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The map label for this gene is rnc [H]

Identifier: 239617283

GI number: 239617283

Start: 944049

End: 944798

Strand: Reverse

Name: rnc [H]

Synonym: Kole_0892

Alternate gene names: 239617283

Gene position: 944798-944049 (Counterclockwise)

Preceding gene: 239617284

Following gene: 239617282

Centisome position: 41.04

GC content: 43.07

Gene sequence:

>750_bases
ATGAAAGAGTATTATAAGAAAGTTCAAGAGTTTTGCAAGAAAAACGATTTGGATATTGACACAGAGTGGATTTTCAAAGC
TCTGTGTCATTCTTCTTATGCAAATGAAGTTGTACGTAAGGGAATGAATGTTGAATCGAATGAAAGATTGGAATTCCTTG
GGGATGCTGTGCTGGCTCTTTCGCTTGCAGATCTCTTGTACAGAGAGTACGACGTAGATGAAGGTGTGATGTCAAAAACA
CGTGCGGTCGTAGCAAGCGAAAAAGTTCTGGCAGAGGTTGCTCGGAATATGAACATAGGGGAGTACCTGCTTCTTGGCAA
AGGAGAGCTAAAGACTGGCGGAAGGGGACGGGACTCGATACTGGCCGATGCTTTTGAGGCTATCCTTGGCGCCCTTTATT
TGAGCGAAGGATTCGAGATAGCGAGGAATTTTGTGAAAGAGAAATTAGGAATCTATATAGAAAAAGCTTTGAATAAAGAA
CTTGTGCTTGATTACAAGACGACCCTTCAAGAATTAACACAGGGTAATCTGGGTGTACGACCTGAATATTCTTACATAGA
AAACATCGGCACTCCTCAGAACAAGCTCTTCCACGTAGAGGTGCGGGTTAATGGAAAAGCGCTTGCCGTTGGTTACGGGA
AAACGAAGAAAGCTGCGGAACAGGACGCCGCGAGAAAGGCTTATGAAAAACTTCTTAAAGATTTAGAAGAGCAGGGGATT
GAGCCAAAAAATAGTGAAAGACTGACGTAG

Upstream 100 bases:

>100_bases
GAATCGATAGGTACTTCATTTCTGGAAGTAAAAAAGACCTTTATAAAATTGCCGGACTTGACGCGGAATCGATAGCTGAA
AGAGTCAGGAAATGGGTGAG

Downstream 100 bases:

>100_bases
TTTTTTGCTTCAGAGAAATATACCGGTTTTGTATCGAAAAAGAAACCATGTGAACAGGAACTGCCCTTTTGCAAACCTTT
GCTGGTGAGCGTTTGATTCT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MKEYYKKVQEFCKKNDLDIDTEWIFKALCHSSYANEVVRKGMNVESNERLEFLGDAVLALSLADLLYREYDVDEGVMSKT
RAVVASEKVLAEVARNMNIGEYLLLGKGELKTGGRGRDSILADAFEAILGALYLSEGFEIARNFVKEKLGIYIEKALNKE
LVLDYKTTLQELTQGNLGVRPEYSYIENIGTPQNKLFHVEVRVNGKALAVGYGKTKKAAEQDAARKAYEKLLKDLEEQGI
EPKNSERLT

Sequences:

>Translated_249_residues
MKEYYKKVQEFCKKNDLDIDTEWIFKALCHSSYANEVVRKGMNVESNERLEFLGDAVLALSLADLLYREYDVDEGVMSKT
RAVVASEKVLAEVARNMNIGEYLLLGKGELKTGGRGRDSILADAFEAILGALYLSEGFEIARNFVKEKLGIYIEKALNKE
LVLDYKTTLQELTQGNLGVRPEYSYIENIGTPQNKLFHVEVRVNGKALAVGYGKTKKAAEQDAARKAYEKLLKDLEEQGI
EPKNSERLT
>Mature_249_residues
MKEYYKKVQEFCKKNDLDIDTEWIFKALCHSSYANEVVRKGMNVESNERLEFLGDAVLALSLADLLYREYDVDEGVMSKT
RAVVASEKVLAEVARNMNIGEYLLLGKGELKTGGRGRDSILADAFEAILGALYLSEGFEIARNFVKEKLGIYIEKALNKE
LVLDYKTTLQELTQGNLGVRPEYSYIENIGTPQNKLFHVEVRVNGKALAVGYGKTKKAAEQDAARKAYEKLLKDLEEQGI
EPKNSERLT

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=190, Percent_Identity=26.3157894736842, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI155030234, Length=190, Percent_Identity=26.3157894736842, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1788920, Length=198, Percent_Identity=34.8484848484849, Blast_Score=109, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17506883, Length=217, Percent_Identity=31.3364055299539, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI193202651, Length=217, Percent_Identity=31.3364055299539, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17137682, Length=216, Percent_Identity=30.0925925925926, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 28074; Mature: 28074

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEYYKKVQEFCKKNDLDIDTEWIFKALCHSSYANEVVRKGMNVESNERLEFLGDAVLAL
CHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
SLADLLYREYDVDEGVMSKTRAVVASEKVLAEVARNMNIGEYLLLGKGELKTGGRGRDSI
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHH
LADAFEAILGALYLSEGFEIARNFVKEKLGIYIEKALNKELVLDYKTTLQELTQGNLGVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCC
PEYSYIENIGTPQNKLFHVEVRVNGKALAVGYGKTKKAAEQDAARKAYEKLLKDLEEQGI
CCHHHHHCCCCCCCCEEEEEEEECCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCC
EPKNSERLT
CCCCCCCCC
>Mature Secondary Structure
MKEYYKKVQEFCKKNDLDIDTEWIFKALCHSSYANEVVRKGMNVESNERLEFLGDAVLAL
CHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
SLADLLYREYDVDEGVMSKTRAVVASEKVLAEVARNMNIGEYLLLGKGELKTGGRGRDSI
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHH
LADAFEAILGALYLSEGFEIARNFVKEKLGIYIEKALNKELVLDYKTTLQELTQGNLGVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCC
PEYSYIENIGTPQNKLFHVEVRVNGKALAVGYGKTKKAAEQDAARKAYEKLLKDLEEQGI
CCHHHHHCCCCCCCCEEEEEEEECCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCC
EPKNSERLT
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]