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The map label for this gene is hpt [H]

Identifier: 239616415

GI number: 239616415

Start: 3606

End: 4154

Strand: Direct

Name: hpt [H]

Synonym: Kole_0004

Alternate gene names: 239616415

Gene position: 3606-4154 (Clockwise)

Preceding gene: 239616412

Following gene: 239616416

Centisome position: 0.16

GC content: 39.34

Gene sequence:

>549_bases
ATGGAGCTTAGCCCCTCCAGAATAAGAATCCTTTTCTCTGAGGAAGATCTCGATAGAATCGTTAAGAAAGTGGCTGAGGA
TATAAACAACTATTACAAGCCCCTGACTGATGAGATCACGGCTATTTGTGTCTTAAAGGGCTCAGTTCATTTTTACAGTG
ATCTGTTGAAAAGGCTCGACCTGAAAGTAAGATACAATTTTGTCCATGTTTCAAGCTATTCTGGCATGCATACCACCGGG
AAGATCAGAGTGAAAACCTGGGTGGACGAATCTTTAACAAATCGCTATGTGCTGGTTGTAGAAGATATACTAGATACAGG
CAATACCTTGCGATACATCATCAACTACATCTGGAAACAGAAACCCAAAGACGTAAAATTGGTATCTTTGTTTGAAAAAA
CCGTCCATAAACATGGGGTTAATCTCGATTTCGTAGGTGAAAAGATCGGTGATGTTTTCGTTATAGGTTATGGCCTCGAT
TACAATGAAATTTACCGAAATTTACCATATGTTGGTTATATTCCCGATGAGGAAAACGAAGAAGGGTAA

Upstream 100 bases:

>100_bases
TCTTCGTGAGAGGAAGCCATAAAAGTCATTTTACACTGCCTTGGAGACCATAAAGTACATTGGTGATATAATAATAGACA
TAAAAACCGGAGGTGAGAAT

Downstream 100 bases:

>100_bases
TTCAACGATTTTCATCACGGTTATTTTGATTTTTGCTCTTGTGGCCGTGGTATCCGCAGGGATACTTAGAATCGGCAGCG
AAATAGTTCGCCTGAGACAG

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 182; Mature: 182

Protein sequence:

>182_residues
MELSPSRIRILFSEEDLDRIVKKVAEDINNYYKPLTDEITAICVLKGSVHFYSDLLKRLDLKVRYNFVHVSSYSGMHTTG
KIRVKTWVDESLTNRYVLVVEDILDTGNTLRYIINYIWKQKPKDVKLVSLFEKTVHKHGVNLDFVGEKIGDVFVIGYGLD
YNEIYRNLPYVGYIPDEENEEG

Sequences:

>Translated_182_residues
MELSPSRIRILFSEEDLDRIVKKVAEDINNYYKPLTDEITAICVLKGSVHFYSDLLKRLDLKVRYNFVHVSSYSGMHTTG
KIRVKTWVDESLTNRYVLVVEDILDTGNTLRYIINYIWKQKPKDVKLVSLFEKTVHKHGVNLDFVGEKIGDVFVIGYGLD
YNEIYRNLPYVGYIPDEENEEG
>Mature_182_residues
MELSPSRIRILFSEEDLDRIVKKVAEDINNYYKPLTDEITAICVLKGSVHFYSDLLKRLDLKVRYNFVHVSSYSGMHTTG
KIRVKTWVDESLTNRYVLVVEDILDTGNTLRYIINYIWKQKPKDVKLVSLFEKTVHKHGVNLDFVGEKIGDVFVIGYGLD
YNEIYRNLPYVGYIPDEENEEG

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=168, Percent_Identity=36.9047619047619, Blast_Score=99, Evalue=1e-21,
Organism=Homo sapiens, GI9910262, Length=176, Percent_Identity=30.1136363636364, Blast_Score=89, Evalue=2e-18,
Organism=Escherichia coli, GI87081689, Length=169, Percent_Identity=31.9526627218935, Blast_Score=107, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17510817, Length=162, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 21216; Mature: 21216

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELSPSRIRILFSEEDLDRIVKKVAEDINNYYKPLTDEITAICVLKGSVHFYSDLLKRLD
CCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHEEEEEEECCHHHHHHHHHHCC
LKVRYNFVHVSSYSGMHTTGKIRVKTWVDESLTNRYVLVVEDILDTGNTLRYIINYIWKQ
EEEEEEEEEEECCCCCCCCCEEEEEEECCHHHCCCEEEEEEHHHCCCHHHHHHHHHHHHC
KPKDVKLVSLFEKTVHKHGVNLDFVGEKIGDVFVIGYGLDYNEIYRNLPYVGYIPDEENE
CCCCHHHHHHHHHHHHHCCCCEEECCCCCCCEEEEEECCCHHHHHHCCCEEEECCCCCCC
EG
CC
>Mature Secondary Structure
MELSPSRIRILFSEEDLDRIVKKVAEDINNYYKPLTDEITAICVLKGSVHFYSDLLKRLD
CCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHEEEEEEECCHHHHHHHHHHCC
LKVRYNFVHVSSYSGMHTTGKIRVKTWVDESLTNRYVLVVEDILDTGNTLRYIINYIWKQ
EEEEEEEEEEECCCCCCCCCEEEEEEECCHHHCCCEEEEEEHHHCCCHHHHHHHHHHHHC
KPKDVKLVSLFEKTVHKHGVNLDFVGEKIGDVFVIGYGLDYNEIYRNLPYVGYIPDEENE
CCCCHHHHHHHHHHHHHCCCCEEECCCCCCCEEEEEECCCHHHHHHCCCEEEECCCCCCC
EG
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA