BacMap

Definition	Kosmotoga olearia TBF 19.5.1, complete genome.
Accession	NC_012785
Length	2,302,126

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The map label for this gene is gmk [H]

Identifier: 239618212

GI number: 239618212

Start: 1979849

End: 1980481

Strand: Reverse

Name: gmk [H]

Synonym: Kole_1848

Alternate gene names: 239618212

Gene position: 1980481-1979849 (Counterclockwise)

Preceding gene: 239618213

Following gene: 239618211

Centisome position: 86.03

GC content: 38.55

Gene sequence:

>633_bases
ATGAGGGGAACAATTTATGTAGTCTCCGGTCCTTCCGGAGCTGGAAAAACATCAATTTTGAAAGAAGTCCTAAAAAAAAT
CCCGAATCTTACATTTTCTGTTTCTTATACAACGCGCCCCAAAAGGCCTGGAGAGATTGATGGGGAAGATTACTTTTTCG
TTAGTAAAGAAAAATTTGTGGAACTGGTAAATAGTGGGGAATTTCTTGAATGGGCGGAAGTCCATGGTAACCTCTACGGA
ACATCAAAAAGTTTCGTTGAGTCAAAGATTGAAAAAGGGATAAACATTATCCTGGATATTGATGTTCAGGGTGCATTGTC
TGTGATGAAAAAACTTCCCGACGCTGTTACCATATTCATATGCCCTCCATCATTCAAAGATCTGAAAAAGCGCCTTGACA
ACCGGGGCACTGAAAAAGAGAAAGATCGGGAAAGAAGACTCAAAGATGCCAAGTGGGAATTATCCCACATTTCAGATTTT
CAATATCTGGTAGTTAACAGAACTTTAAACGAGTCGGTAAAACAACTTGAAGCAGTAATAATAGCAGAACAACTGAGAGT
TGATAGAATAAAAGATCATATGGGACTACAGGACTTCTTTAAGGAGAGTGATAACGATGTCTGTGATAATTAA

Upstream 100 bases:

>100_bases
CAATTCAACCAGAAACAATCGCTTCTCGTTTCATGCAAACCTTCACGGACATCGAGAAACTTCTCGAAGAAATCAGACAG
GCGGAGAGACGGACGGAAGA

Downstream 100 bases:

>100_bases
TTACGACAAACTTCTCAAAAGGATAAGGCATAAGTACGCTATCCCTATAGCCGCTGCGCGTAGAGCCGAGGGTCTAAAAG
ACTTTGGTAGGCCAAAACTC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MRGTIYVVSGPSGAGKTSILKEVLKKIPNLTFSVSYTTRPKRPGEIDGEDYFFVSKEKFVELVNSGEFLEWAEVHGNLYG
TSKSFVESKIEKGINIILDIDVQGALSVMKKLPDAVTIFICPPSFKDLKKRLDNRGTEKEKDRERRLKDAKWELSHISDF
QYLVVNRTLNESVKQLEAVIIAEQLRVDRIKDHMGLQDFFKESDNDVCDN

Sequences:

>Translated_210_residues
MRGTIYVVSGPSGAGKTSILKEVLKKIPNLTFSVSYTTRPKRPGEIDGEDYFFVSKEKFVELVNSGEFLEWAEVHGNLYG
TSKSFVESKIEKGINIILDIDVQGALSVMKKLPDAVTIFICPPSFKDLKKRLDNRGTEKEKDRERRLKDAKWELSHISDF
QYLVVNRTLNESVKQLEAVIIAEQLRVDRIKDHMGLQDFFKESDNDVCDN
>Mature_210_residues
MRGTIYVVSGPSGAGKTSILKEVLKKIPNLTFSVSYTTRPKRPGEIDGEDYFFVSKEKFVELVNSGEFLEWAEVHGNLYG
TSKSFVESKIEKGINIILDIDVQGALSVMKKLPDAVTIFICPPSFKDLKKRLDNRGTEKEKDRERRLKDAKWELSHISDF
QYLVVNRTLNESVKQLEAVIIAEQLRVDRIKDHMGLQDFFKESDNDVCDN

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874831, Length=187, Percent_Identity=36.3636363636364, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI226874833, Length=187, Percent_Identity=36.3636363636364, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI4504221, Length=187, Percent_Identity=36.3636363636364, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI14780902, Length=191, Percent_Identity=27.7486910994764, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI38570142, Length=177, Percent_Identity=28.2485875706215, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI262118255, Length=172, Percent_Identity=28.4883720930233, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI4505237, Length=172, Percent_Identity=28.4883720930233, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI262118263, Length=172, Percent_Identity=28.4883720930233, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI262118259, Length=172, Percent_Identity=28.4883720930233, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI186700629, Length=177, Percent_Identity=24.8587570621469, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI186700627, Length=177, Percent_Identity=24.8587570621469, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI186972120, Length=177, Percent_Identity=24.8587570621469, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI4557529, Length=147, Percent_Identity=31.9727891156463, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI148539578, Length=172, Percent_Identity=31.3953488372093, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI192447426, Length=147, Percent_Identity=31.9727891156463, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI148539628, Length=172, Percent_Identity=31.3953488372093, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI218156338, Length=175, Percent_Identity=32.5714285714286, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI218156270, Length=175, Percent_Identity=32.5714285714286, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI91199538, Length=175, Percent_Identity=32.5714285714286, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI218156340, Length=175, Percent_Identity=32.5714285714286, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI261862237, Length=133, Percent_Identity=30.0751879699248, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI119943108, Length=111, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI21361598, Length=199, Percent_Identity=27.6381909547739, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI119943106, Length=170, Percent_Identity=28.8235294117647, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1790080, Length=192, Percent_Identity=44.7916666666667, Blast_Score=179, Evalue=8e-47,
Organism=Caenorhabditis elegans, GI193203132, Length=175, Percent_Identity=41.7142857142857, Blast_Score=125, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17508835, Length=175, Percent_Identity=41.7142857142857, Blast_Score=124, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71988041, Length=182, Percent_Identity=27.4725274725275, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71988048, Length=182, Percent_Identity=27.4725274725275, Blast_Score=74, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17557440, Length=182, Percent_Identity=29.1208791208791, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71984092, Length=145, Percent_Identity=30.3448275862069, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17556244, Length=121, Percent_Identity=30.5785123966942, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71982296, Length=98, Percent_Identity=35.7142857142857, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=43.7158469945355, Blast_Score=146, Evalue=2e-36,
Organism=Drosophila melanogaster, GI21356141, Length=181, Percent_Identity=35.3591160220994, Blast_Score=114, Evalue=4e-26,
Organism=Drosophila melanogaster, GI221330164, Length=124, Percent_Identity=32.258064516129, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221330166, Length=124, Percent_Identity=32.258064516129, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221330162, Length=124, Percent_Identity=32.258064516129, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI161078487, Length=180, Percent_Identity=26.6666666666667, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI161078485, Length=180, Percent_Identity=26.6666666666667, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24648810, Length=180, Percent_Identity=26.6666666666667, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI281362232, Length=180, Percent_Identity=26.6666666666667, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI281362230, Length=180, Percent_Identity=26.6666666666667, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24648808, Length=180, Percent_Identity=26.6666666666667, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI85816281, Length=140, Percent_Identity=31.4285714285714, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI85816106, Length=140, Percent_Identity=31.4285714285714, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI45551002, Length=145, Percent_Identity=30.3448275862069, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI45554813, Length=120, Percent_Identity=39.1666666666667, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI45554481, Length=183, Percent_Identity=24.0437158469945, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI161077754, Length=120, Percent_Identity=39.1666666666667, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI45554791, Length=120, Percent_Identity=39.1666666666667, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI161077626, Length=183, Percent_Identity=24.0437158469945, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24640542, Length=183, Percent_Identity=24.0437158469945, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI85724806, Length=183, Percent_Identity=24.0437158469945, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24641280, Length=120, Percent_Identity=39.1666666666667, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI45554804, Length=120, Percent_Identity=39.1666666666667, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI281360700, Length=120, Percent_Identity=39.1666666666667, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24641282, Length=120, Percent_Identity=39.1666666666667, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI45554818, Length=120, Percent_Identity=39.1666666666667, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI161077752, Length=120, Percent_Identity=39.1666666666667, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI45554489, Length=183, Percent_Identity=24.0437158469945, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI116007136, Length=183, Percent_Identity=24.0437158469945, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 23949; Mature: 23949

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGTIYVVSGPSGAGKTSILKEVLKKIPNLTFSVSYTTRPKRPGEIDGEDYFFVSKEKFV
CCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCEEEECHHHHH
ELVNSGEFLEWAEVHGNLYGTSKSFVESKIEKGINIILDIDVQGALSVMKKLPDAVTIFI
HHHCCCCCCHHHHHCCCCCCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCCEEEEEE
CPPSFKDLKKRLDNRGTEKEKDRERRLKDAKWELSHISDFQYLVVNRTLNESVKQLEAVI
CCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHH
IAEQLRVDRIKDHMGLQDFFKESDNDVCDN
HHHHHHHHHHHHHCCHHHHHHCCCCCCCCC
>Mature Secondary Structure
MRGTIYVVSGPSGAGKTSILKEVLKKIPNLTFSVSYTTRPKRPGEIDGEDYFFVSKEKFV
CCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCEEEECHHHHH
ELVNSGEFLEWAEVHGNLYGTSKSFVESKIEKGINIILDIDVQGALSVMKKLPDAVTIFI
HHHCCCCCCHHHHHCCCCCCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCCEEEEEE
CPPSFKDLKKRLDNRGTEKEKDRERRLKDAKWELSHISDFQYLVVNRTLNESVKQLEAVI
CCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHH
IAEQLRVDRIKDHMGLQDFFKESDNDVCDN
HHHHHHHHHHHHHCCHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]