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The map label for this gene is thrC [H]

Identifier: 28199157

GI number: 28199157

Start: 1480842

End: 1482134

Strand: Reverse

Name: thrC [H]

Synonym: PD1271

Alternate gene names: 28199157

Gene position: 1482134-1480842 (Counterclockwise)

Preceding gene: 28199158

Following gene: 28199156

Centisome position: 58.82

GC content: 60.63

Gene sequence:

>1293_bases
ATGAACTTCCATTCCACCCGCACCACAGCTCCGGTGACCACCCTCAGCCAGGCAATCGCTGCAGGCTTAGCACCGGATGG
CGGCTTATATGTCCCCGAGTGCTTGCCACCCCTTGGTGACTTGGACCACAGCGCAGATTTAATCAACACCGCCACCGCAC
TACTGACCCCCTTCTTTGCGGGGGATCCGCTAGAAGTGCATGTGCCGTCGATCTGTGCCGAAGCGCTGGATCTCCCCGCA
CCACTGCTGCCCTTGGCTACCCCTGAAGATTATGTCCTTGAGTTATTTCACGGCCCCACTGCTGCCTTCAAGGATTTTGG
CGCACGTTTTCTAGCGGCCTGCCTGACTCGGCTACGACGTGATGCCGAACGTCCCTTGACGATTCTGGTGGCTACCTCCG
GTGATACGGGTGCTGCGGTGGCGGCGGCATTTCATCGGCAACCCGGATTGCGTGTCGTCGTTCTGTACCCGGATGGCCGT
GTATCGCCACGTCAGGCCCACCAATTGGGTTGTTTTGGCGACAACATACATACACTGCGTGTGGCTGGCGTGTTCGATGA
CTGCCAAGCCATGGTCAAGCAGGCCCTGAACGATACCAGCCTCCAAACAGCCGTGCCGCTGAGTTCGGCCAACAGCATCA
GCCTGGGCCGCTTGCTGCCGCAGATGAGCTACTACGCCCATGCAGCCTTGACCCACCGTGCCAGCACGGGCCGCCCTCTG
AACCTCATTGTGCCCACCGGCAACCTCGGCAATGCCTTGGCCGCGATTCTGGCGCGCGCCCTGGGAGTACCCTTAGGACA
GATTGTGTTGGCGACAAACGCCAACCACGTACTCCCTGATTACTTTTCCGGAGCACATTACCGCCCCCAGCCCAGTGTGG
CGACGTTGGCCAATGCAATGGACGTTGGAGCGCCCAGTAATTTTGAACGATTGCGCTGGTTGTATCGCGGCGATGACGCC
GCATTGCGTGCCGCCTTTACCGCCTATTCCGTCGACGACACCGCGATCCGCCAGACCATCACCGCACGGCATCGTCGCTA
CGACGAGATATTTTGTCCCCATACCGCTACGGCGGTGTTTGTGCTTGAGCACTTGCGTGCACAGGGCGTCGCTGGGGATT
GGGCCGTTGTGGCGACCGCGCATCCAGCCAAATTTGAGCAGGTGGTAGAACCGTTGATCGGTACCACCGTGCCCGTGCCG
GCGGCCCTGGATAGCCTCCTGCAACGTCCCGCGCGCGACGAACCGCTTGCCCCAGAGTACCCGGCATTGCGGCACATGCT
ACTGGCCACCTAA

Upstream 100 bases:

>100_bases
AGCCAAGCCTGGGTGACACCACTCACCAGCCCAGGCGCGCGCCTGCTATGAGACCGTTGCCTCCTTCGATTTTTTTCTCT
TTCCACCATCTATGATTCAA

Downstream 100 bases:

>100_bases
CGCAGCATGTGTGTGCCACTGCATGAGTGCGGATCTGAGCCGATCCCTGATCCTATTGAGTGGCTAGAGCGCTAACGCTG
CGCCTATTGCCGTGTGCCGT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MNFHSTRTTAPVTTLSQAIAAGLAPDGGLYVPECLPPLGDLDHSADLINTATALLTPFFAGDPLEVHVPSICAEALDLPA
PLLPLATPEDYVLELFHGPTAAFKDFGARFLAACLTRLRRDAERPLTILVATSGDTGAAVAAAFHRQPGLRVVVLYPDGR
VSPRQAHQLGCFGDNIHTLRVAGVFDDCQAMVKQALNDTSLQTAVPLSSANSISLGRLLPQMSYYAHAALTHRASTGRPL
NLIVPTGNLGNALAAILARALGVPLGQIVLATNANHVLPDYFSGAHYRPQPSVATLANAMDVGAPSNFERLRWLYRGDDA
ALRAAFTAYSVDDTAIRQTITARHRRYDEIFCPHTATAVFVLEHLRAQGVAGDWAVVATAHPAKFEQVVEPLIGTTVPVP
AALDSLLQRPARDEPLAPEYPALRHMLLAT

Sequences:

>Translated_430_residues
MNFHSTRTTAPVTTLSQAIAAGLAPDGGLYVPECLPPLGDLDHSADLINTATALLTPFFAGDPLEVHVPSICAEALDLPA
PLLPLATPEDYVLELFHGPTAAFKDFGARFLAACLTRLRRDAERPLTILVATSGDTGAAVAAAFHRQPGLRVVVLYPDGR
VSPRQAHQLGCFGDNIHTLRVAGVFDDCQAMVKQALNDTSLQTAVPLSSANSISLGRLLPQMSYYAHAALTHRASTGRPL
NLIVPTGNLGNALAAILARALGVPLGQIVLATNANHVLPDYFSGAHYRPQPSVATLANAMDVGAPSNFERLRWLYRGDDA
ALRAAFTAYSVDDTAIRQTITARHRRYDEIFCPHTATAVFVLEHLRAQGVAGDWAVVATAHPAKFEQVVEPLIGTTVPVP
AALDSLLQRPARDEPLAPEYPALRHMLLAT
>Mature_430_residues
MNFHSTRTTAPVTTLSQAIAAGLAPDGGLYVPECLPPLGDLDHSADLINTATALLTPFFAGDPLEVHVPSICAEALDLPA
PLLPLATPEDYVLELFHGPTAAFKDFGARFLAACLTRLRRDAERPLTILVATSGDTGAAVAAAFHRQPGLRVVVLYPDGR
VSPRQAHQLGCFGDNIHTLRVAGVFDDCQAMVKQALNDTSLQTAVPLSSANSISLGRLLPQMSYYAHAALTHRASTGRPL
NLIVPTGNLGNALAAILARALGVPLGQIVLATNANHVLPDYFSGAHYRPQPSVATLANAMDVGAPSNFERLRWLYRGDDA
ALRAAFTAYSVDDTAIRQTITARHRRYDEIFCPHTATAVFVLEHLRAQGVAGDWAVVATAHPAKFEQVVEPLIGTTVPVP
AALDSLLQRPARDEPLAPEYPALRHMLLAT

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=495, Percent_Identity=29.2929292929293, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI149193323, Length=456, Percent_Identity=30.0438596491228, Blast_Score=152, Evalue=6e-37,
Organism=Escherichia coli, GI1786185, Length=433, Percent_Identity=36.7205542725173, Blast_Score=264, Evalue=7e-72,
Organism=Saccharomyces cerevisiae, GI6319901, Length=462, Percent_Identity=31.3852813852814, Blast_Score=198, Evalue=1e-51,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 45886; Mature: 45886

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFHSTRTTAPVTTLSQAIAAGLAPDGGLYVPECLPPLGDLDHSADLINTATALLTPFFA
CCCCCCCCCCHHHHHHHHHHHCCCCCCCEECHHHCCCCCCCCCHHHHHHHHHHHHHHHHC
GDPLEVHVPSICAEALDLPAPLLPLATPEDYVLELFHGPTAAFKDFGARFLAACLTRLRR
CCCCEEEHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
DAERPLTILVATSGDTGAAVAAAFHRQPGLRVVVLYPDGRVSPRQAHQLGCFGDNIHTLR
HCCCCEEEEEEECCCCCHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHCCCCCCCEEEEE
VAGVFDDCQAMVKQALNDTSLQTAVPLSSANSISLGRLLPQMSYYAHAALTHRASTGRPL
EECCHHHHHHHHHHHHCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCE
NLIVPTGNLGNALAAILARALGVPLGQIVLATNANHVLPDYFSGAHYRPQPSVATLANAM
EEEEECCCCHHHHHHHHHHHHCCCHHHEEEECCCCCCCCHHCCCCCCCCCCHHHHHHHHH
DVGAPSNFERLRWLYRGDDAALRAAFTAYSVDDTAIRQTITARHRRYDEIFCPHTATAVF
HCCCCCCHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHH
VLEHLRAQGVAGDWAVVATAHPAKFEQVVEPLIGTTVPVPAALDSLLQRPARDEPLAPEY
HHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCC
PALRHMLLAT
HHHHHHHHCC
>Mature Secondary Structure
MNFHSTRTTAPVTTLSQAIAAGLAPDGGLYVPECLPPLGDLDHSADLINTATALLTPFFA
CCCCCCCCCCHHHHHHHHHHHCCCCCCCEECHHHCCCCCCCCCHHHHHHHHHHHHHHHHC
GDPLEVHVPSICAEALDLPAPLLPLATPEDYVLELFHGPTAAFKDFGARFLAACLTRLRR
CCCCEEEHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
DAERPLTILVATSGDTGAAVAAAFHRQPGLRVVVLYPDGRVSPRQAHQLGCFGDNIHTLR
HCCCCEEEEEEECCCCCHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHCCCCCCCEEEEE
VAGVFDDCQAMVKQALNDTSLQTAVPLSSANSISLGRLLPQMSYYAHAALTHRASTGRPL
EECCHHHHHHHHHHHHCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCE
NLIVPTGNLGNALAAILARALGVPLGQIVLATNANHVLPDYFSGAHYRPQPSVATLANAM
EEEEECCCCHHHHHHHHHHHHCCCHHHEEEECCCCCCCCHHCCCCCCCCCCHHHHHHHHH
DVGAPSNFERLRWLYRGDDAALRAAFTAYSVDDTAIRQTITARHRRYDEIFCPHTATAVF
HCCCCCCHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHH
VLEHLRAQGVAGDWAVVATAHPAKFEQVVEPLIGTTVPVPAALDSLLQRPARDEPLAPEY
HHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCC
PALRHMLLAT
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]