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The map label for this gene is ygcA [C]

Identifier: 238925373

GI number: 238925373

Start: 2902626

End: 2903882

Strand: Reverse

Name: ygcA [C]

Synonym: EUBREC_3028

Alternate gene names: 238925373

Gene position: 2903882-2902626 (Counterclockwise)

Preceding gene: 238925374

Following gene: 238925372

Centisome position: 84.18

GC content: 46.86

Gene sequence:

>1257_bases
ATGGCGGGAAATCAAGGCAATTACAGGGAAAACCCCACGCGTAATGAGAAGAAATACAAAAAAGCCAACGGACAGCCGAG
ACTAAAGGAGAAAAGCAGCCGGGCAAAGAGCGATAACGTATGTCCGTATGCGAAGAAATGTGGCGGATGCGACTATCAGG
GCGTAGAATATAAGGAACAGTTAAAAACCAAGCAGGCATACATGAAAAAGCTGCTAAAGCCTTTTTGCTTTGTGGAGCCG
ATTGTCGGCATGAAAAATCCGCTCTATTATCGTCACAAGGTTCATGCAGCCTTTGACTGTACGAGGCGCGGTCAGATTGT
GGCGGGAGCCTACAGGAAAAACACACATGATGTGGTGGATATAGAAAGCTGCATGATAGAGGAGCAGGAGTCAGATGAGA
TAATAAGGGACATAAAGGATATGCTCCGCTCATTCAGGATAAAGACCTATGATGAGGACACCGGCTATGGGCTTCTCAGA
CATGTGCTTGTAAGAAAGGGTTATGCAACAGGGCAGATAATGGTAGTGCTTGTCCTGGCATCGCCGATACTTCCATCGAA
GAATAATTTCGTAAAAGCACTCAGGAAAAAGCATCCCAATATCACGACAGTGGTGCTCAACGTGAATGATAAAAAGACAA
GCATGGTGCTCGGAGACAGAAACATCACGCTTTATGGCAAGGGCTTCATAGAGGATAAGCTGTGCGGCTGCACCTTTCGC
ATCTCACCAGGCTCGTTTTATCAGGTGAATCCGGTACAGACGGAGCTTTTATACGAAAAAGCCATTCATGAGGCACACCT
CACCGGCAAGGAGCGCATAATCGATGCATACTGCGGCACCGGAACAATAGGCATCATAGCAGCGAAAAATGCAGGTGAAG
TCATCGGGGTCGAGCTAAACCGTGATGCAATCCGCGATGCAGTCATCAATGCAAAGCGAAACGACATCAGAAATATCCGC
TTCTACAATGACGATGCCGGAAAATTCATGGTTGAGATGGCACAAAAGGGTGAGAAAGCGGATGTTGTCATAATGGATCC
TCCAAGAACCGGCAGCGACGAGGCATTTTTATCATCGGTTGTCAAGCTGTCACCGGAGAGAGTGGTGTATGTGTCATGTG
GTCCGGAAACACTGGCGAGGGATTTAAAGTATCTCACAAAGCATGGATATACAGTGAAGCGTGCAACACCATATGACTGT
TTTCCATTTACAAGCCACATTGAAACGGTTTGTTGTCTTACTTTCCAAGGGCGCTAA

Upstream 100 bases:

>100_bases
AGCAGGCGCTTCAAGCGGATGGCACTGTATAGATAATCATGTGTATTTATATAATACATACGGCAAGTAATCAGCACAGC
TGATTTTAAGGAGCGCAGAT

Downstream 100 bases:

>100_bases
AGGTCCGGTGGACCTTTGCTCAGCGCGGACCGAAGTGGAACGGAGACTGGTCGACAGTAGAAAAGTGAACGTTGACTTCT
CTTAAGAGAATATAGATTTA

Product: RNA methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MAGNQGNYRENPTRNEKKYKKANGQPRLKEKSSRAKSDNVCPYAKKCGGCDYQGVEYKEQLKTKQAYMKKLLKPFCFVEP
IVGMKNPLYYRHKVHAAFDCTRRGQIVAGAYRKNTHDVVDIESCMIEEQESDEIIRDIKDMLRSFRIKTYDEDTGYGLLR
HVLVRKGYATGQIMVVLVLASPILPSKNNFVKALRKKHPNITTVVLNVNDKKTSMVLGDRNITLYGKGFIEDKLCGCTFR
ISPGSFYQVNPVQTELLYEKAIHEAHLTGKERIIDAYCGTGTIGIIAAKNAGEVIGVELNRDAIRDAVINAKRNDIRNIR
FYNDDAGKFMVEMAQKGEKADVVIMDPPRTGSDEAFLSSVVKLSPERVVYVSCGPETLARDLKYLTKHGYTVKRATPYDC
FPFTSHIETVCCLTFQGR

Sequences:

>Translated_418_residues
MAGNQGNYRENPTRNEKKYKKANGQPRLKEKSSRAKSDNVCPYAKKCGGCDYQGVEYKEQLKTKQAYMKKLLKPFCFVEP
IVGMKNPLYYRHKVHAAFDCTRRGQIVAGAYRKNTHDVVDIESCMIEEQESDEIIRDIKDMLRSFRIKTYDEDTGYGLLR
HVLVRKGYATGQIMVVLVLASPILPSKNNFVKALRKKHPNITTVVLNVNDKKTSMVLGDRNITLYGKGFIEDKLCGCTFR
ISPGSFYQVNPVQTELLYEKAIHEAHLTGKERIIDAYCGTGTIGIIAAKNAGEVIGVELNRDAIRDAVINAKRNDIRNIR
FYNDDAGKFMVEMAQKGEKADVVIMDPPRTGSDEAFLSSVVKLSPERVVYVSCGPETLARDLKYLTKHGYTVKRATPYDC
FPFTSHIETVCCLTFQGR
>Mature_417_residues
AGNQGNYRENPTRNEKKYKKANGQPRLKEKSSRAKSDNVCPYAKKCGGCDYQGVEYKEQLKTKQAYMKKLLKPFCFVEPI
VGMKNPLYYRHKVHAAFDCTRRGQIVAGAYRKNTHDVVDIESCMIEEQESDEIIRDIKDMLRSFRIKTYDEDTGYGLLRH
VLVRKGYATGQIMVVLVLASPILPSKNNFVKALRKKHPNITTVVLNVNDKKTSMVLGDRNITLYGKGFIEDKLCGCTFRI
SPGSFYQVNPVQTELLYEKAIHEAHLTGKERIIDAYCGTGTIGIIAAKNAGEVIGVELNRDAIRDAVINAKRNDIRNIRF
YNDDAGKFMVEMAQKGEKADVVIMDPPRTGSDEAFLSSVVKLSPERVVYVSCGPETLARDLKYLTKHGYTVKRATPYDCF
PFTSHIETVCCLTFQGR

Specific function: Could Be A 23s rRNA (Uracil-5-)-Methyltransferase. [C]

COG id: COG2265

COG function: function code J; SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRAM domain [H]

Homologues:

Organism=Homo sapiens, GI34222389, Length=321, Percent_Identity=26.1682242990654, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI51173878, Length=321, Percent_Identity=26.1682242990654, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI269784680, Length=207, Percent_Identity=28.9855072463768, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI269784676, Length=207, Percent_Identity=28.9855072463768, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI20149688, Length=207, Percent_Identity=28.9855072463768, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI269784678, Length=207, Percent_Identity=28.9855072463768, Blast_Score=92, Evalue=6e-19,
Organism=Escherichia coli, GI1789148, Length=411, Percent_Identity=26.5206812652068, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1787083, Length=375, Percent_Identity=22.9333333333333, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1790403, Length=386, Percent_Identity=23.8341968911917, Blast_Score=82, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6322909, Length=356, Percent_Identity=27.247191011236, Blast_Score=90, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24666579, Length=446, Percent_Identity=25.7847533632287, Blast_Score=134, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016027
- InterPro:   IPR001566
- InterPro:   IPR002792
- InterPro:   IPR010280 [H]

Pfam domain/function: PF01938 TRAM; PF05958 tRNA_U5-meth_tr [H]

EC number: NA

Molecular weight: Translated: 47231; Mature: 47100

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGNQGNYRENPTRNEKKYKKANGQPRLKEKSSRAKSDNVCPYAKKCGGCDYQGVEYKEQ
CCCCCCCCCCCCCCCHHHHHHCCCCCCHHHHHHCCCCCCCCCHHHHCCCCCCCCCCHHHH
LKTKQAYMKKLLKPFCFVEPIVGMKNPLYYRHKVHAAFDCTRRGQIVAGAYRKNTHDVVD
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHCCCCCEEEECCCCCCCCEEE
IESCMIEEQESDEIIRDIKDMLRSFRIKTYDEDTGYGLLRHVLVRKGYATGQIMVVLVLA
HHHHHCCCCCHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHCCCCCCHHEEEEEHH
SPILPSKNNFVKALRKKHPNITTVVLNVNDKKTSMVLGDRNITLYGKGFIEDKLCGCTFR
CCCCCCCHHHHHHHHHCCCCEEEEEEEECCCEEEEEEECCEEEEEECCCCCCCCCCEEEE
ISPGSFYQVNPVQTELLYEKAIHEAHLTGKERIIDAYCGTGTIGIIAAKNAGEVIGVELN
ECCCCEEEECCHHHHHHHHHHHHHHHCCCHHHEEEHHCCCCCEEEEEECCCCCEEEEEEC
RDAIRDAVINAKRNDIRNIRFYNDDAGKFMVEMAQKGEKADVVIMDPPRTGSDEAFLSSV
HHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHH
VKLSPERVVYVSCGPETLARDLKYLTKHGYTVKRATPYDCFPFTSHIETVCCLTFQGR
HHCCCCEEEEEECCHHHHHHHHHHHHHCCCEEECCCCCCCCCCHHHCCEEEEEEECCC
>Mature Secondary Structure 
AGNQGNYRENPTRNEKKYKKANGQPRLKEKSSRAKSDNVCPYAKKCGGCDYQGVEYKEQ
CCCCCCCCCCCCCCHHHHHHCCCCCCHHHHHHCCCCCCCCCHHHHCCCCCCCCCCHHHH
LKTKQAYMKKLLKPFCFVEPIVGMKNPLYYRHKVHAAFDCTRRGQIVAGAYRKNTHDVVD
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHCCCCCEEEECCCCCCCCEEE
IESCMIEEQESDEIIRDIKDMLRSFRIKTYDEDTGYGLLRHVLVRKGYATGQIMVVLVLA
HHHHHCCCCCHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHCCCCCCHHEEEEEHH
SPILPSKNNFVKALRKKHPNITTVVLNVNDKKTSMVLGDRNITLYGKGFIEDKLCGCTFR
CCCCCCCHHHHHHHHHCCCCEEEEEEEECCCEEEEEEECCEEEEEECCCCCCCCCCEEEE
ISPGSFYQVNPVQTELLYEKAIHEAHLTGKERIIDAYCGTGTIGIIAAKNAGEVIGVELN
ECCCCEEEECCHHHHHHHHHHHHHHHCCCHHHEEEHHCCCCCEEEEEECCCCCEEEEEEC
RDAIRDAVINAKRNDIRNIRFYNDDAGKFMVEMAQKGEKADVVIMDPPRTGSDEAFLSSV
HHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHH
VKLSPERVVYVSCGPETLARDLKYLTKHGYTVKRATPYDCFPFTSHIETVCCLTFQGR
HHCCCCEEEEEECCHHHHHHHHHHHHHCCCEEECCCCCCCCCCHHHCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]