Click here to switch to the map view.

The map label for this gene is coaBC [H]

Identifier: 239618210

GI number: 239618210

Start: 1978418

End: 1979629

Strand: Reverse

Name: coaBC [H]

Synonym: Kole_1846

Alternate gene names: 239618210

Gene position: 1979629-1978418 (Counterclockwise)

Preceding gene: 239618211

Following gene: 239618209

Centisome position: 85.99

GC content: 40.68

Gene sequence:

>1212_bases
ATGATGGAAAGCAGATTTCTGAAAGGTAAGAACATACTTTTAGGTATAAGCAGCGGCATAGCAATCTACAAAGCTGTTGA
TCTTGTAAGTAAACTGAGAAAATTAGGGGCAAATTTAGCAATAATTATGACACCAGAGGCTCAAGGAATGATCTCTGGTG
TTGTTTTTTCCGCTGTCGGCAACTGTCCGGTATACACAGATCTCAACGCTGTAGAAAAAGGATGGATTCCACACACTGAG
CTTTCCCGTTGGGCAGATACTTTAATCATTGCACCAGCAACAGCAAATACTCTAGCAAAAATAGCTCACGGGATAGCCGA
TAATCTTTTGTTGTCAACAGTATTGGCATATAACGGGAATAGAAAGCTTCTCGTTCCTACCATGAACACAAGGATGTTCG
AGAATGTAACAACACAAAGGAACATCGCCATCCTTAAAAATAACGGCTGGTACTTCATCGAACCGGAAGAAGGCCATCTT
GCCTGTGGCGAAACCGGTAAAGGCCGCTATCCAGATAACGACAAAATAATTGAAGAACTGGCATTTCTTCTTTCTCCGAA
ACCCCTTTCTGGAAAGAAAGCGGTTGTCACTGCGGGTCCCACAAGAGAATACATTGACACAGTAAGATTCATAACCAACC
GTTCTTCTGGAAAGATGGGTTATGCGATAGCTCGTGCTCTCAGATATATGGGAGCAGAACTTGTACTCATAAGCGGCCCA
ACGAATTTAACACCACCTTACGGGATCAAAGTAATAAACGTTGTTTCTGCCTCAGAAATGGCTGAAGCTACAATAACCGA
AGTAAAGAAAGCCGATCTTCTTGTTATGACTGCTGCTGTCGCTGATTACACACCGGAGAAAACTTTGAGCGCGAAGCTAA
AAAAGAGTAATAAACCATTACAACTAAACCTCAAAAGAACTAAGGATATATTGAGCAGTCTTGACAAATCTAATGGCAAA
ATATTCGTAGGATTCAGTGCCGAAGATTCACAGGTCTTTGAAAGATCACAGGAAAAACTCAAGAAAAAAGGGTTGAATAT
GATCATCTTCAACGACATATCCAGAAAAGACATAGGCTTTGAATCCGAACTCAACGAAGTGGGAATAATATATGACTCAG
GAGATTTTGAAATGCTACCCCAAATGTCAAAAGCTGAACTGGCTTATGAAATCGTGAAAAGAATAACTGACCGTTATTTC
AAAGAACACTAA

Upstream 100 bases:

>100_bases
AAGCCGGCGACAAGATAAACATTGCCCTTAAAGAATTGGAAGAGGGTCGCATAGTCATCAGAAACGAAGAAATGTTGAAA
ATCCTCGTCCCAAAGGTAAA

Downstream 100 bases:

>100_bases
CTAATTTGATCACTGGAAACAAAAATTTTTTCTGGTATCTTGACAGCTTCTTATTGACCGTTTATAATAAAAACCGAGTG
TCGAGCCAACGTAGCTCAAC

Product: phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MMESRFLKGKNILLGISSGIAIYKAVDLVSKLRKLGANLAIIMTPEAQGMISGVVFSAVGNCPVYTDLNAVEKGWIPHTE
LSRWADTLIIAPATANTLAKIAHGIADNLLLSTVLAYNGNRKLLVPTMNTRMFENVTTQRNIAILKNNGWYFIEPEEGHL
ACGETGKGRYPDNDKIIEELAFLLSPKPLSGKKAVVTAGPTREYIDTVRFITNRSSGKMGYAIARALRYMGAELVLISGP
TNLTPPYGIKVINVVSASEMAEATITEVKKADLLVMTAAVADYTPEKTLSAKLKKSNKPLQLNLKRTKDILSSLDKSNGK
IFVGFSAEDSQVFERSQEKLKKKGLNMIIFNDISRKDIGFESELNEVGIIYDSGDFEMLPQMSKAELAYEIVKRITDRYF
KEH

Sequences:

>Translated_403_residues
MMESRFLKGKNILLGISSGIAIYKAVDLVSKLRKLGANLAIIMTPEAQGMISGVVFSAVGNCPVYTDLNAVEKGWIPHTE
LSRWADTLIIAPATANTLAKIAHGIADNLLLSTVLAYNGNRKLLVPTMNTRMFENVTTQRNIAILKNNGWYFIEPEEGHL
ACGETGKGRYPDNDKIIEELAFLLSPKPLSGKKAVVTAGPTREYIDTVRFITNRSSGKMGYAIARALRYMGAELVLISGP
TNLTPPYGIKVINVVSASEMAEATITEVKKADLLVMTAAVADYTPEKTLSAKLKKSNKPLQLNLKRTKDILSSLDKSNGK
IFVGFSAEDSQVFERSQEKLKKKGLNMIIFNDISRKDIGFESELNEVGIIYDSGDFEMLPQMSKAELAYEIVKRITDRYF
KEH
>Mature_403_residues
MMESRFLKGKNILLGISSGIAIYKAVDLVSKLRKLGANLAIIMTPEAQGMISGVVFSAVGNCPVYTDLNAVEKGWIPHTE
LSRWADTLIIAPATANTLAKIAHGIADNLLLSTVLAYNGNRKLLVPTMNTRMFENVTTQRNIAILKNNGWYFIEPEEGHL
ACGETGKGRYPDNDKIIEELAFLLSPKPLSGKKAVVTAGPTREYIDTVRFITNRSSGKMGYAIARALRYMGAELVLISGP
TNLTPPYGIKVINVVSASEMAEATITEVKKADLLVMTAAVADYTPEKTLSAKLKKSNKPLQLNLKRTKDILSSLDKSNGK
IFVGFSAEDSQVFERSQEKLKKKGLNMIIFNDISRKDIGFESELNEVGIIYDSGDFEMLPQMSKAELAYEIVKRITDRYF
KEH

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=190, Percent_Identity=33.6842105263158, Blast_Score=93, Evalue=6e-19,
Organism=Escherichia coli, GI87082301, Length=401, Percent_Identity=36.9077306733167, Blast_Score=232, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI17560194, Length=171, Percent_Identity=35.0877192982456, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322762, Length=181, Percent_Identity=32.5966850828729, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6322925, Length=111, Percent_Identity=37.8378378378378, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324629, Length=70, Percent_Identity=47.1428571428571, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24657262, Length=191, Percent_Identity=28.7958115183246, Blast_Score=83, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 44433; Mature: 44433

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMESRFLKGKNILLGISSGIAIYKAVDLVSKLRKLGANLAIIMTPEAQGMISGVVFSAVG
CCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCC
NCPVYTDLNAVEKGWIPHTELSRWADTLIIAPATANTLAKIAHGIADNLLLSTVLAYNGN
CCCEEECCCHHHHCCCCCHHHHHHHCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCC
RKLLVPTMNTRMFENVTTQRNIAILKNNGWYFIEPEEGHLACGETGKGRYPDNDKIIEEL
CEEEEEECCCHHHHHCCCCCCEEEEECCCEEEEECCCCCEECCCCCCCCCCCCHHHHHHH
AFLLSPKPLSGKKAVVTAGPTREYIDTVRFITNRSSGKMGYAIARALRYMGAELVLISGP
HHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEECC
TNLTPPYGIKVINVVSASEMAEATITEVKKADLLVMTAAVADYTPEKTLSAKLKKSNKPL
CCCCCCCCEEEEEEECHHHHHHHHHHHHHHCCEEEEEHHHHCCCCCHHHHHHHHCCCCCE
QLNLKRTKDILSSLDKSNGKIFVGFSAEDSQVFERSQEKLKKKGLNMIIFNDISRKDIGF
EEEHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCC
ESELNEVGIIYDSGDFEMLPQMSKAELAYEIVKRITDRYFKEH
CCCCCCEEEEEECCCHHCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MMESRFLKGKNILLGISSGIAIYKAVDLVSKLRKLGANLAIIMTPEAQGMISGVVFSAVG
CCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCC
NCPVYTDLNAVEKGWIPHTELSRWADTLIIAPATANTLAKIAHGIADNLLLSTVLAYNGN
CCCEEECCCHHHHCCCCCHHHHHHHCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCC
RKLLVPTMNTRMFENVTTQRNIAILKNNGWYFIEPEEGHLACGETGKGRYPDNDKIIEEL
CEEEEEECCCHHHHHCCCCCCEEEEECCCEEEEECCCCCEECCCCCCCCCCCCHHHHHHH
AFLLSPKPLSGKKAVVTAGPTREYIDTVRFITNRSSGKMGYAIARALRYMGAELVLISGP
HHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEECC
TNLTPPYGIKVINVVSASEMAEATITEVKKADLLVMTAAVADYTPEKTLSAKLKKSNKPL
CCCCCCCCEEEEEEECHHHHHHHHHHHHHHCCEEEEEHHHHCCCCCHHHHHHHHCCCCCE
QLNLKRTKDILSSLDKSNGKIFVGFSAEDSQVFERSQEKLKKKGLNMIIFNDISRKDIGF
EEEHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCC
ESELNEVGIIYDSGDFEMLPQMSKAELAYEIVKRITDRYFKEH
CCCCCCEEEEEECCCHHCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]