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The map label for this gene is thrB

Identifier: 28199158

GI number: 28199158

Start: 1482184

End: 1483152

Strand: Reverse

Name: thrB

Synonym: PD1272

Alternate gene names: 28199158

Gene position: 1483152-1482184 (Counterclockwise)

Preceding gene: 28199159

Following gene: 28199157

Centisome position: 58.86

GC content: 61.2

Gene sequence:

>969_bases
GTGAATCGGACCTTGCAACCAGACAGCGGCGCATCTCAAACAGCGCCCACAGCGCATCAGGCACGCGCCTTCGCACCGGC
ATCAGTGGCGAACGTTGCCGTTGGTTTTGACTTACTCGGCTACCCCATGGACCAGGTTGGCGACACCGTGACAGTGCGGC
GCATTGATACCCCGCAGGTGCGTATTGCCGCAATCCGTGGAATTGCCCAGCCGCTGCCACTACAGACCGAACGCAATACA
GCCGGTGCCGCCTTACTCTCCATGCATCGTGACTTAGCTCTGCCCTTTGGCTTTGAACTGGAGATCGACAAAGGCATCCC
GCTGAGTTCCGGAATGGGTGGTTCGGCTGCCTCTTGCGTTGCTGCACTGCTGGCCGCCAACGCACTGTTGGATGAACCAT
TGCGCCGTGAACACCTGTATCGCTATGCATTGGATGGCGAAGCGGTCGCCAGCGGTAGCCGTCATGGCGACAATCTGGGA
CCGTTGTTTCTGGGCGGCCTCGTCCTGTGTACCTTGGAGCGCCTGGTCCCGGTGACCGTACCGACTGCCTGGCACAGCTT
GCTTGTCCATCCGGATACCTTGCTGGAAACCCGCCGTGCACGCGAGGTTCTGAAAGAGCCTTACCTACTGCCCGACATTG
TCACCCAGAGCGCTAACCTAGCCTTGGTCTTGGCAGGGTGTTACCACAGTGATGCCGAACTGGTGCGTGCTGGTCTGCGT
GATGTATTGATCGAGCCACGCCGCGCCCCGCTGATTGCTGGCTTTACTGCCGCCCAACAGGCAGCACTGCAGGCTGATGC
GATGGGGGCGAGCATCTCTGGTGCCGGACCCAGCGTATTTGCCTGGTTCCAGACACGCAGCGCCGCCGAAGCCGCCGCAC
CAGCCGTGCGTGCTGCTTTCACCGCGGCTGGTTTTGATAGCCAAGCCTGGGTGACACCACTCACCAGCCCAGGCGCGCGC
CTGCTATGA

Upstream 100 bases:

>100_bases
ACCCCTTGATCGTACAGGGCCCTGGCGCCGGTCCAGAGGTCACCGCAGCCGGTGTTTTTGCGGATTTACTGCGAGTTGCA
GCGGGCGAGGGCGCACGCTT

Downstream 100 bases:

>100_bases
GACCGTTGCCTCCTTCGATTTTTTTCTCTTTCCACCATCTATGATTCAAATGAACTTCCATTCCACCCGCACCACAGCTC
CGGTGACCACCCTCAGCCAG

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MNRTLQPDSGASQTAPTAHQARAFAPASVANVAVGFDLLGYPMDQVGDTVTVRRIDTPQVRIAAIRGIAQPLPLQTERNT
AGAALLSMHRDLALPFGFELEIDKGIPLSSGMGGSAASCVAALLAANALLDEPLRREHLYRYALDGEAVASGSRHGDNLG
PLFLGGLVLCTLERLVPVTVPTAWHSLLVHPDTLLETRRAREVLKEPYLLPDIVTQSANLALVLAGCYHSDAELVRAGLR
DVLIEPRRAPLIAGFTAAQQAALQADAMGASISGAGPSVFAWFQTRSAAEAAAPAVRAAFTAAGFDSQAWVTPLTSPGAR
LL

Sequences:

>Translated_322_residues
MNRTLQPDSGASQTAPTAHQARAFAPASVANVAVGFDLLGYPMDQVGDTVTVRRIDTPQVRIAAIRGIAQPLPLQTERNT
AGAALLSMHRDLALPFGFELEIDKGIPLSSGMGGSAASCVAALLAANALLDEPLRREHLYRYALDGEAVASGSRHGDNLG
PLFLGGLVLCTLERLVPVTVPTAWHSLLVHPDTLLETRRAREVLKEPYLLPDIVTQSANLALVLAGCYHSDAELVRAGLR
DVLIEPRRAPLIAGFTAAQQAALQADAMGASISGAGPSVFAWFQTRSAAEAAAPAVRAAFTAAGFDSQAWVTPLTSPGAR
LL
>Mature_322_residues
MNRTLQPDSGASQTAPTAHQARAFAPASVANVAVGFDLLGYPMDQVGDTVTVRRIDTPQVRIAAIRGIAQPLPLQTERNT
AGAALLSMHRDLALPFGFELEIDKGIPLSSGMGGSAASCVAALLAANALLDEPLRREHLYRYALDGEAVASGSRHGDNLG
PLFLGGLVLCTLERLVPVTVPTAWHSLLVHPDTLLETRRAREVLKEPYLLPDIVTQSANLALVLAGCYHSDAELVRAGLR
DVLIEPRRAPLIAGFTAAQQAALQADAMGASISGAGPSVFAWFQTRSAAEAAAPAVRAAFTAAGFDSQAWVTPLTSPGAR
LL

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily

Homologues:

Organism=Escherichia coli, GI1786184, Length=311, Percent_Identity=32.475884244373, Blast_Score=138, Evalue=6e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KHSE_XYLF2 (B2I5Y6)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001830049.1
- ProteinModelPortal:   B2I5Y6
- SMR:   B2I5Y6
- GeneID:   6202062
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_1357
- HOGENOM:   HBG646290
- OMA:   GSAHADN
- ProtClustDB:   PRK01212
- GO:   GO:0005737
- HAMAP:   MF_00384
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PIRSF:   PIRSF000676
- PRINTS:   PR00958
- TIGRFAMs:   TIGR00191

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.39

Molecular weight: Translated: 33806; Mature: 33806

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRTLQPDSGASQTAPTAHQARAFAPASVANVAVGFDLLGYPMDQVGDTVTVRRIDTPQV
CCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHCCCHHHHCCEEEEEECCCCCC
RIAAIRGIAQPLPLQTERNTAGAALLSMHRDLALPFGFELEIDKGIPLSSGMGGSAASCV
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHH
AALLAANALLDEPLRREHLYRYALDGEAVASGSRHGDNLGPLFLGGLVLCTLERLVPVTV
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCEEC
PTAWHSLLVHPDTLLETRRAREVLKEPYLLPDIVTQSANLALVLAGCYHSDAELVRAGLR
CHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHCCCCEEEEEEECCCCHHHHHHHHHH
DVLIEPRRAPLIAGFTAAQQAALQADAMGASISGAGPSVFAWFQTRSAAEAAAPAVRAAF
HHHCCCCCCCEEECHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHH
TAAGFDSQAWVTPLTSPGARLL
HHCCCCCCCEECCCCCCCCCCC
>Mature Secondary Structure
MNRTLQPDSGASQTAPTAHQARAFAPASVANVAVGFDLLGYPMDQVGDTVTVRRIDTPQV
CCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHCCCHHHHCCEEEEEECCCCCC
RIAAIRGIAQPLPLQTERNTAGAALLSMHRDLALPFGFELEIDKGIPLSSGMGGSAASCV
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHH
AALLAANALLDEPLRREHLYRYALDGEAVASGSRHGDNLGPLFLGGLVLCTLERLVPVTV
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCEEC
PTAWHSLLVHPDTLLETRRAREVLKEPYLLPDIVTQSANLALVLAGCYHSDAELVRAGLR
CHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHCCCCEEEEEEECCCCHHHHHHHHHH
DVLIEPRRAPLIAGFTAAQQAALQADAMGASISGAGPSVFAWFQTRSAAEAAAPAVRAAF
HHHCCCCCCCEEECHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHH
TAAGFDSQAWVTPLTSPGARLL
HHCCCCCCCEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA