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The map label for this gene is phoR [H]

Identifier: 238925299

GI number: 238925299

Start: 2835391

End: 2837814

Strand: Reverse

Name: phoR [H]

Synonym: EUBREC_2953

Alternate gene names: 238925299

Gene position: 2837814-2835391 (Counterclockwise)

Preceding gene: 238925300

Following gene: 238925296

Centisome position: 82.26

GC content: 42.49

Gene sequence:

>2424_bases
ATGAAAAAAATATCAAGGAATCTGTGGCTTAAGCTTGCGGCATTTATAGTGTGCTCGGTCATGGCGGCAGGGCTTGTTGT
AACAACGATAGTTGCAGTGTATACAAACAATTATGAAAGTACAGCACAGCTAAGGGATGAAATTCATGCGAATATTGCAG
GAGCCTATAGCAGACAGATGGTGTACAATTATGAATCCGGTGATGACAATGCATTTTCGCAGATGATGGACGATACCAAT
CTGCAGGCCGCAGTGGTAAAGAGTAATGAAACATCAGAGGACAAGGTAGATGTAAAATCTGATGCAGCAAAGGTGTATTC
AAGTGTGGATGAAATATCAAATCCGGATTATATTTTTAGCTACAAGGCAAAGAACTTAAAGTGGAACAGGCTATCATATC
TGTGGGATGCAATGAGCGGCCGCTATGAAGAGTCAGACGATGCATCAAACAATATGAACAGTGAGAGAATCAGCTCAATC
ATGTATTCCAAGACAAATGGGCTCTTTTATCTGTGCCTGAATGATGGTACCGCTTATGTCATTCCAAAGGTGAGGGTGAT
GACAGGCTCTAACGATAACAGCTCGCTTGGCTTATATAAGGCAGTTGAGAAAACCGATGAGAATGGAAATAATTACTTTG
CCTACGAGGAGATGTTTACAGGCCAGTCACTCGATATTACAGGCTTTGCCGAGTGGAAAAATGTAAAGTGCTATGATGAA
AAAGGAAATCATATAAAGTGTGGCATGAATCTGAGTGATGACGGCGATTCGCGCTTTGATAGTGACGGCTCTTACTACGA
TTATGATGAGGATATTTATTATGACAGCTACGAAATCATAAAAGTGGTGGAGCAGGTGAATGAGAGCTATGAGCTTTTAC
CGGATACCTTTAATATATCGGATACCGGAATTGTGTACTATCCATACACCCAAACGGAAGATAAGCCTGAGTACTATTAT
GTGTATGCAAAGCTTCCCCAGCAGCTTCAGGAAAAGGGCGATTACTTCAATCAGGCAGACAGCTTACTTGACGTCATGGA
ATTTACAGAGGCTCATTTGAGTGTATTGTTTGTCATATTTATACTTGGTTTTGTGATTACAGCGGGGTATCTGCTGACAG
TTGCCGGAAAACGTGAGGATTCGGAAGAAATTAAATTACGATTATATGACAGGCTGTCGTATGAGGTGATGCTTGGAGTG
ACAATGTTTGCAGACTTTATGGTATTTCCGGCAGGCTTTTTACTTACAAAGCAGCTTCCGGTGGTGGCACTCATTTGTCT
GGCGGCAACCATGGTTTCGCTTGAAGCAATCCTGTCAACATACGTAAGAATCAGGGCACATGAGTTCTGGAAGCATACAC
TGTGCTACTATGTTGTGAGATTTTTCTTAAAGCCTGTCAAAAAGCTATGCAGGATGGTATTTGCTCCAATCAGATACGGC
TTTTCATGGATAGAAAGAAATGTACCGCTGTTTTTGATCAGTATGCTGGCATTCGGCCTTTTATGTCTGCTTGAGCTTAT
AGGCTTTGGCATGGAGCTTATTGGCTTTGTATTTATTATAAAGCTTATAGAGCTTGCGCTGCTTATCACATTCATCATGC
AGTATGACAGGATAAGATGCGCCGCAAAGGCAATAGCAAACGGTGATTTTTCACAGCCGGTTGATACATCAAGACTCATG
CTGTTTTTCAGAAAGCATGGCGAGGATTTGAATAATGTGAGCAATGGAATAGAGGCGGCGGTCTCTGAAAAAATGAAGAG
CGAGCGCTTCAGGACGGAGCTCATCACAAATGTGTCGCATGATATCAAGACACCGCTCACCTCGATTATCAATTATGTGG
ACCTGTTGCAGAAGGAGGACATAGATAACGAGAAGGTACGCGAATATCTTGACGTTCTCGACAGACAGTCATCACGTTTG
AAAAAATTAATTCAGGATTTACTCGAAGCGTCAAAGGCATCTACCGGCAGCATAAATGTAGAACTTGAGGAACTGGATGC
GGCTGTTATGCTGTCACAGGTAGCCGGAGAATACAAAGAAAAATTCGAGAAAAATAATCTTGATTTAATTATCAAAAATG
ACGTTACACCTGTCATGATTCAGGCAGACGGACGACATCTGTGGAGAGTGTTTGATAACCTGATGAACAATATCAACAAA
TACGCCCAGCCGGGTACGAGAGTGTATATTGACATCATTCCAAAGGACAGCGGAGCCATCATAACCTTCAAGAATGTATC
AGCTACACCGCTTAATATCTCAAGCGATGAGCTCAAGGAGCGTTTTGTCAGAGGAGACAGCTCGCGAAATACCGAGGGCA
GCGGACTTGGACTGTCTATTGCAGAAAGTCTCATGAAGCTCATGAATGGTACTTTGGAGCTGACTGTGGACGGTGATCTG
TTTAAGGTGACTCTGGAGTTTTGA

