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The map label for this gene is serS

Identifier: 28199204

GI number: 28199204

Start: 1546548

End: 1547828

Strand: Reverse

Name: serS

Synonym: PD1318

Alternate gene names: 28199204

Gene position: 1547828-1546548 (Counterclockwise)

Preceding gene: 28199206

Following gene: 28199203

Centisome position: 61.43

GC content: 50.98

Gene sequence:

>1281_bases
ATGCTCGATCCGACTCTACTCCGTCAACAACTTGCGAAACTCGCTGAATGCTTGTTGACTGTACGCGGTTTCACTCTTGA
TGTTGCAGCCCTTGAAGCATTGGAAAGCGAACGTAAACGTATCCAGGTGCATACCCAAGAGTTGCAATCCCTGCGTAACA
GTAAATCCAAGGCGATTGGCCAAGCCAGGAGCAAGGGTGAAGATGTGTCTGCGTTAATGGCTGAGGTTGCCGCTTTTAGT
GATGATTTAAAAGCCTCGGAGATAGCGTTGGAGGAAATCCGTACTGAATTAGAGAAAGTGGCCTTGGATATTCCCAATTT
GCCACAGCAAGATGTGCCGTTGGGTGCCGATGAACGTGACAACGTAGAGCAGGCCCGTTGGGGAGTGCCACGTACGTTTG
ATTTTGCCATCAAGGATCATGTTGAATTGGGTGCGTGTCATGGTTGGTTAGATGCCGAGAGTGCTGCCAAGCTATCCGGT
GCGCGTTTCACTGTATTGCGTGGCCCCATTGCACGGCTGCATCGCGCACTGGCGCAGTGCATGCTTGACTTACATGTTAG
CCAGCATGGATACGAAGAAGTCAATGTCCCAATCATTGTCAATGCAGACAGCTTACATGGGACTGGTCAACTACCGAAAT
TTGAAGAGGACATGTTCAGTACTCAGCTCGGTGAGCATCGGCGCTATTTGATTTCGACCTCTGAAATTTCACTGACTAAT
TTAGTACGTAACGAGATTATTGAGGCGGATCGCCTGCCGTTGCGTATGGTTGCACACTCATTGTGTTTCCGTTCCGAGGC
AGGCAGCGGTGGTCGTGATACGCGTGGCATGATTCGTCAGCACCAGTTTGAGAAGGTCGAATTGGTCAGCGTATGTAAAC
CGCAAGACAGTGAAGGTGAGCACCATCGTATGACTCGCTGCGCAGAGACAGTGTTGGAAATGCTGGGACTGCCCTACCGC
AAGATCCTGCTGTGTACCGGTGATATGGGATTTGCTGCGACCAAAACCTACGACTTGGAAGTTTGGCTGCCGTCGCAGGG
AATGTATCGCGAGATTTCATCGTGTTCCAACTGCGGTGATTTCCAAGCCAGACGCATGCAAGCCCGTTGGCGCAATTCTG
TCACCGGCAAACCGGAATTGGTACACACACTCAACGGTTCTGGTGTCGCTGTTGGCCGTGCGATGATTGCGGTGATGGAG
AACTATCAGAATGCTGATGGTTCGATTACGGTGCCGGAGGTGTTGCGTCCTTACATGGATGGTTTGAGTCGGATTGGTTG
A

Upstream 100 bases:

>100_bases
CTTCCCATTATTTCATAGCGCAGATGAATGTACGCCGGAGGCATTGATGCCCCTTAACGGGTCATAATCATCATCCGATC
CATTGCACCGTGATGCTTCT

Downstream 100 bases:

>100_bases
GTTCTAAGTGGCGGCAATGTCACAAAGGTGCTGTGATCTGTCAGTGATCTGCCACGGTACACTGTAACGGTGAGCAGAGT
ATCGCTCCCTGTTCAATGAG

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MLDPTLLRQQLAKLAECLLTVRGFTLDVAALEALESERKRIQVHTQELQSLRNSKSKAIGQARSKGEDVSALMAEVAAFS
DDLKASEIALEEIRTELEKVALDIPNLPQQDVPLGADERDNVEQARWGVPRTFDFAIKDHVELGACHGWLDAESAAKLSG
ARFTVLRGPIARLHRALAQCMLDLHVSQHGYEEVNVPIIVNADSLHGTGQLPKFEEDMFSTQLGEHRRYLISTSEISLTN
LVRNEIIEADRLPLRMVAHSLCFRSEAGSGGRDTRGMIRQHQFEKVELVSVCKPQDSEGEHHRMTRCAETVLEMLGLPYR
KILLCTGDMGFAATKTYDLEVWLPSQGMYREISSCSNCGDFQARRMQARWRNSVTGKPELVHTLNGSGVAVGRAMIAVME
NYQNADGSITVPEVLRPYMDGLSRIG

Sequences:

>Translated_426_residues
MLDPTLLRQQLAKLAECLLTVRGFTLDVAALEALESERKRIQVHTQELQSLRNSKSKAIGQARSKGEDVSALMAEVAAFS
DDLKASEIALEEIRTELEKVALDIPNLPQQDVPLGADERDNVEQARWGVPRTFDFAIKDHVELGACHGWLDAESAAKLSG
ARFTVLRGPIARLHRALAQCMLDLHVSQHGYEEVNVPIIVNADSLHGTGQLPKFEEDMFSTQLGEHRRYLISTSEISLTN
LVRNEIIEADRLPLRMVAHSLCFRSEAGSGGRDTRGMIRQHQFEKVELVSVCKPQDSEGEHHRMTRCAETVLEMLGLPYR
KILLCTGDMGFAATKTYDLEVWLPSQGMYREISSCSNCGDFQARRMQARWRNSVTGKPELVHTLNGSGVAVGRAMIAVME
NYQNADGSITVPEVLRPYMDGLSRIG
>Mature_426_residues
MLDPTLLRQQLAKLAECLLTVRGFTLDVAALEALESERKRIQVHTQELQSLRNSKSKAIGQARSKGEDVSALMAEVAAFS
DDLKASEIALEEIRTELEKVALDIPNLPQQDVPLGADERDNVEQARWGVPRTFDFAIKDHVELGACHGWLDAESAAKLSG
ARFTVLRGPIARLHRALAQCMLDLHVSQHGYEEVNVPIIVNADSLHGTGQLPKFEEDMFSTQLGEHRRYLISTSEISLTN
LVRNEIIEADRLPLRMVAHSLCFRSEAGSGGRDTRGMIRQHQFEKVELVSVCKPQDSEGEHHRMTRCAETVLEMLGLPYR
KILLCTGDMGFAATKTYDLEVWLPSQGMYREISSCSNCGDFQARRMQARWRNSVTGKPELVHTLNGSGVAVGRAMIAVME
NYQNADGSITVPEVLRPYMDGLSRIG

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=435, Percent_Identity=33.1034482758621, Blast_Score=212, Evalue=6e-55,
Organism=Homo sapiens, GI8923421, Length=400, Percent_Identity=28.75, Blast_Score=158, Evalue=8e-39,
Organism=Homo sapiens, GI225579074, Length=401, Percent_Identity=29.1770573566085, Blast_Score=158, Evalue=8e-39,
Organism=Escherichia coli, GI1787120, Length=431, Percent_Identity=59.8607888631091, Blast_Score=528, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI17539260, Length=419, Percent_Identity=31.5035799522673, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17542084, Length=333, Percent_Identity=29.7297297297297, Blast_Score=160, Evalue=8e-40,
Organism=Saccharomyces cerevisiae, GI6320226, Length=398, Percent_Identity=32.4120603015075, Blast_Score=202, Evalue=6e-53,
Organism=Saccharomyces cerevisiae, GI6321799, Length=394, Percent_Identity=31.9796954314721, Blast_Score=192, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24581334, Length=445, Percent_Identity=31.4606741573034, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI17737985, Length=286, Percent_Identity=34.965034965035, Blast_Score=174, Evalue=1e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_XYLF2 (B2I631)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001830094.1
- ProteinModelPortal:   B2I631
- SMR:   B2I631
- GeneID:   6202347
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_1402
- HOGENOM:   HBG629391
- OMA:   AHWDLGP
- ProtClustDB:   PRK05431
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 47406; Mature: 47406

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 287-287 BINDING 387-387

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDPTLLRQQLAKLAECLLTVRGFTLDVAALEALESERKRIQVHTQELQSLRNSKSKAIG
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QARSKGEDVSALMAEVAAFSDDLKASEIALEEIRTELEKVALDIPNLPQQDVPLGADERD
HHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
NVEQARWGVPRTFDFAIKDHVELGACHGWLDAESAAKLSGARFTVLRGPIARLHRALAQC
CHHHHHCCCCCEEEHHHHHHHHHHHHCCCCCCHHHHHHCCCEEEEHHCHHHHHHHHHHHH
MLDLHVSQHGYEEVNVPIIVNADSLHGTGQLPKFEEDMFSTQLGEHRRYLISTSEISLTN
HHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHEEEEECCCHHHHH
LVRNEIIEADRLPLRMVAHSLCFRSEAGSGGRDTRGMIRQHQFEKVELVSVCKPQDSEGE
HHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCH
HHRMTRCAETVLEMLGLPYRKILLCTGDMGFAATKTYDLEVWLPSQGMYREISSCSNCGD
HHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEEEEEEEECCCCHHHHHHHCCCCCH
FQARRMQARWRNSVTGKPELVHTLNGSGVAVGRAMIAVMENYQNADGSITVPEVLRPYMD
HHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHH
GLSRIG
HHHHCC
>Mature Secondary Structure
MLDPTLLRQQLAKLAECLLTVRGFTLDVAALEALESERKRIQVHTQELQSLRNSKSKAIG
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QARSKGEDVSALMAEVAAFSDDLKASEIALEEIRTELEKVALDIPNLPQQDVPLGADERD
HHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
NVEQARWGVPRTFDFAIKDHVELGACHGWLDAESAAKLSGARFTVLRGPIARLHRALAQC
CHHHHHCCCCCEEEHHHHHHHHHHHHCCCCCCHHHHHHCCCEEEEHHCHHHHHHHHHHHH
MLDLHVSQHGYEEVNVPIIVNADSLHGTGQLPKFEEDMFSTQLGEHRRYLISTSEISLTN
HHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHEEEEECCCHHHHH
LVRNEIIEADRLPLRMVAHSLCFRSEAGSGGRDTRGMIRQHQFEKVELVSVCKPQDSEGE
HHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCH
HHRMTRCAETVLEMLGLPYRKILLCTGDMGFAATKTYDLEVWLPSQGMYREISSCSNCGD
HHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEEEEEEEECCCCHHHHHHHCCCCCH
FQARRMQARWRNSVTGKPELVHTLNGSGVAVGRAMIAVMENYQNADGSITVPEVLRPYMD
HHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHH
GLSRIG
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA