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The map label for this gene is nadC1 [H]

Identifier: 28377447

GI number: 28377447

Start: 520575

End: 522053

Strand: Direct

Name: nadC1 [H]

Synonym: lp_0565

Alternate gene names: 28377447

Gene position: 520575-522053 (Clockwise)

Preceding gene: 28377445

Following gene: 28377448

Centisome position: 15.74

GC content: 44.22

Gene sequence:

>1479_bases
ATGACGCAAATCTATCCGGATGATAGTTTTACCTTGCATACGGATGCTTATCAAATTAATATGATCCAAACCTACTGGGA
ACAAGGTATTCACAACAAACATGCGGTGTTTGAAGTGTTCTTTCGTAAGATGCCGTTCCGAAATGGGTACGCGGTATTTG
CGGGTCTGGAACGAGTTGTTAATTATATCAATCATTTACATTTTACGGCAACTGACATCGCATATTTACGTGAACTGGGT
GGCTACTCAGACGGTTTTCTAGATTATTTAGCGAATTTCAAATTTGATGCGACGATTCGTGCGGTTCGTGAAGGAGACTT
GGTCTTTAATAATGAACCGTTGTTACAAGTCGAAGGACCACTGGCCACTTGTCAGTTAATTGAAACGGCACTACTCAATA
TTATCAATTATCAAACGTTGATTGCGACTAAAGCGGCGCGCATTAAATCGGTTGTCGGTGAAGATGGCTTACTAGAATTC
GGTACTCGGCGGGCGCAGGAGTTTGATGCGGCCATCTGGGGAACCCGGGCGGCTTATATTGGTGGCTTTGACGCGACGAG
TAACGTGCGGGCTGGCAAAATTTTTGGTATTCCGATTAGCGGGACCCATGCGCATGCGCTCGTGCAGACTTATCGAAACG
ATTATCAAGCTTTCAAGGCCTATGCGGAGACCCATCATGACTGTGTCTTTCTAGTGGATACGTATGATACGTTACGTAGC
GGGGTGCCGAGTGCGATTCGAGTGGCTAAGGAAATGGGTGATAAAATCAATTTCCAAGGGGTTCGTATCGATAGTGGCGA
TATGGCTTACTTATCAAAACGCGTGCGTGAACAGCTAGACGAAGCTGGTTTTCCGGATGCCAAGATTTATGCGTCAAATG
ATTTGGACGAAAAAACGATCCAAAACTTGAAGATGCAAGGTGCAAAAATTAGTGTCTGGGGTGTTGGGACGAAGCTAATC
ACGGCCTTTGACCAACCCGCGTTAGGGGCCGTATACAAGATGGTTTCGATCGAGAATGATCATCATCAGATGGTTGATAC
GATCAAACTTTCAAATAACGCGGAAAAGGTCTCAACGCCTGGTCAAAAACAAGTTTGGCGGATTACGAAGCGTGCGGATG
GCAAGTCGGAAGGTGACTATGTGACGTTGTACGATGAAGATCCGCGCAACGAAGAATCAATTTACATGTTCCATCCAAGC
TATACGTATATTAATAAGACGGTCAGCGATTTTGATGCGCGACCACTATTGGTTCCCATCTATGACCGCGGTCAACAAGT
TTATACTTTACCAACGTTAGATGAAATCAAGGAGTATTCATTTGAAAGTCTAGATGCACTTTGGGACGAATACAAGCGGG
ATTTAAACCCTCAGGATTACCCGGTCGACTTGTCACAAAAACTTTATGATCATAAAATGAATATTATTAACACGGTCAGA
GACCACGTTAACCATAAAGATGAGGAGGAAGCTTACTAA

Upstream 100 bases:

>100_bases
ACTTTTTGGATGCTTAAGCGCATTCTTTTATAAAAAATGCTAAAATAAGCTTAACTTACTGTAAACACGGTTATTACCTA
CGAAATGGAGAATTATACTC

Downstream 100 bases:

