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The map label for this gene is polC [H]

Identifier: 238925353

GI number: 238925353

Start: 2886327

End: 2887064

Strand: Reverse

Name: polC [H]

Synonym: EUBREC_3008

Alternate gene names: 238925353

Gene position: 2887064-2886327 (Counterclockwise)

Preceding gene: 238925354

Following gene: 238925351

Centisome position: 83.69

GC content: 45.53

Gene sequence:

>738_bases
ATGAGCAACATAGACAATATAAAAAATTACACGGTGATTGACCTTGAAATGACAGGTCTTTCAGCTAAAAACGACAAGAT
AATAGAGATAGGTGCGGCACGTGTGAGGGGCGGCGAGATAGTGGATACGATATCCACACTGGTAAATCCGAAGCAGCATA
TTCCACAGCGTGTGCAGGAATTAACGGGAATTACCGACAGTGATGTGGAAAACGCGGCAGATATGGACGAGGCTGTGGAT
AACCTGCTTAATTTTATCGGTGATGATATCATACTCGGGCAGAATGTGACCTTTGATTACAGCTTTTTAAAGCAGTGGGC
GGTAAATCACAAGAGAACCCTCTCGCTGAATGCATATGATACTCTGAAAATAGCCAGAAAATGTCTGCCTGCTGAGCAGT
CAAAGAAGCTGGAGGATTTGTGCGAGTATTTTGGTGTAAGTAGGAAAAATGCCCACAGGGCGCTCGATGATGCGATAGAG
ACAAAGCAGATATTTGAAAAGCTGCTTGCACTGATGGATGAAAAGGGTGAGCCGGTGGAGTCAAAGCCGCTTGTATACAA
GGCAAAAAAACAGACACCAGCCACGGCACATCAGGTCAGACAGCTAAGGGAGCTGATGGCTGAGTATGGGATAGCAGATA
TCATATCGTGGGACAACCTGACCAGAAGTCAGGCCTCAAGGCTGTACGATGAATATCGCAGTAAGTACATTAATAGGTGT
GTGGATGGCTCGGAATAA

Upstream 100 bases:

>100_bases
CGCTTTTCCACTACGACATGAGAGACCCGCTTGACCACCAGGCGCTGGTGGAGTATGTAGATAACAGTAAAAAGCCGGGA
AGGTTTACGGACTAAGAAAA

Downstream 100 bases:

>100_bases
CTTTCAATACAATAAGTTATAATACAATAAGCTATAATACAATAAGCTATAACGTAATTTAATTACCGGCCGAGGCGGTA
TCAGCCTGTAGGCTCTCAAG

Product: DNA polymerase III, epsilon subunit

Products: NA

Alternate protein names: PolIII [H]

Number of amino acids: Translated: 245; Mature: 244

Protein sequence:

>245_residues
MSNIDNIKNYTVIDLEMTGLSAKNDKIIEIGAARVRGGEIVDTISTLVNPKQHIPQRVQELTGITDSDVENAADMDEAVD
NLLNFIGDDIILGQNVTFDYSFLKQWAVNHKRTLSLNAYDTLKIARKCLPAEQSKKLEDLCEYFGVSRKNAHRALDDAIE
TKQIFEKLLALMDEKGEPVESKPLVYKAKKQTPATAHQVRQLRELMAEYGIADIISWDNLTRSQASRLYDEYRSKYINRC
VDGSE

Sequences:

>Translated_245_residues
MSNIDNIKNYTVIDLEMTGLSAKNDKIIEIGAARVRGGEIVDTISTLVNPKQHIPQRVQELTGITDSDVENAADMDEAVD
NLLNFIGDDIILGQNVTFDYSFLKQWAVNHKRTLSLNAYDTLKIARKCLPAEQSKKLEDLCEYFGVSRKNAHRALDDAIE
TKQIFEKLLALMDEKGEPVESKPLVYKAKKQTPATAHQVRQLRELMAEYGIADIISWDNLTRSQASRLYDEYRSKYINRC
VDGSE
>Mature_244_residues
SNIDNIKNYTVIDLEMTGLSAKNDKIIEIGAARVRGGEIVDTISTLVNPKQHIPQRVQELTGITDSDVENAADMDEAVDN
LLNFIGDDIILGQNVTFDYSFLKQWAVNHKRTLSLNAYDTLKIARKCLPAEQSKKLEDLCEYFGVSRKNAHRALDDAIET
KQIFEKLLALMDEKGEPVESKPLVYKAKKQTPATAHQVRQLRELMAEYGIADIISWDNLTRSQASRLYDEYRSKYINRCV
DGSE

Specific function: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG2176

COG function: function code L; DNA polymerase III, alpha subunit (gram-positive type)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 exonuclease domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011708
- InterPro:   IPR006054
- InterPro:   IPR006055
- InterPro:   IPR013520
- InterPro:   IPR016027
- InterPro:   IPR004013
- InterPro:   IPR003141
- InterPro:   IPR006308
- InterPro:   IPR012337 [H]

Pfam domain/function: PF07733 DNA_pol3_alpha; PF00929 Exonuc_X-T; PF02811 PHP [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 27742; Mature: 27611

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNIDNIKNYTVIDLEMTGLSAKNDKIIEIGAARVRGGEIVDTISTLVNPKQHIPQRVQE
CCCCCCCCCEEEEEEEECCCCCCCCCEEEECCHHCCCCHHHHHHHHHCCCHHHHHHHHHH
LTGITDSDVENAADMDEAVDNLLNFIGDDIILGQNVTFDYSFLKQWAVNHKRTLSLNAYD
HHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHCCCCCEEECCHHH
TLKIARKCLPAEQSKKLEDLCEYFGVSRKNAHRALDDAIETKQIFEKLLALMDEKGEPVE
HHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
SKPLVYKAKKQTPATAHQVRQLRELMAEYGIADIISWDNLTRSQASRLYDEYRSKYINRC
CCCCEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VDGSE
CCCCC
>Mature Secondary Structure 
SNIDNIKNYTVIDLEMTGLSAKNDKIIEIGAARVRGGEIVDTISTLVNPKQHIPQRVQE
CCCCCCCCEEEEEEEECCCCCCCCCEEEECCHHCCCCHHHHHHHHHCCCHHHHHHHHHH
LTGITDSDVENAADMDEAVDNLLNFIGDDIILGQNVTFDYSFLKQWAVNHKRTLSLNAYD
HHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHCCCCCEEECCHHH
TLKIARKCLPAEQSKKLEDLCEYFGVSRKNAHRALDDAIETKQIFEKLLALMDEKGEPVE
HHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
SKPLVYKAKKQTPATAHQVRQLRELMAEYGIADIISWDNLTRSQASRLYDEYRSKYINRC
CCCCEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VDGSE
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11792842 [H]