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The map label for this gene is hflC [H]

Identifier: 239616670

GI number: 239616670

Start: 289292

End: 290140

Strand: Direct

Name: hflC [H]

Synonym: Kole_0263

Alternate gene names: 239616670

Gene position: 289292-290140 (Clockwise)

Preceding gene: 239616669

Following gene: 239616671

Centisome position: 12.57

GC content: 44.17

Gene sequence:

>849_bases
ATGAAAGCCATAATAACAATTGTGATTCTGGCGATTATTGCTCTGATACTTGTACCTGAATTCTTCTACATTGTAGATCA
AACCAAACAGGCGGTCGTTCTCCGCTTTGGAGAGATAAAAGAGGTTAGTACCGAACCGGGGCTCCATACCAAACAACCCT
TTGTTGACAAGGTTGTAAGATTCGATAAACGTTTACAGATATACGATGTTCCCGCAGAAAGAATTTTCACAAAGGATAAG
AAAACGCTTCTGGTGGACACCATCGCTGTGTGGAAGATCGTTGATCCTGAAAAATTCGTGAAAACGATGAAATCGGTCGA
TCTTGCTCTGACAAGGATCGACGATGTTGTTTACTCCATCGTGAGAAACACCTTTGGAAAATTGCAGTTTGATGAAGTGA
TCTCCGGTCGCGGCGCGGTTCTCGAGAAAGTCACCCTGGCCGCTGCTGAAGAAATGAAGGACTACGGTATCCTCATTGTA
TCCGTCAGGGTTAAACGTGCTGTCCTTCCTGATGAAAATAAAAACGCTGTTTTCAACAGAATGAAATCTGAACGCTACCA
GGAAGCCGCCCTGATCCGTGCTGAAGGTGAAAAGGAAGCCAATATGATTCGCGCCGAAGCTGATAAATTGAAGGTAATAG
CCCTTGCAGAAGCACAGAAGAAAGCTGAAATAATAAAGGGAACCGCGGAAGCATCAGCTCTGAGAATCTATGCGGAAGCC
TTTTCGGACGACCCGGAATTTTACGAGTTCTGGAAAAGGCTGGTTGTCTATGAAGAGACGCTGCCAGATTCAAAATTCAT
ACTCAGCCCAGATATGAGCTTCATTGAAAAACTGATGAAAGGTGAATAG

Upstream 100 bases:

>100_bases
TGAACAGAATCCTTAAAGATTCTGAAAAATTCGTTCTCCTTAGTAAAGATGGAGTATTGAAGTTCCTGGACCTCTCCAAA
ATGGAAGAAGGTGGTAGCCG

Downstream 100 bases:

>100_bases
GATTGAGCTGTTATCTTTCACTAACTGGGACCGTCTCTTTTGAAGTGAATATAAAGCGTTCCGTTTTCATAGGTAACGCA
GCACATTGTGAAACGGAGGA

Product: HflC protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MKAIITIVILAIIALILVPEFFYIVDQTKQAVVLRFGEIKEVSTEPGLHTKQPFVDKVVRFDKRLQIYDVPAERIFTKDK
KTLLVDTIAVWKIVDPEKFVKTMKSVDLALTRIDDVVYSIVRNTFGKLQFDEVISGRGAVLEKVTLAAAEEMKDYGILIV
SVRVKRAVLPDENKNAVFNRMKSERYQEAALIRAEGEKEANMIRAEADKLKVIALAEAQKKAEIIKGTAEASALRIYAEA
FSDDPEFYEFWKRLVVYEETLPDSKFILSPDMSFIEKLMKGE

Sequences:

>Translated_282_residues
MKAIITIVILAIIALILVPEFFYIVDQTKQAVVLRFGEIKEVSTEPGLHTKQPFVDKVVRFDKRLQIYDVPAERIFTKDK
KTLLVDTIAVWKIVDPEKFVKTMKSVDLALTRIDDVVYSIVRNTFGKLQFDEVISGRGAVLEKVTLAAAEEMKDYGILIV
SVRVKRAVLPDENKNAVFNRMKSERYQEAALIRAEGEKEANMIRAEADKLKVIALAEAQKKAEIIKGTAEASALRIYAEA
FSDDPEFYEFWKRLVVYEETLPDSKFILSPDMSFIEKLMKGE
>Mature_282_residues
MKAIITIVILAIIALILVPEFFYIVDQTKQAVVLRFGEIKEVSTEPGLHTKQPFVDKVVRFDKRLQIYDVPAERIFTKDK
KTLLVDTIAVWKIVDPEKFVKTMKSVDLALTRIDDVVYSIVRNTFGKLQFDEVISGRGAVLEKVTLAAAEEMKDYGILIV
SVRVKRAVLPDENKNAVFNRMKSERYQEAALIRAEGEKEANMIRAEADKLKVIALAEAQKKAEIIKGTAEASALRIYAEA
FSDDPEFYEFWKRLVVYEETLPDSKFILSPDMSFIEKLMKGE

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily [H]

Homologues:

Organism=Homo sapiens, GI7305503, Length=208, Percent_Identity=26.4423076923077, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1790617, Length=304, Percent_Identity=31.25, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1786697, Length=248, Percent_Identity=25.8064516129032, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790616, Length=218, Percent_Identity=27.0642201834862, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI32564147, Length=220, Percent_Identity=27.2727272727273, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17569497, Length=189, Percent_Identity=26.4550264550265, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI193209764, Length=174, Percent_Identity=25.8620689655172, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17569493, Length=174, Percent_Identity=25.8620689655172, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45550506, Length=208, Percent_Identity=26.9230769230769, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI62484448, Length=210, Percent_Identity=25.2380952380952, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI62484274, Length=210, Percent_Identity=25.2380952380952, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI281365664, Length=210, Percent_Identity=25.2380952380952, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24657857, Length=210, Percent_Identity=25.2380952380952, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI18860517, Length=206, Percent_Identity=24.2718446601942, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI45556022, Length=244, Percent_Identity=24.5901639344262, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: 3.4.-.-

Molecular weight: Translated: 32114; Mature: 32114

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAIITIVILAIIALILVPEFFYIVDQTKQAVVLRFGEIKEVSTEPGLHTKQPFVDKVVR
CHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHCCCCCCCCCCCHHHHHHHH
FDKRLQIYDVPAERIFTKDKKTLLVDTIAVWKIVDPEKFVKTMKSVDLALTRIDDVVYSI
HHCCEEEEECCHHHHHCCCCCEEEEEHHHHHEECCHHHHHHHHHHHHHHHHHHHHHHHHH
VRNTFGKLQFDEVISGRGAVLEKVTLAAAEEMKDYGILIVSVRVKRAVLPDENKNAVFNR
HHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHCCEEEEEEEEHHHCCCCCCCHHHHHH
MKSERYQEAALIRAEGEKEANMIRAEADKLKVIALAEAQKKAEIIKGTAEASALRIYAEA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEEEHHHHHHHHHHHCCHHHHHHHHHHHH
FSDDPEFYEFWKRLVVYEETLPDSKFILSPDMSFIEKLMKGE
HCCCHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHCCC
>Mature Secondary Structure
MKAIITIVILAIIALILVPEFFYIVDQTKQAVVLRFGEIKEVSTEPGLHTKQPFVDKVVR
CHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHCCCCCCCCCCCHHHHHHHH
FDKRLQIYDVPAERIFTKDKKTLLVDTIAVWKIVDPEKFVKTMKSVDLALTRIDDVVYSI
HHCCEEEEECCHHHHHCCCCCEEEEEHHHHHEECCHHHHHHHHHHHHHHHHHHHHHHHHH
VRNTFGKLQFDEVISGRGAVLEKVTLAAAEEMKDYGILIVSVRVKRAVLPDENKNAVFNR
HHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHCCEEEEEEEEHHHCCCCCCCHHHHHH
MKSERYQEAALIRAEGEKEANMIRAEADKLKVIALAEAQKKAEIIKGTAEASALRIYAEA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHEEEEEEHHHHHHHHHHHCCHHHHHHHHHHHH
FSDDPEFYEFWKRLVVYEETLPDSKFILSPDMSFIEKLMKGE
HCCCHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10993077 [H]