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The map label for this gene is xdhD [H]

Identifier: 238925498

GI number: 238925498

Start: 3005325

End: 3007700

Strand: Reverse

Name: xdhD [H]

Synonym: EUBREC_3154

Alternate gene names: 238925498

Gene position: 3007700-3005325 (Counterclockwise)

Preceding gene: 238925499

Following gene: 238925497

Centisome position: 87.19

GC content: 48.36

Gene sequence:

>2376_bases
ATGAGCACAAATCAAACTAATGAAAACAGCTTCAACCGCGCCAGAAGGGATTACCACGCGGTTGGAAAATGTATACCTAA
AAAGGACTCGAGCCAGCTTTTACTCGGAAAGCCGGTATTTACCGATGACATCACACCGCGTGATGCGCTTGTCATAAAGC
TTCTTAGAAGCCCATATGCAAATGCAATTGTCGAGGATGTAAAGACAGATATCGCTCTTAAGGTGCCGGGCATGGTCGCA
GTATACACCTGGGAGGATGTTCCGAAAAAGCGTTTTTCTATCGCAGGCCAGACATTTCCGGAGCCGTCACCATATGACAG
ATTAATCCTTGACCGCCATGTGAGAAGCGTAGGTGACGCCGTCGCTATAGTAGTCGGAGAATCTGAAAAGGCGGTGGACA
AGGCTCTTAACATGATAAAAGTAAAGTACACGGTGCTTGAGCCGGTGCTTGACTTCAGAAAGTCGCTGGATAACAAGGTG
CTCGTGCATCCTGAGGATGACTGGTCATCCAGCATAGATACAGGCGATGTAAAGCGCAATCTCATTCACCACGAAGAGGA
TGAGCATGGAAATGTGGAGAAAATTCTGTCAGAGTGCGATGAGATTATTGAGCACACATATCGCATAAAGGCAGCGCAGC
AGGCATATATGGAGACCTGCAGGGCATACTGTGAGATAGACAGATACGGCAGACTTCACTGTATCAGCTCGACACAGATA
GTTTTCCACCTGCGCCGAATACTGGCAAATGCACTTGATATTCCAAAGTCTATGGTGCGCGCTGAAAAGCCGCGTATCGG
AGGCGGTTTCGGTGCCAAGCAGACAGCGGTCTGTGAGGTGTATCCGGCATTTGTTACCTGGAAGACAAAGCGTCCAAGCA
AGATAATCTACAGCAGAAAAGAGTGTCAGACTATCGCGTCACCGCGTCATGAGATGGAAGTTACCGTGCGTCTTGGAGCG
ATGAAAGATGGTCATATAAGGGCGATAGATCTTTATACGCTGTCAAATGGTGGAGCATACGGAGAGCATAGCACTACAAC
AGTAGGACTCTCCGGTCATAAATCGCTTCCTCTTTATACAGGAGGCTGCGAGGCAACCAGATTTTCGTGCGATGTTGTGT
ATACAAACGTGCAGGCGGCAGGAGCATACAGAGGCTATGGAGCCACACAGGGTATATTTGCACTTGAATCAACCGTCAAT
GAGCTTGCAGAAAAGCTGCATATAGACCCGGTTGAGCTTCGTTTGAAAAATATTGTACGTGAGGGCATGTTTATGCCGGC
ATATTTTGGCGAGACAGCCAATGCATGTGCACTTGACAGATGTATAATGCACTGCGCGGACAATTTCCACTGGGCAGAAA
AGTATCCTGTCCGCGATATGGGAAATGGCAAGGTTCGTGCGGCAGGCATGGCGCTTGCAATGCAGGGCTCCTGCATATCC
AATGTAGATGTCGGCTCGTGTACCTTAAAGCTTTCAGACTGTGGCACCTACAATATGATGATAGGTGCGGCAGACATGGG
AACAGGCTGTGATACAATACTTGCGCAGATGGCGGCTGAGGTACTTGACTGCGAGCCGGATGATATAACAGTGTTTGGAG
CGGATACAGATGCTTCTCCTTATGACTCGGGTTCATATGCCTCATCAACCACCTACATCACAGGAATGGCCACACAGAAT
GCAGCACTTGAGCTTCGTGAAAATATAAAGAAAATCGGTGCACAGCTGCTGGGCTGTGCTGCATCAGAGGTGGATTTCGA
CGGTAAAGAGGTGTATATCATAAATCCGGACGGTGCAGACAATGTGGCAGTTTCCGTAAGTCTTTCCGATATAGCAACAA
AAGCACAGGTCAACAACACGATACCTGTAGATGTCACCGCCACATATTCATCACCTGTTTCACCGCCACCATACATGGTA
GGCATGGTCGAGATAGAGCTTGATAAGGAGACCGGAGCAGTTAAAATACTTGATTATCAGGCTGTCGTGGACTGCGGAAT
TCCGGTCAATCCAAACCTTGCACGTGTGCAGACAGAGGGTGGCATAGGTCAGGGAATCGGCATGGCACTTTATGAGAATG
TCACCTACAATGCCGGTGGTAAAATCGCAGAAAATGATTTCATGCAGTACAAGATACCGACACGACAGGATGTGGGACAT
ATCAACGTCGAATTTGAGACAAGCTATGAGCCTTCAGGCCCATTTGGAGTCAAGTCAATCGGCGAGATAGTTATCAATAC
ACCGGCTCCTGCGCTGGCACATGCCATTTATCGCGCAACAGGCGTATGGCACAGGACAGTTCCGTTTACCCCGGAGAAAA
TACTTATGGGAATGGCAGACCCAAACTGGCACGAAAAGGACCTAAGAGTGAAATGA

Upstream 100 bases:

>100_bases
CTCCGCTCAATCAGAAATTTCTTAAACAGTAAGAAAGAGGGCGCACCTCTTAATCTTGAGGCAGGCGTCTATGGAGAGGA
TATCGGAAAGGAGTGGCAGG

Downstream 100 bases:

>100_bases
TTCATATCATATACATGGCGGCTGGAAACAGCCGCCGTTTTGGAAGTAACAAGCTGTTTTATGAGCTGAATGGAAAACCT
ATGTACAGGCATCTGCTTGA

Product: xanthine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 791; Mature: 790

Protein sequence:

>791_residues
MSTNQTNENSFNRARRDYHAVGKCIPKKDSSQLLLGKPVFTDDITPRDALVIKLLRSPYANAIVEDVKTDIALKVPGMVA
VYTWEDVPKKRFSIAGQTFPEPSPYDRLILDRHVRSVGDAVAIVVGESEKAVDKALNMIKVKYTVLEPVLDFRKSLDNKV
LVHPEDDWSSSIDTGDVKRNLIHHEEDEHGNVEKILSECDEIIEHTYRIKAAQQAYMETCRAYCEIDRYGRLHCISSTQI
VFHLRRILANALDIPKSMVRAEKPRIGGGFGAKQTAVCEVYPAFVTWKTKRPSKIIYSRKECQTIASPRHEMEVTVRLGA
MKDGHIRAIDLYTLSNGGAYGEHSTTTVGLSGHKSLPLYTGGCEATRFSCDVVYTNVQAAGAYRGYGATQGIFALESTVN
ELAEKLHIDPVELRLKNIVREGMFMPAYFGETANACALDRCIMHCADNFHWAEKYPVRDMGNGKVRAAGMALAMQGSCIS
NVDVGSCTLKLSDCGTYNMMIGAADMGTGCDTILAQMAAEVLDCEPDDITVFGADTDASPYDSGSYASSTTYITGMATQN
AALELRENIKKIGAQLLGCAASEVDFDGKEVYIINPDGADNVAVSVSLSDIATKAQVNNTIPVDVTATYSSPVSPPPYMV
GMVEIELDKETGAVKILDYQAVVDCGIPVNPNLARVQTEGGIGQGIGMALYENVTYNAGGKIAENDFMQYKIPTRQDVGH
INVEFETSYEPSGPFGVKSIGEIVINTPAPALAHAIYRATGVWHRTVPFTPEKILMGMADPNWHEKDLRVK

Sequences:

>Translated_791_residues
MSTNQTNENSFNRARRDYHAVGKCIPKKDSSQLLLGKPVFTDDITPRDALVIKLLRSPYANAIVEDVKTDIALKVPGMVA
VYTWEDVPKKRFSIAGQTFPEPSPYDRLILDRHVRSVGDAVAIVVGESEKAVDKALNMIKVKYTVLEPVLDFRKSLDNKV
LVHPEDDWSSSIDTGDVKRNLIHHEEDEHGNVEKILSECDEIIEHTYRIKAAQQAYMETCRAYCEIDRYGRLHCISSTQI
VFHLRRILANALDIPKSMVRAEKPRIGGGFGAKQTAVCEVYPAFVTWKTKRPSKIIYSRKECQTIASPRHEMEVTVRLGA
MKDGHIRAIDLYTLSNGGAYGEHSTTTVGLSGHKSLPLYTGGCEATRFSCDVVYTNVQAAGAYRGYGATQGIFALESTVN
ELAEKLHIDPVELRLKNIVREGMFMPAYFGETANACALDRCIMHCADNFHWAEKYPVRDMGNGKVRAAGMALAMQGSCIS
NVDVGSCTLKLSDCGTYNMMIGAADMGTGCDTILAQMAAEVLDCEPDDITVFGADTDASPYDSGSYASSTTYITGMATQN
AALELRENIKKIGAQLLGCAASEVDFDGKEVYIINPDGADNVAVSVSLSDIATKAQVNNTIPVDVTATYSSPVSPPPYMV
GMVEIELDKETGAVKILDYQAVVDCGIPVNPNLARVQTEGGIGQGIGMALYENVTYNAGGKIAENDFMQYKIPTRQDVGH
INVEFETSYEPSGPFGVKSIGEIVINTPAPALAHAIYRATGVWHRTVPFTPEKILMGMADPNWHEKDLRVK
>Mature_790_residues
STNQTNENSFNRARRDYHAVGKCIPKKDSSQLLLGKPVFTDDITPRDALVIKLLRSPYANAIVEDVKTDIALKVPGMVAV
YTWEDVPKKRFSIAGQTFPEPSPYDRLILDRHVRSVGDAVAIVVGESEKAVDKALNMIKVKYTVLEPVLDFRKSLDNKVL
VHPEDDWSSSIDTGDVKRNLIHHEEDEHGNVEKILSECDEIIEHTYRIKAAQQAYMETCRAYCEIDRYGRLHCISSTQIV
FHLRRILANALDIPKSMVRAEKPRIGGGFGAKQTAVCEVYPAFVTWKTKRPSKIIYSRKECQTIASPRHEMEVTVRLGAM
KDGHIRAIDLYTLSNGGAYGEHSTTTVGLSGHKSLPLYTGGCEATRFSCDVVYTNVQAAGAYRGYGATQGIFALESTVNE
LAEKLHIDPVELRLKNIVREGMFMPAYFGETANACALDRCIMHCADNFHWAEKYPVRDMGNGKVRAAGMALAMQGSCISN
VDVGSCTLKLSDCGTYNMMIGAADMGTGCDTILAQMAAEVLDCEPDDITVFGADTDASPYDSGSYASSTTYITGMATQNA
ALELRENIKKIGAQLLGCAASEVDFDGKEVYIINPDGADNVAVSVSLSDIATKAQVNNTIPVDVTATYSSPVSPPPYMVG
MVEIELDKETGAVKILDYQAVVDCGIPVNPNLARVQTEGGIGQGIGMALYENVTYNAGGKIAENDFMQYKIPTRQDVGHI
NVEFETSYEPSGPFGVKSIGEIVINTPAPALAHAIYRATGVWHRTVPFTPEKILMGMADPNWHEKDLRVK

Specific function: Probably has no xanthine dehydrogenase activity; however deletion results in increased adenine sensitivity, suggesting that this protein contributes to the conversion of adenine to guanine nucleotides during purine salvage [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=817, Percent_Identity=24.3574051407589, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI71773480, Length=802, Percent_Identity=24.6882793017456, Blast_Score=149, Evalue=1e-35,
Organism=Escherichia coli, GI1789246, Length=805, Percent_Identity=36.0248447204969, Blast_Score=448, Evalue=1e-127,
Organism=Escherichia coli, GI1789230, Length=766, Percent_Identity=32.6370757180157, Blast_Score=354, Evalue=1e-98,
Organism=Escherichia coli, GI1786478, Length=739, Percent_Identity=26.2516914749662, Blast_Score=143, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17540638, Length=784, Percent_Identity=24.8724489795918, Blast_Score=174, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17539860, Length=723, Percent_Identity=22.4066390041494, Blast_Score=121, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI32566215, Length=571, Percent_Identity=25.0437828371278, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI17737937, Length=723, Percent_Identity=23.3748271092669, Blast_Score=158, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24647199, Length=748, Percent_Identity=20.5882352941176, Blast_Score=96, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24647201, Length=771, Percent_Identity=22.1789883268482, Blast_Score=92, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24647193, Length=825, Percent_Identity=22.9090909090909, Blast_Score=89, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR000674
- InterPro:   IPR008274
- InterPro:   IPR001041
- InterPro:   IPR017699 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2; PF01799 Fer2_2 [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 86608; Mature: 86477

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTNQTNENSFNRARRDYHAVGKCIPKKDSSQLLLGKPVFTDDITPRDALVIKLLRSPYA
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHCCHH
NAIVEDVKTDIALKVPGMVAVYTWEDVPKKRFSIAGQTFPEPSPYDRLILDRHVRSVGDA
HHHHHHHHCCEEEECCCEEEEEECCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCE
VAIVVGESEKAVDKALNMIKVKYTVLEPVLDFRKSLDNKVLVHPEDDWSSSIDTGDVKRN
EEEEECCCHHHHHHHHHHHEEHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHH
LIHHEEDEHGNVEKILSECDEIIEHTYRIKAAQQAYMETCRAYCEIDRYGRLHCISSTQI
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHH
VFHLRRILANALDIPKSMVRAEKPRIGGGFGAKQTAVCEVYPAFVTWKTKRPSKIIYSRK
HHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCEEEEEEEEEEEEECCCCCHHHCCHH
ECQTIASPRHEMEVTVRLGAMKDGHIRAIDLYTLSNGGAYGEHSTTTVGLSGHKSLPLYT
HHHHHHCCCCCEEEEEEEECCCCCCEEEEEEEEECCCCCCCCCCCEEEEECCCCCCCEEE
GGCEATRFSCDVVYTNVQAAGAYRGYGATQGIFALESTVNELAEKLHIDPVELRLKNIVR
CCCCCEEEEEEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
EGMFMPAYFGETANACALDRCIMHCADNFHWAEKYPVRDMGNGKVRAAGMALAMQGSCIS
HCCCCCHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCC
NVDVGSCTLKLSDCGTYNMMIGAADMGTGCDTILAQMAAEVLDCEPDDITVFGADTDASP
CCCCCEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCC
YDSGSYASSTTYITGMATQNAALELRENIKKIGAQLLGCAASEVDFDGKEVYIINPDGAD
CCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCHHHCCCCCCCEEEEECCCCCC
NVAVSVSLSDIATKAQVNNTIPVDVTATYSSPVSPPPYMVGMVEIELDKETGAVKILDYQ
CEEEEEEHHHHHHHHHCCCCCEEEEEEECCCCCCCCCEEEEEEEEEECCCCCEEEEEEEE
AVVDCGIPVNPNLARVQTEGGIGQGIGMALYENVTYNAGGKIAENDFMQYKIPTRQDVGH
EEEECCCCCCCCCEEEEECCCCCCCCCCHHEECEEECCCCCEECCCCEEEECCCCCCCCE
INVEFETSYEPSGPFGVKSIGEIVINTPAPALAHAIYRATGVWHRTVPFTPEKILMGMAD
EEEEEEECCCCCCCCCHHCCCCEEECCCCHHHHHHHHHHHCCEEECCCCCHHHHEEECCC
PNWHEKDLRVK
CCCCCCCCCCC
>Mature Secondary Structure 
STNQTNENSFNRARRDYHAVGKCIPKKDSSQLLLGKPVFTDDITPRDALVIKLLRSPYA
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHCCHH
NAIVEDVKTDIALKVPGMVAVYTWEDVPKKRFSIAGQTFPEPSPYDRLILDRHVRSVGDA
HHHHHHHHCCEEEECCCEEEEEECCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCE
VAIVVGESEKAVDKALNMIKVKYTVLEPVLDFRKSLDNKVLVHPEDDWSSSIDTGDVKRN
EEEEECCCHHHHHHHHHHHEEHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHH
LIHHEEDEHGNVEKILSECDEIIEHTYRIKAAQQAYMETCRAYCEIDRYGRLHCISSTQI
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHH
VFHLRRILANALDIPKSMVRAEKPRIGGGFGAKQTAVCEVYPAFVTWKTKRPSKIIYSRK
HHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCEEEEEEEEEEEEECCCCCHHHCCHH
ECQTIASPRHEMEVTVRLGAMKDGHIRAIDLYTLSNGGAYGEHSTTTVGLSGHKSLPLYT
HHHHHHCCCCCEEEEEEEECCCCCCEEEEEEEEECCCCCCCCCCCEEEEECCCCCCCEEE
GGCEATRFSCDVVYTNVQAAGAYRGYGATQGIFALESTVNELAEKLHIDPVELRLKNIVR
CCCCCEEEEEEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
EGMFMPAYFGETANACALDRCIMHCADNFHWAEKYPVRDMGNGKVRAAGMALAMQGSCIS
HCCCCCHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCC
NVDVGSCTLKLSDCGTYNMMIGAADMGTGCDTILAQMAAEVLDCEPDDITVFGADTDASP
CCCCCEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCC
YDSGSYASSTTYITGMATQNAALELRENIKKIGAQLLGCAASEVDFDGKEVYIINPDGAD
CCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCHHHCCCCCCCEEEEECCCCCC
NVAVSVSLSDIATKAQVNNTIPVDVTATYSSPVSPPPYMVGMVEIELDKETGAVKILDYQ
CEEEEEEHHHHHHHHHCCCCCEEEEEEECCCCCCCCCEEEEEEEEEECCCCCEEEEEEEE
AVVDCGIPVNPNLARVQTEGGIGQGIGMALYENVTYNAGGKIAENDFMQYKIPTRQDVGH
EEEECCCCCCCCCEEEEECCCCCCCCCCHHEECEEECCCCCEECCCCEEEECCCCCCCCE
INVEFETSYEPSGPFGVKSIGEIVINTPAPALAHAIYRATGVWHRTVPFTPEKILMGMAD
EEEEEEECCCCCCCCCHHCCCCEEECCCCHHHHHHHHHHHCCEEECCCCCHHHHEEECCC
PNWHEKDLRVK
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Two 2Fe-2S centers [C]

Metal ions: Fe; Mo [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]