>100_bases
TGCGGCCATTACAAGCTGAGATTATTAAAGCGTTACACGTTGCACCAACGATTGATCCAGAAGTTGAGATTCGTCGAAGT
ATTGATTTTTTGAAGGCTTA

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 492; Mature: 491

Protein sequence:

>492_residues
MTQIYPDDSFTLHTDAYQINMIQTYWEQGIHNKHAVFEVFFRKMPFRNGYAVFAGLERVVNYINHLHFTATDIAYLRELG
GYSDGFLDYLANFKFDATIRAVREGDLVFNNEPLLQVEGPLATCQLIETALLNIINYQTLIATKAARIKSVVGEDGLLEF
GTRRAQEFDAAIWGTRAAYIGGFDATSNVRAGKIFGIPISGTHAHALVQTYRNDYQAFKAYAETHHDCVFLVDTYDTLRS
GVPSAIRVAKEMGDKINFQGVRIDSGDMAYLSKRVREQLDEAGFPDAKIYASNDLDEKTIQNLKMQGAKISVWGVGTKLI
TAFDQPALGAVYKMVSIENDHHQMVDTIKLSNNAEKVSTPGQKQVWRITKRADGKSEGDYVTLYDEDPRNEESIYMFHPS
YTYINKTVSDFDARPLLVPIYDRGQQVYTLPTLDEIKEYSFESLDALWDEYKRDLNPQDYPVDLSQKLYDHKMNIINTVR
DHVNHKDEEEAY

Sequences:

>Translated_492_residues
MTQIYPDDSFTLHTDAYQINMIQTYWEQGIHNKHAVFEVFFRKMPFRNGYAVFAGLERVVNYINHLHFTATDIAYLRELG
GYSDGFLDYLANFKFDATIRAVREGDLVFNNEPLLQVEGPLATCQLIETALLNIINYQTLIATKAARIKSVVGEDGLLEF
GTRRAQEFDAAIWGTRAAYIGGFDATSNVRAGKIFGIPISGTHAHALVQTYRNDYQAFKAYAETHHDCVFLVDTYDTLRS
GVPSAIRVAKEMGDKINFQGVRIDSGDMAYLSKRVREQLDEAGFPDAKIYASNDLDEKTIQNLKMQGAKISVWGVGTKLI
TAFDQPALGAVYKMVSIENDHHQMVDTIKLSNNAEKVSTPGQKQVWRITKRADGKSEGDYVTLYDEDPRNEESIYMFHPS
YTYINKTVSDFDARPLLVPIYDRGQQVYTLPTLDEIKEYSFESLDALWDEYKRDLNPQDYPVDLSQKLYDHKMNIINTVR
DHVNHKDEEEAY
>Mature_491_residues
TQIYPDDSFTLHTDAYQINMIQTYWEQGIHNKHAVFEVFFRKMPFRNGYAVFAGLERVVNYINHLHFTATDIAYLRELGG
YSDGFLDYLANFKFDATIRAVREGDLVFNNEPLLQVEGPLATCQLIETALLNIINYQTLIATKAARIKSVVGEDGLLEFG
TRRAQEFDAAIWGTRAAYIGGFDATSNVRAGKIFGIPISGTHAHALVQTYRNDYQAFKAYAETHHDCVFLVDTYDTLRSG
VPSAIRVAKEMGDKINFQGVRIDSGDMAYLSKRVREQLDEAGFPDAKIYASNDLDEKTIQNLKMQGAKISVWGVGTKLIT
AFDQPALGAVYKMVSIENDHHQMVDTIKLSNNAEKVSTPGQKQVWRITKRADGKSEGDYVTLYDEDPRNEESIYMFHPSY
TYINKTVSDFDARPLLVPIYDRGQQVYTLPTLDEIKEYSFESLDALWDEYKRDLNPQDYPVDLSQKLYDHKMNIINTVRD
HVNHKDEEEAY

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=518, Percent_Identity=32.046332046332, Blast_Score=253, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI71997952, Length=522, Percent_Identity=37.5478927203065, Blast_Score=317, Evalue=8e-87,
Organism=Caenorhabditis elegans, GI71997947, Length=522, Percent_Identity=37.5478927203065, Blast_Score=317, Evalue=9e-87,
Organism=Caenorhabditis elegans, GI71997955, Length=206, Percent_Identity=47.0873786407767, Blast_Score=195, Evalue=5e-50,
Organism=Drosophila melanogaster, GI24581587, Length=518, Percent_Identity=36.2934362934363, Blast_Score=280, Evalue=1e-75,
Organism=Drosophila melanogaster, GI161076680, Length=204, Percent_Identity=44.1176470588235, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24581595, Length=204, Percent_Identity=44.1176470588235, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI28574709, Length=204, Percent_Identity=44.1176470588235, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24581593, Length=204, Percent_Identity=44.1176470588235, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24581591, Length=204, Percent_Identity=44.1176470588235, Blast_Score=169, Evalue=3e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 56108; Mature: 55976

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQIYPDDSFTLHTDAYQINMIQTYWEQGIHNKHAVFEVFFRKMPFRNGYAVFAGLERVV
CCCCCCCCCEEEECCCEEEHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHH
NYINHLHFTATDIAYLRELGGYSDGFLDYLANFKFDATIRAVREGDLVFNNEPLLQVEGP
HHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEEEEECCCEEECCCCEEEECCC
LATCQLIETALLNIINYQTLIATKAARIKSVVGEDGLLEFGTRRAQEFDAAIWGTRAAYI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEE
GGFDATSNVRAGKIFGIPISGTHAHALVQTYRNDYQAFKAYAETHHDCVFLVDTYDTLRS
ECCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHH
GVPSAIRVAKEMGDKINFQGVRIDSGDMAYLSKRVREQLDEAGFPDAKIYASNDLDEKTI
CCCHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHH
QNLKMQGAKISVWGVGTKLITAFDQPALGAVYKMVSIENDHHQMVDTIKLSNNAEKVSTP
HHHHHCCCEEEEEECCHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHEEECCCCHHCCCC
GQKQVWRITKRADGKSEGDYVTLYDEDPRNEESIYMFHPSYTYINKTVSDFDARPLLVPI
CHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCEEEECCCHHHHHHHHHCCCCCCEEEEE
YDRGQQVYTLPTLDEIKEYSFESLDALWDEYKRDLNPQDYPVDLSQKLYDHKMNIINTVR
ECCCCEEEECCCHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
DHVNHKDEEEAY
HHCCCCCCCCCC
>Mature Secondary Structure 
TQIYPDDSFTLHTDAYQINMIQTYWEQGIHNKHAVFEVFFRKMPFRNGYAVFAGLERVV
CCCCCCCCEEEECCCEEEHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHH
NYINHLHFTATDIAYLRELGGYSDGFLDYLANFKFDATIRAVREGDLVFNNEPLLQVEGP
HHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEEEEECCCEEECCCCEEEECCC
LATCQLIETALLNIINYQTLIATKAARIKSVVGEDGLLEFGTRRAQEFDAAIWGTRAAYI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEE
GGFDATSNVRAGKIFGIPISGTHAHALVQTYRNDYQAFKAYAETHHDCVFLVDTYDTLRS
ECCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHH
GVPSAIRVAKEMGDKINFQGVRIDSGDMAYLSKRVREQLDEAGFPDAKIYASNDLDEKTI
CCCHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHH
QNLKMQGAKISVWGVGTKLITAFDQPALGAVYKMVSIENDHHQMVDTIKLSNNAEKVSTP
HHHHHCCCEEEEEECCHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHEEECCCCHHCCCC
GQKQVWRITKRADGKSEGDYVTLYDEDPRNEESIYMFHPSYTYINKTVSDFDARPLLVPI
CHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCEEEECCCHHHHHHHHHCCCCCCEEEEE
YDRGQQVYTLPTLDEIKEYSFESLDALWDEYKRDLNPQDYPVDLSQKLYDHKMNIINTVR
ECCCCEEEECCCHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
DHVNHKDEEEAY
HHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]