Click here to switch to the map view.

The map label for this gene is dhaT [H]

Identifier: 239617896

GI number: 239617896

Start: 1635746

End: 1636861

Strand: Reverse

Name: dhaT [H]

Synonym: Kole_1524

Alternate gene names: 239617896

Gene position: 1636861-1635746 (Counterclockwise)

Preceding gene: 239617897

Following gene: 239617895

Centisome position: 71.1

GC content: 44.71

Gene sequence:

>1116_bases
ATGTGGCATTATTATTTACCAACACATGTTTTTTTCGGTGAAACAGTTGTTGAGAAACATGGAAAAGTGGTGCAGGAATG
CGGAGCAAAAGCTCTCATAGTTACCGGAAGGCGTTCTGCAAGGTTATCAGGAGCGTTGCACGACATTATAAAGGTTTTGA
CTGAATTGAAGATCCCTTACATACATTTTGATAGGGTGGAAGAAAACCCGTCCTTTGAAACGGTGAGAAAGGGCACCGAA
CTTCTGAGAAAAGAAAATTGTGATTTTGTCATCGCCATTGGTGGCGGAAGCCCATTAGATGCCGGGAAAGCTATGGCCAT
AATGGGTACCGATCCTGATCTTAAAGTGGAAGATCTTTACGATCGCGAGAGTTATCTTTTCTCACTGCCTGTTGTCGCAA
TCCCTACAACCTCTGGTACAGGAAGTGAAGTCACCCAGTATTCTGTTCTAACGGACGACGAAGGCAATAAGAAAGGCTTT
GCCACACCTCATGCCTTCCCGATGTATTCCTTCCTCGACCCCCGCTACACGATAACAATGACCGAAGAAACTACCATAGC
TACCGCTCTAGATGCCCTGTCCCATTCTATTGAAGGCGAACTGTTGAACAACGCCGTTAACCCTATCGTTAAAAACCATT
CCAGGGTCACAAATGAACTCATCAAAAACAATCTGAAAAATGCAACAATCACCCCGGAAGATATCCCTGTAAGGTCTTTA
TTGCAATATGCCGCGATGCTTGCAGGAATAGTAATAGCTCACACAGGGACAACAGTGGTTCACGCCGCAGGATACCCTTT
ATCCAGTAAAAGAGGGATAAAACACGGCATAGCGAATGCCGTTTTTCTGGTAGAAGTGCTTCGAAAAGTCGAAGAATCAG
ATCCGGATAGAGTCAAAAATGCCATTGACCCCTTTGAGTCGCTGAACGAACTCGAAGCTTTCTTGAACTCTTTCGGGGTA
AACGAATATAAGATAGAACTCTCAGACGATGAACTGGAAAGCTGGGCGGAAAAAGCTGCCAGAGCTCCACACAATGCAAG
AACCCCGGGTGAGTTCGATGTCGAGTTTTATAGAAACCTCTATAAAAAGGTGAGAAAGTGCCAGAATACAGAGTAA

Upstream 100 bases:

>100_bases
AAGTTAAGGGCTACCTATCTAGAGAAATTAGATGAAACCGTTGACAGATCAATAAAACTCATAAATAAAATCCTGGATTG
AACCGGGGGAGGTGAGTTCG

Downstream 100 bases:

>100_bases
AACTAAAAAAAGAAATAAAAAGACGAATTGCCTTCGGCCATCCCTGGATATACGAAAACGAGATAGCAGAAGAGCCTTCA
TGTGAAAACGGTTCTCTGGT

Product: iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: 1,3-propanediol oxidoreductase; 3-hydroxypropionaldehyde reductase [H]

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MWHYYLPTHVFFGETVVEKHGKVVQECGAKALIVTGRRSARLSGALHDIIKVLTELKIPYIHFDRVEENPSFETVRKGTE
LLRKENCDFVIAIGGGSPLDAGKAMAIMGTDPDLKVEDLYDRESYLFSLPVVAIPTTSGTGSEVTQYSVLTDDEGNKKGF
ATPHAFPMYSFLDPRYTITMTEETTIATALDALSHSIEGELLNNAVNPIVKNHSRVTNELIKNNLKNATITPEDIPVRSL
LQYAAMLAGIVIAHTGTTVVHAAGYPLSSKRGIKHGIANAVFLVEVLRKVEESDPDRVKNAIDPFESLNELEAFLNSFGV
NEYKIELSDDELESWAEKAARAPHNARTPGEFDVEFYRNLYKKVRKCQNTE

Sequences:

>Translated_371_residues
MWHYYLPTHVFFGETVVEKHGKVVQECGAKALIVTGRRSARLSGALHDIIKVLTELKIPYIHFDRVEENPSFETVRKGTE
LLRKENCDFVIAIGGGSPLDAGKAMAIMGTDPDLKVEDLYDRESYLFSLPVVAIPTTSGTGSEVTQYSVLTDDEGNKKGF
ATPHAFPMYSFLDPRYTITMTEETTIATALDALSHSIEGELLNNAVNPIVKNHSRVTNELIKNNLKNATITPEDIPVRSL
LQYAAMLAGIVIAHTGTTVVHAAGYPLSSKRGIKHGIANAVFLVEVLRKVEESDPDRVKNAIDPFESLNELEAFLNSFGV
NEYKIELSDDELESWAEKAARAPHNARTPGEFDVEFYRNLYKKVRKCQNTE
>Mature_371_residues
MWHYYLPTHVFFGETVVEKHGKVVQECGAKALIVTGRRSARLSGALHDIIKVLTELKIPYIHFDRVEENPSFETVRKGTE
LLRKENCDFVIAIGGGSPLDAGKAMAIMGTDPDLKVEDLYDRESYLFSLPVVAIPTTSGTGSEVTQYSVLTDDEGNKKGF
ATPHAFPMYSFLDPRYTITMTEETTIATALDALSHSIEGELLNNAVNPIVKNHSRVTNELIKNNLKNATITPEDIPVRSL
LQYAAMLAGIVIAHTGTTVVHAAGYPLSSKRGIKHGIANAVFLVEVLRKVEESDPDRVKNAIDPFESLNELEAFLNSFGV
NEYKIELSDDELESWAEKAARAPHNARTPGEFDVEFYRNLYKKVRKCQNTE

Specific function: Most active with substrates containing two primary alcohol groups separated by one or two carbon atoms. In the physiological direction, 3-hydroxypropionaldehyde is the preferred substrate [H]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=289, Percent_Identity=24.9134948096886, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI48994951, Length=286, Percent_Identity=32.1678321678322, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1789163, Length=285, Percent_Identity=31.5789473684211, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI87082107, Length=347, Percent_Identity=27.3775216138329, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1787493, Length=311, Percent_Identity=30.5466237942122, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1789386, Length=308, Percent_Identity=25.3246753246753, Blast_Score=94, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17537053, Length=412, Percent_Identity=25.4854368932039, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6321181, Length=379, Percent_Identity=28.7598944591029, Blast_Score=124, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24657991, Length=327, Percent_Identity=24.1590214067278, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.202 [H]

Molecular weight: Translated: 41213; Mature: 41213

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWHYYLPTHVFFGETVVEKHGKVVQECGAKALIVTGRRSARLSGALHDIIKVLTELKIPY
CCEEECCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCE
IHFDRVEENPSFETVRKGTELLRKENCDFVIAIGGGSPLDAGKAMAIMGTDPDLKVEDLY
EEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEECCCCCCCHHHHH
DRESYLFSLPVVAIPTTSGTGSEVTQYSVLTDDEGNKKGFATPHAFPMYSFLDPRYTITM
CCCCEEEECCEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHCCCCEEEEE
TEETTIATALDALSHSIEGELLNNAVNPIVKNHSRVTNELIKNNLKNATITPEDIPVRSL
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
LQYAAMLAGIVIAHTGTTVVHAAGYPLSSKRGIKHGIANAVFLVEVLRKVEESDPDRVKN
HHHHHHHHHHHHEECCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHH
AIDPFESLNELEAFLNSFGVNEYKIELSDDELESWAEKAARAPHNARTPGEFDVEFYRNL
HHCHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
YKKVRKCQNTE
HHHHHHHCCCC
>Mature Secondary Structure
MWHYYLPTHVFFGETVVEKHGKVVQECGAKALIVTGRRSARLSGALHDIIKVLTELKIPY
CCEEECCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCE
IHFDRVEENPSFETVRKGTELLRKENCDFVIAIGGGSPLDAGKAMAIMGTDPDLKVEDLY
EEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEECCCCCCCHHHHH
DRESYLFSLPVVAIPTTSGTGSEVTQYSVLTDDEGNKKGFATPHAFPMYSFLDPRYTITM
CCCCEEEECCEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHCCCCEEEEE
TEETTIATALDALSHSIEGELLNNAVNPIVKNHSRVTNELIKNNLKNATITPEDIPVRSL
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
LQYAAMLAGIVIAHTGTTVVHAAGYPLSSKRGIKHGIANAVFLVEVLRKVEESDPDRVKN
HHHHHHHHHHHHEECCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHH
AIDPFESLNELEAFLNSFGVNEYKIELSDDELESWAEKAARAPHNARTPGEFDVEFYRNL
HHCHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
YKKVRKCQNTE
HHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7721705 [H]