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The map label for this gene is hisA

Identifier: 28199149

GI number: 28199149

Start: 1472416

End: 1473225

Strand: Reverse

Name: hisA

Synonym: PD1263

Alternate gene names: 28199149

Gene position: 1473225-1472416 (Counterclockwise)

Preceding gene: 28199150

Following gene: 28199148

Centisome position: 58.47

GC content: 61.36

Gene sequence:

>810_bases
ATGAATTTCATTGTCTATCCAGCCTTGGACATCCGTAACGGTGCTGTGGTGCGTCTCCAGCAGGGGGATTACGCGCGCCA
GACGCGCTATGACGATCAGGTATTGCCGCGCGCACAGGCGTTTGCCGACAGTGGCGCCACGTGGATGCATCTGGTTGATC
TGGATGCCGCCAAAGCGGGCGGGTATACCTTGGCACCCTTGTTGCGCCAGATTACCCGTGCAACAGGACTCCAGGTGCAG
ACCGGCGGCGGGGTGCGTTCCCGTGATGATGTTGCGCGGATTCTCGACGCAGGCGCGGCACGTGTGGTGATCGGTTCATT
GGCGGTGCGCCAGATGACGTGTGTCATTGAGTGGTTGCAGGCCTTCGGCCCTGAACGGATCACCGTTGCATTGGACACGC
GTCAAGATGCCGGTGGCGTGTGGCGCTTGCCGGTTCATGGCTGGACCGAGGTTGCCGAGGCAACGTTGGAGGCGCTGGCG
CAGCAGTATGCAGCAGCCGGGTTGCGCCATCTGTTGTGTACGGACATTGCCCGTGACGGCATGTTGTCCGGTCCCAACAT
GGATGTATATGCGTACCTGCGGGCCTTGGTCCCTGCAGTGCAGATCCAAGTGTCTGGTGGGGCGCGGGATGTGGCCGATG
TCGTCGCCGCCAAGATGGCCGGTTGTGCGGGTATTGTCCTCGGTAAAGCGCTGTTGGAGGGCCGCCTTGCACTCAAGGAG
GCAGTGCAGCATGGCAGTGTTGCCGATCCCGGCGATCCCTTGCCTTGCGGGGAACTAACGGAGCCAGTATGTCGCTACAG
ATCAGTGTGA

Upstream 100 bases:

>100_bases
TTGTGCAGCAGGGAGTGCGTTGTGGCGCGCAATTCCATCCAGAGCGTTCGGCCGAAACAGGCGCACGTATCCTGCGTAAT
TTTCTTGAAATGGATGCCGC

Downstream 100 bases:

>100_bases
TGCTTGCGGTGTATCTCCCGCCGGGGACGCCATGTGCCAATGGGCGGATGCGGCCCTATCGCCGTTGCACACTACACCGT
GACCACTTGCAGCAAGAGGC

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MNFIVYPALDIRNGAVVRLQQGDYARQTRYDDQVLPRAQAFADSGATWMHLVDLDAAKAGGYTLAPLLRQITRATGLQVQ
TGGGVRSRDDVARILDAGAARVVIGSLAVRQMTCVIEWLQAFGPERITVALDTRQDAGGVWRLPVHGWTEVAEATLEALA
QQYAAAGLRHLLCTDIARDGMLSGPNMDVYAYLRALVPAVQIQVSGGARDVADVVAAKMAGCAGIVLGKALLEGRLALKE
AVQHGSVADPGDPLPCGELTEPVCRYRSV

Sequences:

>Translated_269_residues
MNFIVYPALDIRNGAVVRLQQGDYARQTRYDDQVLPRAQAFADSGATWMHLVDLDAAKAGGYTLAPLLRQITRATGLQVQ
TGGGVRSRDDVARILDAGAARVVIGSLAVRQMTCVIEWLQAFGPERITVALDTRQDAGGVWRLPVHGWTEVAEATLEALA
QQYAAAGLRHLLCTDIARDGMLSGPNMDVYAYLRALVPAVQIQVSGGARDVADVVAAKMAGCAGIVLGKALLEGRLALKE
AVQHGSVADPGDPLPCGELTEPVCRYRSV
>Mature_269_residues
MNFIVYPALDIRNGAVVRLQQGDYARQTRYDDQVLPRAQAFADSGATWMHLVDLDAAKAGGYTLAPLLRQITRATGLQVQ
TGGGVRSRDDVARILDAGAARVVIGSLAVRQMTCVIEWLQAFGPERITVALDTRQDAGGVWRLPVHGWTEVAEATLEALA
QQYAAAGLRHLLCTDIARDGMLSGPNMDVYAYLRALVPAVQIQVSGGARDVADVVAAKMAGCAGIVLGKALLEGRLALKE
AVQHGSVADPGDPLPCGELTEPVCRYRSV

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=239, Percent_Identity=45.1882845188285, Blast_Score=209, Evalue=1e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_XYLF2 (B2I5X7)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001830040.1
- ProteinModelPortal:   B2I5X7
- GeneID:   6202213
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_1348
- HOGENOM:   HBG541613
- OMA:   SIIYTDI
- ProtClustDB:   PRK00748
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00007

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 28687; Mature: 28687

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: ACT_SITE 10-10 ACT_SITE 132-132

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFIVYPALDIRNGAVVRLQQGDYARQTRYDDQVLPRAQAFADSGATWMHLVDLDAAKAG
CCEEEEECEEECCCCEEEEECCCCHHHHCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCC
GYTLAPLLRQITRATGLQVQTGGGVRSRDDVARILDAGAARVVIGSLAVRQMTCVIEWLQ
CEEHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
AFGPERITVALDTRQDAGGVWRLPVHGWTEVAEATLEALAQQYAAAGLRHLLCTDIARDG
HCCCCEEEEEEECCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
MLSGPNMDVYAYLRALVPAVQIQVSGGARDVADVVAAKMAGCAGIVLGKALLEGRLALKE
CCCCCCCHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVQHGSVADPGDPLPCGELTEPVCRYRSV
HHHCCCCCCCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MNFIVYPALDIRNGAVVRLQQGDYARQTRYDDQVLPRAQAFADSGATWMHLVDLDAAKAG
CCEEEEECEEECCCCEEEEECCCCHHHHCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCC
GYTLAPLLRQITRATGLQVQTGGGVRSRDDVARILDAGAARVVIGSLAVRQMTCVIEWLQ
CEEHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
AFGPERITVALDTRQDAGGVWRLPVHGWTEVAEATLEALAQQYAAAGLRHLLCTDIARDG
HCCCCEEEEEEECCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
MLSGPNMDVYAYLRALVPAVQIQVSGGARDVADVVAAKMAGCAGIVLGKALLEGRLALKE
CCCCCCCHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVQHGSVADPGDPLPCGELTEPVCRYRSV
HHHCCCCCCCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA