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The map label for this gene is cusR [H]

Identifier: 239616953

GI number: 239616953

Start: 602197

End: 602898

Strand: Reverse

Name: cusR [H]

Synonym: Kole_0551

Alternate gene names: 239616953

Gene position: 602898-602197 (Counterclockwise)

Preceding gene: 239616954

Following gene: 239616952

Centisome position: 26.19

GC content: 37.18

Gene sequence:

>702_bases
GTGAGAATTCTTCTTGTGGAAGATGAAGAAGCAATCACAGAATTTGTAAAAAAAGGGTTATCGGAAGAAGGATACATTGT
TGATACTGTTGATAATGGAGAAGATGCATTGAATAAGATATTTGATGTGGACTATGATCTAATTATATTAGATATTATGC
TGCCTGTGAAAGACGGTTTAAAAGTATGCCGTGAAGTTCGAGAAAATGGTATTTCAACACCCATACTTATGCTTACAGCC
CTTGATAGCACTGAAGATAAAGTTACCGGATTGAATGCAGGAGCAGATGATTATCTTGTAAAACCATTCTCTTTCAGCGA
ACTTCTTGCACGTATAAGAGCCATCTTAAGGCGTCCTCCCACAATTTTAAATTTGAAGCTTCAAGTAGGCGATCTTGTCC
TTGATACTGTAACCCATCATGTTGAGCGCTCTGGAAAGAGGATAGACTTAACACCAAGAGAATATGCACTGCTGGAGTTC
TTAATGCGTCATCCAAATCAAGTATTGAGCAGAACACGAATAGTTGAACACGTCTGGAACTTAGATTTTTATACAGAGTC
AAACATTGTAGATGTATACATACGCTATTTGAGAAAGAAAATAGACAATGGGTTTGAGAACAAACTAATACATACAGTAC
ATGGTGTGGGGTATATGATAGGAGAAATACAGCCAAATAAAAGTAAGGGAGGCGAATCTTGA

Upstream 100 bases:

>100_bases
AAGAGGAGATGGAAAATGAATGAAGAAGACGTGGTAAAATAAGATTACTTTACTCGGTGCCTAATGGCACCGAGTTTCAA
ATTCACGGGGAGTGATACTT

Downstream 100 bases:

>100_bases
TTTTTTAATATGAAAACAATAACAATAAGAACCAAGTTAACAATTTGGTATGTAACTTTTCTAGCGATTGTACTCATAAC
GTTCACGGTAGTTCTCTATT

Product: two component transcriptional regulator, winged helix family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MRILLVEDEEAITEFVKKGLSEEGYIVDTVDNGEDALNKIFDVDYDLIILDIMLPVKDGLKVCREVRENGISTPILMLTA
LDSTEDKVTGLNAGADDYLVKPFSFSELLARIRAILRRPPTILNLKLQVGDLVLDTVTHHVERSGKRIDLTPREYALLEF
LMRHPNQVLSRTRIVEHVWNLDFYTESNIVDVYIRYLRKKIDNGFENKLIHTVHGVGYMIGEIQPNKSKGGES

Sequences:

>Translated_233_residues
MRILLVEDEEAITEFVKKGLSEEGYIVDTVDNGEDALNKIFDVDYDLIILDIMLPVKDGLKVCREVRENGISTPILMLTA
LDSTEDKVTGLNAGADDYLVKPFSFSELLARIRAILRRPPTILNLKLQVGDLVLDTVTHHVERSGKRIDLTPREYALLEF
LMRHPNQVLSRTRIVEHVWNLDFYTESNIVDVYIRYLRKKIDNGFENKLIHTVHGVGYMIGEIQPNKSKGGES
>Mature_233_residues
MRILLVEDEEAITEFVKKGLSEEGYIVDTVDNGEDALNKIFDVDYDLIILDIMLPVKDGLKVCREVRENGISTPILMLTA
LDSTEDKVTGLNAGADDYLVKPFSFSELLARIRAILRRPPTILNLKLQVGDLVLDTVTHHVERSGKRIDLTPREYALLEF
LMRHPNQVLSRTRIVEHVWNLDFYTESNIVDVYIRYLRKKIDNGFENKLIHTVHGVGYMIGEIQPNKSKGGES

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=51.131221719457, Blast_Score=228, Evalue=2e-61,
Organism=Escherichia coli, GI87082012, Length=218, Percent_Identity=47.7064220183486, Blast_Score=203, Evalue=7e-54,
Organism=Escherichia coli, GI1789402, Length=222, Percent_Identity=41.8918918918919, Blast_Score=175, Evalue=2e-45,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=39.0909090909091, Blast_Score=165, Evalue=2e-42,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=38.6363636363636, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1788394, Length=220, Percent_Identity=36.3636363636364, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1789809, Length=237, Percent_Identity=33.7552742616034, Blast_Score=134, Evalue=3e-33,
Organism=Escherichia coli, GI1787375, Length=219, Percent_Identity=34.2465753424658, Blast_Score=130, Evalue=9e-32,
Organism=Escherichia coli, GI1786911, Length=219, Percent_Identity=32.8767123287671, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1790860, Length=225, Percent_Identity=32.4444444444444, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI2367329, Length=233, Percent_Identity=35.6223175965665, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1787229, Length=231, Percent_Identity=32.4675324675325, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=29.9559471365639, Blast_Score=97, Evalue=7e-22,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=29.7413793103448, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=34.5794392523364, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1790437, Length=120, Percent_Identity=30.8333333333333, Blast_Score=67, Evalue=7e-13,
Organism=Escherichia coli, GI1788191, Length=121, Percent_Identity=32.2314049586777, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790299, Length=114, Percent_Identity=28.9473684210526, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=33.6633663366337, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1788713, Length=132, Percent_Identity=30.3030303030303, Blast_Score=61, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=106, Percent_Identity=33.9622641509434, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26552; Mature: 26552

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILLVEDEEAITEFVKKGLSEEGYIVDTVDNGEDALNKIFDVDYDLIILDIMLPVKDGL
CEEEEECCHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHCCCCHHEEEHHHHHHHHHH
KVCREVRENGISTPILMLTALDSTEDKVTGLNAGADDYLVKPFSFSELLARIRAILRRPP
HHHHHHHHCCCCCCEEEEEECCCCCCHHCCCCCCCCCCEECCCCHHHHHHHHHHHHHCCC
TILNLKLQVGDLVLDTVTHHVERSGKRIDLTPREYALLEFLMRHPNQVLSRTRIVEHVWN
CEEEEEEHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHCHHHHHHHHHHHHHHHC
LDFYTESNIVDVYIRYLRKKIDNGFENKLIHTVHGVGYMIGEIQPNKSKGGES
CCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEECCCCCCCCCCCC
>Mature Secondary Structure
MRILLVEDEEAITEFVKKGLSEEGYIVDTVDNGEDALNKIFDVDYDLIILDIMLPVKDGL
CEEEEECCHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHCCCCHHEEEHHHHHHHHHH
KVCREVRENGISTPILMLTALDSTEDKVTGLNAGADDYLVKPFSFSELLARIRAILRRPP
HHHHHHHHCCCCCCEEEEEECCCCCCHHCCCCCCCCCCEECCCCHHHHHHHHHHHHHCCC
TILNLKLQVGDLVLDTVTHHVERSGKRIDLTPREYALLEFLMRHPNQVLSRTRIVEHVWN
CEEEEEEHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHCHHHHHHHHHHHHHHHC
LDFYTESNIVDVYIRYLRKKIDNGFENKLIHTVHGVGYMIGEIQPNKSKGGES
CCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]