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The map label for this gene is guaC

Identifier: 255767737

GI number: 255767737

Start: 3303042

End: 3304022

Strand: Direct

Name: guaC

Synonym: BSU32130

Alternate gene names: 255767737

Gene position: 3303042-3304022 (Clockwise)

Preceding gene: 255767736

Following gene: 255767739

Centisome position: 78.35

GC content: 45.16

Gene sequence:

>981_bases
ATGGAAAACGTATTTGATTACGAAGATATTCAGCTAATTCCTGCAAAATGCATTGTGAATAGCCGTTCAGAATGTGATAC
ATCCGTACGTTTAGGCGGACATACATTTAAATTGCCCGTCGTCCCTGCCAATATGCAGACGATTATAGATGAAAAACTAG
CGATTTCATTAGCCGAAAATGGCTACTTTTATGTGATGCACCGATTTGAGCCTGAGACACGAATTGATTTTATTAAAGAT
ATGAACGCACGCGGGTTATTCTCTTCTATCAGCGTGGGCGTCAAAGATGAGGAGTATGAATTTGTCCGCCAGCTGGCAGA
AGAAAATCTGACTCCTGAATACGTGACAATTGACATTGCTCACGGGCACTCAAATGCTGTCATTGAAATGATCCAGCACC
TTAAAAAACATTTGCCGGACAGCTTTGTTATTGCTGGCAATGTCGGAACGCCGGAAGCGGTCAGAGAGCTTGAAAATGCG
GGAGCGGATGCCACTAAAGTCGGCATCGGACCGGGAAAAGTATGTATTACGAAAATCAAAACAGGCTTCGGCACAGGCGG
CTGGCAATTAGCAGCGCTGCGCTGGTGTGCCAAGGCTGCCAGCAAACCGATTATCGCGGATGGCGGCATCCGCACCCATG
GCGACATCGCAAAATCAATCCGATTCGGCGCAACGATGGTCATGATCGGTTCACTATTTGCCGGACACGAAGAATCGCCA
GGCCAAACGATCGAAAAAGACGGAAAGCTTTACAAGGAGTACTTCGGCTCAGCCTCTGAATTCCAAAAAGGCGAAAAGAA
AAATGTCGAAGGCAAAAAAATGCACGTGGCGCATAAAGGCTCAATCAAGGATACACTGATTGAAATGGAGCAGGATCTTC
AATCTTCTATTTCTTATGCAGGCGGAACAAAGCTTAACGCCATCCGCAATGTGGATTATGTGATTGTGAAGAATTCCATT
TTTAATGGGGATAAATATTAA

Upstream 100 bases:

>100_bases
AATCATAATGTTTGACATCCTAAATAAAACAGAGTACATTATATAAGGCGAACATTTCATATATTATACTTTTAAATATT
CGTTTTTAGGAGTGAAAACC

Downstream 100 bases:

>100_bases
TCATAAAAAAACGCCAAGTCAGCGGTTCTCCGCTTGAGTTGGCGTTTTCTGCTACTTCTTCAGCAAAGTAAGCTTATATT
TGCTTTTTGAGTTTATCTTC

Product: guanosine 5'-monophosphate oxidoreductase

Products: NA

Alternate protein names: Guanosine 5'-monophosphate oxidoreductase; Guanosine monophosphate reductase [H]

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MENVFDYEDIQLIPAKCIVNSRSECDTSVRLGGHTFKLPVVPANMQTIIDEKLAISLAENGYFYVMHRFEPETRIDFIKD
MNARGLFSSISVGVKDEEYEFVRQLAEENLTPEYVTIDIAHGHSNAVIEMIQHLKKHLPDSFVIAGNVGTPEAVRELENA
GADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAASKPIIADGGIRTHGDIAKSIRFGATMVMIGSLFAGHEESP
GQTIEKDGKLYKEYFGSASEFQKGEKKNVEGKKMHVAHKGSIKDTLIEMEQDLQSSISYAGGTKLNAIRNVDYVIVKNSI
FNGDKY

Sequences:

>Translated_326_residues
MENVFDYEDIQLIPAKCIVNSRSECDTSVRLGGHTFKLPVVPANMQTIIDEKLAISLAENGYFYVMHRFEPETRIDFIKD
MNARGLFSSISVGVKDEEYEFVRQLAEENLTPEYVTIDIAHGHSNAVIEMIQHLKKHLPDSFVIAGNVGTPEAVRELENA
GADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAASKPIIADGGIRTHGDIAKSIRFGATMVMIGSLFAGHEESP
GQTIEKDGKLYKEYFGSASEFQKGEKKNVEGKKMHVAHKGSIKDTLIEMEQDLQSSISYAGGTKLNAIRNVDYVIVKNSI
FNGDKY
>Mature_326_residues
MENVFDYEDIQLIPAKCIVNSRSECDTSVRLGGHTFKLPVVPANMQTIIDEKLAISLAENGYFYVMHRFEPETRIDFIKD
MNARGLFSSISVGVKDEEYEFVRQLAEENLTPEYVTIDIAHGHSNAVIEMIQHLKKHLPDSFVIAGNVGTPEAVRELENA
GADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAASKPIIADGGIRTHGDIAKSIRFGATMVMIGSLFAGHEESP
GQTIEKDGKLYKEYFGSASEFQKGEKKNVEGKKMHVAHKGSIKDTLIEMEQDLQSSISYAGGTKLNAIRNVDYVIVKNSI
FNGDKY

Specific function: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides [H]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI50541956, Length=338, Percent_Identity=34.6153846153846, Blast_Score=178, Evalue=5e-45,
Organism=Homo sapiens, GI50541954, Length=338, Percent_Identity=34.6153846153846, Blast_Score=178, Evalue=6e-45,
Organism=Homo sapiens, GI50541952, Length=338, Percent_Identity=34.6153846153846, Blast_Score=178, Evalue=6e-45,
Organism=Homo sapiens, GI50541948, Length=338, Percent_Identity=34.6153846153846, Blast_Score=178, Evalue=6e-45,
Organism=Homo sapiens, GI156104880, Length=338, Percent_Identity=30.1775147928994, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI66933016, Length=245, Percent_Identity=31.8367346938775, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI217035150, Length=245, Percent_Identity=31.0204081632653, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI217035148, Length=245, Percent_Identity=30.6122448979592, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI217035146, Length=245, Percent_Identity=30.6122448979592, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI156616279, Length=245, Percent_Identity=31.0204081632653, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI34328930, Length=245, Percent_Identity=31.0204081632653, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI217035152, Length=245, Percent_Identity=31.0204081632653, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI34328928, Length=245, Percent_Identity=31.0204081632653, Blast_Score=102, Evalue=3e-22,
Organism=Escherichia coli, GI1786293, Length=340, Percent_Identity=32.0588235294118, Blast_Score=166, Evalue=1e-42,
Organism=Escherichia coli, GI1788855, Length=215, Percent_Identity=38.6046511627907, Blast_Score=113, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17560440, Length=331, Percent_Identity=31.1178247734139, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71994385, Length=178, Percent_Identity=34.8314606741573, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71994389, Length=178, Percent_Identity=34.8314606741573, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323585, Length=267, Percent_Identity=31.8352059925094, Blast_Score=112, Evalue=9e-26,
Organism=Saccharomyces cerevisiae, GI6323464, Length=267, Percent_Identity=31.8352059925094, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6322012, Length=253, Percent_Identity=32.8063241106719, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6319352, Length=138, Percent_Identity=34.0579710144928, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28571163, Length=257, Percent_Identity=32.6848249027237, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24641071, Length=257, Percent_Identity=32.6848249027237, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24641073, Length=257, Percent_Identity=32.6848249027237, Blast_Score=115, Evalue=5e-26,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005994
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: =1.7.1.7 [H]

Molecular weight: Translated: 35850; Mature: 35850

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENVFDYEDIQLIPAKCIVNSRSECDTSVRLGGHTFKLPVVPANMQTIIDEKLAISLAEN
CCCCCCCCCEEEEEHHHHCCCCCCCCCEEEECCEEEEEEEECCCHHHHHHHHHEEEEECC
GYFYVMHRFEPETRIDFIKDMNARGLFSSISVGVKDEEYEFVRQLAEENLTPEYVTIDIA
CEEEEEEECCCCHHHHHHHCCCCCCCHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEEEE
HGHSNAVIEMIQHLKKHLPDSFVIAGNVGTPEAVRELENAGADATKVGIGPGKVCITKIK
CCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCCCEEECCCCCCEEEEEEC
TGFGTGGWQLAALRWCAKAASKPIIADGGIRTHGDIAKSIRFGATMVMIGSLFAGHEESP
CCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
GQTIEKDGKLYKEYFGSASEFQKGEKKNVEGKKMHVAHKGSIKDTLIEMEQDLQSSISYA
CCHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHC
GGTKLNAIRNVDYVIVKNSIFNGDKY
CCCEEHHHCCCEEEEEECCCCCCCCC
>Mature Secondary Structure
MENVFDYEDIQLIPAKCIVNSRSECDTSVRLGGHTFKLPVVPANMQTIIDEKLAISLAEN
CCCCCCCCCEEEEEHHHHCCCCCCCCCEEEECCEEEEEEEECCCHHHHHHHHHEEEEECC
GYFYVMHRFEPETRIDFIKDMNARGLFSSISVGVKDEEYEFVRQLAEENLTPEYVTIDIA
CEEEEEEECCCCHHHHHHHCCCCCCCHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEEEE
HGHSNAVIEMIQHLKKHLPDSFVIAGNVGTPEAVRELENAGADATKVGIGPGKVCITKIK
CCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCCCEEECCCCCCEEEEEEC
TGFGTGGWQLAALRWCAKAASKPIIADGGIRTHGDIAKSIRFGATMVMIGSLFAGHEESP
CCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
GQTIEKDGKLYKEYFGSASEFQKGEKKNVEGKKMHVAHKGSIKDTLIEMEQDLQSSISYA
CCHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHC
GGTKLNAIRNVDYVIVKNSIFNGDKY
CCCEEHHHCCCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA