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The map label for this gene is atoC [H]

Identifier: 239617964

GI number: 239617964

Start: 1708017

End: 1709357

Strand: Reverse

Name: atoC [H]

Synonym: Kole_1592

Alternate gene names: 239617964

Gene position: 1709357-1708017 (Counterclockwise)

Preceding gene: 239617965

Following gene: 239617963

Centisome position: 74.25

GC content: 43.77

Gene sequence:

>1341_bases
ATGAAAAGAAAATTGCTGGTTGTGGACGATGATATGGCATTCAATTTAATACTTTGCGAAGCACTGGAAAGCGAAGGATA
TCTCGTAACAAAAGCCCACGATCTAAAAAGCGCAAAAGAACTGCTTCAGGAAGAAAGTTTCGACTGTGCTTTGCTCGACA
TCAGGTTACCTGATGGTGATGGAATTGAGTTGATAGACTTCGCTAGAAGTCAGGAAACTATCGTCATTGTTATGTCCGCC
CACGGTAACATAGAAACTGCTGTTTCAGCGGTAAAGAAAGGGGCTTACAATTTCCTCGAGAAACCCTTCGATTTGAATCA
TGCACTCGTAGAGGTTGAGAGAGCCCTGAAGTTCGCTGAGCTTCAACGGGAACATCGCTTGCTGTTGAAAAAAGTCAAGC
AGCTGGGCTTTACCGATGAGTTGCTCGGCGTTTCGGAATCAATCGTTTCAATAAAAAAACTCATAGAAAACATAGCACCC
AAAAAAGTAACCGTACTTATTCAGGGCGAAAGCGGCACGGGCAAAGAGGTTATCGCAAGGATGATCCATAAACTCAGTGG
GAGAAAAGAATTTGTTGATATAAACTGTGGGGCTATCCCCGAAAATCTCTTTGAAAGTGAGATCTTCGGTTATGAAAAGG
GAGCCTTTACCGGTGCTGGAGATTCGAAAAAGGGGCTTGTGGAAGAAGCCGACAGGGGAACGCTTTTCCTGGACGAAATT
TCTGAACTACCAATAACACTTCAACCAAAACTGCTCCGTTTTATTGAAACGGGCACCTTCCAGAGAATAGGGAGTACAAA
AAGGAAAAAAACGGATGTCAGAATAATCTGCGCTACCAATAGAGACCTGGAAAAACTCGTGGAAGAAGGGAAGTTTCGTG
AGGACCTGTTTTACCGTCTCAACGTCGTGCGTATAAAGCTCCCGCCATTAAGAGAGAGGCCGGAAGACATTGCGATTCTC
GCAAAACAGTTCGTCAAAGACATCTCTGCGGAACTCGGCTTGAGAAAACGACCGAAAATTTCCGAAACCTTTATTCAGGC
GTTGATGAACTATCACTGGCCTGGAAATGTCAGAGAACTGAGAAACTGTCTTCTATCAATACTCGCAGTTCACGATAGTT
CTGAGACACTTGAAGAATGGATGCTTTTCGACGTACTTGGGTCAAGAATAGATAATTCCAGAGATGCCTCCAATGAAGAT
TTGACCCTAGAGGAACTCGAGAAGCGTTACATACGCAAGTTACTGAAAAAGTACTCCGGAAATAAAACGAAGGTCGCTCA
AGTACTTGGAATCAGTAAGAGCACTCTCTACGAAAAACTCAAAAGGTGGGAACCCTTTTGA

Upstream 100 bases:

>100_bases
GCCAAAAGCTTTTGTGAGGACAATGGTGCTATATTAAGATTTAAGAGTATTCCTGGAAAGGGTACCGTTTTTTCGCTAAC
GATGAAGAAGGTGGAGTGAA

Downstream 100 bases:

>100_bases
AAATTATAACGACGCATGTTAACCCTGATTTTGATGGGGTCGCTTCAGCGGTAGCGGCTCAGAGGCTTTTCCCTGACCAC
CAAATCGTTTTTGGTGGAAA

Product: two component, sigma54 specific, transcriptional regulator, Fis family

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MKRKLLVVDDDMAFNLILCEALESEGYLVTKAHDLKSAKELLQEESFDCALLDIRLPDGDGIELIDFARSQETIVIVMSA
HGNIETAVSAVKKGAYNFLEKPFDLNHALVEVERALKFAELQREHRLLLKKVKQLGFTDELLGVSESIVSIKKLIENIAP
KKVTVLIQGESGTGKEVIARMIHKLSGRKEFVDINCGAIPENLFESEIFGYEKGAFTGAGDSKKGLVEEADRGTLFLDEI
SELPITLQPKLLRFIETGTFQRIGSTKRKKTDVRIICATNRDLEKLVEEGKFREDLFYRLNVVRIKLPPLRERPEDIAIL
AKQFVKDISAELGLRKRPKISETFIQALMNYHWPGNVRELRNCLLSILAVHDSSETLEEWMLFDVLGSRIDNSRDASNED
LTLEELEKRYIRKLLKKYSGNKTKVAQVLGISKSTLYEKLKRWEPF

Sequences:

>Translated_446_residues
MKRKLLVVDDDMAFNLILCEALESEGYLVTKAHDLKSAKELLQEESFDCALLDIRLPDGDGIELIDFARSQETIVIVMSA
HGNIETAVSAVKKGAYNFLEKPFDLNHALVEVERALKFAELQREHRLLLKKVKQLGFTDELLGVSESIVSIKKLIENIAP
KKVTVLIQGESGTGKEVIARMIHKLSGRKEFVDINCGAIPENLFESEIFGYEKGAFTGAGDSKKGLVEEADRGTLFLDEI
SELPITLQPKLLRFIETGTFQRIGSTKRKKTDVRIICATNRDLEKLVEEGKFREDLFYRLNVVRIKLPPLRERPEDIAIL
AKQFVKDISAELGLRKRPKISETFIQALMNYHWPGNVRELRNCLLSILAVHDSSETLEEWMLFDVLGSRIDNSRDASNED
LTLEELEKRYIRKLLKKYSGNKTKVAQVLGISKSTLYEKLKRWEPF
>Mature_446_residues
MKRKLLVVDDDMAFNLILCEALESEGYLVTKAHDLKSAKELLQEESFDCALLDIRLPDGDGIELIDFARSQETIVIVMSA
HGNIETAVSAVKKGAYNFLEKPFDLNHALVEVERALKFAELQREHRLLLKKVKQLGFTDELLGVSESIVSIKKLIENIAP
KKVTVLIQGESGTGKEVIARMIHKLSGRKEFVDINCGAIPENLFESEIFGYEKGAFTGAGDSKKGLVEEADRGTLFLDEI
SELPITLQPKLLRFIETGTFQRIGSTKRKKTDVRIICATNRDLEKLVEEGKFREDLFYRLNVVRIKLPPLRERPEDIAIL
AKQFVKDISAELGLRKRPKISETFIQALMNYHWPGNVRELRNCLLSILAVHDSSETLEEWMLFDVLGSRIDNSRDASNED
LTLEELEKRYIRKLLKKYSGNKTKVAQVLGISKSTLYEKLKRWEPF

