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The map label for this gene is hutU [H]

Identifier: 239616853

GI number: 239616853

Start: 476796

End: 478820

Strand: Reverse

Name: hutU [H]

Synonym: Kole_0448

Alternate gene names: 239616853

Gene position: 478820-476796 (Counterclockwise)

Preceding gene: 239616855

Following gene: 239616852

Centisome position: 20.8

GC content: 44.74

Gene sequence:

>2025_bases
ATGATTTCAAATTTTGATATTTCACAAGCTATGACTATCAAGCTCGATCCGGTTCTACCGCCTGATCCGGAGTTCCTACC
AGGGATAAGGAGAGCGCCAAAAAGGGAATTAACGCTGAACAAAAAAGAGATAAAGCTGGCGCTGAAAAACGCTCTGCGAT
ATATTCCCGAGGAACTTCATGAGAAGCTGGCACCCGAATTTCTTAACGAACTGCTCACCAGAGGAAGAATTTACGGTTAC
CGGTTCCGACCTAAAGGCCCTATAAAGGGAAAACCTGTGCATGAGTACAAAGGAAAGACTCTGGAGGGAAAGGCCCTTCA
GGTTATGATCGACAACAATCTGGATTTCGATGTCGCGCTCTATCCTTATGAACTGGTTACATACGGTGAGACAGGTCAGG
TGTTTCAAAACTGGATGCAATACCAGCTTACGAAGAAATATCTTGAAGTTATGACGGAAGAGCAAACGCTTGTGGTAATG
TCGGGACATCCTCTGGGGCTTTTCAAATCTTCAAGAAACGCGCCAAGGGTTATCATTACCAATGCGCTCATGGTAGGGAT
GTTTGACAACCAGGAAAACTGGATAAAAGCGCAAGCACTTGGTGTGGCTAACTACGGGCAAATGACCGCTGGCGGCTGGA
TGTACATCGGCCCTCAGGGGATCGTACACGGAACGTTCAATACTATTTTGAATGCAGGAAGACAGAAACTTGGTGTACCC
GAAGATGGCGACTTGAGAGGTTATCTTTTTGTTTCTTCCGGATTGGGTGGAATGAGTGGTGCTCAGGGTAAAGCTGTGAG
AATTGCCAATGGAGTTGGAGTAATCGCCGAGGTTGATTATTCAAGAATACAGACGAGACTTGAACAGGGATGGATTGATG
TGGTTCTTGATGATCTCAATGAAGTCTTTAAGACTGCTCTCGAGTATAAGAAAAACGGAAAAAGCATAGCCATTGCTTAT
TACGGAAACGTGGTTGATCTCCTTCAGTACGCTGTGGATAACAACATTCACATCGATCTGTTGTCCGACCAAACTTCCTG
TCATGCTGCTTACGATGGTGGATACTGTCCTCAAGGCATTACTTTTGAAGAGAGAACAGAACTTCTTAGAACGAACAAAC
AGAAATTCAGAGAGCTGGTCGACAAATCTCTTAGAAAGCATTTTGAGCTCATTAAGACTCTGGTAGAACGGGGAACGTAT
TTCTTCGATTATGGCAACAGTTTCATGAAGGCCGTTTTCGACGCCGGGGTCAAAGAGATAGCCAAAAATGGTGTCGATAC
TAGCGAAGGCTTTATTTTTCCTTCTTATGTAGAGGATATCATGGGGCCCATGCTTTTTGACTACGGTTACGGTCCTTTCA
GATGGGTCTGTCTCAGTGGCAAGCATGAGGATCTCGTAAAAACCGATAAAGCTGCTATGGAGTGTATAGATCCGACAAGG
CGAGGGCAAGACAGGGATAATTACATCTGGATAAGAGATGCTGAGAAAAATAAGTTAGTAGTTGGCATCCAGGCTAGGAT
TCTTTATTCTGATGCTGAAGGGAGAATTCGAATAGCTCTCAAGTTCAATGAGATGGTAAGACGCGGAGAAGTAGGACCAA
TCATGATAGGAAGGGATCACCATGACACGGGTGGTACAGATTCCCCATTTAGAGAAACCTCGAATATAAAGGATGGAAGT
AACATAATGGCGGACATGGCTACCCACTGTTTCGCCGGGAATGCTGCAAGAGGAATGACGCTAGTAGCACTTCATAACGG
TGGTGGAGTCGGTATTGGAAAGGCTATCAACGGAGGGTTCGGCCTCGTGCTTGATGGTAGTAGAAGGGTTGACGAAGTAA
TAAAGACTGCTATCGCATGGGATGTTATGAGTGGTGTGTCTAGAAGAGCCTGGGCGAGAAATGAGCACTCAATTGAAACT
GCAATAGAGTATAATAAGAAAAACGTAGGCGAAGATCACATAACTCTTCCCTATCTTGTAGATGATGGACTTGTGGATAA
GCTTGTGGATAATCTGGAAGCTTAA

Upstream 100 bases:

>100_bases
GATTTTTAATATCATTTTTTTGGGATAACGCGAAGTGATAAAATTACATTGTATGTAAAATGTTCAATAATAAAATTCTT
ACAAATCGGGGGAGGTTTCT

Downstream 100 bases:

>100_bases
TTTCTATTCCGGGGCCTGGGCCCCGGTTTCTATAAGGAGGCGATGGAATGCTGTTTGCCATCGTAATATTAGGTGCACTC
GTGACTTTGCTGCTTTATAT

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 674; Mature: 674

Protein sequence:

>674_residues
MISNFDISQAMTIKLDPVLPPDPEFLPGIRRAPKRELTLNKKEIKLALKNALRYIPEELHEKLAPEFLNELLTRGRIYGY
RFRPKGPIKGKPVHEYKGKTLEGKALQVMIDNNLDFDVALYPYELVTYGETGQVFQNWMQYQLTKKYLEVMTEEQTLVVM
SGHPLGLFKSSRNAPRVIITNALMVGMFDNQENWIKAQALGVANYGQMTAGGWMYIGPQGIVHGTFNTILNAGRQKLGVP
EDGDLRGYLFVSSGLGGMSGAQGKAVRIANGVGVIAEVDYSRIQTRLEQGWIDVVLDDLNEVFKTALEYKKNGKSIAIAY
YGNVVDLLQYAVDNNIHIDLLSDQTSCHAAYDGGYCPQGITFEERTELLRTNKQKFRELVDKSLRKHFELIKTLVERGTY
FFDYGNSFMKAVFDAGVKEIAKNGVDTSEGFIFPSYVEDIMGPMLFDYGYGPFRWVCLSGKHEDLVKTDKAAMECIDPTR
RGQDRDNYIWIRDAEKNKLVVGIQARILYSDAEGRIRIALKFNEMVRRGEVGPIMIGRDHHDTGGTDSPFRETSNIKDGS
NIMADMATHCFAGNAARGMTLVALHNGGGVGIGKAINGGFGLVLDGSRRVDEVIKTAIAWDVMSGVSRRAWARNEHSIET
AIEYNKKNVGEDHITLPYLVDDGLVDKLVDNLEA

Sequences:

>Translated_674_residues
MISNFDISQAMTIKLDPVLPPDPEFLPGIRRAPKRELTLNKKEIKLALKNALRYIPEELHEKLAPEFLNELLTRGRIYGY
RFRPKGPIKGKPVHEYKGKTLEGKALQVMIDNNLDFDVALYPYELVTYGETGQVFQNWMQYQLTKKYLEVMTEEQTLVVM
SGHPLGLFKSSRNAPRVIITNALMVGMFDNQENWIKAQALGVANYGQMTAGGWMYIGPQGIVHGTFNTILNAGRQKLGVP
EDGDLRGYLFVSSGLGGMSGAQGKAVRIANGVGVIAEVDYSRIQTRLEQGWIDVVLDDLNEVFKTALEYKKNGKSIAIAY
YGNVVDLLQYAVDNNIHIDLLSDQTSCHAAYDGGYCPQGITFEERTELLRTNKQKFRELVDKSLRKHFELIKTLVERGTY
FFDYGNSFMKAVFDAGVKEIAKNGVDTSEGFIFPSYVEDIMGPMLFDYGYGPFRWVCLSGKHEDLVKTDKAAMECIDPTR
RGQDRDNYIWIRDAEKNKLVVGIQARILYSDAEGRIRIALKFNEMVRRGEVGPIMIGRDHHDTGGTDSPFRETSNIKDGS
NIMADMATHCFAGNAARGMTLVALHNGGGVGIGKAINGGFGLVLDGSRRVDEVIKTAIAWDVMSGVSRRAWARNEHSIET
AIEYNKKNVGEDHITLPYLVDDGLVDKLVDNLEA
>Mature_674_residues
MISNFDISQAMTIKLDPVLPPDPEFLPGIRRAPKRELTLNKKEIKLALKNALRYIPEELHEKLAPEFLNELLTRGRIYGY
RFRPKGPIKGKPVHEYKGKTLEGKALQVMIDNNLDFDVALYPYELVTYGETGQVFQNWMQYQLTKKYLEVMTEEQTLVVM
SGHPLGLFKSSRNAPRVIITNALMVGMFDNQENWIKAQALGVANYGQMTAGGWMYIGPQGIVHGTFNTILNAGRQKLGVP
EDGDLRGYLFVSSGLGGMSGAQGKAVRIANGVGVIAEVDYSRIQTRLEQGWIDVVLDDLNEVFKTALEYKKNGKSIAIAY
YGNVVDLLQYAVDNNIHIDLLSDQTSCHAAYDGGYCPQGITFEERTELLRTNKQKFRELVDKSLRKHFELIKTLVERGTY
FFDYGNSFMKAVFDAGVKEIAKNGVDTSEGFIFPSYVEDIMGPMLFDYGYGPFRWVCLSGKHEDLVKTDKAAMECIDPTR
RGQDRDNYIWIRDAEKNKLVVGIQARILYSDAEGRIRIALKFNEMVRRGEVGPIMIGRDHHDTGGTDSPFRETSNIKDGS
NIMADMATHCFAGNAARGMTLVALHNGGGVGIGKAINGGFGLVLDGSRRVDEVIKTAIAWDVMSGVSRRAWARNEHSIET
AIEYNKKNVGEDHITLPYLVDDGLVDKLVDNLEA

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=664, Percent_Identity=47.289156626506, Blast_Score=588, Evalue=1e-168,
Organism=Homo sapiens, GI260306182, Length=369, Percent_Identity=44.1734417344173, Blast_Score=310, Evalue=4e-84,
Organism=Caenorhabditis elegans, GI71997891, Length=671, Percent_Identity=47.9880774962742, Blast_Score=597, Evalue=1e-171,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 75374; Mature: 75374