Upstream 100 bases:

>100_bases
TAAAGGTCATCTGGGGTCGCGGATACAAAATTGACGCTGAATAGGTGCATGCTTGATAAAGTTTGTCAAGTGAAGCACTA
TAAAATGGAAGGTGAATGAT

Downstream 100 bases:

>100_bases
GCTTTTTAAAACTATATTATATATTGAACTTATACGACATAAGAAACAACAAAAGCCGGGGCAGATGCCCCGGTCTTTAC
ACGCAAACATTTCAATTGTG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 807; Mature: 807

Protein sequence:

>807_residues
MKKISRNLWLKLAAFIVCSVMAAGLVVTTIVAVYTNNYESTAQLRDEIHANIAGAYSRQMVYNYESGDDNAFSQMMDDTN
LQAAVVKSNETSEDKVDVKSDAAKVYSSVDEISNPDYIFSYKAKNLKWNRLSYLWDAMSGRYEESDDASNNMNSERISSI
MYSKTNGLFYLCLNDGTAYVIPKVRVMTGSNDNSSLGLYKAVEKTDENGNNYFAYEEMFTGQSLDITGFAEWKNVKCYDE
KGNHIKCGMNLSDDGDSRFDSDGSYYDYDEDIYYDSYEIIKVVEQVNESYELLPDTFNISDTGIVYYPYTQTEDKPEYYY
VYAKLPQQLQEKGDYFNQADSLLDVMEFTEAHLSVLFVIFILGFVITAGYLLTVAGKREDSEEIKLRLYDRLSYEVMLGV
TMFADFMVFPAGFLLTKQLPVVALICLAATMVSLEAILSTYVRIRAHEFWKHTLCYYVVRFFLKPVKKLCRMVFAPIRYG
FSWIERNVPLFLISMLAFGLLCLLELIGFGMELIGFVFIIKLIELALLITFIMQYDRIRCAAKAIANGDFSQPVDTSRLM
LFFRKHGEDLNNVSNGIEAAVSEKMKSERFRTELITNVSHDIKTPLTSIINYVDLLQKEDIDNEKVREYLDVLDRQSSRL
KKLIQDLLEASKASTGSINVELEELDAAVMLSQVAGEYKEKFEKNNLDLIIKNDVTPVMIQADGRHLWRVFDNLMNNINK
YAQPGTRVYIDIIPKDSGAIITFKNVSATPLNISSDELKERFVRGDSSRNTEGSGLGLSIAESLMKLMNGTLELTVDGDL
FKVTLEF

Sequences:

