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The map label for this gene is fabH1

Identifier: 28377469

GI number: 28377469

Start: 562296

End: 563267

Strand: Direct

Name: fabH1

Synonym: lp_0588

Alternate gene names: 28377469

Gene position: 562296-563267 (Clockwise)

Preceding gene: 28377468

Following gene: 28377470

Centisome position: 17.0

GC content: 47.22

Gene sequence:

>972_bases
ATGCCAACTTATACAAAATTAACCGCCATGGGACAATATGTTCCGGGACGCGTTGTTGATAATGACGAATTAGCAGCCAT
TATGGACACTAGCGACGAATGGATTCAGGCGCATACTGGGATTAAAACCCGACACTACGCGATGAATGATGAAAACACCT
CGGATTTAGCCACCCAGGTCGCCCAGCAGTTACTACAAAAAAGTGGTTTAGCTGCCAGTGCCATTGATTTGATCCTAGTT
ACGACAATTACGCCCGATGCCTTAACACCTGCGACGGCTTGTTTAGTGCAAGCTAATATTGGCGCTGATAATGCGTTTGC
GTTCGACCTGAGTGCAGCGTGTGCTGGGTTCACGTTTGGCCTAGCAACGGCTGACAAGTTTATTCGCAGTGGGCAATACC
AAAATGTGATGGTGATCAGTGCGGAAGTTAATTCCAAGATGATGGACTTTCAGGACCGGACGGCAGCCGTCTTCTTTGGG
GACGGTGCTGGTGGCGCGTTATTACAAGCTACTGACAATCCAGATGAAAACAGCTTGATCGCTGAGAAATTAGAATCGCA
AGGAAACGCTACGGTCATTCACTCTGGACGAGTACGGCCGATTACTGAAGTTGCCGCAACGAACTACCCGCAAACGGATG
CGTTTTACCAAGTTGGACGGGATGTTTTTCAATTTGCCACGACGGTTGTTCCAGAACAGATGCGTGGGTTAATTGCGAGT
GCGCAACTGACACCCAGTGATTTACAATACGTGATCTGTCATCAAGCTAATTTACGGATCATTGAAAAAATTGCGGCTAA
CTTGGCGTTACCAATGACGAAGTTTCCACATAATGTTGATCATTATGGTAATACGTCCTCAGCTGGGGTGGCAATGGCCT
TAGCCAATGTTTTTGATACCTTAACTGGGCCAGTGTTGTTAACAGCATTTGGTGGCGGGCTAGCGTATGGCTCAGTCTTG
ATCAAGAAGTAG

Upstream 100 bases:

>100_bases
TTTCTAAGGATTTACCAAAAATACAGCCGTAAACTTTGACGGATAGGCTTTTATTGATAAAATTAAACTAATCGAAACGG
AAAGTAGCGGGGGTTTAAAA

Downstream 100 bases:

>100_bases
GGGTGTGCAGATGGAATTAAAAGATTTAGATCGATTAGTTGAGAAATACGCGCGACAGGGTTATCAGCAAATTCGCGTTA
AAGCCGGCGACTTGGAGATT

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III protein 1; Beta-ketoacyl-ACP synthase III 1; KAS III 1

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MPTYTKLTAMGQYVPGRVVDNDELAAIMDTSDEWIQAHTGIKTRHYAMNDENTSDLATQVAQQLLQKSGLAASAIDLILV
TTITPDALTPATACLVQANIGADNAFAFDLSAACAGFTFGLATADKFIRSGQYQNVMVISAEVNSKMMDFQDRTAAVFFG
DGAGGALLQATDNPDENSLIAEKLESQGNATVIHSGRVRPITEVAATNYPQTDAFYQVGRDVFQFATTVVPEQMRGLIAS
AQLTPSDLQYVICHQANLRIIEKIAANLALPMTKFPHNVDHYGNTSSAGVAMALANVFDTLTGPVLLTAFGGGLAYGSVL
IKK

Sequences:

