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The map label for this gene is ubiB

Identifier: 28198931

GI number: 28198931

Start: 1233175

End: 1234833

Strand: Reverse

Name: ubiB

Synonym: PD1034

Alternate gene names: 28198931

Gene position: 1234833-1233175 (Counterclockwise)

Preceding gene: 28198932

Following gene: 28198925

Centisome position: 49.01

GC content: 52.14

Gene sequence:

>1659_bases
ATGAAGGCGTTATTCCGGGCCTGCCGCATTGGCAAGGTCATGCTGCGCTACCGCCTGGATACGTTGCTGGACGGTACAGC
CGTAGAGCGCTGGTTGCGTTTGGCTAAGCCTTTTGTACCTCGCATCAGCGCTGAAATTGTTGAGCAGTCCAGAGGGCGTC
GGTTGCGTTTGGCACTGCAGGAATTGGGGCCTATTTTTGTGAAGTTTGGGCAGATTCTGTCCACTCGCAGGGACTTGGTA
CCCCAGGATATCGGTGATGAGCTGGTCATGCTACAAGACCGAGTAGAGCCTTTCGAGGGGCAGACTGCGCGCAGTATCAT
CGAAACTGCGCTAGGCAAGTCGGTTGAAAGTGCATTCGCACACTTCGATACTGTGCCACTGGCCAGTGCTTCAATCTCGC
AGGTCCATGCAGCTACGCTGCATGACCGACGTGCAGTTGTGGTCAAAGTGTTGCGTCCTGATATTGAGCATCAGATCAGT
GACGACATCGCCTTGCTTAAATCGCTGGCTACGTTGGTCGAGCATACTCACCCTAATGCGGATAAAATCCGTCCGCGCGA
GATTGTGGCGGAGATAGAAACCACCTTGGCGGCTGAGTTGGATTTGCAACGTGAAGGTGCCAACGCCAGTGTGTTGCGTC
GCTTCTGGGAGGCGTCCGACGACATATATGTACCTGAAGTAATTTGGTCGCACACCGCCGAACGGGTGCTGACTCTGGAA
CGTATGTATGGCATTCCCTCGGACGATATTGCGTTGCTTGATGCCTCGGGTATTGATCGTAAAGCTCTTTCGAGCAAGGG
AATCCGCGTGTTTTATACCCAGGTGTTCCGCGATAATTTTTTCCATGCCGATGCGCACTCTGGAAACATTTGGGTCGACA
GTGATCCGGCACGCAAATCCAATCCACGTTTTATTGTGCTGGATTTCGGCATCATGGGCCAACTGTCGCAGAAAGATCAG
TACTATTTGGCAGAGAATTTCATGGCCATCTTCCATAAAGACTACCGGCGAATCGCTGAGTTGCATGTGGAAGCAGGCTG
GATACCTCCGCATGTCCGCATTGAGGAGTTGGAAGCAGCGGCACGTTCAGTCTGTGAACCATACTTTACGAGGCCTTTAT
CCCAGATCTCGCTTGCTGAAGTAATGATGAAATTGTTCCATGTTGCCCGACGTTACCAGCTTACGTTACAGCCTCAATTG
ATTTTGCTTCAAAAGACGCTGCTCAATATTGAGGGTGTAGGTCGTCAACTCGATCCTGAATTGGATATCTGGGTCGTAGC
GCGCCCAGTGCTCGAACGCATTCTACGTGCCCGTTACAGTCCGCGTCATGCGTTGAAGGAGTTAAATAAACGCTTGCCTG
AGATCATGACTCATGCCCCAGACACACCGCGCCTCATACATACCTGGTTAGTACAGCAGGTCGAAAGCCGGAAACAGAAT
GACGTTTATTTGCAACAAATACGCGCGTTAGCTATGACTTTGCAAGGCTTGCAGCGCCGTGTGGTCAATGCGATTGTGGG
TAGCGGCTTGCTGGTGGCGGCTGCGGTATTGTATGGCCTACATCCGGATGGTTTGTACTTGGGAACGATTCCAGTGTGGA
GCTTGATTAGTGGGTGCATCGGCGCGTTGGCCTTGTTCAGTGCTTGGTGGCGAAGCTAA

Upstream 100 bases:

>100_bases
GTGCTGAGTTGGAAGCGTTCTACGAGGATGTTGATGTGCTACGTGATGATGTCGAGCGCTTGGCTACTCGACTGATGAAA
TTGTGTTCGGAAATGGCAGC

Downstream 100 bases:

>100_bases
TGGCGTCGGACTGCAGGTAGCACCCAGTTGGTCACTGGGAAGAATCCCAGTGTGGACCGAGATCAGCTTGGCTTTACTTC
ACAGTGCTTGGTGGTGAGGG

Product: putative ubiquinone biosynthesis protein UbiB

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 552; Mature: 552

Protein sequence:

>552_residues
MKALFRACRIGKVMLRYRLDTLLDGTAVERWLRLAKPFVPRISAEIVEQSRGRRLRLALQELGPIFVKFGQILSTRRDLV
PQDIGDELVMLQDRVEPFEGQTARSIIETALGKSVESAFAHFDTVPLASASISQVHAATLHDRRAVVVKVLRPDIEHQIS
DDIALLKSLATLVEHTHPNADKIRPREIVAEIETTLAAELDLQREGANASVLRRFWEASDDIYVPEVIWSHTAERVLTLE
RMYGIPSDDIALLDASGIDRKALSSKGIRVFYTQVFRDNFFHADAHSGNIWVDSDPARKSNPRFIVLDFGIMGQLSQKDQ
YYLAENFMAIFHKDYRRIAELHVEAGWIPPHVRIEELEAAARSVCEPYFTRPLSQISLAEVMMKLFHVARRYQLTLQPQL
ILLQKTLLNIEGVGRQLDPELDIWVVARPVLERILRARYSPRHALKELNKRLPEIMTHAPDTPRLIHTWLVQQVESRKQN
DVYLQQIRALAMTLQGLQRRVVNAIVGSGLLVAAAVLYGLHPDGLYLGTIPVWSLISGCIGALALFSAWWRS

Sequences:

>Translated_552_residues
MKALFRACRIGKVMLRYRLDTLLDGTAVERWLRLAKPFVPRISAEIVEQSRGRRLRLALQELGPIFVKFGQILSTRRDLV
PQDIGDELVMLQDRVEPFEGQTARSIIETALGKSVESAFAHFDTVPLASASISQVHAATLHDRRAVVVKVLRPDIEHQIS
DDIALLKSLATLVEHTHPNADKIRPREIVAEIETTLAAELDLQREGANASVLRRFWEASDDIYVPEVIWSHTAERVLTLE
RMYGIPSDDIALLDASGIDRKALSSKGIRVFYTQVFRDNFFHADAHSGNIWVDSDPARKSNPRFIVLDFGIMGQLSQKDQ
YYLAENFMAIFHKDYRRIAELHVEAGWIPPHVRIEELEAAARSVCEPYFTRPLSQISLAEVMMKLFHVARRYQLTLQPQL
ILLQKTLLNIEGVGRQLDPELDIWVVARPVLERILRARYSPRHALKELNKRLPEIMTHAPDTPRLIHTWLVQQVESRKQN
DVYLQQIRALAMTLQGLQRRVVNAIVGSGLLVAAAVLYGLHPDGLYLGTIPVWSLISGCIGALALFSAWWRS
>Mature_552_residues
MKALFRACRIGKVMLRYRLDTLLDGTAVERWLRLAKPFVPRISAEIVEQSRGRRLRLALQELGPIFVKFGQILSTRRDLV
PQDIGDELVMLQDRVEPFEGQTARSIIETALGKSVESAFAHFDTVPLASASISQVHAATLHDRRAVVVKVLRPDIEHQIS
DDIALLKSLATLVEHTHPNADKIRPREIVAEIETTLAAELDLQREGANASVLRRFWEASDDIYVPEVIWSHTAERVLTLE
RMYGIPSDDIALLDASGIDRKALSSKGIRVFYTQVFRDNFFHADAHSGNIWVDSDPARKSNPRFIVLDFGIMGQLSQKDQ
YYLAENFMAIFHKDYRRIAELHVEAGWIPPHVRIEELEAAARSVCEPYFTRPLSQISLAEVMMKLFHVARRYQLTLQPQL
ILLQKTLLNIEGVGRQLDPELDIWVVARPVLERILRARYSPRHALKELNKRLPEIMTHAPDTPRLIHTWLVQQVESRKQN
DVYLQQIRALAMTLQGLQRRVVNAIVGSGLLVAAAVLYGLHPDGLYLGTIPVWSLISGCIGALALFSAWWRS

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily

Homologues:

Organism=Homo sapiens, GI40254938, Length=275, Percent_Identity=30.1818181818182, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI41393593, Length=272, Percent_Identity=31.9852941176471, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI217035081, Length=230, Percent_Identity=30, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI32261307, Length=322, Percent_Identity=24.8447204968944, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI34147522, Length=279, Percent_Identity=24.3727598566308, Blast_Score=73, Evalue=8e-13,
Organism=Homo sapiens, GI27363457, Length=214, Percent_Identity=28.9719626168224, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI217416386, Length=205, Percent_Identity=26.8292682926829, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI2367309, Length=546, Percent_Identity=42.8571428571429, Blast_Score=432, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI32565180, Length=242, Percent_Identity=31.404958677686, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17559152, Length=285, Percent_Identity=25.2631578947368, Blast_Score=100, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6323282, Length=297, Percent_Identity=26.9360269360269, Blast_Score=110, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6325148, Length=487, Percent_Identity=21.9712525667351, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6321319, Length=333, Percent_Identity=25.2252252252252, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24662575, Length=256, Percent_Identity=30.078125, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI22024280, Length=280, Percent_Identity=25.3571428571429, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI18859849, Length=273, Percent_Identity=26.7399267399267, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIB_XYLF2 (B2I583)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001829800.1
- ProteinModelPortal:   B2I583
- GeneID:   6203899
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_1098
- HOGENOM:   HBG593509
- OMA:   RIQRVVI
- ProtClustDB:   PRK04750
- HAMAP:   MF_00414
- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232
- TIGRFAMs:   TIGR01982

Pfam domain/function: PF03109 ABC1; SSF56112 Kinase_like

EC number: NA

Molecular weight: Translated: 62681; Mature: 62681

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xcb445d8)-; HASH(0xd21ba3c)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALFRACRIGKVMLRYRLDTLLDGTAVERWLRLAKPFVPRISAEIVEQSRGRRLRLALQ
CHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHH
ELGPIFVKFGQILSTRRDLVPQDIGDELVMLQDRVEPFEGQTARSIIETALGKSVESAFA
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCHHHHHHHH
HFDTVPLASASISQVHAATLHDRRAVVVKVLRPDIEHQISDDIALLKSLATLVEHTHPNA
HHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
DKIRPREIVAEIETTLAAELDLQREGANASVLRRFWEASDDIYVPEVIWSHTAERVLTLE
CCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHH
RMYGIPSDDIALLDASGIDRKALSSKGIRVFYTQVFRDNFFHADAHSGNIWVDSDPARKS
HHHCCCCCCEEEEECCCCCHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCC
NPRFIVLDFGIMGQLSQKDQYYLAENFMAIFHKDYRRIAELHVEAGWIPPHVRIEELEAA
CCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
ARSVCEPYFTRPLSQISLAEVMMKLFHVARRYQLTLQPQLILLQKTLLNIEGVGRQLDPE
HHHHHCHHHHCCHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHCCCCCCCCC
LDIWVVARPVLERILRARYSPRHALKELNKRLPEIMTHAPDTPRLIHTWLVQQVESRKQN
CCEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
DVYLQQIRALAMTLQGLQRRVVNAIVGSGLLVAAAVLYGLHPDGLYLGTIPVWSLISGCI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHH
GALALFSAWWRS
HHHHHHHHHHCH
>Mature Secondary Structure
MKALFRACRIGKVMLRYRLDTLLDGTAVERWLRLAKPFVPRISAEIVEQSRGRRLRLALQ
CHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHH
ELGPIFVKFGQILSTRRDLVPQDIGDELVMLQDRVEPFEGQTARSIIETALGKSVESAFA
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCHHHHHHHH
HFDTVPLASASISQVHAATLHDRRAVVVKVLRPDIEHQISDDIALLKSLATLVEHTHPNA
HHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
DKIRPREIVAEIETTLAAELDLQREGANASVLRRFWEASDDIYVPEVIWSHTAERVLTLE
CCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHH
RMYGIPSDDIALLDASGIDRKALSSKGIRVFYTQVFRDNFFHADAHSGNIWVDSDPARKS
HHHCCCCCCEEEEECCCCCHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCC
NPRFIVLDFGIMGQLSQKDQYYLAENFMAIFHKDYRRIAELHVEAGWIPPHVRIEELEAA
CCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
ARSVCEPYFTRPLSQISLAEVMMKLFHVARRYQLTLQPQLILLQKTLLNIEGVGRQLDPE
HHHHHCHHHHCCHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHCCCCCCCCC
LDIWVVARPVLERILRARYSPRHALKELNKRLPEIMTHAPDTPRLIHTWLVQQVESRKQN
CCEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
DVYLQQIRALAMTLQGLQRRVVNAIVGSGLLVAAAVLYGLHPDGLYLGTIPVWSLISGCI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHH
GALALFSAWWRS
HHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA