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The map label for this gene is hslU [H]

Identifier: 239618025

GI number: 239618025

Start: 1782217

End: 1783611

Strand: Reverse

Name: hslU [H]

Synonym: Kole_1654

Alternate gene names: 239618025

Gene position: 1783611-1782217 (Counterclockwise)

Preceding gene: 239618026

Following gene: 239618024

Centisome position: 77.48

GC content: 46.59

Gene sequence:

>1395_bases
ATGCCACAGATAGACGAAGATCTGGCACAGCTTACCCCAAAAAAAATAGTCGAAGAGCTGGACAAATACATCGTAGGCCA
GGCGGAAGCGAAACGTGCCGTAGCGGTAGCCTTGAGAAACAGAATCAGACGGCAGAAACTACCGGAAGATGTCAGAAAGG
AAATCATACCCAAAAATATCCTCATGATCGGGCCTACCGGTGTGGGTAAAACCGAGATTGCCAGGAGACTGGCGGAATTA
TCAAAATCCCCGTTCATAAAGGTTGAAGCCACCCGCTTCACAGAAGTGGGTTACGTCGGTAAAAATGTGGATTCCATGAT
CCGCGAATTGGTGGCCTTTGGCGTCAACATGGTAAAACAGGAAAAAATGAAGGAAGTAGAAGAAAAAGCAAAGCAGTTCG
TAGAGGACCGGATACTTGAAGCGCTTGTCCCAGGATTGAAACACAGAGCGGGCCAGCCGAAAAACATCTTCGAACTCTTC
CAGGGCGTCCCCCAGCAAAGAATCTCCCCGGAAGAAGCGGAAAATCTGCGGAGAAAAAGGGAAGAATATCGTCAAAAATT
GAGAGACGGCGAACTGGAAAACCTCCAGATCGAAATCGAACTTGAGGAACAGCCAAAGCAGATGATAATGATTCCCGGTA
TGGAAGAAATGGGAATAGATATGTCCGGCATGTTTGGCGACATGCTCCCAAAAAGAAAGAAAAAGAAGAGAATGTCGGTA
GCAGAAGCCAGAAAAGTCCTTCTGCCGATCGAATCCGAGAAACTTCTGGATATGGATAAGGTTATCGCAGAAGCCATCGA
ACGAGTTGAAAACAGGGGTATCGTTTTCATAGATGAAATCGACAAAGTTACCGCCCGCGGAAGCCACGGACCCGATGTCT
CCAGAGAAGGTGTGCAGAGAGACCTTCTGCCAATAATCGAGGGAACAACGATTAACACCAAATATGGACCTGTAAGGACC
GATTTCATACTGTTCATTGCAGCAGGTGCTTTCCATCTTGCGAAGCCCTCCGACCTCATACCGGAATTTCAGGGTAGATT
TCCCATACGCGTTGAACTGAACCCTTTGACAGAGCAGGATTTCCTGAGAATACTCACAGAACCCAAAAACGCTATCACCA
AACAGTACAAAGCCCTTCTGGAAACAGAAGGGATCACCCTTGAATTCACTGAAGCAGGTCTCAAAGAAATCGCACGCGTT
GCTCATGACCTGAACGAAAGGATTGAAAATATCGGGGCCAGAAGATTGTACACAGTTGTAGAAAAGGTTCTCGAGGAAAT
CTCCTTTGAAGCACCCGACGTTTCTGAACCAAAGGTTATTATCACCGAAGATTACGTAAACACGAGAATAAAAGAAATCC
TGGCCGATGAGGATTTGAGCGCATTTATCCTGTGA

Upstream 100 bases:

>100_bases
ATGCCGAAGGAATAGCCAAACAGGCGATGAAAATAGCGAGTGAGATATGCATTTACACCAACTCGAACTTCACCGTAGAA
GCCCTGGAGGTGAAAAAATA

Downstream 100 bases:

>100_bases
GCTATGAATAGGTTAGAATACGCGATACTGGCTTTAGCGGGAGATCTAACTGTTGATGATCTCTCGATTTTGCAATCACA
TAATATCGGGTTAAAAGAAC

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MPQIDEDLAQLTPKKIVEELDKYIVGQAEAKRAVAVALRNRIRRQKLPEDVRKEIIPKNILMIGPTGVGKTEIARRLAEL
SKSPFIKVEATRFTEVGYVGKNVDSMIRELVAFGVNMVKQEKMKEVEEKAKQFVEDRILEALVPGLKHRAGQPKNIFELF
QGVPQQRISPEEAENLRRKREEYRQKLRDGELENLQIEIELEEQPKQMIMIPGMEEMGIDMSGMFGDMLPKRKKKKRMSV
AEARKVLLPIESEKLLDMDKVIAEAIERVENRGIVFIDEIDKVTARGSHGPDVSREGVQRDLLPIIEGTTINTKYGPVRT
DFILFIAAGAFHLAKPSDLIPEFQGRFPIRVELNPLTEQDFLRILTEPKNAITKQYKALLETEGITLEFTEAGLKEIARV
AHDLNERIENIGARRLYTVVEKVLEEISFEAPDVSEPKVIITEDYVNTRIKEILADEDLSAFIL

Sequences:

>Translated_464_residues
MPQIDEDLAQLTPKKIVEELDKYIVGQAEAKRAVAVALRNRIRRQKLPEDVRKEIIPKNILMIGPTGVGKTEIARRLAEL
SKSPFIKVEATRFTEVGYVGKNVDSMIRELVAFGVNMVKQEKMKEVEEKAKQFVEDRILEALVPGLKHRAGQPKNIFELF
QGVPQQRISPEEAENLRRKREEYRQKLRDGELENLQIEIELEEQPKQMIMIPGMEEMGIDMSGMFGDMLPKRKKKKRMSV
AEARKVLLPIESEKLLDMDKVIAEAIERVENRGIVFIDEIDKVTARGSHGPDVSREGVQRDLLPIIEGTTINTKYGPVRT
DFILFIAAGAFHLAKPSDLIPEFQGRFPIRVELNPLTEQDFLRILTEPKNAITKQYKALLETEGITLEFTEAGLKEIARV
AHDLNERIENIGARRLYTVVEKVLEEISFEAPDVSEPKVIITEDYVNTRIKEILADEDLSAFIL
>Mature_463_residues
PQIDEDLAQLTPKKIVEELDKYIVGQAEAKRAVAVALRNRIRRQKLPEDVRKEIIPKNILMIGPTGVGKTEIARRLAELS
KSPFIKVEATRFTEVGYVGKNVDSMIRELVAFGVNMVKQEKMKEVEEKAKQFVEDRILEALVPGLKHRAGQPKNIFELFQ
GVPQQRISPEEAENLRRKREEYRQKLRDGELENLQIEIELEEQPKQMIMIPGMEEMGIDMSGMFGDMLPKRKKKKRMSVA
EARKVLLPIESEKLLDMDKVIAEAIERVENRGIVFIDEIDKVTARGSHGPDVSREGVQRDLLPIIEGTTINTKYGPVRTD
FILFIAAGAFHLAKPSDLIPEFQGRFPIRVELNPLTEQDFLRILTEPKNAITKQYKALLETEGITLEFTEAGLKEIARVA
HDLNERIENIGARRLYTVVEKVLEEISFEAPDVSEPKVIITEDYVNTRIKEILADEDLSAFIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Homo sapiens, GI7242140, Length=95, Percent_Identity=44.2105263157895, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1790366, Length=460, Percent_Identity=53.0434782608696, Blast_Score=483, Evalue=1e-137,
Organism=Escherichia coli, GI1786642, Length=261, Percent_Identity=34.0996168582375, Blast_Score=112, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6319704, Length=124, Percent_Identity=35.4838709677419, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24648291, Length=264, Percent_Identity=32.5757575757576, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24648289, Length=264, Percent_Identity=32.5757575757576, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491
- InterPro:   IPR020851 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 52926; Mature: 52795

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQIDEDLAQLTPKKIVEELDKYIVGQAEAKRAVAVALRNRIRRQKLPEDVRKEIIPKNI
CCCCHHHHHHCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCE
LMIGPTGVGKTEIARRLAELSKSPFIKVEATRFTEVGYVGKNVDSMIRELVAFGVNMVKQ
EEECCCCCCHHHHHHHHHHHCCCCCEEEEECHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
EKMKEVEEKAKQFVEDRILEALVPGLKHRAGQPKNIFELFQGVPQQRISPEEAENLRRKR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHCCCHHHHHHHHHHH
EEYRQKLRDGELENLQIEIELEEQPKQMIMIPGMEEMGIDMSGMFGDMLPKRKKKKRMSV
HHHHHHHCCCCCCCEEEEEEECCCCCCEEECCCHHHHCCCHHHHHHHHCCHHHHHHHHHH
AEARKVLLPIESEKLLDMDKVIAEAIERVENRGIVFIDEIDKVTARGSHGPDVSREGVQR
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHCCCCCCCCCHHHHHH
DLLPIIEGTTINTKYGPVRTDFILFIAAGAFHLAKPSDLIPEFQGRFPIRVELNPLTEQD
HHHHHHCCCEECCCCCCCHHHHHHHHHHCHHHCCCCHHHCHHHCCCCCEEEEECCCCHHH
FLRILTEPKNAITKQYKALLETEGITLEFTEAGLKEIARVAHDLNERIENIGARRLYTVV
HHHHHHCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKVLEEISFEAPDVSEPKVIITEDYVNTRIKEILADEDLSAFIL
HHHHHHHCCCCCCCCCCEEEEECHHHHHHHHHHHHCCCCHHHCC
>Mature Secondary Structure 
PQIDEDLAQLTPKKIVEELDKYIVGQAEAKRAVAVALRNRIRRQKLPEDVRKEIIPKNI
CCCHHHHHHCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCE
LMIGPTGVGKTEIARRLAELSKSPFIKVEATRFTEVGYVGKNVDSMIRELVAFGVNMVKQ
EEECCCCCCHHHHHHHHHHHCCCCCEEEEECHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
EKMKEVEEKAKQFVEDRILEALVPGLKHRAGQPKNIFELFQGVPQQRISPEEAENLRRKR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHCCCHHHHHHHHHHH
EEYRQKLRDGELENLQIEIELEEQPKQMIMIPGMEEMGIDMSGMFGDMLPKRKKKKRMSV
HHHHHHHCCCCCCCEEEEEEECCCCCCEEECCCHHHHCCCHHHHHHHHCCHHHHHHHHHH
AEARKVLLPIESEKLLDMDKVIAEAIERVENRGIVFIDEIDKVTARGSHGPDVSREGVQR
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHCCCCCCCCCHHHHHH
DLLPIIEGTTINTKYGPVRTDFILFIAAGAFHLAKPSDLIPEFQGRFPIRVELNPLTEQD
HHHHHHCCCEECCCCCCCHHHHHHHHHHCHHHCCCCHHHCHHHCCCCCEEEEECCCCHHH
FLRILTEPKNAITKQYKALLETEGITLEFTEAGLKEIARVAHDLNERIENIGARRLYTVV
HHHHHHCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKVLEEISFEAPDVSEPKVIITEDYVNTRIKEILADEDLSAFIL
HHHHHHHCCCCCCCCCCEEEEECHHHHHHHHHHHHCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]