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The map label for this gene is folP [H]

Identifier: 239616682

GI number: 239616682

Start: 301518

End: 302348

Strand: Direct

Name: folP [H]

Synonym: Kole_0275

Alternate gene names: 239616682

Gene position: 301518-302348 (Clockwise)

Preceding gene: 239616681

Following gene: 239616683

Centisome position: 13.1

GC content: 41.64

Gene sequence:

>831_bases
TTGAAAAAGCTCCTGGCAAGAGGTCGTTATCTCGACCTTTCAGAAACAGTTGTAATGGGAATAATAAATGTTACCCCGGA
CTCGTTCTACACCGGAAGCCGCTATCAGGGCATAGAAGACGCTGTTAAAAAAGCCGTTGAAATGTATGAAGAAGGAGCAA
AAATACTGGATATCGGGGGCGAGTCGTCAAGACCTGGAGCAGATCCGGTAGAACCACAGGAAGAGATAAGACGTGTTGTT
CCCGTAATCAAAGAGCTAAGAAAATTAATACCTGATTGTTTCATCTCGATAGATACTTACCATCCAGAGACCGCAAAAGC
CGCACTGGATAGCGGTGCAGATATAGTGAACGATATTACGGGTTTACGAAACGAGAAAATGATGAGATTGGTATATGAAA
ACAATGCTGGCGTGATTTTAATGCACATGAAGGGAACGCCAAAAACAATGCAGAATGAACCATATTACGAAGATGTTGTA
AGCGAGGTTAAAGAATTACTCAAAGCCAATGCGGAAAAAGCCGTTGAAATGGGTATTCCTTCAGAAAGCATAGTGATTGA
TCCGGGTATTGGTTTCGGAAAAAGATTCGAAGATAACCTGGAAATTTTAAGAAAACTTGACATTTTTAAGAAACTCGGGT
ATTCTGTACTGATAGGGCACTCAAGGAAAAGTTTTATAGGGTACATCCTCGACCTTCCGCCAGAGGAAAGGCTTGAAGGC
ACATTGGCTGTTTCGGCATACTGTTATTTGAAAAACGTTGAGATTATCAGGGTCCACGATGTGAGAGAGCATATCAGGCT
GTTCAAGGTTTTAAGTGCGTTAAAAAACTAG

Upstream 100 bases:

>100_bases
GGATACAGTATCATCCTGAATTCAAATCAAGAGTGGGAGATCCCCACCCTCTCTTTAAAGCTTATGTTGAAGCGGTTGAA
GCAAAAGGAGGGCATACAAC

Downstream 100 bases:

>100_bases
ATGATATAATGAACTTAGCGCAAAAAAAAATTCCTGGGAGGGTGCGAAGTGGCTTATAGTAAGTATTCAAAGAAATACTG
GCGAGAGACGCTCCACGCAT

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MKKLLARGRYLDLSETVVMGIINVTPDSFYTGSRYQGIEDAVKKAVEMYEEGAKILDIGGESSRPGADPVEPQEEIRRVV
PVIKELRKLIPDCFISIDTYHPETAKAALDSGADIVNDITGLRNEKMMRLVYENNAGVILMHMKGTPKTMQNEPYYEDVV
SEVKELLKANAEKAVEMGIPSESIVIDPGIGFGKRFEDNLEILRKLDIFKKLGYSVLIGHSRKSFIGYILDLPPEERLEG
TLAVSAYCYLKNVEIIRVHDVREHIRLFKVLSALKN

Sequences:

>Translated_276_residues
MKKLLARGRYLDLSETVVMGIINVTPDSFYTGSRYQGIEDAVKKAVEMYEEGAKILDIGGESSRPGADPVEPQEEIRRVV
PVIKELRKLIPDCFISIDTYHPETAKAALDSGADIVNDITGLRNEKMMRLVYENNAGVILMHMKGTPKTMQNEPYYEDVV
SEVKELLKANAEKAVEMGIPSESIVIDPGIGFGKRFEDNLEILRKLDIFKKLGYSVLIGHSRKSFIGYILDLPPEERLEG
TLAVSAYCYLKNVEIIRVHDVREHIRLFKVLSALKN
>Mature_276_residues
MKKLLARGRYLDLSETVVMGIINVTPDSFYTGSRYQGIEDAVKKAVEMYEEGAKILDIGGESSRPGADPVEPQEEIRRVV
PVIKELRKLIPDCFISIDTYHPETAKAALDSGADIVNDITGLRNEKMMRLVYENNAGVILMHMKGTPKTMQNEPYYEDVV
SEVKELLKANAEKAVEMGIPSESIVIDPGIGFGKRFEDNLEILRKLDIFKKLGYSVLIGHSRKSFIGYILDLPPEERLEG
TLAVSAYCYLKNVEIIRVHDVREHIRLFKVLSALKN

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=271, Percent_Identity=42.8044280442804, Blast_Score=228, Evalue=3e-61,
Organism=Saccharomyces cerevisiae, GI6324073, Length=321, Percent_Identity=31.1526479750779, Blast_Score=140, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 31059; Mature: 31059

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS50972 PTERIN_BINDING ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLLARGRYLDLSETVVMGIINVTPDSFYTGSRYQGIEDAVKKAVEMYEEGAKILDIGG
CCCHHHCCCCCCCHHHHHHHEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECC
ESSRPGADPVEPQEEIRRVVPVIKELRKLIPDCFISIDTYHPETAKAALDSGADIVNDIT
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHCCHHHHHHHH
GLRNEKMMRLVYENNAGVILMHMKGTPKTMQNEPYYEDVVSEVKELLKANAEKAVEMGIP
CCCCHHEEEEEEECCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCC
SESIVIDPGIGFGKRFEDNLEILRKLDIFKKLGYSVLIGHSRKSFIGYILDLPPEERLEG
CCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHEECCCCHHHHCC
TLAVSAYCYLKNVEIIRVHDVREHIRLFKVLSALKN
HHHEEEEEEEECCEEEEEHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKLLARGRYLDLSETVVMGIINVTPDSFYTGSRYQGIEDAVKKAVEMYEEGAKILDIGG
CCCHHHCCCCCCCHHHHHHHEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECC
ESSRPGADPVEPQEEIRRVVPVIKELRKLIPDCFISIDTYHPETAKAALDSGADIVNDIT
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHCCHHHHHHHH
GLRNEKMMRLVYENNAGVILMHMKGTPKTMQNEPYYEDVVSEVKELLKANAEKAVEMGIP
CCCCHHEEEEEEECCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCC
SESIVIDPGIGFGKRFEDNLEILRKLDIFKKLGYSVLIGHSRKSFIGYILDLPPEERLEG
CCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHEECCCCHHHHCC
TLAVSAYCYLKNVEIIRVHDVREHIRLFKVLSALKN
HHHEEEEEEEECCEEEEEHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]