>Translated_323_residues
MPTYTKLTAMGQYVPGRVVDNDELAAIMDTSDEWIQAHTGIKTRHYAMNDENTSDLATQVAQQLLQKSGLAASAIDLILV
TTITPDALTPATACLVQANIGADNAFAFDLSAACAGFTFGLATADKFIRSGQYQNVMVISAEVNSKMMDFQDRTAAVFFG
DGAGGALLQATDNPDENSLIAEKLESQGNATVIHSGRVRPITEVAATNYPQTDAFYQVGRDVFQFATTVVPEQMRGLIAS
AQLTPSDLQYVICHQANLRIIEKIAANLALPMTKFPHNVDHYGNTSSAGVAMALANVFDTLTGPVLLTAFGGGLAYGSVL
IKK
>Mature_322_residues
PTYTKLTAMGQYVPGRVVDNDELAAIMDTSDEWIQAHTGIKTRHYAMNDENTSDLATQVAQQLLQKSGLAASAIDLILVT
TITPDALTPATACLVQANIGADNAFAFDLSAACAGFTFGLATADKFIRSGQYQNVMVISAEVNSKMMDFQDRTAAVFFGD
GAGGALLQATDNPDENSLIAEKLESQGNATVIHSGRVRPITEVAATNYPQTDAFYQVGRDVFQFATTVVPEQMRGLIASA
QLTPSDLQYVICHQANLRIIEKIAANLALPMTKFPHNVDHYGNTSSAGVAMALANVFDTLTGPVLLTAFGGGLAYGSVLI
KK

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=327, Percent_Identity=35.7798165137615, Blast_Score=200, Evalue=1e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH1_LACPL (Q88YZ4)

Other databases:

- EMBL:   AB025973
- EMBL:   AL935253
- RefSeq:   NP_784361.1
- ProteinModelPortal:   Q88YZ4
- SMR:   Q88YZ4
- GeneID:   1061551
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_0588
- NMPDR:   fig|220668.1.peg.495
- HOGENOM:   HBG649927
- OMA:   LPATACM
- ProtClustDB:   PRK12879
- BioCyc:   LPLA220668:LP_0588-MONOMER
- BRENDA:   2.3.1.180
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.180

Molecular weight: Translated: 34391; Mature: 34260

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: ACT_SITE 114-114 ACT_SITE 254-254 ACT_SITE 284-284

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTYTKLTAMGQYVPGRVVDNDELAAIMDTSDEWIQAHTGIKTRHYAMNDENTSDLATQV
CCCCHHHHHHCCCCCCEEECCCCEEEEECCCHHHHHHHCCCCEEEEECCCCCHHHHHHHH
AQQLLQKSGLAASAIDLILVTTITPDALTPATACLVQANIGADNAFAFDLSAACAGFTFG
HHHHHHHCCCCHHHEEEEEEEECCCCCCCCHHHEEEEECCCCCCEEEEEHHHHHHHHHHH
LATADKFIRSGQYQNVMVISAEVNSKMMDFQDRTAAVFFGDGAGGALLQATDNPDENSLI
HHHHHHHHHCCCCCEEEEEEECCCCHHHCCCCCEEEEEEECCCCCEEEEECCCCCCCHHH
AEKLESQGNATVIHSGRVRPITEVAATNYPQTDAFYQVGRDVFQFATTVVPEQMRGLIAS
HHHHHCCCCEEEEECCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQLTPSDLQYVICHQANLRIIEKIAANLALPMTKFPHNVDHYGNTSSAGVAMALANVFDT
CCCCCCCCEEEEEECCCHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
LTGPVLLTAFGGGLAYGSVLIKK
HCCCEEEEHHCCHHHCCEEEECC
>Mature Secondary Structure 
PTYTKLTAMGQYVPGRVVDNDELAAIMDTSDEWIQAHTGIKTRHYAMNDENTSDLATQV
CCCHHHHHHCCCCCCEEECCCCEEEEECCCHHHHHHHCCCCEEEEECCCCCHHHHHHHH
AQQLLQKSGLAASAIDLILVTTITPDALTPATACLVQANIGADNAFAFDLSAACAGFTFG
HHHHHHHCCCCHHHEEEEEEEECCCCCCCCHHHEEEEECCCCCCEEEEEHHHHHHHHHHH
LATADKFIRSGQYQNVMVISAEVNSKMMDFQDRTAAVFFGDGAGGALLQATDNPDENSLI
HHHHHHHHHCCCCCEEEEEEECCCCHHHCCCCCEEEEEEECCCCCEEEEECCCCCCCHHH
AEKLESQGNATVIHSGRVRPITEVAATNYPQTDAFYQVGRDVFQFATTVVPEQMRGLIAS
HHHHHCCCCEEEEECCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQLTPSDLQYVICHQANLRIIEKIAANLALPMTKFPHNVDHYGNTSSAGVAMALANVFDT
CCCCCCCCEEEEEECCCHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
LTGPVLLTAFGGGLAYGSVLIKK
HCCCEEEEHHCCHHHCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11133475; 12566566