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The map label for this gene is trpC [H]

Identifier: 238925322

GI number: 238925322

Start: 2860132

End: 2860920

Strand: Reverse

Name: trpC [H]

Synonym: EUBREC_2977

Alternate gene names: 238925322

Gene position: 2860920-2860132 (Counterclockwise)

Preceding gene: 238925323

Following gene: 238925321

Centisome position: 82.93

GC content: 43.85

Gene sequence:

>789_bases
ATGAATATTTTAGATCAGCTAGCAGAATATTCAAGGCTTCGCGTGGCAGAGGACAAGAAAAAAATAAGCCTTGAGGAAAT
GAAAAATATCGCGATTCAGATGAAAAACGAAAAGCTTTGTGATTTTGCATTTGAAAAAACACTCAAAAAGGATGGCTTGA
GCTTCATATGCGAGTGCAAGAAGGCTTCACCGTCAAAGGGGCTTATAGAGCCGGATTTCAGATATCTTGAAATTGCAAGG
GAATACGAGGCGGCAGGTGCGGATTGCATCTCGGTACTGACAGAGCCGAAGTGGTTTTTAGGCTCGGATGAGTATCTTAA
GGAGATTGCAAAAACGGTTTCGATTCCGTGCATCCGAAAAGATTTTACGGTTAATGAATATCAGATATATCAGGCAAAGA
CACTCGGTGCCGCTGCGGTGCTTTTAATCTGCTCCATACTGTCAGAGGAACAGCTTGGTGAATATATAAAAATCTGTGAC
AGTCTTGGCATAAGCGCCCTTGTGGAGATACACGATGAAAAAGAGGCAGGGATGGCGGTAAGAGCCGGTGCCAGAATAAT
AGGTGTCAACAACCGCAATCTGAAGGATTTTACAGTTGATACAGCTAACAGCAGAAAGCTTCGTGACCTGATTCCCGATG
ACATCATATTTGTATCGGAAAGCGGTGTAAAGAGCACAGACGATATCAGGGCAATACGTGAAATCGGAGCTGACGCAGTG
CTTATCGGAGAGACGCTGATGAGAGCGGACGACAAAAAGGCTAAGCTTGATGAATTGCGATTAAGCTAA

Upstream 100 bases:

>100_bases
TAGCAGCTGAAATCATTGATTCAGGAAAAGCACTTGAAACACTCGATAAGCTCATTGATGTAAGCAACAGCTAAGCACAC
AAAACAGGAAAGGAAAAGCG

Downstream 100 bases:

>100_bases
TAGAGATATATAAGTATCTTCATGGTTTTAAGAATATCTGTAACTATTCAGTACAGAAAACAAAATATTTACAAATATAC
ATCAGAAGGGAAAACATCAT

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MNILDQLAEYSRLRVAEDKKKISLEEMKNIAIQMKNEKLCDFAFEKTLKKDGLSFICECKKASPSKGLIEPDFRYLEIAR
EYEAAGADCISVLTEPKWFLGSDEYLKEIAKTVSIPCIRKDFTVNEYQIYQAKTLGAAAVLLICSILSEEQLGEYIKICD
SLGISALVEIHDEKEAGMAVRAGARIIGVNNRNLKDFTVDTANSRKLRDLIPDDIIFVSESGVKSTDDIRAIREIGADAV
LIGETLMRADDKKAKLDELRLS

Sequences:

>Translated_262_residues
MNILDQLAEYSRLRVAEDKKKISLEEMKNIAIQMKNEKLCDFAFEKTLKKDGLSFICECKKASPSKGLIEPDFRYLEIAR
EYEAAGADCISVLTEPKWFLGSDEYLKEIAKTVSIPCIRKDFTVNEYQIYQAKTLGAAAVLLICSILSEEQLGEYIKICD
SLGISALVEIHDEKEAGMAVRAGARIIGVNNRNLKDFTVDTANSRKLRDLIPDDIIFVSESGVKSTDDIRAIREIGADAV
LIGETLMRADDKKAKLDELRLS
>Mature_262_residues
MNILDQLAEYSRLRVAEDKKKISLEEMKNIAIQMKNEKLCDFAFEKTLKKDGLSFICECKKASPSKGLIEPDFRYLEIAR
EYEAAGADCISVLTEPKWFLGSDEYLKEIAKTVSIPCIRKDFTVNEYQIYQAKTLGAAAVLLICSILSEEQLGEYIKICD
SLGISALVEIHDEKEAGMAVRAGARIIGVNNRNLKDFTVDTANSRKLRDLIPDDIIFVSESGVKSTDDIRAIREIGADAV
LIGETLMRADDKKAKLDELRLS

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=219, Percent_Identity=36.5296803652968, Blast_Score=143, Evalue=9e-36,
Organism=Saccharomyces cerevisiae, GI6322638, Length=212, Percent_Identity=38.6792452830189, Blast_Score=143, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 29323; Mature: 29323

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILDQLAEYSRLRVAEDKKKISLEEMKNIAIQMKNEKLCDFAFEKTLKKDGLSFICECK
CCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHEEECCCHHHHHHHHHHHHHCCCCEEEECC
KASPSKGLIEPDFRYLEIAREYEAAGADCISVLTEPKWFLGSDEYLKEIAKTVSIPCIRK
CCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCC
DFTVNEYQIYQAKTLGAAAVLLICSILSEEQLGEYIKICDSLGISALVEIHDEKEAGMAV
CCCCCCEEEEHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCHHHEEEECCCHHCCEEE
RAGARIIGVNNRNLKDFTVDTANSRKLRDLIPDDIIFVSESGVKSTDDIRAIREIGADAV
ECCEEEEECCCCCCCEEEEECCCCCHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCCEE
LIGETLMRADDKKAKLDELRLS
EHHHHHHHCCCCHHHHHHHCCC
>Mature Secondary Structure
MNILDQLAEYSRLRVAEDKKKISLEEMKNIAIQMKNEKLCDFAFEKTLKKDGLSFICECK
CCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHEEECCCHHHHHHHHHHHHHCCCCEEEECC
KASPSKGLIEPDFRYLEIAREYEAAGADCISVLTEPKWFLGSDEYLKEIAKTVSIPCIRK
CCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCC
DFTVNEYQIYQAKTLGAAAVLLICSILSEEQLGEYIKICDSLGISALVEIHDEKEAGMAV
CCCCCCEEEEHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCHHHEEEECCCHHCCEEE
RAGARIIGVNNRNLKDFTVDTANSRKLRDLIPDDIIFVSESGVKSTDDIRAIREIGADAV
ECCEEEEECCCCCCCEEEEECCCCCHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCCEE
LIGETLMRADDKKAKLDELRLS
EHHHHHHHCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA