Definition Lactobacillus plantarum WCFS1, complete genome.
Accession NC_004567
Length 3,308,274

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The map label for this gene is npsB [H]

Identifier: 28377462

GI number: 28377462

Start: 553290

End: 555707

Strand: Direct

Name: npsB [H]

Synonym: lp_0581

Alternate gene names: 28377462

Gene position: 553290-555707 (Clockwise)

Preceding gene: 28377461

Following gene: 28377463

Centisome position: 16.72

GC content: 36.06

Gene sequence:

>2418_bases
ATGAATAGAGAAGAAGTCTTAAATGTGATTTTATCATATGCGGAAATCACACCTAATAGTCTTGCAGTTGTTGATAATTC
TGACGAGTTAACATATAGCGAGTTGAGAGTAGCTGTTGAGAGGACTAGCCAGTTGTTGCAAAAAAATCAGCTTAATGATC
AAATTGTTGTCTTGCGTTTGCCGCGAGGAGTCAAATTTACAGTAATGGTTTTAGCACTAACTAAGATGAAAATTACCTTC
ATTCCTCAGGACATTGCGCAACCATTAGCAAGATTAGATGCAATGGTTGAAACTGCAGGTGCAGAAACTTTAATTGAACT
TAAAGATGATCACTACACTTTTAGTACGGTACCAAATAGTAGTAAGAATCATTCTACGGCCTGGGCAATTTACTTTACTT
CTGGTTCAACTGGCAATCCTAAGGGCGTTGAGATTCCTTTTCGAACAGTAGCAAATACTGTTGAAACACAAAAAGAAGAT
TATCAATTAACGACGGATGATAGAGTAGCAAGTTTTACTCCATACTCATTCGTAGTTAGTTACTATGATCTTTTTTCTAG
TCTTTACTCTGGATCAACATTGTATGTATTAGGAGAAACTGAGCGGCATGATTTAAATAAATTAGAGAAGTATTTACAAG
ATAATAAGATCACTTTTATGAATGCTTCAACTATGATTGGTGAAATCATTATGCGATCCATGAAGTTACCAAGTATGCGT
TTATTAACGTTGGCGGGGCAGCGTTTTCCAGATGTAGACATTGGTCAATTAAACTATCAAATTATGAATGTTTATGGTAA
TACTGAATGTGCGTGTGCAACAATTTGTCGTGTAAGACCTGGTGAGACAGTGACAATTGGAAAACCAATTCGCAACATGC
ATGCTTTGATTTTAGATGATCAACAACGTGTGCTACCGCATGGATCTGTTGGAGAGTTGTTTATTTATGGTGTTCAAGTA
ACCAATGGGTATTTTTTAAACGAAAAGGCCACAAATAAAGCTTTTACCAGTGTTAGCTATCAAAATCAAAACATATGGGG
CTATCGAACGGGAGATTACGCAAAAGTACTACCCAACGGTGAATTGGAATATCGTGGTCGTCGAGACAGTCAATATAAGA
TTAATGGTGTGAGAATCGATTTGAGCGAAGTGGGGAGCGTATGTCGAGAAATTATTCCGAACCTTAAACAGTGTTATTTA
GCGGTGAAAGCAAATTGTATTTATTGTTGGGTAACTAGTGCAAAAGCGATTGATGAATCTCAAATACTAAATGCACTTGC
TAGTCGGTTACCAAGCGTTATGATACCCATTGGGATTCATCAACTAACAAGTTTCCCATTAAATATTAATGGAAAAATTG
ATGAACGACGAATGATAAAGGAATGGTCGCGACAATCTCTAACCAAAGATAACCGTCATTTGTCAAAGTCTCAAAGGGAA
AACGAACAATTTCTGATTAATGCATGGAGTGAAGTGCTTGATGCTGATCCAGATACAATTAACTATCAGAGTAACTTTAG
AATGTTAGGGGCAACCTCGCTACAAATTATGGAATTGGGCGTTAGAATCTTGGATGAGCGACATAAACAATTAAACTTTG
TCGATTTATACTATCATCCTGTACTGGCAGATATGGCCGCATTATTGTCTCAAAAAAATGTTTTTAAGGCTATTTATACG
TTTGTGCCACGAACGGATGATATGGGTGACAAGCCTGCTCTCTTTGTAATTCACTCTGGTAATACTGGGAGTGATGTGTA
TCGACCATTATTTACGGGAATTAAGCGGCCAAGCTTTCCGATATATGTCATTGAACCACATAATCTGTTGAATCCTGAAG
ATCAAATTTATGGTATTGAAAATCTGGCAAAATATTATCTTCAAATGATCAACAAATTTTTGCCAGAAAGCTCAAAACGT
GAAATTAATTTAATGGGATGGAGTTATGGTGGCGTTGTTGCTAGTGAGATGTGTTATCAGCTAGAGCATGAAACGAGTTT
ACTACATGTGAATCAGTTGACTGTGTTAGATTCTTCATTTTATCTTAGCTCAGAAGATTTACAAAGAGTTCGTAAACGAG
AAGCTAACGGATTTTATGCAAAATATTTTACAGAGACTCATATTTTTGAAGGAATGGATAAAAAGAATGTCACAACGGAA
CGTTTAATTGCGAATAATCATCAAGTGTGTGAGGATCTTTTTAATTATCATTCTAAGCAAGTTAATGTTGCAACGACCTT
TGTTCGTAGTATGGTAGAAGAGAATCCTTTAACAGATGAGCAAATCAAACTATTATTTAAGCATGTAACGATTAAAAATG
TGTATGATGGTCATGATTATTTGTTTGTTCATGAGTCAAGTAGGAGCCTTATTCAGGATGTTTTGGGATTAGCTGCAAAG
GTAGTTAAAGAAAAGTGA

Upstream 100 bases:

>100_bases
CTGAAAAGTTTTCCACAGATACCTAGTAACCATAATTCATTATTGTGGGTTGTGGTGATGAGCTGGATATGCCAGAAAAG
CATTAAATGTGAGGTGGAAG

Downstream 100 bases:

>100_bases
AACAATTATTGTATTACTTGAATAATCAGAGCATGTATTCAAAATTAGAAAAATTTGTTAGGGCATTTGCTCCTGAGCGT
TATCAGTATGCTATGAGTTT

Product: non-ribosomal peptide synthetase NpsB

Products: NA

Alternate protein names: Tyrocidine synthase II; ATP-dependent proline adenylase; ProA; Proline activase; ATP-dependent phenylalanine adenylase; PheA; Phenylalanine activase; ATP-dependent D-phenylalanine adenylase; D-PheA; D-phenylalanine activase; Phenylalanine racemase [ATP-hydrolyzing] [H]

Number of amino acids: Translated: 805; Mature: 805

Protein sequence:

>805_residues
MNREEVLNVILSYAEITPNSLAVVDNSDELTYSELRVAVERTSQLLQKNQLNDQIVVLRLPRGVKFTVMVLALTKMKITF
IPQDIAQPLARLDAMVETAGAETLIELKDDHYTFSTVPNSSKNHSTAWAIYFTSGSTGNPKGVEIPFRTVANTVETQKED
YQLTTDDRVASFTPYSFVVSYYDLFSSLYSGSTLYVLGETERHDLNKLEKYLQDNKITFMNASTMIGEIIMRSMKLPSMR
LLTLAGQRFPDVDIGQLNYQIMNVYGNTECACATICRVRPGETVTIGKPIRNMHALILDDQQRVLPHGSVGELFIYGVQV
TNGYFLNEKATNKAFTSVSYQNQNIWGYRTGDYAKVLPNGELEYRGRRDSQYKINGVRIDLSEVGSVCREIIPNLKQCYL
AVKANCIYCWVTSAKAIDESQILNALASRLPSVMIPIGIHQLTSFPLNINGKIDERRMIKEWSRQSLTKDNRHLSKSQRE
NEQFLINAWSEVLDADPDTINYQSNFRMLGATSLQIMELGVRILDERHKQLNFVDLYYHPVLADMAALLSQKNVFKAIYT
FVPRTDDMGDKPALFVIHSGNTGSDVYRPLFTGIKRPSFPIYVIEPHNLLNPEDQIYGIENLAKYYLQMINKFLPESSKR
EINLMGWSYGGVVASEMCYQLEHETSLLHVNQLTVLDSSFYLSSEDLQRVRKREANGFYAKYFTETHIFEGMDKKNVTTE
RLIANNHQVCEDLFNYHSKQVNVATTFVRSMVEENPLTDEQIKLLFKHVTIKNVYDGHDYLFVHESSRSLIQDVLGLAAK
VVKEK

Sequences:

>Translated_805_residues
MNREEVLNVILSYAEITPNSLAVVDNSDELTYSELRVAVERTSQLLQKNQLNDQIVVLRLPRGVKFTVMVLALTKMKITF
IPQDIAQPLARLDAMVETAGAETLIELKDDHYTFSTVPNSSKNHSTAWAIYFTSGSTGNPKGVEIPFRTVANTVETQKED
YQLTTDDRVASFTPYSFVVSYYDLFSSLYSGSTLYVLGETERHDLNKLEKYLQDNKITFMNASTMIGEIIMRSMKLPSMR
LLTLAGQRFPDVDIGQLNYQIMNVYGNTECACATICRVRPGETVTIGKPIRNMHALILDDQQRVLPHGSVGELFIYGVQV
TNGYFLNEKATNKAFTSVSYQNQNIWGYRTGDYAKVLPNGELEYRGRRDSQYKINGVRIDLSEVGSVCREIIPNLKQCYL
AVKANCIYCWVTSAKAIDESQILNALASRLPSVMIPIGIHQLTSFPLNINGKIDERRMIKEWSRQSLTKDNRHLSKSQRE
NEQFLINAWSEVLDADPDTINYQSNFRMLGATSLQIMELGVRILDERHKQLNFVDLYYHPVLADMAALLSQKNVFKAIYT
FVPRTDDMGDKPALFVIHSGNTGSDVYRPLFTGIKRPSFPIYVIEPHNLLNPEDQIYGIENLAKYYLQMINKFLPESSKR
EINLMGWSYGGVVASEMCYQLEHETSLLHVNQLTVLDSSFYLSSEDLQRVRKREANGFYAKYFTETHIFEGMDKKNVTTE
RLIANNHQVCEDLFNYHSKQVNVATTFVRSMVEENPLTDEQIKLLFKHVTIKNVYDGHDYLFVHESSRSLIQDVLGLAAK
VVKEK
>Mature_805_residues
MNREEVLNVILSYAEITPNSLAVVDNSDELTYSELRVAVERTSQLLQKNQLNDQIVVLRLPRGVKFTVMVLALTKMKITF
IPQDIAQPLARLDAMVETAGAETLIELKDDHYTFSTVPNSSKNHSTAWAIYFTSGSTGNPKGVEIPFRTVANTVETQKED
YQLTTDDRVASFTPYSFVVSYYDLFSSLYSGSTLYVLGETERHDLNKLEKYLQDNKITFMNASTMIGEIIMRSMKLPSMR
LLTLAGQRFPDVDIGQLNYQIMNVYGNTECACATICRVRPGETVTIGKPIRNMHALILDDQQRVLPHGSVGELFIYGVQV
TNGYFLNEKATNKAFTSVSYQNQNIWGYRTGDYAKVLPNGELEYRGRRDSQYKINGVRIDLSEVGSVCREIIPNLKQCYL
AVKANCIYCWVTSAKAIDESQILNALASRLPSVMIPIGIHQLTSFPLNINGKIDERRMIKEWSRQSLTKDNRHLSKSQRE
NEQFLINAWSEVLDADPDTINYQSNFRMLGATSLQIMELGVRILDERHKQLNFVDLYYHPVLADMAALLSQKNVFKAIYT
FVPRTDDMGDKPALFVIHSGNTGSDVYRPLFTGIKRPSFPIYVIEPHNLLNPEDQIYGIENLAKYYLQMINKFLPESSKR
EINLMGWSYGGVVASEMCYQLEHETSLLHVNQLTVLDSSFYLSSEDLQRVRKREANGFYAKYFTETHIFEGMDKKNVTTE
RLIANNHQVCEDLFNYHSKQVNVATTFVRSMVEENPLTDEQIKLLFKHVTIKNVYDGHDYLFVHESSRSLIQDVLGLAAK
VVKEK

Specific function: Activates the second to fourth amino acids in tyrocidine (in tyrocidine A, Pro, Phe, and D-Phe) and epimerizes the last one [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 3 acyl carrier domains [H]

Homologues:

Organism=Homo sapiens, GI45580730, Length=436, Percent_Identity=26.605504587156, Blast_Score=97, Evalue=7e-20,
Organism=Escherichia coli, GI1786801, Length=803, Percent_Identity=25.653798256538, Blast_Score=185, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI32564422, Length=481, Percent_Identity=24.948024948025, Blast_Score=100, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI32564420, Length=481, Percent_Identity=24.948024948025, Blast_Score=100, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17550940, Length=680, Percent_Identity=22.5, Blast_Score=96, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17556356, Length=447, Percent_Identity=25.0559284116331, Blast_Score=95, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319591, Length=675, Percent_Identity=22.0740740740741, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319699, Length=364, Percent_Identity=26.3736263736264, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24648676, Length=485, Percent_Identity=26.1855670103093, Blast_Score=126, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24648260, Length=291, Percent_Identity=23.7113402061856, Blast_Score=66, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR009081
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR001242
- InterPro:   IPR010060
- InterPro:   IPR006163
- InterPro:   IPR020806
- InterPro:   IPR006162 [H]

Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF00550 PP-binding [H]

EC number: =5.1.1.11 [H]

Molecular weight: Translated: 91791; Mature: 91791

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS50075 ACP_DOMAIN ; PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNREEVLNVILSYAEITPNSLAVVDNSDELTYSELRVAVERTSQLLQKNQLNDQIVVLRL
CCHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEC
PRGVKFTVMVLALTKMKITFIPQDIAQPLARLDAMVETAGAETLIELKDDHYTFSTVPNS
CCCCCHHHHEEHHHHHEEEECCHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEECCCC
SKNHSTAWAIYFTSGSTGNPKGVEIPFRTVANTVETQKEDYQLTTDDRVASFTPYSFVVS
CCCCCEEEEEEEECCCCCCCCCEECCHHHHHHHHHCCCCCCEECCCCCCCCCCHHHHHHH
YYDLFSSLYSGSTLYVLGETERHDLNKLEKYLQDNKITFMNASTMIGEIIMRSMKLPSMR
HHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHCCCCCH
LLTLAGQRFPDVDIGQLNYQIMNVYGNTECACATICRVRPGETVTIGKPIRNMHALILDD
HHHHCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHEECCCCCEEEECCCCCCCEEEEECC
QQRVLPHGSVGELFIYGVQVTNGYFLNEKATNKAFTSVSYQNQNIWGYRTGDYAKVLPNG
CHHHCCCCCCCCEEEEEEEEECCEEECCCCCCCHHEEEEECCCCEEEEECCCEEEECCCC
ELEYRGRRDSQYKINGVRIDLSEVGSVCREIIPNLKQCYLAVKANCIYCWVTSAKAIDES
CEEECCCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHH
QILNALASRLPSVMIPIGIHQLTSFPLNINGKIDERRMIKEWSRQSLTKDNRHLSKSQRE
HHHHHHHHHCCCEEEECCHHHHHCCCEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCC
NEQFLINAWSEVLDADPDTINYQSNFRMLGATSLQIMELGVRILDERHKQLNFVDLYYHP
CHHHHHHHHHHHHCCCCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHCCEEEEHHHH
VLADMAALLSQKNVFKAIYTFVPRTDDMGDKPALFVIHSGNTGSDVYRPLFTGIKRPSFP
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCC
IYVIEPHNLLNPEDQIYGIENLAKYYLQMINKFLPESSKREINLMGWSYGGVVASEMCYQ
EEEECCCCCCCCHHHEECHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHH
LEHETSLLHVNQLTVLDSSFYLSSEDLQRVRKREANGFYAKYFTETHIFEGMDKKNVTTE
HHCCCCEEEEEEEEEEECCCEECHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCCCCHH
RLIANNHQVCEDLFNYHSKQVNVATTFVRSMVEENPLTDEQIKLLFKHVTIKNVYDGHDY
HHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEEECCCCE
LFVHESSRSLIQDVLGLAAKVVKEK
EEEECCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNREEVLNVILSYAEITPNSLAVVDNSDELTYSELRVAVERTSQLLQKNQLNDQIVVLRL
CCHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEC
PRGVKFTVMVLALTKMKITFIPQDIAQPLARLDAMVETAGAETLIELKDDHYTFSTVPNS
CCCCCHHHHEEHHHHHEEEECCHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEECCCC
SKNHSTAWAIYFTSGSTGNPKGVEIPFRTVANTVETQKEDYQLTTDDRVASFTPYSFVVS
CCCCCEEEEEEEECCCCCCCCCEECCHHHHHHHHHCCCCCCEECCCCCCCCCCHHHHHHH
YYDLFSSLYSGSTLYVLGETERHDLNKLEKYLQDNKITFMNASTMIGEIIMRSMKLPSMR
HHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHCCCCCH
LLTLAGQRFPDVDIGQLNYQIMNVYGNTECACATICRVRPGETVTIGKPIRNMHALILDD
HHHHCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHEECCCCCEEEECCCCCCCEEEEECC
QQRVLPHGSVGELFIYGVQVTNGYFLNEKATNKAFTSVSYQNQNIWGYRTGDYAKVLPNG
CHHHCCCCCCCCEEEEEEEEECCEEECCCCCCCHHEEEEECCCCEEEEECCCEEEECCCC
ELEYRGRRDSQYKINGVRIDLSEVGSVCREIIPNLKQCYLAVKANCIYCWVTSAKAIDES
CEEECCCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHH
QILNALASRLPSVMIPIGIHQLTSFPLNINGKIDERRMIKEWSRQSLTKDNRHLSKSQRE
HHHHHHHHHCCCEEEECCHHHHHCCCEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCC
NEQFLINAWSEVLDADPDTINYQSNFRMLGATSLQIMELGVRILDERHKQLNFVDLYYHP
CHHHHHHHHHHHHCCCCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHCCEEEEHHHH
VLADMAALLSQKNVFKAIYTFVPRTDDMGDKPALFVIHSGNTGSDVYRPLFTGIKRPSFP
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCC
IYVIEPHNLLNPEDQIYGIENLAKYYLQMINKFLPESSKREINLMGWSYGGVVASEMCYQ
EEEECCCCCCCCHHHEECHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHH
LEHETSLLHVNQLTVLDSSFYLSSEDLQRVRKREANGFYAKYFTETHIFEGMDKKNVTTE
HHCCCCEEEEEEEEEEECCCEECHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCCCCHH
RLIANNHQVCEDLFNYHSKQVNVATTFVRSMVEENPLTDEQIKLLFKHVTIKNVYDGHDY
HHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEEECCCCE
LFVHESSRSLIQDVLGLAAKVVKEK
EEEECCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9352938 [H]