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=450, Percent_Identity=40.8888888888889, Blast_Score=323, Evalue=2e-89,
Organism=Escherichia coli, GI1790299, Length=469, Percent_Identity=38.592750533049, Blast_Score=313, Evalue=1e-86,
Organism=Escherichia coli, GI1790437, Length=445, Percent_Identity=39.5505617977528, Blast_Score=288, Evalue=6e-79,
Organism=Escherichia coli, GI1788905, Length=454, Percent_Identity=37.4449339207048, Blast_Score=269, Evalue=3e-73,
Organism=Escherichia coli, GI1789233, Length=325, Percent_Identity=45.5384615384615, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI1789087, Length=346, Percent_Identity=43.9306358381503, Blast_Score=253, Evalue=1e-68,
Organism=Escherichia coli, GI87082117, Length=342, Percent_Identity=41.2280701754386, Blast_Score=238, Evalue=5e-64,
Organism=Escherichia coli, GI87081872, Length=321, Percent_Identity=38.3177570093458, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1786524, Length=322, Percent_Identity=40.3726708074534, Blast_Score=218, Evalue=5e-58,
Organism=Escherichia coli, GI1787583, Length=312, Percent_Identity=37.5, Blast_Score=208, Evalue=6e-55,
Organism=Escherichia coli, GI87082152, Length=245, Percent_Identity=44.0816326530612, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI1789828, Length=171, Percent_Identity=45.0292397660819, Blast_Score=138, Evalue=7e-34,
Organism=Escherichia coli, GI87081858, Length=370, Percent_Identity=28.3783783783784, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1786599, Length=107, Percent_Identity=33.6448598130841, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50737; Mature: 50737

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRKLLVVDDDMAFNLILCEALESEGYLVTKAHDLKSAKELLQEESFDCALLDIRLPDGD
CCCEEEEEECCCHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHCCCCEEEEEEECCCCC
GIELIDFARSQETIVIVMSAHGNIETAVSAVKKGAYNFLEKPFDLNHALVEVERALKFAE
CCCCEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
LQREHRLLLKKVKQLGFTDELLGVSESIVSIKKLIENIAPKKVTVLIQGESGTGKEVIAR
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHH
MIHKLSGRKEFVDINCGAIPENLFESEIFGYEKGAFTGAGDSKKGLVEEADRGTLFLDEI
HHHHHCCCCEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCEEHHHH
SELPITLQPKLLRFIETGTFQRIGSTKRKKTDVRIICATNRDLEKLVEEGKFREDLFYRL
HCCCCEECHHHHHHHHCCCHHHHCCCCCCCCCEEEEEECCHHHHHHHHCCCHHHHHHHEE
NVVRIKLPPLRERPEDIAILAKQFVKDISAELGLRKRPKISETFIQALMNYHWPGNVREL
EEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHH
RNCLLSILAVHDSSETLEEWMLFDVLGSRIDNSRDASNEDLTLEELEKRYIRKLLKKYSG
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
NKTKVAQVLGISKSTLYEKLKRWEPF
CHHHHHHHHCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MKRKLLVVDDDMAFNLILCEALESEGYLVTKAHDLKSAKELLQEESFDCALLDIRLPDGD
CCCEEEEEECCCHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHCCCCEEEEEEECCCCC
GIELIDFARSQETIVIVMSAHGNIETAVSAVKKGAYNFLEKPFDLNHALVEVERALKFAE
CCCCEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
LQREHRLLLKKVKQLGFTDELLGVSESIVSIKKLIENIAPKKVTVLIQGESGTGKEVIAR
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHH
MIHKLSGRKEFVDINCGAIPENLFESEIFGYEKGAFTGAGDSKKGLVEEADRGTLFLDEI
HHHHHCCCCEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCEEHHHH
SELPITLQPKLLRFIETGTFQRIGSTKRKKTDVRIICATNRDLEKLVEEGKFREDLFYRL
HCCCCEECHHHHHHHHCCCHHHHCCCCCCCCCEEEEEECCHHHHHHHHCCCHHHHHHHEE
NVVRIKLPPLRERPEDIAILAKQFVKDISAELGLRKRPKISETFIQALMNYHWPGNVREL
EEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHH
RNCLLSILAVHDSSETLEEWMLFDVLGSRIDNSRDASNEDLTLEELEKRYIRKLLKKYSG
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
NKTKVAQVLGISKSTLYEKLKRWEPF
CHHHHHHHHCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]