCCCCCHHHHHCCCCEEEEECCCCCCCEEEEECCCCCCEEECCCCC
NPKNEGAIFVQLINMGIRDVHIKKGERIAQGIFTPYLTVTDETNVTTTRSGGFGSTNK
CCCCCCEEEEEEECCCCEEEEECCCHHHHHHHCCCEEEEECCCCCEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]