>Translated_807_residues
MKKISRNLWLKLAAFIVCSVMAAGLVVTTIVAVYTNNYESTAQLRDEIHANIAGAYSRQMVYNYESGDDNAFSQMMDDTN
LQAAVVKSNETSEDKVDVKSDAAKVYSSVDEISNPDYIFSYKAKNLKWNRLSYLWDAMSGRYEESDDASNNMNSERISSI
MYSKTNGLFYLCLNDGTAYVIPKVRVMTGSNDNSSLGLYKAVEKTDENGNNYFAYEEMFTGQSLDITGFAEWKNVKCYDE
KGNHIKCGMNLSDDGDSRFDSDGSYYDYDEDIYYDSYEIIKVVEQVNESYELLPDTFNISDTGIVYYPYTQTEDKPEYYY
VYAKLPQQLQEKGDYFNQADSLLDVMEFTEAHLSVLFVIFILGFVITAGYLLTVAGKREDSEEIKLRLYDRLSYEVMLGV
TMFADFMVFPAGFLLTKQLPVVALICLAATMVSLEAILSTYVRIRAHEFWKHTLCYYVVRFFLKPVKKLCRMVFAPIRYG
FSWIERNVPLFLISMLAFGLLCLLELIGFGMELIGFVFIIKLIELALLITFIMQYDRIRCAAKAIANGDFSQPVDTSRLM
LFFRKHGEDLNNVSNGIEAAVSEKMKSERFRTELITNVSHDIKTPLTSIINYVDLLQKEDIDNEKVREYLDVLDRQSSRL
KKLIQDLLEASKASTGSINVELEELDAAVMLSQVAGEYKEKFEKNNLDLIIKNDVTPVMIQADGRHLWRVFDNLMNNINK
YAQPGTRVYIDIIPKDSGAIITFKNVSATPLNISSDELKERFVRGDSSRNTEGSGLGLSIAESLMKLMNGTLELTVDGDL
FKVTLEF
>Mature_807_residues
MKKISRNLWLKLAAFIVCSVMAAGLVVTTIVAVYTNNYESTAQLRDEIHANIAGAYSRQMVYNYESGDDNAFSQMMDDTN
LQAAVVKSNETSEDKVDVKSDAAKVYSSVDEISNPDYIFSYKAKNLKWNRLSYLWDAMSGRYEESDDASNNMNSERISSI
MYSKTNGLFYLCLNDGTAYVIPKVRVMTGSNDNSSLGLYKAVEKTDENGNNYFAYEEMFTGQSLDITGFAEWKNVKCYDE
KGNHIKCGMNLSDDGDSRFDSDGSYYDYDEDIYYDSYEIIKVVEQVNESYELLPDTFNISDTGIVYYPYTQTEDKPEYYY
VYAKLPQQLQEKGDYFNQADSLLDVMEFTEAHLSVLFVIFILGFVITAGYLLTVAGKREDSEEIKLRLYDRLSYEVMLGV
TMFADFMVFPAGFLLTKQLPVVALICLAATMVSLEAILSTYVRIRAHEFWKHTLCYYVVRFFLKPVKKLCRMVFAPIRYG
FSWIERNVPLFLISMLAFGLLCLLELIGFGMELIGFVFIIKLIELALLITFIMQYDRIRCAAKAIANGDFSQPVDTSRLM
LFFRKHGEDLNNVSNGIEAAVSEKMKSERFRTELITNVSHDIKTPLTSIINYVDLLQKEDIDNEKVREYLDVLDRQSSRL
KKLIQDLLEASKASTGSINVELEELDAAVMLSQVAGEYKEKFEKNNLDLIIKNDVTPVMIQADGRHLWRVFDNLMNNINK
YAQPGTRVYIDIIPKDSGAIITFKNVSATPLNISSDELKERFVRGDSSRNTEGSGLGLSIAESLMKLMNGTLELTVDGDL
FKVTLEF

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=247, Percent_Identity=28.7449392712551, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1788393, Length=264, Percent_Identity=26.5151515151515, Blast_Score=81, Evalue=3e-16,
Organism=Escherichia coli, GI1789149, Length=231, Percent_Identity=25.974025974026, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI87082128, Length=232, Percent_Identity=28.448275862069, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1786912, Length=238, Percent_Identity=26.4705882352941, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1786600, Length=207, Percent_Identity=26.0869565217391, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1788713, Length=239, Percent_Identity=20.9205020920502, Blast_Score=67, Evalue=6e-12,
Organism=Escherichia coli, GI1787894, Length=232, Percent_Identity=26.7241379310345, Blast_Score=66, Evalue=8e-12,
Organism=Escherichia coli, GI1786783, Length=214, Percent_Identity=25.2336448598131, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 91817; Mature: 91817

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKISRNLWLKLAAFIVCSVMAAGLVVTTIVAVYTNNYESTAQLRDEIHANIAGAYSRQM
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCE
VYNYESGDDNAFSQMMDDTNLQAAVVKSNETSEDKVDVKSDAAKVYSSVDEISNPDYIFS
EEEECCCCCHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEE
YKAKNLKWNRLSYLWDAMSGRYEESDDASNNMNSERISSIMYSKTNGLFYLCLNDGTAYV
EECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCEEE
IPKVRVMTGSNDNSSLGLYKAVEKTDENGNNYFAYEEMFTGQSLDITGFAEWKNVKCYDE
EEEEEEEECCCCCCCCHHHHHHHHCCCCCCCEEEEHHHHCCCCCCEEEECCCCCCEEECC
KGNHIKCGMNLSDDGDSRFDSDGSYYDYDEDIYYDSYEIIKVVEQVNESYELLPDTFNIS
CCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCEECHHHHHHHHHHHCCHHHCCCCCCCCC
DTGIVYYPYTQTEDKPEYYYVYAKLPQQLQEKGDYFNQADSLLDVMEFTEAHLSVLFVIF
CCCEEEECCCCCCCCCCEEEEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ILGFVITAGYLLTVAGKREDSEEIKLRLYDRLSYEVMLGVTMFADFMVFPAGFLLTKQLP
HHHHHHHHHHHEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHH
VVALICLAATMVSLEAILSTYVRIRAHEFWKHTLCYYVVRFFLKPVKKLCRMVFAPIRYG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSWIERNVPLFLISMLAFGLLCLLELIGFGMELIGFVFIIKLIELALLITFIMQYDRIRC
HHHHHCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAKAIANGDFSQPVDTSRLMLFFRKHGEDLNNVSNGIEAAVSEKMKSERFRTELITNVSH
HHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DIKTPLTSIINYVDLLQKEDIDNEKVREYLDVLDRQSSRLKKLIQDLLEASKASTGSINV
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEE
ELEELDAAVMLSQVAGEYKEKFEKNNLDLIIKNDVTPVMIQADGRHLWRVFDNLMNNINK
EHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCHHHHHHHHHHHHHHHH
YAQPGTRVYIDIIPKDSGAIITFKNVSATPLNISSDELKERFVRGDSSRNTEGSGLGLSI
HCCCCCEEEEEEEECCCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHH
AESLMKLMNGTLELTVDGDLFKVTLEF
HHHHHHHHCCCEEEEECCCEEEEEEEC
>Mature Secondary Structure
MKKISRNLWLKLAAFIVCSVMAAGLVVTTIVAVYTNNYESTAQLRDEIHANIAGAYSRQM
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCE
VYNYESGDDNAFSQMMDDTNLQAAVVKSNETSEDKVDVKSDAAKVYSSVDEISNPDYIFS
EEEECCCCCHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEE
YKAKNLKWNRLSYLWDAMSGRYEESDDASNNMNSERISSIMYSKTNGLFYLCLNDGTAYV
EECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCEEE
IPKVRVMTGSNDNSSLGLYKAVEKTDENGNNYFAYEEMFTGQSLDITGFAEWKNVKCYDE
EEEEEEEECCCCCCCCHHHHHHHHCCCCCCCEEEEHHHHCCCCCCEEEECCCCCCEEECC
KGNHIKCGMNLSDDGDSRFDSDGSYYDYDEDIYYDSYEIIKVVEQVNESYELLPDTFNIS
CCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCEECHHHHHHHHHHHCCHHHCCCCCCCCC
DTGIVYYPYTQTEDKPEYYYVYAKLPQQLQEKGDYFNQADSLLDVMEFTEAHLSVLFVIF
CCCEEEECCCCCCCCCCEEEEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ILGFVITAGYLLTVAGKREDSEEIKLRLYDRLSYEVMLGVTMFADFMVFPAGFLLTKQLP
HHHHHHHHHHHEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHH
VVALICLAATMVSLEAILSTYVRIRAHEFWKHTLCYYVVRFFLKPVKKLCRMVFAPIRYG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSWIERNVPLFLISMLAFGLLCLLELIGFGMELIGFVFIIKLIELALLITFIMQYDRIRC
HHHHHCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAKAIANGDFSQPVDTSRLMLFFRKHGEDLNNVSNGIEAAVSEKMKSERFRTELITNVSH
HHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DIKTPLTSIINYVDLLQKEDIDNEKVREYLDVLDRQSSRLKKLIQDLLEASKASTGSINV
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEE
ELEELDAAVMLSQVAGEYKEKFEKNNLDLIIKNDVTPVMIQADGRHLWRVFDNLMNNINK
EHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCHHHHHHHHHHHHHHHH
YAQPGTRVYIDIIPKDSGAIITFKNVSATPLNISSDELKERFVRGDSSRNTEGSGLGLSI
HCCCCCEEEEEEEECCCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHH
AESLMKLMNGTLELTVDGDLFKVTLEF
HHHHHHHHCCCEEEEECCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]