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The map label for this gene is dnaA

Identifier: 239616412

GI number: 239616412

Start: 103

End: 1446

Strand: Direct

Name: dnaA

Synonym: Kole_0001

Alternate gene names: 239616412

Gene position: 103-1446 (Clockwise)

Preceding gene: NA

Following gene: 239616415

Centisome position: 0.0

GC content: 41.52

Gene sequence:

>1344_bases
GTGTCAAATCGAATAATAAGCATCCTTAAGAAAAGGCTTGCCAGGAAAACCTGGGACAACTGGTTCACAACCTTTCAGGT
AAAAAAGGTAACTGACGACAAGATCATTTTCAGCGTCGGTAACCTTTTCATAAAAGATTGGCTTCAATCCAAGTATGGAA
GCGTTATTTCGAAAGCCATTAAGGAAGCTTATGGAAAAAATCTTGATTATGAGATCGTTTATGAAACGACAGAACCTGAA
GCCTTTAACAAAAGCAATGAAAGTTACAAAGGACCGCTGGTTAAGAAGAAACCCCTTTTAATATCTAATCTTAACGCTAA
CTACACCTTTGAAAATTTCGTGGTTGGTCCTGAAAACAGGGTGCTGTATGAGGTTTCACTGGAGATATCCAGGAACCCGG
GGAGATACAATCCCTTTTTCGTCTATGGTATGGTAGGACTCGGAAAGACACACCTCCTGCAGGCTATAGCTCACAAGATC
ATGGAACTCCATCCCGAAATGAGAGTACTTTACATAACCAGCGAGCAATTCATGAATGATATGATAGATTCCATAAAATA
CGGTTCTGTAAGAGACTTCAGGGAGCATTACAGAAAAAAAGCCGATGTTTTATTGATCGATGACATCCAGTTTCTTATCG
GGAAAAACGGCGTTCAGAAAGAATTATTCCACACCTTCAATGAGCTCTACGACGCAGGAAAGCAAATAGTGATATGTTCT
GACAGAAACCCTGAGGAACTCAACGGATTCCATGACCGCCTTGTTTCGCGGTTCCAAATGGGAATGGTAATGGAAATCTG
CCCGCCAGAAAAAGACACCCGTTTTAAGATTGCGAAGAAGTTTGCCGAAAGGGAATCCGTGTCTTTGCCGGATGATGTAG
CGCAGCTTCTTGCGGATAGTGTGGACGGAAACCTTAGAATTCTGAGGGGCGTCATCATAAAGTTGATTGTTCAGAGCAGC
ATAAACAAAGAAAGGATCGGGGCTGCTTTGACTAATCAGATACTTGCTGCTTTTAACAAAACAACCGTTTCGATAAAAAG
GATGAAAGAAGAAGACCTTATCATGAGTACTATCGAAGCGGTTATGGGAGTAAGCCCCGAAGAGATTAAAGGAACCAGTA
GAAAGCAAAACATTGTACTCTCAAGGCAGCTTTTGATGTACATTCTAAAGCGCCATCATGGGAAGAGCATAAAAGAAATC
TCTAAAATAACAGGCAAGCGCCATTCAACAGTGATTCATTCCATCAAAAAAATTGAGATGAGTGTCATCAAAGGCAACAC
AGTGGTAAAGGAAAAGCTGGCCAAAATTTTAAACACGATGGCTACAAGCTCGGCTGCAGGATAG

Upstream 100 bases:

>100_bases
TTAGTTCTGGGGTTACTCAGCCTCGTTGGATCGATTTTCATTTATTGTTTGGGGTATTGTTTCGCTTCCAGACGATATTT
TCTTTCCACTGGAGGTAAAT

Downstream 100 bases:

>100_bases
AAACACAGTTCCATCATCGTTCATCCTTTTTCTTTCTCGTCATCAGCTCTTCTATCGCTTTCTTCGGTTCCTTTTCTTCG
TAAAGAACAGCATAAACCTG

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 447; Mature: 446

Protein sequence:

>447_residues
MSNRIISILKKRLARKTWDNWFTTFQVKKVTDDKIIFSVGNLFIKDWLQSKYGSVISKAIKEAYGKNLDYEIVYETTEPE
AFNKSNESYKGPLVKKKPLLISNLNANYTFENFVVGPENRVLYEVSLEISRNPGRYNPFFVYGMVGLGKTHLLQAIAHKI
MELHPEMRVLYITSEQFMNDMIDSIKYGSVRDFREHYRKKADVLLIDDIQFLIGKNGVQKELFHTFNELYDAGKQIVICS
DRNPEELNGFHDRLVSRFQMGMVMEICPPEKDTRFKIAKKFAERESVSLPDDVAQLLADSVDGNLRILRGVIIKLIVQSS
INKERIGAALTNQILAAFNKTTVSIKRMKEEDLIMSTIEAVMGVSPEEIKGTSRKQNIVLSRQLLMYILKRHHGKSIKEI
SKITGKRHSTVIHSIKKIEMSVIKGNTVVKEKLAKILNTMATSSAAG

Sequences:

>Translated_447_residues
MSNRIISILKKRLARKTWDNWFTTFQVKKVTDDKIIFSVGNLFIKDWLQSKYGSVISKAIKEAYGKNLDYEIVYETTEPE
AFNKSNESYKGPLVKKKPLLISNLNANYTFENFVVGPENRVLYEVSLEISRNPGRYNPFFVYGMVGLGKTHLLQAIAHKI
MELHPEMRVLYITSEQFMNDMIDSIKYGSVRDFREHYRKKADVLLIDDIQFLIGKNGVQKELFHTFNELYDAGKQIVICS
DRNPEELNGFHDRLVSRFQMGMVMEICPPEKDTRFKIAKKFAERESVSLPDDVAQLLADSVDGNLRILRGVIIKLIVQSS
INKERIGAALTNQILAAFNKTTVSIKRMKEEDLIMSTIEAVMGVSPEEIKGTSRKQNIVLSRQLLMYILKRHHGKSIKEI
SKITGKRHSTVIHSIKKIEMSVIKGNTVVKEKLAKILNTMATSSAAG
>Mature_446_residues
SNRIISILKKRLARKTWDNWFTTFQVKKVTDDKIIFSVGNLFIKDWLQSKYGSVISKAIKEAYGKNLDYEIVYETTEPEA
FNKSNESYKGPLVKKKPLLISNLNANYTFENFVVGPENRVLYEVSLEISRNPGRYNPFFVYGMVGLGKTHLLQAIAHKIM
ELHPEMRVLYITSEQFMNDMIDSIKYGSVRDFREHYRKKADVLLIDDIQFLIGKNGVQKELFHTFNELYDAGKQIVICSD
RNPEELNGFHDRLVSRFQMGMVMEICPPEKDTRFKIAKKFAERESVSLPDDVAQLLADSVDGNLRILRGVIIKLIVQSSI
NKERIGAALTNQILAAFNKTTVSIKRMKEEDLIMSTIEAVMGVSPEEIKGTSRKQNIVLSRQLLMYILKRHHGKSIKEIS
KITGKRHSTVIHSIKKIEMSVIKGNTVVKEKLAKILNTMATSSAAG

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family

Homologues:

Organism=Escherichia coli, GI2367267, Length=469, Percent_Identity=30.4904051172708, Blast_Score=233, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNAA_KOSOT (C5CH91)

Other databases:

- EMBL:   CP001634
- RefSeq:   YP_002939734.1
- GeneID:   7968583
- GenomeReviews:   CP001634_GR
- KEGG:   kol:Kole_0001
- ProtClustDB:   PRK14088
- GO:   GO:0005737
- HAMAP:   MF_00377
- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921
- Gene3D:   G3DSA:1.10.1750.10
- PRINTS:   PR00051
- SMART:   SM00382
- SMART:   SM00760
- TIGRFAMs:   TIGR00362

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C; SSF48295 Trp_repress_rep

EC number: NA

Molecular weight: Translated: 51061; Mature: 50930

Theoretical pI: Translated: 10.11; Mature: 10.11

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNRIISILKKRLARKTWDNWFTTFQVKKVTDDKIIFSVGNLFIKDWLQSKYGSVISKAI
CCCHHHHHHHHHHHHHHHHHHHEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEAYGKNLDYEIVYETTEPEAFNKSNESYKGPLVKKKPLLISNLNANYTFENFVVGPENR
HHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCEEEEEEECCCCC
VLYEVSLEISRNPGRYNPFFVYGMVGLGKTHLLQAIAHKIMELHPEMRVLYITSEQFMND
EEEEEEEEEECCCCCCCCEEEEEEHHCCHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHH
MIDSIKYGSVRDFREHYRKKADVLLIDDIQFLIGKNGVQKELFHTFNELYDAGKQIVICS
HHHHCCCCCHHHHHHHHHHHCCEEEEECHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEEC
DRNPEELNGFHDRLVSRFQMGMVMEICPPEKDTRFKIAKKFAERESVSLPDDVAQLLADS
CCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHC
VDGNLRILRGVIIKLIVQSSINKERIGAALTNQILAAFNKTTVSIKRMKEEDLIMSTIEA
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VMGVSPEEIKGTSRKQNIVLSRQLLMYILKRHHGKSIKEISKITGKRHSTVIHSIKKIEM
HHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHH
SVIKGNTVVKEKLAKILNTMATSSAAG
HHHCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SNRIISILKKRLARKTWDNWFTTFQVKKVTDDKIIFSVGNLFIKDWLQSKYGSVISKAI
CCHHHHHHHHHHHHHHHHHHHEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEAYGKNLDYEIVYETTEPEAFNKSNESYKGPLVKKKPLLISNLNANYTFENFVVGPENR
HHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCEEEEEEECCCCC
VLYEVSLEISRNPGRYNPFFVYGMVGLGKTHLLQAIAHKIMELHPEMRVLYITSEQFMND
EEEEEEEEEECCCCCCCCEEEEEEHHCCHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHH
MIDSIKYGSVRDFREHYRKKADVLLIDDIQFLIGKNGVQKELFHTFNELYDAGKQIVICS
HHHHCCCCCHHHHHHHHHHHCCEEEEECHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEEC
DRNPEELNGFHDRLVSRFQMGMVMEICPPEKDTRFKIAKKFAERESVSLPDDVAQLLADS
CCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHC
VDGNLRILRGVIIKLIVQSSINKERIGAALTNQILAAFNKTTVSIKRMKEEDLIMSTIEA
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VMGVSPEEIKGTSRKQNIVLSRQLLMYILKRHHGKSIKEISKITGKRHSTVIHSIKKIEM
HHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHH
SVIKGNTVVKEKLAKILNTMATSSAAG
HHHCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA