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The map label for this gene is argH [H]

Identifier: 239616503

GI number: 239616503

Start: 107679

End: 108875

Strand: Direct

Name: argH [H]

Synonym: Kole_0093

Alternate gene names: 239616503

Gene position: 107679-108875 (Clockwise)

Preceding gene: 239616502

Following gene: 239616504

Centisome position: 4.68

GC content: 39.68

Gene sequence:

>1197_bases
ATGTCTATAAAACTCTGGGAAAAGGGATATGAAGTTGATCCCATAATAGAAGCATTTACAATTGGAAACGACTACAAAAC
GGACATGAGGCTAATAAAATACGATATAAAAGCCTCTATGGCCCATGCAGAAATGCTTTGCAAAATGGGATACCTATCTC
GGAAAGAACTTAAAGAGATTAAAAAAGCCCTTGAAGAGCTTCTGGCTCTTGTCAACAACGGAAAGTTCGTAATAAAACCC
GAAGATGAAGATTGCCATACGGCCATAGAAAATTTTTTGACACAAAAAATAGGAGAAGCGGGAAAGAAAATACACACTGC
AAGATCAAGAAACGATCAGGTTTTAACTGCTCTAAGACTCTTTTACAAAGACGAACTCGAAAACATCGTGCAACTCATAA
AACTGCTTCAAAAAGCAATTGAGGATTTTTCAACGAAGTATGGTCATGTTCAATTTGCAGGTTTTACACACACCCGAAAG
GCAATGCCAACGGACTTTAAAACGTGGAGCGAGGCATTATACGATTCCCTCGAAGATGACTTGAAACTCCTAAAAACAGC
CTATGAAATAATAGACCAATCGCCTCTCGGCACAGGTGCTGGTTATGGTATCCCGATCGAGATAGACAGGGAATACACTG
CAAATGAACTTGCTTTCTCCAGAATCCAGAAAAATCCTATTTATTCACAAAACAGCAGGGGAAAGTTTGATTATTTGATC
CTTCATGTGCTTTCTCAGATAAGTTACGACCTTAACAGAGTTTCAAGCGATATCATATTCTTCTCACTTCCTGAAGTGGG
ATATATGGATCTCCCAAAAGAGCTCTGCACTGGAAGTTCAATAATGCCACAGAAATTGAACCCGGATCCTCTCGAGCTCG
TTAGAGGGTATCACAACAGGATCGTATCGAGAATGATGGAAAGCGTCATTACATCCTCAAATTTGATATCCGGATATCAC
AGAGATTTCCAGCTTTTAAAAGAAAGTGTCATAGAGTGCTTCGATGTTGCGAAGACTCTTTTAAAGGTAATGAAAATCGT
ATTCGAAAGGCTGAGCGTCAACAAGGAAAATTGCGAAAAAAGCATAACGGAAGAGGTCCTTGCGACTCAAAAGGTTTATG
AAATGGTTAAAAAAGGTACCCCGTTTAGGGACGCTTACAGAAAAATAGCCCAAAGTTACGGAGGCGAGAAGAAATGA

Upstream 100 bases:

>100_bases
GATTCTAAAGGCTTTATAAACATACACGCTCTCAGGCTTAAAGCTCATAATCTTGTTTTAAAAGGAAAAGACCCCTTCGC
CTGGAGAAAGGAGATTGGAA

Downstream 100 bases:

>100_bases
TAAGGGTTGGAATAATAGGTGCAACTGGCTACACAGGATTGGAACTCGTGAGAATACTCACCAATCACCCTGATGTTAAA
ATAACCTTTCTTTCTTCCAG

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MSIKLWEKGYEVDPIIEAFTIGNDYKTDMRLIKYDIKASMAHAEMLCKMGYLSRKELKEIKKALEELLALVNNGKFVIKP
EDEDCHTAIENFLTQKIGEAGKKIHTARSRNDQVLTALRLFYKDELENIVQLIKLLQKAIEDFSTKYGHVQFAGFTHTRK
AMPTDFKTWSEALYDSLEDDLKLLKTAYEIIDQSPLGTGAGYGIPIEIDREYTANELAFSRIQKNPIYSQNSRGKFDYLI
LHVLSQISYDLNRVSSDIIFFSLPEVGYMDLPKELCTGSSIMPQKLNPDPLELVRGYHNRIVSRMMESVITSSNLISGYH
RDFQLLKESVIECFDVAKTLLKVMKIVFERLSVNKENCEKSITEEVLATQKVYEMVKKGTPFRDAYRKIAQSYGGEKK

Sequences:

>Translated_398_residues
MSIKLWEKGYEVDPIIEAFTIGNDYKTDMRLIKYDIKASMAHAEMLCKMGYLSRKELKEIKKALEELLALVNNGKFVIKP
EDEDCHTAIENFLTQKIGEAGKKIHTARSRNDQVLTALRLFYKDELENIVQLIKLLQKAIEDFSTKYGHVQFAGFTHTRK
AMPTDFKTWSEALYDSLEDDLKLLKTAYEIIDQSPLGTGAGYGIPIEIDREYTANELAFSRIQKNPIYSQNSRGKFDYLI
LHVLSQISYDLNRVSSDIIFFSLPEVGYMDLPKELCTGSSIMPQKLNPDPLELVRGYHNRIVSRMMESVITSSNLISGYH
RDFQLLKESVIECFDVAKTLLKVMKIVFERLSVNKENCEKSITEEVLATQKVYEMVKKGTPFRDAYRKIAQSYGGEKK
>Mature_397_residues
SIKLWEKGYEVDPIIEAFTIGNDYKTDMRLIKYDIKASMAHAEMLCKMGYLSRKELKEIKKALEELLALVNNGKFVIKPE
DEDCHTAIENFLTQKIGEAGKKIHTARSRNDQVLTALRLFYKDELENIVQLIKLLQKAIEDFSTKYGHVQFAGFTHTRKA
MPTDFKTWSEALYDSLEDDLKLLKTAYEIIDQSPLGTGAGYGIPIEIDREYTANELAFSRIQKNPIYSQNSRGKFDYLIL
HVLSQISYDLNRVSSDIIFFSLPEVGYMDLPKELCTGSSIMPQKLNPDPLELVRGYHNRIVSRMMESVITSSNLISGYHR
DFQLLKESVIECFDVAKTLLKVMKIVFERLSVNKENCEKSITEEVLATQKVYEMVKKGTPFRDAYRKIAQSYGGEKK

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=387, Percent_Identity=34.625322997416, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI68303542, Length=387, Percent_Identity=34.625322997416, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI68303549, Length=387, Percent_Identity=32.8165374677003, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI68303547, Length=387, Percent_Identity=33.3333333333333, Blast_Score=197, Evalue=1e-50,
Organism=Escherichia coli, GI1790398, Length=375, Percent_Identity=33.0666666666667, Blast_Score=210, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6321806, Length=397, Percent_Identity=32.2418136020151, Blast_Score=201, Evalue=2e-52,
Organism=Drosophila melanogaster, GI221473854, Length=391, Percent_Identity=32.4808184143223, Blast_Score=211, Evalue=9e-55,
Organism=Drosophila melanogaster, GI78706858, Length=391, Percent_Identity=32.4808184143223, Blast_Score=211, Evalue=9e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 45701; Mature: 45570

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIKLWEKGYEVDPIIEAFTIGNDYKTDMRLIKYDIKASMAHAEMLCKMGYLSRKELKEI
CCCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
KKALEELLALVNNGKFVIKPEDEDCHTAIENFLTQKIGEAGKKIHTARSRNDQVLTALRL
HHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
FYKDELENIVQLIKLLQKAIEDFSTKYGHVQFAGFTHTRKAMPTDFKTWSEALYDSLEDD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHCCCCCHHHHHHHHHHHHHHH
LKLLKTAYEIIDQSPLGTGAGYGIPIEIDREYTANELAFSRIQKNPIYSQNSRGKFDYLI
HHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHH
LHVLSQISYDLNRVSSDIIFFSLPEVGYMDLPKELCTGSSIMPQKLNPDPLELVRGYHNR
HHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHH
IVSRMMESVITSSNLISGYHRDFQLLKESVIECFDVAKTLLKVMKIVFERLSVNKENCEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
SITEEVLATQKVYEMVKKGTPFRDAYRKIAQSYGGEKK
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SIKLWEKGYEVDPIIEAFTIGNDYKTDMRLIKYDIKASMAHAEMLCKMGYLSRKELKEI
CCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
KKALEELLALVNNGKFVIKPEDEDCHTAIENFLTQKIGEAGKKIHTARSRNDQVLTALRL
HHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
FYKDELENIVQLIKLLQKAIEDFSTKYGHVQFAGFTHTRKAMPTDFKTWSEALYDSLEDD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHCCCCCHHHHHHHHHHHHHHH
LKLLKTAYEIIDQSPLGTGAGYGIPIEIDREYTANELAFSRIQKNPIYSQNSRGKFDYLI
HHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHH
LHVLSQISYDLNRVSSDIIFFSLPEVGYMDLPKELCTGSSIMPQKLNPDPLELVRGYHNR
HHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHH
IVSRMMESVITSSNLISGYHRDFQLLKESVIECFDVAKTLLKVMKIVFERLSVNKENCEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
SITEEVLATQKVYEMVKKGTPFRDAYRKIAQSYGGEKK
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10732680 [H]