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The map label for this gene is pcoS [H]

Identifier: 239616952

GI number: 239616952

Start: 600817

End: 602187

Strand: Reverse

Name: pcoS [H]

Synonym: Kole_0550

Alternate gene names: 239616952

Gene position: 602187-600817 (Counterclockwise)

Preceding gene: 239616953

Following gene: 239616945

Centisome position: 26.16

GC content: 34.57

Gene sequence:

>1371_bases
ATGAAAACAATAACAATAAGAACCAAGTTAACAATTTGGTATGTAACTTTTCTAGCGATTGTACTCATAACGTTCACGGT
AGTTCTCTATTTCAGCTTCTCTACTAATTTACGGAGAACTATAGATAAAAATTTGGAGTTCATAGCCTCCCAACTAATAA
TAAATATTGATTATGATGATAATAAACTTGCCTTTCAAAACACGGAAAATGGAGCTAATTTGATAAAAAATTTTATTGGT
AAAGAACTCTTTGCTCGTATCCTGGACGAAAACGGAAACGTTATTGATGGTTTTGGAAACTATTTTCTTTTACCAGCGGA
TCCGAAAATTTTAAAAAAAGGTTTTTTGACCATATTAACTGATTCTGGAGAATGGCGTGTTTACACAGTAAAGCTTAGTT
TAGGTTGGCTCCAGGTAGCAGAGTTTACGGAACCATTCGGAGAAACTCTGGAAAAATTTAGAAGTTTGCTTGTAATTTTT
ATACCACTAACACTTATTATCGCATCTATTGGTAGTTATTTGCTTGCTAAAAAAACGCTGAAACCAATAGACCGTATCAC
AAACCTGGCAAGAGAAATTAACGCTGAAAAAATAGATCGGCGCCTTGATATAGATCTTCCAGATGACGAATTGGGGCGTT
TATCAAAAACGTTTAATCAAATGCTTGATCGGTTGGAAAATGCATTGAATAGCCAAAAACAATTTTCTGCAAATGCTGCT
CATGATCTGCGAACTCCTTTGACATCGATAAAAGGCATAATAGATGTAACACTTAATCGTGAACGGGATGCGCTAGAATA
TAAAGACTCTTTAATACAAATAAGAAAACAAGTTGAAAGAATGAGCAAGCTTGTAGACACTCTTCTCATAGTTGCGCGCT
TTGACAGTAAAGCAATAAAACTACACAAAGAAAAGATAGATTTAACGGAATTGCTTGAAGTTGTCGTTGAACAAATGCAA
TATGCGGCAAATAGAAAAGGAATCATATTAAAAGCGGATTTACAGGACAATCTGACAATTGTTGGAGATTTTGATCTTGT
AGTTCGCTTGTTTCTTAATTTAATCGATAATGCCATAAAGTACAACCAACCAGGTGGGCAAGTTACAGTCACTGCAAAGC
TTTCTGAGAAGAAAAAAGGTCTTAAACATGTCCTTGTATCTATTTGTGACACTGGCCAGGGTATACCAGAAAATGAACTC
GAAAGGATTTTCGATAAATTTTATAGAATAGACAAATCACGCTCGAGAGTTGAAGGAGCTGGTTTGGGACTTTCTATCGT
TAAAGAAATAGCTTTAGCTCATAATGCTGAAATACAAGTAAAAAGTCAATTAGGAAAGGGAAGTATATTTATAGTAAAGT
TTCCGATTTGA

Upstream 100 bases:

>100_bases
GTTTGAGAACAAACTAATACATACAGTACATGGTGTGGGGTATATGATAGGAGAAATACAGCCAAATAAAAGTAAGGGAG
GCGAATCTTGATTTTTTAAT

Downstream 100 bases:

>100_bases
CAGATCACCTCTTATTGCCCTATAATCACCAACAAATGTAATAGCTGCTCTTTTGTAGGCTCTTCGCGCTACAGAGTGCC
AGCTTTGTTTTCGGCTGCTT

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MKTITIRTKLTIWYVTFLAIVLITFTVVLYFSFSTNLRRTIDKNLEFIASQLIINIDYDDNKLAFQNTENGANLIKNFIG
KELFARILDENGNVIDGFGNYFLLPADPKILKKGFLTILTDSGEWRVYTVKLSLGWLQVAEFTEPFGETLEKFRSLLVIF
IPLTLIIASIGSYLLAKKTLKPIDRITNLAREINAEKIDRRLDIDLPDDELGRLSKTFNQMLDRLENALNSQKQFSANAA
HDLRTPLTSIKGIIDVTLNRERDALEYKDSLIQIRKQVERMSKLVDTLLIVARFDSKAIKLHKEKIDLTELLEVVVEQMQ
YAANRKGIILKADLQDNLTIVGDFDLVVRLFLNLIDNAIKYNQPGGQVTVTAKLSEKKKGLKHVLVSICDTGQGIPENEL
ERIFDKFYRIDKSRSRVEGAGLGLSIVKEIALAHNAEIQVKSQLGKGSIFIVKFPI

Sequences:

>Translated_456_residues
MKTITIRTKLTIWYVTFLAIVLITFTVVLYFSFSTNLRRTIDKNLEFIASQLIINIDYDDNKLAFQNTENGANLIKNFIG
KELFARILDENGNVIDGFGNYFLLPADPKILKKGFLTILTDSGEWRVYTVKLSLGWLQVAEFTEPFGETLEKFRSLLVIF
IPLTLIIASIGSYLLAKKTLKPIDRITNLAREINAEKIDRRLDIDLPDDELGRLSKTFNQMLDRLENALNSQKQFSANAA
HDLRTPLTSIKGIIDVTLNRERDALEYKDSLIQIRKQVERMSKLVDTLLIVARFDSKAIKLHKEKIDLTELLEVVVEQMQ
YAANRKGIILKADLQDNLTIVGDFDLVVRLFLNLIDNAIKYNQPGGQVTVTAKLSEKKKGLKHVLVSICDTGQGIPENEL
ERIFDKFYRIDKSRSRVEGAGLGLSIVKEIALAHNAEIQVKSQLGKGSIFIVKFPI
>Mature_456_residues
MKTITIRTKLTIWYVTFLAIVLITFTVVLYFSFSTNLRRTIDKNLEFIASQLIINIDYDDNKLAFQNTENGANLIKNFIG
KELFARILDENGNVIDGFGNYFLLPADPKILKKGFLTILTDSGEWRVYTVKLSLGWLQVAEFTEPFGETLEKFRSLLVIF
IPLTLIIASIGSYLLAKKTLKPIDRITNLAREINAEKIDRRLDIDLPDDELGRLSKTFNQMLDRLENALNSQKQFSANAA
HDLRTPLTSIKGIIDVTLNRERDALEYKDSLIQIRKQVERMSKLVDTLLIVARFDSKAIKLHKEKIDLTELLEVVVEQMQ
YAANRKGIILKADLQDNLTIVGDFDLVVRLFLNLIDNAIKYNQPGGQVTVTAKLSEKKKGLKHVLVSICDTGQGIPENEL
ERIFDKFYRIDKSRSRVEGAGLGLSIVKEIALAHNAEIQVKSQLGKGSIFIVKFPI

Specific function: Probable member of a two-component regulatory system pcoS/pcoR. May activate pcoR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=302, Percent_Identity=30.4635761589404, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1788393, Length=278, Percent_Identity=29.8561151079137, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1788279, Length=367, Percent_Identity=27.5204359673025, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1786600, Length=284, Percent_Identity=28.169014084507, Blast_Score=121, Evalue=9e-29,
Organism=Escherichia coli, GI1790436, Length=310, Percent_Identity=28.7096774193548, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1787894, Length=315, Percent_Identity=28.2539682539683, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1789403, Length=283, Percent_Identity=28.2685512367491, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790861, Length=269, Percent_Identity=28.2527881040892, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790346, Length=296, Percent_Identity=24.6621621621622, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1786912, Length=221, Percent_Identity=29.8642533936652, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1789149, Length=234, Percent_Identity=30.7692307692308, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI48994928, Length=234, Percent_Identity=29.4871794871795, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI145693157, Length=248, Percent_Identity=26.2096774193548, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790551, Length=284, Percent_Identity=26.4084507042254, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1788549, Length=225, Percent_Identity=26.2222222222222, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1787374, Length=297, Percent_Identity=24.5791245791246, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1788713, Length=284, Percent_Identity=22.1830985915493, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI87082128, Length=325, Percent_Identity=23.6923076923077, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI87081816, Length=258, Percent_Identity=26.7441860465116, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789808, Length=291, Percent_Identity=21.9931271477663, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51750; Mature: 51750

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTITIRTKLTIWYVTFLAIVLITFTVVLYFSFSTNLRRTIDKNLEFIASQLIINIDYDD
CCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEEEEECCC
NKLAFQNTENGANLIKNFIGKELFARILDENGNVIDGFGNYFLLPADPKILKKGFLTILT
CEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEECCCHHHHHCCCEEEEE
DSGEWRVYTVKLSLGWLQVAEFTEPFGETLEKFRSLLVIFIPLTLIIASIGSYLLAKKTL
CCCCEEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KPIDRITNLAREINAEKIDRRLDIDLPDDELGRLSKTFNQMLDRLENALNSQKQFSANAA
HHHHHHHHHHHHHCHHHHCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCH
HDLRTPLTSIKGIIDVTLNRERDALEYKDSLIQIRKQVERMSKLVDTLLIVARFDSKAIK
HHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
LHKEKIDLTELLEVVVEQMQYAANRKGIILKADLQDNLTIVGDFDLVVRLFLNLIDNAIK
HHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEECHHHHHHHHHHHHHHHHH
YNQPGGQVTVTAKLSEKKKGLKHVLVSICDTGQGIPENELERIFDKFYRIDKSRSRVEGA
CCCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHCCC
GLGLSIVKEIALAHNAEIQVKSQLGKGSIFIVKFPI
CCCHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECC
>Mature Secondary Structure
MKTITIRTKLTIWYVTFLAIVLITFTVVLYFSFSTNLRRTIDKNLEFIASQLIINIDYDD
CCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEEEEECCC
NKLAFQNTENGANLIKNFIGKELFARILDENGNVIDGFGNYFLLPADPKILKKGFLTILT
CEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEECCCHHHHHCCCEEEEE
DSGEWRVYTVKLSLGWLQVAEFTEPFGETLEKFRSLLVIFIPLTLIIASIGSYLLAKKTL
CCCCEEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KPIDRITNLAREINAEKIDRRLDIDLPDDELGRLSKTFNQMLDRLENALNSQKQFSANAA
HHHHHHHHHHHHHCHHHHCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCH
HDLRTPLTSIKGIIDVTLNRERDALEYKDSLIQIRKQVERMSKLVDTLLIVARFDSKAIK
HHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
LHKEKIDLTELLEVVVEQMQYAANRKGIILKADLQDNLTIVGDFDLVVRLFLNLIDNAIK
HHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEECHHHHHHHHHHHHHHHHH
YNQPGGQVTVTAKLSEKKKGLKHVLVSICDTGQGIPENELERIFDKFYRIDKSRSRVEGA
CCCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHCCC
GLGLSIVKEIALAHNAEIQVKSQLGKGSIFIVKFPI
CCCHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8594334 [H]