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The map label for this gene is phoR [H]

Identifier: 239617103

GI number: 239617103

Start: 758806

End: 759798

Strand: Reverse

Name: phoR [H]

Synonym: Kole_0705

Alternate gene names: 239617103

Gene position: 759798-758806 (Counterclockwise)

Preceding gene: 239617104

Following gene: 239617094

Centisome position: 33.0

GC content: 39.58

Gene sequence:

>993_bases
TTGAACCGTGATTTTAAAACGATATTCGACAGCCTTTCTGATGGCATATTAGAGGTTGATGAAACTCTGCGGATTATTGA
TTGTAACCGTGTTGCAGAGGGATTGTTTGGTGATGTTTTAGGGAAATCTATCGACGAGGTTCTTAAAGTTCCCGGAGTTT
TCGAGATTGCGGAGTGCCTGTTGAATAAAGAGAATGGCGAGTTTCAGGTTGAACTTTCAGCAGAAAGCTCCACGAAATAC
ATGATTATAAAGATCAGGAAGAATTTCCTGATTTTAAAAGATATTACCGAAAAGAAGATTCTTGAAACTGCTAAAACAGA
TTTTGTGAACTTCTTCGTTCACGAGATTTCTACACCTCTGGCTGTGGTGAGTGGTTATGCGCAGCTTATTTTCGACAGAA
AAGATGAGATCCCGCCCGAACTGAGTGAAGCAGCCTCTGGTATCCTCAAAAGCTCGGAAAGATTGTCCAAACTAATTGAA
GAACTTGGAGAACTTGCCAATATTGAACTGGGTAACTATGTGGTGAAAAGAGAAATTATCCATCTAAAATCCTTGATAGA
AGAGATTATAGAGGATTTTGAGACGAAGATCAAAAGAAAAAAACTGAAGATAAAAACACTTGTGTCCCCGGAACATTACG
TAGAATCCGATTCTTTATTGCTTTACAGAATTCTTGCCAATCTGGTTTCAAACGCCGTGAAATACTCCCTCGATGGTGGG
AACATAGAAATTAATGCAGTAGAGAAAGATGATGAAATCCAGATATCGGTCAAGGACGAAGGAATCGGAATCGAAAGGGA
TGAAATTCACCGGATCTTCGAAAGGTTTTACCGGGGAACAAATGCAAAGAAACTTTCGATAAACGGTCTCGGAATAGGTT
TATCAATAGTCAAGCACGCTTCAGACCTCATCGACGCAAAAATTCAGGTAAAGTCACTTCCTATGCTTGAAACAGTTTTC
ACCTTAAGGCTTCCCTCAACAGGAAAAAAGTAA

Upstream 100 bases:

>100_bases
ATGTTCATATAAGCAAACTCAGAGAGAAAATCGGGAGCGAATTCATAAAAACTGTGCGAGGAGTTGGGTACAAACTCGTT
ATCCCGGAGGATGAGAAGAG

Downstream 100 bases:

>100_bases
AATACAGAAAAAGAAGTCAATGACAGTCTTTTTCTGATCCTTTAAGTTTTTCGATAGCATGGGGAATAGCATTTATTATA
GCGTTGAGATTTTCTTTAAC

Product: PAS/PAC sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MNRDFKTIFDSLSDGILEVDETLRIIDCNRVAEGLFGDVLGKSIDEVLKVPGVFEIAECLLNKENGEFQVELSAESSTKY
MIIKIRKNFLILKDITEKKILETAKTDFVNFFVHEISTPLAVVSGYAQLIFDRKDEIPPELSEAASGILKSSERLSKLIE
ELGELANIELGNYVVKREIIHLKSLIEEIIEDFETKIKRKKLKIKTLVSPEHYVESDSLLLYRILANLVSNAVKYSLDGG
NIEINAVEKDDEIQISVKDEGIGIERDEIHRIFERFYRGTNAKKLSINGLGIGLSIVKHASDLIDAKIQVKSLPMLETVF
TLRLPSTGKK

Sequences:

>Translated_330_residues
MNRDFKTIFDSLSDGILEVDETLRIIDCNRVAEGLFGDVLGKSIDEVLKVPGVFEIAECLLNKENGEFQVELSAESSTKY
MIIKIRKNFLILKDITEKKILETAKTDFVNFFVHEISTPLAVVSGYAQLIFDRKDEIPPELSEAASGILKSSERLSKLIE
ELGELANIELGNYVVKREIIHLKSLIEEIIEDFETKIKRKKLKIKTLVSPEHYVESDSLLLYRILANLVSNAVKYSLDGG
NIEINAVEKDDEIQISVKDEGIGIERDEIHRIFERFYRGTNAKKLSINGLGIGLSIVKHASDLIDAKIQVKSLPMLETVF
TLRLPSTGKK
>Mature_330_residues
MNRDFKTIFDSLSDGILEVDETLRIIDCNRVAEGLFGDVLGKSIDEVLKVPGVFEIAECLLNKENGEFQVELSAESSTKY
MIIKIRKNFLILKDITEKKILETAKTDFVNFFVHEISTPLAVVSGYAQLIFDRKDEIPPELSEAASGILKSSERLSKLIE
ELGELANIELGNYVVKREIIHLKSLIEEIIEDFETKIKRKKLKIKTLVSPEHYVESDSLLLYRILANLVSNAVKYSLDGG
NIEINAVEKDDEIQISVKDEGIGIERDEIHRIFERFYRGTNAKKLSINGLGIGLSIVKHASDLIDAKIQVKSLPMLETVF
TLRLPSTGKK

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=336, Percent_Identity=25.297619047619, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1788393, Length=260, Percent_Identity=25, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI145693157, Length=229, Percent_Identity=26.6375545851528, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI87082128, Length=228, Percent_Identity=28.0701754385965, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788713, Length=232, Percent_Identity=26.2931034482759, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1786912, Length=214, Percent_Identity=28.5046728971963, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87081816, Length=331, Percent_Identity=22.3564954682779, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI1786783, Length=196, Percent_Identity=26.0204081632653, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788279, Length=221, Percent_Identity=28.0542986425339, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1789149, Length=243, Percent_Identity=27.5720164609054, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1790861, Length=222, Percent_Identity=27.9279279279279, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI48994928, Length=251, Percent_Identity=26.6932270916335, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788549, Length=218, Percent_Identity=27.5229357798165, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1790436, Length=238, Percent_Identity=26.4705882352941, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1790551, Length=286, Percent_Identity=27.2727272727273, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI1787894, Length=197, Percent_Identity=28.4263959390863, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1790346, Length=234, Percent_Identity=26.9230769230769, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787374, Length=246, Percent_Identity=24.390243902439, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 37184; Mature: 37184

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRDFKTIFDSLSDGILEVDETLRIIDCNRVAEGLFGDVLGKSIDEVLKVPGVFEIAECL
CCCHHHHHHHHHCCCCEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LNKENGEFQVELSAESSTKYMIIKIRKNFLILKDITEKKILETAKTDFVNFFVHEISTPL
HCCCCCCEEEEEECCCCCEEEEEEEECCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCHH
AVVSGYAQLIFDRKDEIPPELSEAASGILKSSERLSKLIEELGELANIELGNYVVKREII
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
HLKSLIEEIIEDFETKIKRKKLKIKTLVSPEHYVESDSLLLYRILANLVSNAVKYSLDGG
HHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHCCCCCHHHHHHHHHHHHHHHEEEECCC
NIEINAVEKDDEIQISVKDEGIGIERDEIHRIFERFYRGTNAKKLSINGLGIGLSIVKHA
CEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHH
SDLIDAKIQVKSLPMLETVFTLRLPSTGKK
HHHHHHHHEECCCCHHHHHHEEECCCCCCC
>Mature Secondary Structure
MNRDFKTIFDSLSDGILEVDETLRIIDCNRVAEGLFGDVLGKSIDEVLKVPGVFEIAECL
CCCHHHHHHHHHCCCCEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LNKENGEFQVELSAESSTKYMIIKIRKNFLILKDITEKKILETAKTDFVNFFVHEISTPL
HCCCCCCEEEEEECCCCCEEEEEEEECCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCHH
AVVSGYAQLIFDRKDEIPPELSEAASGILKSSERLSKLIEELGELANIELGNYVVKREII
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
HLKSLIEEIIEDFETKIKRKKLKIKTLVSPEHYVESDSLLLYRILANLVSNAVKYSLDGG
HHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHCCCCCHHHHHHHHHHHHHHHEEEECCC
NIEINAVEKDDEIQISVKDEGIGIERDEIHRIFERFYRGTNAKKLSINGLGIGLSIVKHA
CEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHH
SDLIDAKIQVKSLPMLETVFTLRLPSTGKK
HHHHHHHHEECCCCHHHHHHEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]