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISNFDISQAMTIKLDPVLPPDPEFLPGIRRAPKRELTLNKKEIKLALKNALRYIPEELH
CCCCCCCCCEEEEEECCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
EKLAPEFLNELLTRGRIYGYRFRPKGPIKGKPVHEYKGKTLEGKALQVMIDNNLDFDVAL
HHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHCCCEECCCEEEEEECCCCCEEEEE
YPYELVTYGETGQVFQNWMQYQLTKKYLEVMTEEQTLVVMSGHPLGLFKSSRNAPRVIIT
ECEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEECCCCCCCEEEEE
NALMVGMFDNQENWIKAQALGVANYGQMTAGGWMYIGPQGIVHGTFNTILNAGRQKLGVP
EEEEEEEECCCCCEEEEEEECCCCCCCCCCCCEEEECCCCEEEHHHHHHHHCCHHHCCCC
EDGDLRGYLFVSSGLGGMSGAQGKAVRIANGVGVIAEVDYSRIQTRLEQGWIDVVLDDLN
CCCCEEEEEEEECCCCCCCCCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHH
EVFKTALEYKKNGKSIAIAYYGNVVDLLQYAVDNNIHIDLLSDQTSCHAAYDGGYCPQGI
HHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCCCEEEEEECCCCCCEEECCCCCCCCCC
TFEERTELLRTNKQKFRELVDKSLRKHFELIKTLVERGTYFFDYGNSFMKAVFDAGVKEI
CHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHH
AKNGVDTSEGFIFPSYVEDIMGPMLFDYGYGPFRWVCLSGKHEDLVKTDKAAMECIDPTR
HHCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHCCHHH
RGQDRDNYIWIRDAEKNKLVVGIQARILYSDAEGRIRIALKFNEMVRRGEVGPIMIGRDH
CCCCCCCEEEEEECCCCEEEEEEEEEEEEECCCCEEEEEEEEHHHHHCCCCCCEEEECCC
HDTGGTDSPFRETSNIKDGSNIMADMATHCFAGNAARGMTLVALHNGGGVGIGKAINGGF
CCCCCCCCCCHHCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEECCCCCCCE
GLVLDGSRRVDEVIKTAIAWDVMSGVSRRAWARNEHSIETAIEYNKKNVGEDHITLPYLV
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCEEEEEEE
DDGLVDKLVDNLEA
CCCHHHHHHHHHCC
>Mature Secondary Structure
MISNFDISQAMTIKLDPVLPPDPEFLPGIRRAPKRELTLNKKEIKLALKNALRYIPEELH
CCCCCCCCCEEEEEECCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
EKLAPEFLNELLTRGRIYGYRFRPKGPIKGKPVHEYKGKTLEGKALQVMIDNNLDFDVAL
HHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHCCCEECCCEEEEEECCCCCEEEEE
YPYELVTYGETGQVFQNWMQYQLTKKYLEVMTEEQTLVVMSGHPLGLFKSSRNAPRVIIT
ECEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEECCCCCCCEEEEE
NALMVGMFDNQENWIKAQALGVANYGQMTAGGWMYIGPQGIVHGTFNTILNAGRQKLGVP
EEEEEEEECCCCCEEEEEEECCCCCCCCCCCCEEEECCCCEEEHHHHHHHHCCHHHCCCC
EDGDLRGYLFVSSGLGGMSGAQGKAVRIANGVGVIAEVDYSRIQTRLEQGWIDVVLDDLN
CCCCEEEEEEEECCCCCCCCCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHH
EVFKTALEYKKNGKSIAIAYYGNVVDLLQYAVDNNIHIDLLSDQTSCHAAYDGGYCPQGI
HHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCCCEEEEEECCCCCCEEECCCCCCCCCC
TFEERTELLRTNKQKFRELVDKSLRKHFELIKTLVERGTYFFDYGNSFMKAVFDAGVKEI
CHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHH
AKNGVDTSEGFIFPSYVEDIMGPMLFDYGYGPFRWVCLSGKHEDLVKTDKAAMECIDPTR
HHCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHCCHHH
RGQDRDNYIWIRDAEKNKLVVGIQARILYSDAEGRIRIALKFNEMVRRGEVGPIMIGRDH
CCCCCCCEEEEEECCCCEEEEEEEEEEEEECCCCEEEEEEEEHHHHHCCCCCCEEEECCC
HDTGGTDSPFRETSNIKDGSNIMADMATHCFAGNAARGMTLVALHNGGGVGIGKAINGGF
CCCCCCCCCCHHCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEECCCCCCCE
GLVLDGSRRVDEVIKTAIAWDVMSGVSRRAWARNEHSIETAIEYNKKNVGEDHITLPYLV
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCEEEEEEE
DDGLVDKLVDNLEA
CCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA